Key terms related to validation of an analytical method
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- Опубліковано 20 вер 2024
- Accuracy: The closeness of the measured value to the true value.
Precision: The closeness of repeated measurements to each other.
Linearity: The ability of the method to produce results that are directly proportional to the concentration of the analyte.
Limit of Detection (LOD): The lowest concentration of an analyte that can be reliably detected.
Limit of Quantitation (LOQ): The lowest concentration of an analyte that can be reliably measured and quantified.
Robustness: The ability of the method to remain unaffected by small variations in experimental conditions.
Specificity: The ability of the method to accurately measure the analyte in the presence of interfering substances.
Selectivity: The ability of the method to distinguish the analyte from other components in the sample.
Repeatability: The precision obtained when a method is repeated under the same conditions.
Reproducibility: The precision obtained when a method is repeated by different analysts, instruments, or laboratories.
Recovery: The percentage of the analyte that is accurately measured after being added to a sample.
Matrix effect: The interference caused by the sample matrix on the measurement of the analyte.
Calibration curve: A plot of measured values against known concentrations used to quantify the analyte in a sample.
Internal standard: A compound added to the sample in a known concentration to correct for variations in sample preparation and analysis.
Blank: A sample that does not contain the analyte, used to assess background interference.
Spike recovery: The percentage of the analyte that is accurately measured after being added to a sample at a known concentration.
System suitability: The evaluation of the analytical system to ensure it is functioning properly before sample analysis.
Validation parameters: The characteristics evaluated during method validation to ensure the method is fit for its intended purpose.
Performance characteristics: The attributes of an analytical method that determine its suitability for a specific application.
Analytical method validation: The process of demonstrating that an analytical method is suitable for its intended purpose through a series of experiments and evaluations.
#analytical chemistry, #validation , #methodvalidation , #accuracy #precision #linearity #LOD #LOQ, #robustness, #specificity, selectivity, repeatability, #reproducibility, recovery, matrix effect, calibration curve, internal standard, blank, spike recovery, system suitability, performance characteristics.
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