HRCT: Centrilobular Disease

In this presentation titled "HRCT: Centrilobular Disease," Dr. David Naidich from NYU discusses the anatomical and pathological correlations of centrilobular disease on CT scans. He begins by explaining the basic anatomy of the lung and introduces the concept of secondary lobules. Dr. Naidich then focuses on centrilobular structures and describes how changes in these structures can indicate abnormalities. The three main signs of centrilobular disease include poorly defined ground glass nodules, punched-out lucencies around centrilobular arteries, and tree and bud branching opacities. Dr. Naidich illustrates these findings with CT images and discusses differential diagnoses, emphasizing the importance of recognizing specific patterns for accurate diagnosis, particularly in differentiating centrilobular disease from other conditions like hypersensitivity pneumonitis and respiratory bronchiolitis associated with smoking.