@@plowe6751 no I mean b1, there was a case of a boy who was very sickly and when bloods were drawn he had very high b9 and (b12) if I remember correctly. When the drs asked the mother she said she never gave him any b vitamins or specifically b9 and when the drs administered b1 he began feeling better and the b9 and 12 levels reduced. Even b6 requires b1. I'm not a medical professional or trying to give anyone Medical advice but in my personal experience and lots of research this is true.
How do I know if I'm undermethylating or overmethylating? I have very high folate (but not been supplementing), b12 525 but have been supplenting oral cyanocobalamin for years, Hb 126 (trending low), HCT 0.37 (trending low), MCV 94 (trending high), MCH 32 (trending high), Hb 126 (trending low), ferritin 31. The lab doesn't state my level for folate - they just note that it's >45 (the upper limit).I have no terminal ileum but was not aware that oral b12 supplements can raise blood levels but not cell/tissue levels. I have been having low b12 sx for years but developing rapidly worsening neuro sx as well as severe weightloss over the last few years. My Dr says nothing to see here because my serum b12 level is normal. The high folate is strange & I'm worried it's masking some of the cbc markers. Due to the lack of ileum & chronic SIBO from having no ileocaecal valve I'm not sure if I should take folic acid or methylfolate when I can find someone happy to prescribe b12 injections, which are only available as hydroxycobalamin where I live. I gather it depends if you under or over methylate, but I don't know how I'd know this. If I have this genetic polymorphism thing (I'm not sure what you mean by that), will b12 injections of hydroxycobalamin even fix my b12 deficiency??
Have only watched part of video as time and brain enrgery allows, but have been researching more on CBC espec MCH, MCHC and how effected by iron, ferritin, B12 as get symptoms for both but only a few times low Hg. Lately high MCV, but ok MCH and low MCHC. Sometimees think run on adrenaline .
Have had low RBC or WBC on occasion, have currently "high" B12 and folate, but have read that B12 analyzers that use antibodies , a person if have antibodies will cause suspect results! Am guessing my MTHFR snp has turned on as feel problems. Have you ever tried the selfdecode info if works for you?
my homocysteine is 20 umol/L . and i have all the symptoms of decreased methylation that u have mentioned here . what should be my way forward as my life has become a living hell ?
Queen, if you are an under methylator then take the correct form of folate which is Methylfolate and limit the intake of leafy green veggies. If you are an over methylator then you have too much folate in your diet and want to limit that as well.
I have experienced very severe neurological disorders with the use of PPIs. I have the characteristics under methylation _ I learned this with my own research after the disorder_ I can't get rid of paresthesias, especially pins and needles. What can you suggest me about this?thanks thanks
I'm sorry to hear that. We like to use natural forms of vitamins and minerals whenever possible such as organ meats (or organ capsule supplements if you don't like organ meats) and nutrient dense food. Also working with someone to get off the PPI is the biggest thing as you will continue to have poor absorption until you get this corrected and get off the PPI
@@DrewTimmermansND in fact, it may have been a year or a little more before, a gap had formed at the lower end of the left big toe nail, but I did not feel any problems, I consumed a lot of yogurt (in the beginning) with injections, and on the fifth of a monthly injection of B1 ,B6,B12(HYDROXY), the paresthesias started again, and I noticed that the gap had formed again
I would have loved to wait thru all the classroom directed talk and lab jargon in order to get to the “what to do now part” but nope couldn’t do it!
LoL!
The dude in the blue t-Shirt was posting on Instagram during lecture.
hahahah amazing
So how do we solve this?
Methyl donors like SAMe
Why would i have very very high folate in blood but don't take folate!!
There can be a multitude of reasons dealing with folate metabolism. Wouldn't be able to know without doing a medical workup
@@DrewTimmermansND thx
@@plowe6751 no I mean b1, there was a case of a boy who was very sickly and when bloods were drawn he had very high b9 and (b12) if I remember correctly. When the drs asked the mother she said she never gave him any b vitamins or specifically b9 and when the drs administered b1 he began feeling better and the b9 and 12 levels reduced.
