Andexanet Alfa - Antidote for Factor Xa Inhibitors

#Andexanet_Alfa #Antidote_for_Factor Xa_Inhibitors Description at: johnsonfrancis.org/profession...
Discussion on Andexanet Alfa - Antidote for factor Xa inhibitors.
Andexanet Alfa is a recombinant modified human factor Xa decoy protein, which reverses the effect of factor Xa inhibitors like rivaroxaban by binding to these drugs. It does not have intrinsic catalytic activity.
In other words, it is a modified recombinant inactive form of human factor Xa which bind and sequester factor Xa inhibitor molecules. The drug competes with endogenous factor Xa to bind with factor Xa inhibitors, thus elevating levels of free endogenous factor Xa.