MOA Of Erythromycin, Azithromycin, Clarithromycin, Chloramphenicol & Clindamycin🩺

#Erythromycin #azithromycin #Clarithromycin #Chloramphenicol #clindamycin
MOA Of Erythromycin, Azithromycin, Clarithromycin Chloramphenicol & Clindamycin
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▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
00:00:00 Introduction and overview of lecture
00:01:29 Overview of similarities between Clindamycin, Macrolide and chloramphenicol
00:02:17 Clindamycin, macrolide (Erythromycin) and chloramphenicol work as protein synthesis inhibitors
00:02:29 MOA of clindamycin, macrolide (Erythromycin) and chloramphenicol on Bacterial Ribosomes
00:02:44 MOA of clindamycin, macrolide (Erythromycin) and chloramphenicol on larger 50s ribosomal subunit
00:03:28 Action of clindamycin , macrolide (Erythromycin) and Chloramphenicol on 23s Ribosomal RNA
00:05:55 Summary of above 4 similarities in the MOA of Clindamycin , Macrolide (Erythromycin) and Chloramphenicol
00:06:27 MOA of Clindamycin, Macrolide (Erythromycin) and Chloramphenicol on Ribozyme
00:07:01 What is Peptidyl Transferase?
00:07:57 Summary of all above similarities between Clindamycin, Macrolide (Erythromycin) and Chloramphenicol
00:09:26 Detailed explanation on the functions of Peptidyl Transferase
00:22:08 Transpeptidation and Ribosomal Translocation
00:22:57 Peptide chain elongation
00:26:31 How Clindamycin, Macrolide (Erythromycin) and chloramphenicol inhibit the protein synthesis by inhibiting the chain elongation process?
00:28:19 Summary of similarities between Clindamycin, Macrolide (Erythromycin) and Chloramphenicol
00:31:46 MOA; Clindamycin
00:39:56 MOA; Clindamycin as bacteriostatic and bactericidal
00:52:14 Summary of MOA of Clindamycin
00:53:32 MOA; Macrolides (Erythromycin)
00:59:18 MOA; Chloramphenicol binding site.
01:00:55 MOA; Comparison of binding site of clindamycin vs macrolide vs chloramphenicol.
01:01:30 MOA; Chloramphenicol.
Erythromycin acts by inhibition of protein synthesis by binding to the 23S ribosomal RNA molecule in the 50S subunit of ribosomes in susceptible bacterial organisms.
Azithromycin mechanism of action including the inhibition of bacterial protein synthesis, inhibition of proinflammatory cytokine production, inhibition of neutrophil infestation, and macrophage polarization alteration, gives it the ability to act against a wide range of microorganisms.
Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process.
Chloramphenicol inhibits microbial protein synthesis by binding to the 50 S subunit of the 70 S ribosome and inhibiting the action of peptidyl transferase, thus preventing peptide bond formation. This mechanism also prevents the binding of aminoacyl transfer RNA to the peptidyl transferase active site.
Clindamycin acts by inhibiting bacterial protein synthesis at the level of the 50S ribosome. As a result, it exerts a prolonged post antibiotic effect. It may decrease toxin production and increase microbial opsonization and phagocytosis even at subinhibitory concentrations.
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To watch the complete video which includes following points:
1. Chloramphenicol; Adverse effects.
2. Why clindamycin and macrolide (Erythromycin) don’t produce gray baby syndrome?
3. Clinical co-relation; Competitive Inhibition;
4. Why clindamycin and erythromycin are not used together for the treatment of any infection?
5. Summary of the role of clindamycin in TSS.
6. Clinical co-relation; Cross-resistance.
7. Mechanism of resistance involving the changes at the binding site, 23s rRNA.
8. Mechanism#1; Mutant ribosomal protein.
9. Mechanism#2; Mutation of adenine group at target site, 23s rRNA.
10. Mechanism#3; Methylation of adenine group at target site, 23s rRNA.
11. Clinical co-relation; Cross resistance because of erm genes.
12. Clinical co-relation; post-antibiotic effect in relation to clindamycin, erythromycin
13. Secondary effect#1; Reduced quantity of proteins
14. Secondary effect#2; Distorted proteins.
15. Bacteriostatic action/ Bactericidal action
16. Surface bacterial proteins altered; Decreased adherence of bacteria.
17. Excellent choice for abscesses produced by the susceptible bacteria.
18. Penetration of drug; Bones.
19. Penetration of drug; Can’t cross BBB.
20. Summary of all effects produced by clindamycin.
21. Black box warning for Clindamycin.
22. Pathogenesis of Pseudomembranous colitis.
23. Risk factors for Pseudomembranous colitis.
24. Directions to be given to the patient while prescribing clindamycin.
25. Treatment for C. diff colitis.
26. Summary of Black box warning for Clindamycin.
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