Molecular Neuroscience: C Elegans

Screening of small molecule inhibitors to interfere with protein aggregation associated with Alzheimer's disease
Alzheimer's disease (AD) is a disorder caused by death of nerve cells (neurons) in the brain, and associated with progressive decline of memory. AD is characterised by the accumulation of amyloid plaques in the brain. C. elegans are small earthworms which can be easily genetically modified to express human genes. Here, we use C. elegans to model this disease and explore potential therapies. We have generated worms which develop amyloid aggregates. The older the worms are, the higher the amyloid aggregation, which then leads to the death of neurons and a decrease in movement. We are currently screening compounds for amyloid anti-aggregation activity. Some treatments have been observed to delay or inhibit aggregation and improve movement, and we are continuing to analyse further ones. We hope to find treatments that can be used in humans to improve brain health and reduce disease symptoms.