The little roots are pseudopods. They are projections of the cell surface membrane that the cell uses to make contact with other cells. Depending on the cell type, they can help the cell move around or contact another cell before binding to it to make a sheet of cells. Because this is a time lapse film, the pseudopods look very frantic. In real time they are projected quite slowly and cells move around slowly so appear to be quite static. Hela cells are a type of cancer cell and like all cancers are quite mobile. That is why cancer cells are dangerously invasive in life. Epithelial cells will tend to form rather stable sheets of cells and will not move very far. A single cell in isolation is a rather unnatural state fro any cell so they will tend to throw out pseudopods looking for a neighbour. These can attach to a substrate and if pull the cell about so that it moves in the direction that creates the most pseudopods..
Yes. Some cells like Monocytes move a little like amoebae but cancer cells are ..well.. cancer cells! They do not all crawl about but simply grow and divide uncontrollably in one place. Hence a tumour.
Idk if you're still answering questions, but how do they give nutrients to the cells for them to divide like that? Is it a solution they're in that give the cells enough resources to continually divide? Thanks in advance.
The cell rounds up prior to dividing and then the two daughter cells flatten out again and start growing. Each cell will divide approximately every 24hrs. This movie has been sped up so that each second of playback represents about 20 minutes in real time.
David Barlow Is there any footage available to demonstrate movement in real time? I have noticed a phenomenon using my Iphone6plus at 10X magnification. If I take a picture at full mag.; and watch the still picture image; it shows activity that continues on. Any idea how?
The cells are cells are already growing in a n optimum medium and temperature. Changes up or down in either tend to slow the process rather than increase it. Since the process is exponential ( 2,4 8,16,32 etc) it is rally rather quick. Bacteria are a lot faster. Some will divide every twenty minutes (see video of Lactobacillus growing). that is why bacterial infections can be overwhelming if allowed to go unchecked.
The microscope is an Olympus IX81 inverted microscope using phase contrast optics and false colour processing with a digital camera. The magnification of the objective lens was X40. There is another magnification factor for the camera adapter but I am not sure exactly what that is. I think it might be x2 but not certain without checking.
Y'know, I used to hate learning about cells in middle school. But after reading 7 chapters of *The Immortal Life of Henrietta Lacks* I got interest real quick.
Well it only takes it about 20 minutes to pull apart and about an hour for the whole division process. The other 23 hours are spend growing in size. You can see that it is the biggest cells that divide. Cells that have just divided are a lot smaller than ones that have been growing for a while prior to division.
Scary in a way. Imagine an entire lifeform with stem cells based off the HeLa template instead of just regular ol' stem animal cell. Or any cell based on a mutation from a smidgoen of any viral DNA piece added due to good ol fashioned covalent bond or whatever it is.
Imagine if you will. if what we saw right now, were not cells in a Petri-dish, but the very universe itself. what if, the rounding of the cell, is like the collapse of the universe just before a Big Bang. then the universe divides & expands as the big bang. Thus allowing the formation of the Multiverse. after each successive big bang. at some level if felt i was looking at the universe as god, & at the same time it also felt as if i was looking at god. -A woman who died of cervical cancer at the age of 31, still lives & you & i just saw her. i am agnostic, but what i see does seem miraculous in a way as Immortal cell lines in human's have not been replicated with such potency. i think bacterial cell lines are preferred now. But thanks to ethical considerations in research atleast The Henrietta lacks family can acknowledge our gratitude. Thank you Henrietta lacks, for being who you are. am immortal super human, that saved more lives than any human combined. (hpv 18 consideration is needed, it could be the source from Hela lines)
Well said.... Indeed, as I often say, a cell is a universe in itself. In many ways, the boundary of what we call universe is limited by our own limits of perception
