I really do feel like chemical restrictions are way over the top at this point. None of this seems to noticably stop any criminal activity, but it does crush amateur chemistry absolutely. So much of what is banned is basic building blocks of chemical synthesis. Acids, basic lab equipment, even elements like bromine or iodine. None of that gets seen as a downside, because the effects are not immediately visible, but they render it impossible to exercise your curiosity and scientific interest in one of the major scientific disciplines, chemistry, and you drive a society towards a path where science isn't understood or respected. I think the rejection of science is at least partly a result of restrictions like these, stifling natural curiosity, and leading to anti-intellectuallism.
I wonder how many new inventions per year don't happen because of this. So many of the great things we discovered over the years happened coincidentally by people just messing around. It's no longer possible.
The entire war on drugs is complete failure. No cartel violence has been stopped by banning MDMA/LSD/etc, no fentanyl overdoses, no lives ruined by heroin. You can say even less for banning amateur chemistry. All these laws have done have caused suffering, and ensure America has a morally repulsive private prison (slave) industry. The only approaches that have worked for dealing with drugs, are ones that come at it from a compassionate stand - therapy, harm reduction, etc Much like the red scare, the war on drugs was cooked up by a bunch of short-sighted, ignorant, moral-panicking conservatives who had no business making decisions at a government level. And yet people keep voting them in.
@@YouCanHasAccount I enjoyed chemistry as a child and teenager. Now I only watch videos occasionally. I must say that the effort to limit is appalling. Rather than inventions, I wonder how many young people don't get into chemistry at all because it's difficult to get started. My path went elsewhere, but as a child I discovered a box with some laboratory glassware, and I bought everything in the ordinary village drugstore without any problems. It is no longer possible to buy half of it (in the EU) because of the fight against terrorists and drugs. I don't know whether to laugh or cry.
You can make meth out of Legos if you have enough chemistry knowledge. Prohibition doesn’t work, just let pharma companies sell everything to anyone. That would make more money (in terms of GDP) than jailing people.
I don’t know if you can blame the DEA here for once. The FDA banned safrole in food in 1960. It caused cancer in rats but in such huge doses banning it was probably unnecessary. MDMA didn’t really pop off until the 70’s and 80’s, and wasn’t made illegal until 1985.
Please don't distil diethyl ether like that... I dude from my lab turned into the ghost rider doing something similar... he's okay, only minor burns... But given that he was fully engulfed in flames (head to toe), it could have gone alot worse. So, stay safe.
Its ok my guy, your lab partner must have just had down syndrome if there is any real truth to that story, which I suspect there is not as you are just regurgitating armchair chemist fear mongering with little to no valid reasoning. Tell me, dont distil it like what? Huh? You trying to tell people to never distill Ether ? What should he do? Air it into the room? Splash it onto a window and lick it?
Let us all turn to USENET and revive the OLD WAYS: "Old ZWITTERION, feeling especially felonious this weekend, decided to START A THREE-ALARM FIRE, and felt that there would be NO better way to do this than to isomerize some safrole."
I’m an 8th grade dropout and I kinda understand what he’s talking about. The safrole molecule is composed of different groups, they know how and what chemicals they need to alter each group on the molecule, and they basically remodel the safrole molecule one group at a time until it’s MDMA.
Molecular sieves are best used for polishing water content when you make anhydrous solvents, and they need time, like 24 hours minimum. Using them for drying the organic phase after extraction is a bit of waste of them, believe me, you won't see a big difference with such short drying between anhydrous sodium/magnesium sulfate and a mix of it with sieves. Besides that, great chem! I love the mechanism part ;) Keep on cooking!
When steam distilling it, I have noticed I have a TON of losses when my condenser water is too cold. I have to turn off the water occasionally let the steam creep up and melt it off. Also, it really likes ethyl acetate as a solvent. Save your ether!
The synthesis for MDA is easier than MDMA from saffrole, and back when the DEA caught wind of this I believe majority of the use for saffrole was making MDA not MDMA, hence MDA is sometimes known as Sassafrass or Sally (kind of a play on Molly)
@@YuckFoutube-e1z mda is methylenedioxyamphetamine. While MDMA is methylenedioxyamphetamine. MDMA is like exstacy or molly. I had it a long time ago I could tell a lot of difference but MDMA supposed to be stronger I think.
