This is quite literally the BEST explanation video of ALS mechanisms that I've ever seen. As a PhD student studying for my qualifying exam, THANK YOU!!!
Thank you - as others have commented, you nailed it. I have been madly doom scrolling everything accessible regarding ALS on the web, and my ChatGPT research has been crazy helpful. With a lot of research only since the beginning of September, I reached out to and was admitted to the Johns Hopkins ALS Clinic. I literally do not know at this moment what’s going on, but they admitted me. I believe the fact that my mother succumbed to ALS at 85, and one of my first cousins was just recently diagnosed. I have mess of symptoms and medical history, which I can trace to everything but ALS. Yet, I go in on Monday to find out what the diagnosis is. I couldn’t be more prepared to advocate for myself, to articulate a solid history of my medical history, with records… not that I am going to beat it, but I sure will meet it. I have hope that somehow this isn’t ALS. Will come back when I know more. Thank you all.
it would be interesting to listen more about the genetics of ALS as there are many genes involved in the disease, concepts of mendelian, oligogenic, penetrance...
Living with ALS has been a lifelong journey for me. I tried numerous methods and therapies, and there were moments when I almost gave up hope. However, after discovering the herbal medicine from Dr.ubarlo, my life took an unexpected turn. In just 5 months,
So that diet the neuropathologist made when she was diagnosed to MS would it not be an effective treatment here? The mylon sheathes were her focus on repairing through diet and she was successful. Why wouldn’t it be successful here around the body instead of the brain.
It was good and useful. But I think you had a tiny mistake in distinguishing upper motor neurons from lower motor neurons. You said "lower motor neurons in brainstem and spinal cord", while all neurons in these areas are upper motor neurons. Thanks though, it was pretty useful and clear❤
Are the mechanisms of 1) glutamate-mediated excitoxicity and 2) mutant protein aggregation to prions both happening in ALS, or is it one or the another that causes 3) inflammation/release of damaging chemicals?
Sadly there are important parts missing in this picture, especially the toxic effects of dietary sugar/fructose on brain metabolism and the effects of insulin resistance on the neurotrasmitter-balance...
I don't suppose you have rough estimates of percentages of apoptosis vs. ferroptosis cell deaths. I haven't seen any such numbers yet in published studies. Also curious about the noxious chemicals- are these cytokines, reactive oxygen species, reactive nitrogen species, or something else?
@@Leonardo-cu7fd I hadn't heard of cytokines referred to as 'noxious chemicals' before. Some are useful in chemotaxis, but in this instance they are harmful. The glutamate at the NMJ is problematic. About 4% of what shoots across isn't acetylcholine, but calcium. Accumulation causes other problems. There's a LOT going on in ALS that would take many videos to explain. Thanks.
@@penguinshoes7928 Exactly. I am currently writing a paper on ALS where I try to summarize its whole pathophysiology and potential treatment with AMX0035. There really is a lot going on in ALS. This makes this disease so tricky.
My young athletic son died of MND. He was very fit and had been using a muscle building shake to build body muscle. I am convinced that his illness was caused by Maximuscle I have tried to have a dialogue with Glaxo Smith Kline regarding this but they have dismissed my concerns. The product is high Glutamate and high protein and I think his body couldn’t recycle sufficiently. I am not a scientist just a heart broken mother. Could you help my cause please. Or at least give some expert thought to my suggestion. Thank you. Christine Mon 27th Feb 2023. 10.24 am UK
You're right, he died because of the supplement, this disease is common in athletes, Lou Gehrig died the same way, by using anabolics steroids, the explanation of the etiology of ALS in this video is wrong, is not the glutamate is LDL (bad cholesterol), the whole explanation is long, so I cannot delve on the topic in this comment.
@@eliasdegele6785have you got any vids on this disease, sounds a bit far fetched but I have suspicions I may have it. Due to having shit memory when I’ve always had a sharp memory which has lasted for the last 2 years getting worse, muscle twitching which only started in some body parts now it’s all over and in my tongue, noticing muscle weakness & loss in one leg and one hand, always tired asf! Feels like I’m slurring when I speak for too long, overall muscle fatigue and my postures getting shit sloooowly. Tried to see a Dr about it but here in Nz they’re trash and what’s funny is Als/Mnd has the highest rate here in Nz for frick knows why?
