Factors Shifting Oxygen Hemoglobin Dissociation Curve

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Video Summary:
It's recommended that you watch the first video on oxygen hemoglobin dissociation curve before starting this video. All the basic are covered in that video. In this video we are focusing on the shift in oxygen hemoglobin dissociation curve. This video is in two parts. First I have mentioned how the binding of oxygen with hemoglobin is affected with shift in the curve. Here I have avoided siting any examples. Then in second part, we will see factors that shift the curve. Here we have increased temperature, carbon dioxide, hydrogen ion and 2,3 DPG which shift the curve to left. Shift in curve to right by increased carbon dioxide and hydrogen is also called Bohr's effect. It helps deliver more oxygen to tissues. 2,3 DPG level is increased in hypoxia and it helps in adaptation to it. Carbon monoxide shifts the curve to left. It increases affinity of hemoglobin so much that hemoglobin don't release oxygen at peripheral sites, depriving the tissue of oxygen.
🎞More videos on Respiratory Physiology:
● Transport of Gases
- Oxygen Hemoglobin Dissociation Curve: • Oxygen Hemoglobin Diss...
- Factors Shifting Oxygen Hemoglobin Dissociation Curve: • Factors Shifting Oxyge...
- Oxygen Hemoglobin Dissociation Curve during Exercise: • Oxygen Hemoglobin Diss...
- Transport Of Carbon Dioxide: • Transport of Carbon Di...
- Carbon Dioxide Dissociation Curve: • Carbon Dioxide Dissoci...
- Haldane Effect: • Haldane Effect in Tran...
● Lung Mechanics
- Alveolar Pressure and Pleural Pressure: • Alveolar Pressure and ...
- Surface Tension in Lung Alveoli: • Surface Tension in Lun...
- Surfactants Mechanism of Action: • Surfactants Mechanism ...
- Functions of Surfactants: • Functions of Surfactan...
- Compliance of Lungs: • Compliance of Lungs
- Diseases Affecting Lung Compliance: • Diseases Affecting Lun...
• Ventilation & Dead Spaces in Respiratory Tract: • Ventilation & Dead Spa...
• Lung Volumes and Capacities: • Lung volumes and capac...
• What Determines Lung Volume?: • What Determines Lung V...
00:00 Introduction
00:21 What a shift means
02:38 Factors shifting the curve
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DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorised websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.

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[@prof.dr.habibrehman7354]

One of the best clip I would say even clear my concept. Congratulation for making so much informative video along with learning materials in a very short time

[@NonstopNeuron]

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[@arshithgowda8728]

@@NonstopNeuron sir does the dissolved O2 perfuse tissues

[@arshithgowda8728]

I mean unbounded oxygen with hemoglobin

[@adityamane7084]

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[@NonstopNeuron]

Thank you Aditya. The motto is to make medical education as easy as watching cartoons. Hope we succeed. 😊

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Highly appreciated .very easy to understand in such short time

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Excellent description

[@NonstopNeuron]

Thanks!

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[@NonstopNeuron]

That’s exactly the goal of my work “to make the medical education as easy as watching cartoons”. So such complements mean a lot. If you are enjoying it and want to support, please share the videos with all your friends and colleagues too. Thank you.😊

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[@NonstopNeuron]

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[@NonstopNeuron]

Most welcome. Please share the video. We need your support. Thank you 😊

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[@NonstopNeuron]

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Thank you sir.

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Wonderful explanation

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thanks a lot, this is the best vid i v seen about this topic

[@NonstopNeuron]

Welcome 😊

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Thank you so much sir 😊

[@s.rishteee]

Thank you so so much sir but🤍 ......is that much detailed questions comes under NEET or cbse board papers ?

[@medicinskomail9376]

Very good but the example with CO is not the best choice since CO also shifts the curve down... Better example is Fetal hemoglobin ...

[@UPHROSHAN]

Thanks a lot for this video

[@NonstopNeuron]

Most welcome 😊

[@showkathkp3506]

Thanku.. For ur wonderful explanation☺️❤️

[@NonstopNeuron]

My pleasure 😊

[@ghostoflego3390]

Sir i have a doubt. You say that carbon monoxide increases affinity for oxygen in haemoglobin. But isnt carbon monoxide itself suppose to attach with haemoglobin( forming carboxyhaemoglobin ) and prevent oxygen combining.

[@NonstopNeuron]

I will have to re-check the textbooks I referred.

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[@NonstopNeuron]

Most welcome

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[@abdulrahmansyed7608]

Do partial pressure of O2 affects the shifting of curve

[@NonstopNeuron]

the curve is recorded at different pressure of O2 itself. The partial pressure is fundamental factor to produce the curve whether shifted or not. Then we study effect of different factors how they affect O2 saturation at different partial pressures. I hope you are getting it.

[@user-rx5zd2um3g]

First time I have fully understood this. I guess that’s why they say to read Ganong but in reality med students chose to learn from other books which are less time consuming but skip on the core concept making.

[@NonstopNeuron]

I am glad it helped 😊

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❤

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Very nice sir. Per bht fast h..

[@NonstopNeuron]

Fast speed is deliberate so that you can revise quickly. Still you can use speed control feature of UA-cam as per your confirt.

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