Membranous Nephropathy: New Insights Regarding Pathogenesis

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[@manikantamanish4095]

Excellent. Mind-blowing no words to say how good he explained it 😍😍😘😘

[@Rene-uz3eb]

magnesium fits here also because together with vitamin D it is needed for proper immune regulation preventing autoimmunity, and because kidney disease and magnesium loss go hand in hand. Although it would be more important to address the underlying problem, e.g. sufficient kidney perfusion, I doubt you can absorb enough magnesium by the gut to fully make up for the ongoing losses.
Also in the heart, hypomagnesemia results in membrane thickening too, so you really have several indicators that magnesium is the problem here.
" Culprit medications linked to hypomagnesemia include antibiotics (e.g. aminoglycosides, amphotericin B), diuretics, antineoplastic drugs (cisplatin and cetuximab), calcineurin inhibitors, and proton pump inhibitors."
"Tobacco smoking is a cause of hypomagnesemia in susceptible patients"
Targeting antipla2r directly is probably a good idea too if antibodies can be made that only target these antibodies, but won't fix a magnesium deficiency which will probably have other comorbidities.
19:09 'it takes 9 months for proteinuria to disappear'