Oh dear, you just experienced the joy of playing with catechols; they oxidize and polymerize every chance they get... You're probably oxidizing a bunch of it since catechols are VERY easily oxidized in basic media and Al3+ has also been show to increase the rate of oxidation under acidic conditions. Even in rigourously deoxygenated conditions, a tiny amount of ortho-quinone impurities in you catechol coming from air oxidation can comproportionate with the catechol during the reaction and form 2 equivalents of semi-quinone radicals, which can initiate radical polymerization. This would also explain all the weirdly colored oils you observed.
Isn't it better to introduce the AlCl3 over a period of time as well? Also, the BP of the solvent matters. I believe chlorobenzene yields higher, and a good second best is DCE.
Chem is just amazing! Not sure why I can spend hour upon hour of watching videos of reactions, distillations, washing, baths, and stir bars spinning. Just brings me joy and peace for some reason. Makes me wish I had become a Chemist, and not a Cyber Security "expert".
Yeah agree 100% we should make all drugs legal and regulated. Because all we got is a bunch of dead people, life wasted in prison, and lots of worse drugs then heroin like fentanyl. Legalize all drugs.
I hear you; it's stupid to have these medications and then tell people that either you don't need them ( take Tylenol) or your insurance won't cover the pain meds. I have Ankylosing spondylosis in my neck and lower back, and I have to fight for the medication so that I can function and have a "normal" life. Am I supposed to be in pain because some doctors overprescribed pain meds that have nothing to do with my disability? Don't make pain medications if the doctors are too scared to prescribe them.
The DEA doesn’t prescribe meds. If your doctor believed they would help your condition, your doc can prescribe. Advocating to get rid of the regulatory agency ignores the fact that thousands of people die from overdose every year. Is your solution really to allow free access to pain meds? I’m sorry you hate people so much….
@ other countries actually allow people to purchase their own medication such as Mexico, Canada, the Netherlands, Denmark, Sweden, just because we have an overdose situation here doesn’t mean that that is the standard way of living. People who have these issues tend to have more deep rooted mental health issues which this country is sorely lacking the ability to deal with that is why we have so many overdoses. It doesn’t have anything to do with the regulation of medication for pain that lead to overdoses. If what you’re saying was true then every country that had pain meds would have a high rate of overdose which the statistics just aren’t there.
a brine wash before adding any drying agent is a good habit to build, you find most of the water is removed and you barley need to add any drying agent! also dissolving the crude material in a small amount of solvent and transferring to a vile makes for an easier transfer later on, saves washing your pipettes out and improves yield! Love your stuff dude, keep it up!
@@chemdelicthank you. you are the best of all I know. maybe this method is simpler? can hydroxytyrozol cas 10597-60-1 be used for synthesis, please tell me about it? I think it would be a great idea to make a video about it
Clearly Lying.. No gay person's gonna start their name off as violent.. I lie.. A female with testosterone done whooped my ass for not caring what he was saying as I dropped his queer ass off from work at 5 or 6 AM.. broke my phone, and of course the cops didn't do a Fucking thing..
Great video, I figured that a way to synthesize the methylene dioxy bridge had been discovered when the price of MDMA crashed 16 or so years ago. A question that could be a video possibly... my pet hamster found that dissolving street cocaine hydrochloride in room temp dry isopropanol dumped out the good salt while dissolving the contaminants. Another hamster suggested that isopropanol would react with the good salt, and my hamster found that around 60 degs C this would be the case. Luckily my pet hamster isn't into crack as such a discovery would have made a real mess of his life. Am I seeking confirmation of this method? I have no idea, I just think its fun to play around with these things and see what gives.
You should invest in TLC plates so you don't have to decide on a random reaction time. Also, a future update with an NMR or IR spectrum (former preferred but more expensive) would be desirable. The secret to good yields is (usually) purity. Pyridine looked too dirty; you could've distilled and dried it before use; AlCl3 seemed too yellow. Also, deciding upon a purification method beforehand is desirable so that messing around with different methods won't eat your yield. But still, these are just suggestions.
