De Novo Purine Synthesis | USMLE Step 1 Biochemistry Mnemonic
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- Опубліковано 29 гру 2018
- De novo purine synthesis refers to the biochemical pathway that creates purine nucleotides from simple molecules. This is in contrast to purine salvage, in which purines nucleotides are recycled after partial degradation.
First, de novo purine synthesis starts with the precursor molecule R5P (ribose-5-phosphate). R5P is then converted to its high energy, "activated" form, PRPP. Since PRPP is high energy, it allows the transfer of phosphoribosyl groups (such as R5P). In de novo purine synthesis, it is this R5P from PRPP that forms the pentose sugar of the eventual purine nucleotide.
Next, PRPP undergoes additional reactions that require aspartate, glycine, THF, glutamine, and others. It is these steps that convert PRPP to IMP (inosine monophosphate), the purine precursor molecule. The conversion of PRPP to IMP can be inhibited by the drug 6-MP (6-mercaptopurine) as well as by its prodrug azathioprine.
Next, IMP can be converted to either AMP (adenosine monophosphate) or GMP (guanine monophosphate). The former reaction is especially important, as a couple drugs can be used at this step. The drugs mycophenolate and ribavirin inhibit the enzyme IMP dehydrogenase, which converts IMP to GMP.
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OMG!!!! Best video I have watched thus far on purine synthesis. straight to the point and very catchy. Thank youu!!!!
Thank you Jennifer!
This is amazing and you really help me cultivate a lot of interest in biochemistry. God bless and love from Kenya!
Wow. That was absoloutely magnificent how you connected them all together!
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I lack the vocabulary to describe how thankful I am✨
. From 🇸🇦
Thanks so much, bro. its the first time I see wonderful explanation of biochemistry in this creative way.
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What!!!!!!!!!!! I spent all day learning this pathway and I'm currently at step 7 but you just made me understand this waaaaaaaaaaaaaaaay way better. I must ace my test tomorrow. MUST!
Great!❤️❤️❤️one thing I hope u add is the mnemonics in the last pic as summary (each words with its link) so we can screenshot and revise it later👍🏻
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true but still accredited to sketchy
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Thanks Tshegofatso! We appreciate your support.
Great video, but.... Why the pron music? I keep waiting for the enzyme to offer to fix the copy machine.
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Thanks! 🙌
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Glad you like it!
Thank you for your efforts. Wish you all the best. Keep up the great work!
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Thank you Maryam!
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Love from 🇮🇳
2nd prof?
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Awesome vid!
This is both the denovo and the salavage pathway!
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I do have a request, if you could do Series of videos for all vitamins and their deficiencies please
Hi Shaily, thanks for the feedback! You can find our mnemonics for all vitamins and their deficiencies at pixorize.com!
Wow
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I wish I found this sooner! It takes me ages and still struggle to remember this, and take under 10 min to forever remember this from watching this video
Thanks - yep, it's amazing how our brains are much better at remembering a picture!
absolutelly right
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can you please make one for pyrimidine synthesis?
Best video ever, havingmy exam in 2 hours. Wish me good luck!
We hope your exam went well!!
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Thanks! All good things come with patience :)
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Thanks Darius! We think so too :)
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Thanks Mohd, we appreciate your support!
Tysm
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creative
May God bless you your soul your kids your parents your grand parents your friends your neighbours may you never get hurt by anyone or anything ameen
Are you Muslim
Take a kiss man💋
Also take this award🏆for the best explanation.
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dynamic
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Really fertile imaginations😮😄
Hope tomorrow i pass🙂
Sir pls make videos in eng language
can you make one for pyrimidine synthesis please!
that what i was thinking off
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7 rings❌
Purine rings✅
it more confusing....
Swears
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This story helps me to sleep
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Bla bla bla and skips 11 steps😢
PERFECT!