Even b6 requires b1.
I'm not a medical professional or trying to give anyone Medical advice but in my personal experience and lots of research this is true.
Quite hard to find any information on LOW HOMOCYSTEINE levels. Im sitting at 1.1.... All you hear about is high homocysteine.
How do I know if I'm undermethylating or overmethylating? I have very high folate (but not been supplementing), b12 525 but have been supplenting oral cyanocobalamin for years, Hb 126 (trending low), HCT 0.37 (trending low), MCV 94 (trending high), MCH 32 (trending high), Hb 126 (trending low), ferritin 31. The lab doesn't state my level for folate - they just note that it's >45 (the upper limit).I have no terminal ileum but was not aware that oral b12 supplements can raise blood levels but not cell/tissue levels. I have been having low b12 sx for years but developing rapidly worsening neuro sx as well as severe weightloss over the last few years. My Dr says nothing to see here because my serum b12 level is normal. The high folate is strange & I'm worried it's masking some of the cbc markers. Due to the lack of ileum & chronic SIBO from having no ileocaecal valve I'm not sure if I should take folic acid or methylfolate when I can find someone happy to prescribe b12 injections, which are only available as hydroxycobalamin where I live. I gather it depends if you under or over methylate, but I don't know how I'd know this. If I have this genetic polymorphism thing (I'm not sure what you mean by that), will b12 injections of hydroxycobalamin even fix my b12 deficiency??
What is the software shown at 7:00 and is it possible for anyone with their raw genetic data from 23andme to use this software? Thanks
This is the Functional Genomic Analysis Software, which is only available for physicians. You can find them online
@@DrewTimmermansND Amazing, thank you Drew.
Have only watched part of video as time and brain enrgery allows, but have been researching more on CBC espec MCH, MCHC and how effected by iron, ferritin, B12 as get symptoms for both but only a few times low Hg. Lately high MCV, but ok MCH and low MCHC. Sometimees think run on adrenaline .
Have had low RBC or WBC on occasion, have currently "high" B12 and folate, but have read that B12 analyzers that use antibodies , a person if have antibodies will cause suspect results! Am guessing my MTHFR snp has turned on as feel problems. Have you ever tried the selfdecode info if works for you?
my homocysteine is 20 umol/L . and i have all the symptoms of decreased methylation that u have mentioned here . what should be my
way forward as my life has become a living hell ?
What do you mean by changing diet?
Like do something different with your nutritional choices
@@DrewTimmermansND duh
@@DrewTimmermansND more specifically?
Queen, if you are an under methylator then take the correct form of folate which is Methylfolate and limit the intake of leafy green veggies. If you are an over methylator then you have too much folate in your diet and want to limit that as well.
@@royedwards51 what about sam-e supplementation?
I have experienced very severe neurological disorders with the use of PPIs.
I have the characteristics under methylation _ I learned this with my own research after the disorder_
I can't get rid of paresthesias, especially pins and needles.
What can you suggest me about this?thanks thanks
I'm sorry to hear that. We like to use natural forms of vitamins and minerals whenever possible such as organ meats (or organ capsule supplements if you don't like organ meats) and nutrient dense food. Also working with someone to get off the PPI is the biggest thing as you will continue to have poor absorption until you get this corrected and get off the PPI
@@DrewTimmermansND I only used it for 10 days, it was the summer of 2021 ,could this be the cause of paresthesias? how long can the effect last ? ☹
Unlikely the cause as your body would have restored levels if they became deficient (which they likely didn't with only 10 days of use)
@@DrewTimmermansND in fact, it may have been a year or a little more before, a gap had formed at the lower end of the left big toe nail, but I did not feel any problems, I consumed a lot of yogurt (in the beginning) with injections, and on the fifth of a monthly injection of B1 ,B6,B12(HYDROXY), the paresthesias started again, and I noticed that the gap had formed again
Is it possible to book a consultation with you?