HASHIMOTO'S THYROIDITIS: Etiopathogenesis, Morphology & Complications
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- Опубліковано 29 вер 2024
- Hashimoto’s thyroididtis
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Most common cause of hypothyroidism in areas where iodine levels are sufficient.
Gradual thyroid failure due to autoimmune destruction of thyroid gland
Definition:
It is Characterized by
1. Diffuse goitrous enlargement of the thyroid
2. Lymphocytic infiltration of the thyroid gland
3. Presence of thyroid autoantibodies.
Age incidence: 45 - 65yrs.
Male: Female: 1:10 to 1:20
It can occur in children and is a major cause of nonendemic goiter in children.
1. Genetic predisposition.
2. Immune causes: Autoantibody production
3. Environmental factors: In a genetically susceptible individual environmental factors, such as infection, dietary factors (iodine), stress and pregnancy, may initiate autoimmunity in the thyroid.
Genetic predisposition:HLA-DR3 & DR5
Immune causes
Immune Regulatory Genes
[CTLA4, PTPN22]
cytotoxic T lymphocyte-associated antigen-4 (CTLA4)
protein tyrosine phosphatase-22
Thyroid specific genes
(thyroglobulin and thyroid-stimulating hormone [TSH] receptor )
GROSS
-Diffuse enlargement , may be Nodular
- Gland well demarcated
Cut section; Pale, yellow tan, rubbery to firm/nodular
MICRO
Atrophy of the follicles
Diffuse infiltration by mononuclear cells
Formation of lymphoid follicles
Hurthle cell metaplasia
Interstitial connective tissue may be increased
Clinical features : Middle aged women
Painless enlargement
Variable degree of
hypothyroidism
Laboratory findings: T3 & T4 decreased
TSH increased
Antithyroid antibodies
Diagnostic tests: FNAC
HPE of Biopsy
COMPLICATIONS
Hashitoxicosis
B-cell Non Hodgkin Lymphoma
Increased risk for other autoimmune diseases
Diabetes type 1, Adrenalitis, SLE, Myasthenia Gravis..
Increased risk(variable) thyroid epithelial neoplasms.. Papillary Carcinoma
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Please watch: "WARBURG EFFECT: Hallmark of CANCER. What, Why & How?"
• NEOPLASIA 6: WARBURG E...
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Very useful, especially for the part where you described the actual attack on the tyroid tissue. Thank you
autoimmune hashimotos -( low thyroid) is most often caused by (Blastocystis hominis was isolated through a stool microbiologic examination, implicating that this parasite can cause the development of Hashimoto's thyroiditis and chronic urticaria ) and can be cured with ivermectin high dose
Very good explanation indeed.
thnks frm Nepal..very helpful
I very much like your explanation :) Its sad really that you posted so little - you are a great teacher please share it with with the world :)
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Super
💯
Top-notch conceptual correlation and beautifully crafted and articulated session on Hashimotos thyroiditis.
Thank you so much, Sir.
Lots of love ❤️.
18/DEC/2021.
It's from prashant Patel book
I’ve had a thyroid punction test and they found ; Lymfocytaire Thyreoditis. They found a lot of lymfoid cells / macrofagen/ histiocytes. I am feeling very bad and still have to wait to see a specialist in 3 months... Could you tell me what my results mean? And what can be done? Or do I need more blood tests? Thank you in advance 🙏🏻
I hope u r fine now
what are the treatment of hashimoto,s disease
Sir please make more videos on CNS pathology
Sir, Please do make videos on FEMALE REPRODUCTIVE SYSTEM PATHOLOGY. Thank you. 🙏🏻
Have uploaded few..shall be completing in sometime 😊
@@ilovepathologyVijayPatho Sir, Please do it asap before our finals on 19th January 21.
How to cure this naturally permanently
I have Hashimotos and I remembered how I felt when the doctor told me it will be very hard for me to conceive but, all to the glory of GOD that after using DR RORPOPOR HERBAL on UA-cam natural infective herbal medication am a mother of four kids......
@@innocentamaeruchi4845 wow.. thanks sis.. could u pls share the link of the video
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Thank you sir ❤️
Very much helpful thank you bhai
Your videos are good but can you please try to speak little clearly...
Please upload tutorial on graves disease
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Awesome sir 👌🏻 did u made on follicular carcinoma of thyroid
👍👍👍 very efficient for exam point of view👌
Subscribed!!!
U r awesome 👍👍👍
Thanks a lott!
Thanks... Very helpful
Hashimotos thyriditis and left adenoma 32*22mm thyroid gland enlarged. Its major or what
You are ok sir g
Tysm 😊
Thank you sir, very helpful to understand the concept
Best 👍 best 👍 Best
Please post more !
Nice video thx
excellent sir
too good
👍👍👍👍
Is this curable or not?
Sir ur videos are really helpful...why dont u make more sich videos??
Very useful.
Is it safe to take the covid vaccines if you have Hashimotos?
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No. That injection isnt safe.