@@bval2201I see you commented a lot on this video, especially in a rude way. Access to NMR, FTIR, GC-MS are harder to come by as a at home amateur chemist. So determining structure, impurities, etc can be more of a challenge. I am about to graduate with a B.S in biochemistry and plan to go to grad school so you’re incorrect about knowing “jackshit”. I do not go super in depth about everything as there are people who might not have that level of knowledge. I also actively study, read papers, etc. to build my knowledge but of course I still have so much to learn. Rather than just leave hateful comments, it’s more constructive to give constructive criticism. I’m not gonna block you commenting on this channel, but I want you to think about how you are presenting yourself to others.
@@chemdelic You know what..... You are right! I apologize. You are a smart guy and you are doing a great job at these videos. Something about the video triggered a memory of my past and the hate I had for the DEA agents and that was projected toward you foolishly. I see an old version of myself in the way you speak I am a biochemical engineer, organic chemist, cosmetic chemist and product formulator. I finally clawed my way back and have several patents and a legitimate company now but almost whet to jail. I was a "big time" clandestine chemist. Undetectable PEDs for NFL teams and piperazine derivative stimulants, etc etc Think big time as metric ton quantity purchases from sinochem Jiangsu CHINA and multi 50L reactor synthesis often. Made all of the watched chemicals benzyl chloride etc and all of these chems were of my design... Totally off the radar of Fed's.... For awhile lol. DEA made a mistake and tried to analog statute me. They said something was 10 times more powerful than meth when it was 10 times less... real idiots. Buttttt they still knocked down the front door and ruined my life.. temporarily... Someone, not me, spent a decade of spare time designing low/undetectable chemical and bioweapons to unleash on the agents for their bullshiit to avenge. Real good stuff... next level shit. They even got all of the agents home addresses, I heard, after years of networking, I can't say how to get all these people's home addresses just in case somebody reads it and uses it, but let's just say Chance favors the prepared mind. It would have been an unprecedented reversal of fortune for some people and would have been front page news lol. But, I heard about what they were planning :) and convinced them that there's no need to avenge me. That my troubles were my own fault and not the agents. So they gave it up and I decided to make cool legal chemical business'. So I say this as a warning, I have guys still following me 20 years later. I'm not kidding you. No they're not following me everyday but every year or so I catch dudes, most likely DEA or FBI agents, following me to see what I'm up to see if I'm staying clean or designing the synthesis of meth, MDMA or fentanyl from undetectable gas phase catylic synthesis using ethane, nitrogen and hydrogen with catalysts like Platinum, nickel, vanadium pendoxide, zeolite, chromium, molybdenum etc. :) once you buy one watched chemical they always watch you and your internet connection. They will let years go by before they arrest you so that they can build up a network of who you're working with. If you don't ever want to get caught gas phase synthesis of all materials from day one!!!!!
The best kind of not-illegal. Also thanks for reminding me of where I'd previously heard of Myristicin and Piperine, now I don't have to look those up. Leave those parts of the video in IMO.
2:38 is he holding one of the books? For me, only owning Trachsel's "Psychedelic Chemistry", i never had made anything out of the book, but learned a lot about reactions and proceeder and had a few good laughs.
I made the allylcatechol with IBX (for demethylation of eugenol), which I generated with 2-iodobenzoic acid and Oxone. When the IBX is spent, you can just filter it out and recycle it with more Oxone :) For the later step, I used caesium fluoride + DCM and a PTC.
I've looked into eugenol, I have a few little toothache bottles that are 85%. I was thinking about doing exactly what you did here and stopping. No manufacturing charges for me thanks!
It irritates me greatly that I'd need to import sassafras oil (for culinary use... the amounts I'd use are so small that any illicit use would be infeasible in any case). Birch oil is available but a very poor substitute. The DEA would regulate carbon atoms if they could... Fun story: I once trolled the DEA by asking them about the legalities of buying street meth and converting it into pseudoephedrine because I objected to the identification demand (the pharmacy fills my (actual) narcotics prescriptions without batting an eye.. go figure). They responded humorlessly that since I'd need to possess the methamphetamine I'd be breaking the law. I replied "OK; I won't help you get meth off the street, though you obviously can't do your job yourselves" -- I won't say it's connected, but since this exchange I am "randomly" selected for secondary airport screening much more than statistically plausible.
@@MemphisGRIZ901 I emailed them, asking what I related. They responded humorlessly, also by email. I refuse to show identification for something ostensibly OTC. Fortunately I seldom need decongestants.