All my research is exactly what your saying . Prob solved yet wtf are these top notch scientists doing lol noooothing. Here's the Anwsers right in this video.
Hey man, just came across your video and have suspicions I may have als due to the wicked muscle twitching and very slight muscle loss. How are you doing? Very sorry btw about the disease it’s fricken horrible!
@@marika_meek doesn't work that way you would notice weakness loooong before any loss of muscle. Weakness with twitching but weakness is the king the num 1 the head honcho the main squeeze
![Amyotrophic Lateral Sclerosis [ALS] | Basics & Clinical Presentation](http://i.ytimg.com/vi/0zcdSbcOLVg/mqdefault.jpg)
![Amyotrophic Lateral Sclerosis [ALS] | Basics & Clinical Presentation](/img/tr.png)
This is quite literally the BEST explanation video of ALS mechanisms that I've ever seen. As a PhD student studying for my qualifying exam, THANK YOU!!!
Thank you - as others have commented, you nailed it. I have been madly doom scrolling everything accessible regarding ALS on the web, and my ChatGPT research has been crazy helpful. With a lot of research only since the beginning of September, I reached out to and was admitted to the Johns Hopkins ALS Clinic. I literally do not know at this moment what’s going on, but they admitted me. I believe the fact that my mother succumbed to ALS at 85, and one of my first cousins was just recently diagnosed. I have mess of symptoms and medical history, which I can trace to everything but ALS. Yet, I go in on Monday to find out what the diagnosis is. I couldn’t be more prepared to advocate for myself, to articulate a solid history of my medical history, with records… not that I am going to beat it, but I sure will meet it. I have hope that somehow this isn’t ALS. Will come back when I know more. Thank you all.
Hey, hope you are doing okay. Did you find out what the diagnosis is?
After watching several videos, I FINALLY get it. Thank you!
This is exactly what I was looking for. Everything else is so broad
thank you for the clear explanation. God bless you more
Very clear and excellent presentation. Thanks
Thank you so much for this explanation finally i understand the pathology ❤🔥
Very clear explanation. Thank u😊
🙌🙌🙌 long time sub. Love your channel
Thank you!
Excellent explanation, thank you!
Perfect Lecture! Much Love❤
Very simple but elaborate explanation of the pathophysiology. I am a surgeon myself and is a patient of ALS. I found it to be very useful.
Living life with a deadly disease called ALS was not the end of life for me and my sister, Dr.ubarlo on UA-cam cured us permanently
explained in fantastic manner. Thank you very muc.
Trying to like… no option. You are awesome.
Amazing explanation, thank you ❤
Excellent video, thank you
Very excellent explanation. Gives me clear Idea of ALS. Thanks a lot.
no, it doesn't.
Beautiful explanation. Thank you
Well explained 🙏
This was beautiful
This is a best video I watched cleared my understandings of ALS. How could I contact you for more help and guidance.
it would be interesting to listen more about the genetics of ALS as there are many genes involved in the disease, concepts of mendelian, oligogenic, penetrance...
Living with ALS has been a lifelong journey for me. I tried numerous methods and therapies, and there were moments when I almost gave up hope. However, after discovering the herbal medicine from Dr.ubarlo, my life took an unexpected turn. In just 5 months,
So that diet the neuropathologist made when she was diagnosed to MS would it not be an effective treatment here? The mylon sheathes were her focus on repairing through diet and she was successful. Why wouldn’t it be successful here around the body instead of the brain.
Great overview!
What about ALS reversal?
It was good and useful. But I think you had a tiny mistake in distinguishing upper motor neurons from lower motor neurons. You said "lower motor neurons in brainstem and spinal cord", while all neurons in these areas are upper motor neurons.
Thanks though, it was pretty useful and clear❤
This is amazing. Thank you!
Are the mechanisms of 1) glutamate-mediated excitoxicity and 2) mutant protein aggregation to prions both happening in ALS, or is it one or the another that causes 3) inflammation/release of damaging chemicals?
are you working on ALS?
