The “objection “ fails to understand or oblivious to a very basic (foundational ) concept in peripheral (vs. Lungs) tissue oxygenation; the Bohr-Haldane Effect. ..basic science 101 (physiology), anyone?😊
Wow, how is fMRI meaningful at all as a measure of brain activity? I seem to have missed that part😅 By definition neuronal firing (down its axon); APs , like EPSP, ISPS? Even if you summate and average all dendritc inputs in a particular region, if that’s all it can do , does not tell us neuronal firing or brain activity in any meaningful sense, not even remotely close. And big medical institutions use/rely on fMRI to confirm brain activity or not to pull the plug on someone. So depressing
i see you are asking how fMRI is meaningful but then you answer your question by saying that it cannot tell us anything meaningful about neural activity. is there something you would suggest we use instead? is there a reason you think that measures of neural activity besides specific IPSPs and EPSPs are meaningless? would you be open to changing your mind if i gave you a more specific example which satisfies your definition of a meaningful metric? genuinely curious, you seem to really know what you're talking about!
Great talk
The “objection “ fails to understand or oblivious to a very basic (foundational ) concept in peripheral (vs. Lungs) tissue oxygenation; the Bohr-Haldane Effect. ..basic science 101 (physiology), anyone?😊
Wow, how is fMRI meaningful at all as a measure of brain activity? I seem to have missed that part😅 By definition neuronal firing (down its axon); APs , like EPSP, ISPS? Even if you summate and average all dendritc inputs in a particular region, if that’s all it can do , does not tell us neuronal firing or brain activity in any meaningful sense, not even remotely close. And big medical institutions use/rely on fMRI to confirm brain activity or not to pull the plug on someone. So depressing
i see you are asking how fMRI is meaningful but then you answer your question by saying that it cannot tell us anything meaningful about neural activity. is there something you would suggest we use instead? is there a reason you think that measures of neural activity besides specific IPSPs and EPSPs are meaningless? would you be open to changing your mind if i gave you a more specific example which satisfies your definition of a meaningful metric? genuinely curious, you seem to really know what you're talking about!