Jim Bob I have thought about the same thing in your reply many times myself. I have a theory of what I call "Life in the Rabbit Hole: Always Alive Thru Infinitely Bigness and Infinitely Smallness".....basically the point is this....ask yourself, "Do these cells/mitochondria/microscopic organisms(just living objects in general), living in that world or scale of this world, are they actually aware that they are living on/in another bigger organism(humans) who is living it's own life not paying any attention to these microscopic organisms on our bodies?" No. I am sure they only are aware of things happening on their scale of life. Things they can actually affect. Well maybe that goes for us as well. Maybe the earth is the equivalent to an atom or maybe a blood cell of sort. Maybe something similar. And what we call space is actually equivalent to blood or plasma or some bodily fluid. In fact maybe black holes are where this fluid is being drawn up in a syringe or maybe just being used by the body of the larger organism that our scaled universe is part of. Maybe we are just floating around inside one cell or maybe inside the body of an organism. In fact if you look at humans in this manner, you see we are consumers. We are VERY much like parasites. We thrive on our host and it's resources. We TRY to live in harmony with our host in order to insure our survival and make sure our species reproduces and continues on. Which seems to be the meaning of life in all forms of life...survival and to pass on genes. Survive and sex. Lol. But just as parasites, we will eventually kill our host as we grow too needy and use up all the hosts resources. Which we will have to find a way to transfer to a new host or adaptation will give up on us and we will have grown as far as possible and slowly become extinct. Makes since when you look at it. Also maybe our microscopic organisms have smaller organisms on them in our situation. And maybe the organism we live on/in is only the microscopic organism of another larger organism. And on and on and Infinitely Big and Infinitely Small. Blows my mind. And yes I was really high on marijuana when I thought this up. Lol. To my surprise it was already sort of a thought that already existed. Lol. Not entirely the same, but really similar. Look at the second Men in Black film. At the end they realize they live in a locker in a bigger universe.
what is the cell collecting/intaking im pretty sure if you fed the cells a concentrated form of "that" it would speed the process of multiplying by alot
Hi David - I am producing a documentary for the BBC about Henrietta Lacks and would love to use this video in the piece. Do you have an email address or other way I could best contact you about this? Thanks, Dan
I have read that cancer cells need constant energy to grow, like blood, glucose and other important stuffs, but the question is there is no power supply for this one, how this one is growing, is there is something called DNA teleportation where it is taking energy from all human body bits by bits and leaving biomarks for cancer malignancy
someday all truths will be revealed. if you succeed in cheating someone, don't think that the person is a fool. realiize that the person trusted you much more than you deserved.
The little wiggly lines are pseudopods. These are temporary projections of the cell membrane filled with a thin layer of the celll's internal cytuplasm. They appear to be moving quickly in this video because it is a time lapse sequence which has speeded up the action a lot. However, you can see the projections moving slowly when you observe the cells in real time. The cells obtain energy from nutrients provided in the blood and cconverted into energy within the cell itself. In this sequence the cells are bathed in a nutrient solution which contains, amongst other things, glucose to provide an energy source.
There are nutrients in the medium in which they are growing. This simulates the conditions in the body where nutrients, carried around in the blood, leak from capillaries and bathe all the cells to provide all the necessary oxygen and nutrients
The cells do die especially if they run out of nutrients, so colonies do not grow forever. In the lab that would not happen anyway. However, that is why cancers can kill you. If they grow untreated then they produce so much mass in your body that the cancer cells disrupt the normal operation of the organs and the body will eventually fail.
This isn't the cell reproduction pattern I learned about in biology... I've seen videos of other animal cells dividing and this just looks completely different from the other ones.
There are a number of factors that can make things appear different. Division in plant cells is the same but looks different because plant cells have a rigid cell wall that holds the cell in shape. This makes the process of division and the separation of the chromosomes much clearer to watch. Animal cells are very flexible and so can round up when they divide. This often makes the chromosomes lining up and pulling apart less clear but they are still there.You can see it here as black bars separating just before the first cell division. The other factor is what the shot is showing. Here we are trying to emphasise the way cancer cells proliferate. You are watching a series of divisions over about a week in a few seconds but the separation of the chromosomes actually only takes about 20 minutes so that looks quite fast at this time lapse rate and is easy to miss. Free cells like HeLa cells, tend to have a more amoeboid look with all sorts of bulges and spikes developing that look frantic when sped up but in real time are quite slow.