Sounds like making a mountain out of a mole hill. Showing ID takes 2 seconds. Raising dea and transportation authority and whoever else eyebrows with your email seems to be more disruptive to you (eg secondary holds on flights where you also need to show same ID). Ps of course they don't respond with sarcasm or memes, it's in writing from federal employee and is about you purchasing and posessing meth
@@SoulDelSol I derived more amusement* than aggravation, and any time they waste fruitlessly investigating me is time not spent on mischief. As to it being a molehill, I refer you to slippery slopes and standing on principle. --- * One can certainly argue that I'm easily amused. Guilty as charged.
I have 6 years of chemistry schools behind me, and wanted to go study chemistry in 7 months. Was doubting it alot recently tho, this video showed me how great chemistry really is again. Thank you for that you potentially changed my life with that
I would never synth something from youtube lol but this is still interesting to learn how you started the process, anything in theory with the chain you want could make something else
Government wants control through chaos, confusion, ignorance, poverty and sickness. Live your life how you want and move through the system like a high agency individual
Uh oh! You put the double bond in the wrong place silly goose! That olefin is gonna substitute in the terminal carbon if you react it with HBr! Now you'll have to reflux it with potassium tert-butoxide over molecular sieves to scooch it over, then you can substitute at the alpha position 😊
Great stuff!!....had a thought....if sticky product gets stuck in pipettes....maybe find a way to plug the end of the pipettes and gently warm them in an oil bath.
@@DezyFlores lolol....after a second read of my words, it DOES sound like that...but i assure you...I was only thinking about yield..i got to be an official olde pharte by NOT putting chemicals in me ;)
I like how ur chemical sus rating seems to go. Fails vibe check, ur getting a fine, ur getting a friendly visit, ur losing ur front door and ur gonna jail. Its kinda educational without feeling like ur learning. Really enjoy ur style of content.
Actually that's just the YT comments sections hyperbolic impression of the reality of the law. What he's doing is perfectly legal. Safrole is regulated on a quantity basis for purchase. Possession is same/similar. Homie made like 3ml
Aluminum chloride doesn't directly demethylate the methoxy group in eugenol. Instead, aluminum chloride could facilitate the electrophilic aromatic substitution of the allyl group but not directly remove the methoxy group.. Also the formation of the methylenedioxy bridge (methyleneation) typically requires a different reagent, such as formaldehyde and a strong base (e.g., sodium hydroxide) or a specific methylene transfer reagent like dichloromethane in the presence of a base like K2CO3 can work but usually in different conditions.
Ehhh.... on a slightly different kick, you can just use sesame seed oil to make sesamol, which is actually better for some synthesis then Saffrole. The easiest way is to simply heat the oil in air until it hits it's smoke point and the sesamol begins to naturally accumulate in the oil.
Based on the memes and jokes in this video, I'm concerned about you too, Pookie. I've diagnosed you with Ligma. Algorithmic Psychosis has taken hold. Dont let the psyops get you.
How many precursors can I watch be made with zero chemistry experience before I wind up on a watchlist? 🤔 can’t recreate any of this but it’s mad fun to watch 🤷🏽♂️
i heard about natural ingredients for rootbeer flavor being banned and that all commercially sold rootbeer is artificially flavored. though it said the fda claimed the ingredient was banned for allegedly being carcinogenic. i see now the real reason is for the potential to make hallucinogenics
yea and the legal crap is probbaly more toxic! weed ILLEGAL NOT ALLOWED< wait got GMO toxic weed now APPROVED!, clot shot APPROVED life saving drug DENIED. i bet the elite scum have access too all the banned stuff masses are nto allowed. now i wonder if there is bootleg rootbeer.
@@chemdelic - "AI" as in "All In". ;D The glowies can't believe this while scrambling to ban more sh*t. lol Anyway, you've got a great sense of chemical humor. :)
they've really adapted in the last decade ish. always have, but man kudos to them. they watched breaking bad & knew they could up their game. so they did. now they really are converting shit into shit they convert into more shit to make the shit they was originally set out to produce 😂 but they wouldn't be if it wasn't still wicked profitable.