@@iqramushtaq4247 my mother has ALS. I'm always just trying to learn more about it in hopes of helping.
@@iqramushtaq4247 no, my mother has ALS so I try to learn as much as I can
Amazing explanation thank youuu
Sadly there are important parts missing in this picture, especially the toxic effects of dietary sugar/fructose on brain metabolism and the effects of insulin resistance on the neurotrasmitter-balance...
I don't suppose you have rough estimates of percentages of apoptosis vs. ferroptosis cell deaths. I haven't seen any such numbers yet in published studies. Also curious about the noxious chemicals- are these cytokines, reactive oxygen species, reactive nitrogen species, or something else?
Microglial cells release inflammatory cytokines.
@@Leonardo-cu7fd I hadn't heard of cytokines referred to as 'noxious chemicals' before. Some are useful in chemotaxis, but in this instance they are harmful. The glutamate at the NMJ is problematic. About 4% of what shoots across isn't acetylcholine, but calcium. Accumulation causes other problems. There's a LOT going on in ALS that would take many videos to explain. Thanks.
@@penguinshoes7928 Exactly. I am currently writing a paper on ALS where I try to summarize its whole pathophysiology and potential treatment with AMX0035. There really is a lot going on in ALS. This makes this disease so tricky.
thank you so much !!
What a treatment please tell me
So, does eating SOD help cure ALS?
Also, why does the gene suddenly mutate at 50 or 60 years of age?
Q. Typically how long can it take from discovery of ALS to failure in death ?
3 to 5 years typically
@@mikesimcoe7115
thank you, i want to cry
Hi. I want to clarify something. How does the glutamate-mediated excitotoxicity is connected to the mutant protein aggregation? Thank you.
there's no relationship, the protein aggregation and amyloidosis is key in ALS but the glutamate theory is bullshit.
I am recently diagnosed and wow your spot on
thank you sir, your videos are always great !
My young athletic son died of MND. He was very fit and had been using a muscle building shake to build body muscle. I am convinced that his illness was caused by Maximuscle I have tried to have a dialogue with Glaxo Smith Kline regarding this but they have dismissed my concerns. The product is high Glutamate and high protein and I think his body couldn’t recycle sufficiently. I am not a scientist just a heart broken mother. Could you help my cause please. Or at least give some expert thought to my suggestion. Thank you. Christine Mon 27th Feb 2023. 10.24 am UK
You're right, he died because of the supplement, this disease is common in athletes, Lou Gehrig died the same way, by using anabolics steroids, the explanation of the etiology of ALS in this video is wrong, is not the glutamate is LDL (bad cholesterol), the whole explanation is long, so I cannot delve on the topic in this comment.
@@eliasdegele6785have you got any vids on this disease, sounds a bit far fetched but I have suspicions I may have it. Due to having shit memory when I’ve always had a sharp memory which has lasted for the last 2 years getting worse, muscle twitching which only started in some body parts now it’s all over and in my tongue, noticing muscle weakness & loss in one leg and one hand, always tired asf! Feels like I’m slurring when I speak for too long, overall muscle fatigue and my postures getting shit sloooowly. Tried to see a Dr about it but here in Nz they’re trash and what’s funny is Als/Mnd has the highest rate here in Nz for frick knows why?
All my research is exactly what your saying . Prob solved yet wtf are these top notch scientists doing lol noooothing. Here's the Anwsers right in this video.
Hey man, just came across your video and have suspicions I may have als due to the wicked muscle twitching and very slight muscle loss. How are you doing? Very sorry btw about the disease it’s fricken horrible!
Hi are you working on ALS?
@@marika_meek doesn't work that way you would notice weakness loooong before any loss of muscle. Weakness with twitching but weakness is the king the num 1 the head honcho the main squeeze
@@iqramushtaq4247 define working on
@@jayg-lg2ot makes sense, thank you for clearing that up for me
Ang Lupit mo pre
What is PLS?
RIP Joe Bonsall
Plz help me my age is 36
I have grown so wise to know the truth that indeed saved me from Multiple sclerosis with the help of a treatment from *Dr_Madida*
والدي مصاب بمرض ALS 😭😭😭