Also, these are cancer cells and will look different to a normal cell. However, the process of cell division is the same but just uncontrolled and rapid. That is what makes a cancer cell dangerous.
Yes many cells throw out pseudopods when in cell culture. In a body they would all be in close contact and the projections are kept squashed in. When a sheet of cells become continuous , the pseudopods are less prominent. The pseudopods are the way cells detect other cells around them.
Well yes. HeLa cells were originally harvested from a cervical tumour which is a multi cellular organ of the body (the cervix not the tumour). HeLa are one of many model systems that are now used in cancer and other cellular research. If left in a sterile dish with enough nutrients, HeLa will proliferate into a large sheet of cells.
No. All cells require very controlled and precise conditions to survive. Hela cells are from a human and so will only grow in the conditions found in the human body. It is also very difficult for cells from one human to infect another because of our immune systems which are very good at detecting and destroying anything foreign.
so are heLa cells still considered human cells? they have a lot more chromosomes than normal human cells and their highly mutated. ....and their purple for some reason.
Wow. Those cancer cells are prolific. One could have only imagined the pain that she endured.
The footage is sped up so it was bad just not that bad
The little roots are pseudopods. They are projections of the cell surface membrane that the cell uses to make contact with other cells. Depending on the cell type, they can help the cell move around or contact another cell before binding to it to make a sheet of cells. Because this is a time lapse film, the pseudopods look very frantic. In real time they are projected quite slowly and cells move around slowly so appear to be quite static. Hela cells are a type of cancer cell and like all cancers are quite mobile. That is why cancer cells are dangerously invasive in life. Epithelial cells will tend to form rather stable sheets of cells and will not move very far. A single cell in isolation is a rather unnatural state fro any cell so they will tend to throw out pseudopods looking for a neighbour. These can attach to a substrate and if pull the cell about so that it moves in the direction that creates the most pseudopods..
Thank you for your detailed explanations, it helps to understand what's happening in the video
Yes. Some cells like Monocytes move a little like amoebae but cancer cells are ..well.. cancer cells! They do not all crawl about but simply grow and divide uncontrollably in one place. Hence a tumour.
Idk if you're still answering questions, but how do they give nutrients to the cells for them to divide like that? Is it a solution they're in that give the cells enough resources to continually divide? Thanks in advance.
@@samissa9921 Hi Samissa, yes, that's the case!
What if u inject this cell into normal human are he goanna die?
There should be a live stream of this
several days later the room is filled with hela tumors
@@lcdream4213 lol
The cell rounds up prior to dividing and then the two daughter cells flatten out again and start growing. Each cell will divide approximately every 24hrs. This movie has been sped up so that each second of playback represents about 20 minutes in real time.
It take ONE DAY for a cell to divide? Wow
David Barlow
Is there any footage available to demonstrate movement in real time?
I have noticed a phenomenon using my Iphone6plus at 10X magnification.
If I take a picture at full mag.; and watch the still picture image; it shows activity that continues on.
Any idea how?
The immortal cells of HEnrietta LAcks.
I just got here because of TED-ed
Me too
Me too
10months ago? I watched it just today
That video is a disgrace to all the scientists who dedicated their lives in research...
Same
The cells are cells are already growing in a n optimum medium and temperature. Changes up or down in either tend to slow the process rather than increase it. Since the process is exponential ( 2,4 8,16,32 etc) it is rally rather quick. Bacteria are a lot faster. Some will divide every twenty minutes (see video of Lactobacillus growing). that is why bacterial infections can be overwhelming if allowed to go unchecked.
I like how it turns into a magical orb before dividing
The microscope is an Olympus IX81 inverted microscope using phase contrast optics and false colour processing with a digital camera. The magnification of the objective lens was X40. There is another magnification factor for the camera adapter but I am not sure exactly what that is. I think it might be x2 but not certain without checking.
Y'know, I used to hate learning about cells in middle school. But after reading 7 chapters of *The Immortal Life of Henrietta Lacks* I got interest real quick.
