the easy shortcut that I used without even doing any work is, whenever you have an alcohol and the reactant has an alcohol, the attacking OH steals the H from the molecule, then leaves, leaving O connecting to the remaining chain (CH3CH2).
This video is doing all kinds of possibilities and is making it confusing for people that are less advanced. The method you speak of is the most realistic approach for sure
i have a test tomorrow on Carboxylic acid derivative reactions as well as reactions involving amines and then the Aldol reactions and the Claisen reactions.
Mmm, I feel like it's more likely that the hydroxyl group on the right will pick up the hydrogen that you say might be picked up from an ethanol molecule. Then, because water is a good leaving group, the lone pairs will come down, reform the carbonyl, and result in the ester
Question: you pointed to the carbonyl saying it was a good leaving group... how is this so? Isn't it the acid catalysed water molecule that eventually forms a good leavin group?
11:45-12:00 Why does one of the two hydroxyls have to protonate in step 4? I can't understand why the reaction doesn't stop at the stage of thetraedal (sp3 carbon) intermediate. I mean, of course this has something to do (as always) with overall better molecule stability and lower energy state, but I don't seem to get the point of that H2O elimination.
Because when you add a nucleophile to an ester or a carboxylic acid the O cliffs off because the overall compound is highly reactive when it has 3 oxygen atoms attached to the same carbon carbon. if you have a book with you I advice you to look at grignard reactions when they react to esters. Hope this helps.
Hello, I had to carry out this reaction in practice, and I had to heat the mixture of propanoic acid, sulfuric acid and ethanol in a water bath. My question is, why did I have to heat it, since according to the enthalpies of formation this reaction should be slightly exothermal ?
@5.32 Would not the proton from the acid go to the oxygen next to the hydrogen besides attracting towards carbonyl oxygen in the initial carboxylic acid?
Actually both spellings are correct. 'Sulfur' is Latin, 'sulphur' has been modified to obey conventions of the English language. Pretty sure he knows more about chemistry than you do :-)
This guy continues to save my life every time I take an organic chemistry related class. Thank you!!
the easy shortcut that I used without even doing any work is, whenever you have an alcohol and the reactant has an alcohol, the attacking OH steals the H from the molecule, then leaves, leaving O connecting to the remaining chain (CH3CH2).
thank you so much for this
This video is doing all kinds of possibilities and is making it confusing for people that are less advanced. The method you speak of is the most realistic approach for sure
This video was extremely well done.
you are great ! i have an exam on monday, you helped me so much !!! thank you thank you a lot !!
Incredible, I've learned invaluable things from this, thank you!
"Let's think about what might be happen".
Very well explained than the other videos out on UA-cam.
Thanks Sal
A gifted teacher who is not highly conversant in organic chemistry. There are better videos on the web.
This was such a great help! Thank you!!! I totally understand it now :)
Really this was a very realistic and practical explanation.We are being taught very strict mechanisms .
Thanks Sal.
I don't see how you could have made a Fisher esterification any more complicated, difficult to understand, and long. I'm goong back to my Organic book
i have a test tomorrow on Carboxylic acid derivative reactions as well as reactions involving amines and then the Aldol reactions and the Claisen reactions.
Saved my extended essay, saved my day :')
Heard you on NPR a while ago :) I was excited because I had seen your videos before. Congrats :) Keep up the good work.
Thank you, Sal!
Pndped, protonated, nucleophillic addition, deprotonate, protonated, eliminate and deprotonate brilliant video really helpful thanks.
Yes, VERY USEFUL! Thanks!
Thanks Khan! I finally get it!!
Wow Sal, fantastic explanation of Fischer *esturfurcation* !
Noone likes you
Thanks Khan! your video lecture helps me alot. A Big Thank You!
THANK YOU SO MUCH SAL!
YOU ARE AMAZING SIR! THANK YOU!!!!
Mmm, I feel like it's more likely that the hydroxyl group on the right will pick up the hydrogen that you say might be picked up from an ethanol molecule. Then, because water is a good leaving group, the lone pairs will come down, reform the carbonyl, and result in the ester
superb video sal. thank you
@salamut2202 they don't really bond. Its just the oxygen who likes to hug more electrons, so it takes the hydrogen ones.
Brilliant, thanks!
Question: you pointed to the carbonyl saying it was a good leaving group... how is this so? Isn't it the acid catalysed water molecule that eventually forms a good leavin group?
@11:03 "two three four five six seven doubl...oh actully SINGLE BOND HERE!"
very confusing but now its easy........after watching the video second time
here's a suggestion make the courser more VISIBLE. i mean seriously a black background and a tiny courser its just not visible.
11:45-12:00
Why does one of the two hydroxyls have to protonate in step 4? I can't understand why the reaction doesn't stop at the stage of thetraedal (sp3 carbon) intermediate. I mean, of course this has something to do (as always) with overall better molecule stability and lower energy state, but I don't seem to get the point of that H2O elimination.
Because when you add a nucleophile to an ester or a carboxylic acid the O cliffs off because the overall compound is highly reactive when it has 3 oxygen atoms attached to the same carbon carbon. if you have a book with you I advice you to look at grignard reactions when they react to esters. Hope this helps.
11:14 color change from yellow to purple was a bit distracting
So can we say that in the elimination of water the H comes from ethanol and OH comes from the acid??
Hello, I had to carry out this reaction in practice, and I had to heat the mixture of propanoic acid, sulfuric acid and ethanol in a water bath. My question is, why did I have to heat it, since according to the enthalpies of formation this reaction should be slightly exothermal ?
Take all the tuition I've ever paid UT.
@5.32 Would not the proton from the acid go to the oxygen next to the hydrogen besides attracting towards carbonyl oxygen in the initial carboxylic acid?
top-tier nitpicking
Nice one on the spelling of Sulphur :)
Actually both spellings are correct. 'Sulfur' is Latin, 'sulphur' has been modified to obey conventions of the English language. Pretty sure he knows more about chemistry than you do :-)
Pretty sure you know absolutely nothing about me whatsoever :)
Chewie Lewie Of course I don't.
What was the point of this interaction right here? Lmao
took me almost an hour to understand this.haha
I think this is not the Typical Fischer-Speier Esterification because then Dry HCl gas needs to be used instead of H2SO4.
Won't intramolecular H deprotonation be more probable at 12:07?
sulphuric?
+Justin DeGroat lol sulfuric
English FTW
beast...
How do hydrogen ions bond to water to create hydronium?
Sir, can HCl work as a catalyst?
Yes it can work but then Cl^- will not be as stable as HSO4^- so the second one is preferred....also proves that sulphuric acid is a better acid.
12:40 repetition legitimizes
Can anybody help me to let me know that how to avoid reverse formation of ester to acid??any1 plz
I think it's more easily pronounced eh-stair-ification haha
pretty sure it's Fischer
*Sulfuric acid
*Fischer Esterification
loool "Screen real estate" XD
Ye dw, he says it all the time. You’ll get used to it, then it won’t be as funny
@@avtarasit's always nice to revisit a comment from 7 years ago and have no idea why you wrote it. Thanks for taking me back to 2013, good times
Is there no talking in this video?
have you seen the movie limitless?... My conclusion.
LETS FIND THE PILL
lit
@58203ju Canada and America has different spellings
sulFuric acid
Jezuz, how much time should it really take to explain this reaction?
You went really was on the first example 😔
@tjoseph230 I've seen people with the last name Fischer and Fisher before -__-
Stop changing color please..
+Exercic There is a point to the color change.
very boring😡😡
Dude you don't have to explain to us how to name an alcohol or why sulfuric acid is an acid.
Stop changing color please..