Lab Med and Pathology Research & Discovery Seminar | Kurt Zimmerman, PhD

Using single cell omics to understand macrophage function in polycystic kidney disease
Kurt Zimmerman, PhD
Assistant Professor, Department of Internal Medicine
Division of Nephrology
University of Oklahoma Health Sciences Center
Why Attend this Seminar?
Polycystic kidney disease (PKD) is caused by genetic mutations in cilia related genes and results in large fluid filled cysts throughout the kidney, eventually resulting in end stage kidney disease. Over the last several years, data from our lab and others have shown that macrophages promote PKD. In this seminar, we will present new single cell RNA sequencing data showing that the phenotype (i.e. subsets) and function of macrophages in PKD is highly variable and depends on the rate of cyst progression. Further, we will present data challenging the paradigm that all macrophages promote cyst growth.
Chapters:
0:00 - Introduction by Mariya Sweetwyne
2:52 - Dr. Zimmerman's Presentation
48:41 - Q&A