Well it only takes it about 20 minutes to pull apart and about an hour for the whole division process. The other 23 hours are spend growing in size. You can see that it is the biggest cells that divide. Cells that have just divided are a lot smaller than ones that have been growing for a while prior to division.
wow this is dope.. ive been looking for vids showing hela cells dividing, and this is just, so thanks man
It's like the monster at the end of Akira.
Actually kind of scary.
dude this is dope, i cant belive im looking at cells
Those cells are HeLa cell, they are immortal :0
Amazing 3:15 minutes of my life. Thank you Henrietta Lacks
Wow amazing. RIP to the GREAT Henrietta lacks.. i hope her family received some wealth after they used her cells to experiment...
coolkidmars We Didnt
No wealth but Henrietta Lacks has gotten her overdue worldwide recognition and the family now has a say as to what the cells are used for.
coolkidmars She’s kinda still alive.
of course not, they are black like Moses and Samson
Wow this is a really cool video of HeLa cells. Thanks so much for this video.
Scary in a way. Imagine an entire lifeform with stem cells based off the HeLa template instead of just regular ol' stem animal cell. Or any cell based on a mutation from a smidgoen of any viral DNA piece added due to good ol fashioned covalent bond or whatever it is.
wow!! heLa cells in action!
Magnificent!👍
This is beautiful 😍
The first captured immortal human
All so hela sounds like healer
I need some of those cells so I can awaken my Rinnegan
Imagine if you will.
if what we saw right now, were not cells in a Petri-dish, but the very universe itself.
what if, the rounding of the cell, is like the collapse of the universe just before a Big Bang.
then the universe divides & expands as the big bang.
Thus allowing the formation of the Multiverse. after each successive big bang.
at some level if felt i was looking at the universe as god, & at the same time it also felt as if i was looking at god.
-A woman who died of cervical cancer at the age of 31, still lives & you & i just saw her.
i am agnostic, but what i see does seem miraculous in a way
as Immortal cell lines in human's have not been replicated with such potency.
i think bacterial cell lines are preferred now.
But thanks to ethical considerations in research atleast The Henrietta lacks family can acknowledge our gratitude.
Thank you Henrietta lacks, for being who you are. am immortal super human, that saved more lives than any human combined.
(hpv 18 consideration is needed, it could be the source from Hela lines)
Well said.... Indeed, as I often say, a cell is a universe in itself. In many ways, the boundary of what we call universe is limited by our own limits of perception
Jim Bob I have thought about the same thing in your reply many times myself. I have a theory of what I call "Life in the Rabbit Hole: Always Alive Thru Infinitely Bigness and Infinitely Smallness".....basically the point is this....ask yourself, "Do these cells/mitochondria/microscopic organisms(just living objects in general), living in that world or scale of this world, are they actually aware that they are living on/in another bigger organism(humans) who is living it's own life not paying any attention to these microscopic organisms on our bodies?" No. I am sure they only are aware of things happening on their scale of life. Things they can actually affect. Well maybe that goes for us as well. Maybe the earth is the equivalent to an atom or maybe a blood cell of sort. Maybe something similar. And what we call space is actually equivalent to blood or plasma or some bodily fluid. In fact maybe black holes are where this fluid is being drawn up in a syringe or maybe just being used by the body of the larger organism that our scaled universe is part of. Maybe we are just floating around inside one cell or maybe inside the body of an organism. In fact if you look at humans in this manner, you see we are consumers. We are VERY much like parasites. We thrive on our host and it's resources. We TRY to live in harmony with our host in order to insure our survival and make sure our species reproduces and continues on. Which seems to be the meaning of life in all forms of life...survival and to pass on genes. Survive and sex. Lol. But just as parasites, we will eventually kill our host as we grow too needy and use up all the hosts resources. Which we will have to find a way to transfer to a new host or adaptation will give up on us and we will have grown as far as possible and slowly become extinct. Makes since when you look at it. Also maybe our microscopic organisms have smaller organisms on them in our situation. And maybe the organism we live on/in is only the microscopic organism of another larger organism. And on and on and Infinitely Big and Infinitely Small. Blows my mind. And yes I was really high on marijuana when I thought this up. Lol. To my surprise it was already sort of a thought that already existed. Lol. Not entirely the same, but really similar. Look at the second Men in Black film. At the end they realize they live in a locker in a bigger universe.
haa so stoned reAding this right now and yea makes ya think alright
i like how you threw in the movie ref, haven;t seen that one but i get it
man you guys are sooo stoned lmao
This woman is amazing, she’s still alive…
What type of microscope and what magnification are you using?
what is the cell collecting/intaking im pretty sure if you fed the cells a concentrated form of "that" it would speed the process of multiplying by alot
Can we please get a 24 hour livestream of this?
Are the black spots in the middle of the cells multiple nuclei?
how do you grow it?
does it just duplicate on it's own with the right temperature?
or do you feed it something somehow?
love it, make more!
And what microscopy did you use to record this?
So fascinating
crazy to see this happening in
Awesome, what kind of microscope was used?
Amazing!
Legendary.
1:26 Its so powerful the entire earth will become a big hela full of cells!
Класное видио. Теперь ясен процесс роста цилул. Спасибо за видос
Hela cells: let's multiply *turns into a magical light orb
Hi David - I am producing a documentary for the BBC about Henrietta Lacks
and would love to use this video in the piece. Do you have an email
address or other way I could best contact you about this? Thanks, Dan
If you go to davidbarlowarchive.com you can find contact details for my agent there. Thank you for your interest.
I that real time? or fast forward?
I have read that cancer cells need constant energy to grow, like blood, glucose and other important stuffs, but the question is there is no power supply for this one, how this one is growing, is there is something called DNA teleportation where it is taking energy from all human body bits by bits and leaving biomarks for cancer malignancy
someday all truths will be revealed. if you succeed in cheating someone, don't think that the person is a fool. realiize that the person trusted you much more than you deserved.
how are this related to Hela cells?
that was random
wow okay...
accurate and needed
I knew what you were saying!
What are all those root-like parts of the cell?
Cilia?
Nope that's pseudopod
Huh. So that’s what they look like... They’re almost combined together, like they never fully separated. I don’t know what to think.
How many days did it take to make this?
Inspirational
Where are they getting energy for the cell division? Are they kept in some kind of nurturing medium
Either oxygen or a glucose source.
Awesome 😱😱
Living legacy
This content is just... _cancer_
literally if you can't tell its a joke.
Cancer? You can know know if it divides really rapidly
@@lightingdragonstar1238He is talking about Henrietta Lacks
@@lightingdragonstar1238 its cancer but special
LOOLLL xD
That joke was Hela good
Ok. I’ll leave.
Where did you get them
So awesome so fast
So crazy!
guys we did it we saw our cell glow by looking into HeLa and how they dividing which is just immortal human cells
Wow. What are the wiggling lines on the outside of the cell? And where do the cells get the energy from to continuously divide?
The little wiggly lines are pseudopods. These are temporary projections of the cell membrane filled with a thin layer of the celll's internal cytuplasm. They appear to be moving quickly in this video because it is a time lapse sequence which has speeded up the action a lot. However, you can see the projections moving slowly when you observe the cells in real time. The cells obtain energy from nutrients provided in the blood and cconverted into energy within the cell itself. In this sequence the cells are bathed in a nutrient solution which contains, amongst other things, glucose to provide an energy source.
@@davidbarlowarchive thank you
Where do HeLa cells get the mass required to divide? Do they eat something? Or is there some kind of nutrient source available to them?
There are nutrients in the medium in which they are growing. This
simulates the conditions in the body where nutrients, carried around in
the blood, leak from capillaries and bathe all the cells to provide all
the necessary oxygen and nutrients
David Barlow i have so many quecions... if they keep on duplicate, will they eat the universe soon or what?
The cells do die especially if they run out of nutrients, so colonies do not grow forever. In the lab that would not happen anyway. However, that is why cancers can kill you. If they grow untreated then they produce so much mass in your body that the cancer cells disrupt the normal operation of the organs and the body will eventually fail.
It looks like stars fusing but the opposite😍
RIP HL.
Cant imagine how many mutations are on those cells
Is this in real time?
How the hell can I recreate this in Cell Lab?
Where do hela cells get energy to multiply
They’re cancer cells. They can’t stop multiplying. Think of the Tribbles from Star Trek.
whats the time scale?
This is so crazy to look st
So the cells are not round,
perfeito
This isn't the cell reproduction pattern I learned about in biology... I've seen videos of other animal cells dividing and this just looks completely different from the other ones.
There are a number of factors that can make things appear different. Division in plant cells is the same but looks different because plant cells have a rigid cell wall that holds the cell in shape. This makes the process of division and the separation of the chromosomes much clearer to watch. Animal cells are very flexible and so can round up when they divide. This often makes the chromosomes lining up and pulling apart less clear but they are still there.You can see it here as black bars separating just before the first cell division. The other factor is what the shot is showing. Here we are trying to emphasise the way cancer cells proliferate. You are watching a series of divisions over about a week in a few seconds but the separation of the chromosomes actually only takes about 20 minutes so that looks quite fast at this time lapse rate and is easy to miss. Free cells like HeLa cells, tend to have a more amoeboid look with all sorts of bulges and spikes developing that look frantic when sped up but in real time are quite slow.
Also, these are cancer cells and will look different to a normal cell. However, the process of cell division is the same but just uncontrolled and rapid. That is what makes a cancer cell dangerous.
Does it re collapse after dividing ?
Nope
They turn into a circle to divide!
I don’t get it. Hela comes from human cell but they have pseudopod? Compressed timeline of cell evolution?
Yes many cells throw out pseudopods when in cell culture. In a body they would all be in close contact and the projections are kept squashed in. When a sheet of cells become continuous , the pseudopods are less prominent. The pseudopods are the way cells detect other cells around them.
David Barlow oh, so in a sense, hela could be multicellular?
Well yes. HeLa cells were originally harvested from a cervical tumour which is a multi cellular organ of the body (the cervix not the tumour). HeLa are one of many model systems that are now used in cancer and other cellular research. If left in a sterile dish with enough nutrients, HeLa will proliferate into a large sheet of cells.
David Barlow wow, that’s fascinating. I’m curious, tho. Could a HeLa cell perform autolysis?
When they die. Sure.
Wow ❤️
But what if they manage to escape? Wouldn't they just spread indefinitely?
No. All cells require very controlled and precise conditions to survive. Hela cells are from a human and so will only grow in the conditions found in the human body. It is also very difficult for cells from one human to infect another because of our immune systems which are very good at detecting and destroying anything foreign.
I see, thanks for clearing it up for me.
Is it possible to reincarnate Henrietta Lacks??
Idk.. But maybe we can recreate hwr cervix, but only with cancer cells 😬
I think the best part for me initially was from 1:27 to 1:31
This is a amazing discovery! Also can it duplicate allergen cells? It would really help our food economy.
so are heLa cells still considered human cells? they have a lot more chromosomes than normal human cells and their highly mutated. ....and their purple for some reason.
Jeff the bot they came from a human
They were invented by Power Rangers
Do these cells contain the DNA of Henrietta Lacks?
Ya.
Awesome. It's incredible how alien and strange life really is.
After tarun sir?
Yes
"Life... ah, finds a way."
This thing killed her?
Yes and thats a cancer cell.
HENRIETTA LACKS
But, this cells still being humans...? A human body will be cloned from thems...?
Nope, because the number of mutations is way too much to be compatible to that of humans. Also they are cancer cells.
Something out of resident evil
that’s *Hela* Fast
GUYS IF THIS WERE ATTACHED TO THE HEART THEN WE CAN DIVIDE!!!!!
Wtf... Why does it turn into Jesus for 2 secs then become multiplied
it looks like the spiderman virus from spiderman 3
This is how coronavirus started
Congrats you have a child
A mutation in cells
Why is it so weirdly beautiful when it glows?? If only this wasn't basically cancer.
That's just light from the microscope..itself doesn't emit any light..
Come to me my HeLa army
I got here because of Thoughty2
This just looks evil.
The evil inside.
Anyone else here from science class?
Freaking creepy
jesus
wtf is this cell ....its so fast
They are cancerous.
nani?