2:57 IT TRULLY IS!!! Pretty much SHREDDED MY PTDS! Safrol is THAT DIVINE! Its Ketone SMELLS LIKE A MEDOW FINE, Its Amine IS…A GIFT FROM ABOVE!!! “Stranga Are the Ways of the Lord!” When I heard that I NEVER IMAGINED THAT a way TOWARD HIS LOVE & GRACE FITS IN Fishscale like BITTER Crystaline Substance!!!😊 Only One True God CAN BE THAT AWESOME & THAT HUMBLE at THE SAME TIME! ❤❤❤
I have no background nor interest in this at all. YT just decided to autoplay it. But I actually found it very interesting and watched the whole thing. Good job.
You can just do the whole thing in DCM Start with the eugenol dissolved in DCM, add the AlCl3 (fresh anhydrous), acidify with HCl, reflux with excess DCM and either NaOH and phase transfer catalyst (fabric conditioner) or use DMSO (faster higher yield) Vacuum still the product
20 years ago I would have been in love with you this is something I really wanted to try when I was younger. Out of necessity I've been doing a mindless job for the last 20 years. I've completely lost the knowledge and the skill.
Idk if safrole itself might be a good flavoring agent for a fun food project.. I've been thinking about good smelling but probably never considered as spice plants like kavakava and sassafras. I think a marshmallow infused with the leaf aroma of either kava plant or even sassafras leaf into a marshmallow or souffle or even marshmallow souffle pancakes with either or both aromas I fused into it or them might be devilishly delicious. And where are THOSE jellybeans???
I really do feel like chemical restrictions are way over the top at this point. None of this seems to noticably stop any criminal activity, but it does crush amateur chemistry absolutely.
So much of what is banned is basic building blocks of chemical synthesis. Acids, basic lab equipment, even elements like bromine or iodine.
None of that gets seen as a downside, because the effects are not immediately visible, but they render it impossible to exercise your curiosity and scientific interest in one of the major scientific disciplines, chemistry, and you drive a society towards a path where science isn't understood or respected.
I think the rejection of science is at least partly a result of restrictions like these, stifling natural curiosity, and leading to anti-intellectuallism.
I wonder how many new inventions per year don't happen because of this. So many of the great things we discovered over the years happened coincidentally by people just messing around. It's no longer possible.
The entire war on drugs is complete failure. No cartel violence has been stopped by banning MDMA/LSD/etc, no fentanyl overdoses, no lives ruined by heroin. You can say even less for banning amateur chemistry. All these laws have done have caused suffering, and ensure America has a morally repulsive private prison (slave) industry. The only approaches that have worked for dealing with drugs, are ones that come at it from a compassionate stand - therapy, harm reduction, etc
Much like the red scare, the war on drugs was cooked up by a bunch of short-sighted, ignorant, moral-panicking conservatives who had no business making decisions at a government level.
And yet people keep voting them in.
@@YouCanHasAccount I enjoyed chemistry as a child and teenager. Now I only watch videos occasionally. I must say that the effort to limit is appalling. Rather than inventions, I wonder how many young people don't get into chemistry at all because it's difficult to get started. My path went elsewhere, but as a child I discovered a box with some laboratory glassware, and I bought everything in the ordinary village drugstore without any problems. It is no longer possible to buy half of it (in the EU) because of the fight against terrorists and drugs. I don't know whether to laugh or cry.
You can make meth out of Legos if you have enough chemistry knowledge. Prohibition doesn’t work, just let pharma companies sell everything to anyone. That would make more money (in terms of GDP) than jailing people.
Its the same everywhere.
Banning "hackertools" for example
1 for the money
2 for the better green
3, 4-methylenedioxymethamphetamine...
👌🥸
@@Skunkhunt_42 Heh, if you know, you know...
For those who don't know, now you know: ua-cam.com/video/3k0LezNohJk/v-deo.html
All caps when you spell the name
Giggidy
Oh no you di'n't hehe
Instructions unclear. Wanted to make root beer but made MDMA.
That's okay it's not illegal if it was an honest mistake
(Not legal advice)
😱😱😭😱😱
It's just a more spicy form of root beer.
Truck load of root beer on Mexican border.
Await lab analysis and weights for exchange of Goods ;)
a common mistake.
Yay for root beer! DEA ruined root beer by restricting the main ingredient and forcing crappy substitutes on us.
The same kind of thinking that gave us fentanyl
@@John_Candy the DEA will be looked at as draconian and stupid as the lobotomy in history books decades from now
I don’t know if you can blame the DEA here for once. The FDA banned safrole in food in 1960. It caused cancer in rats but in such huge doses banning it was probably unnecessary. MDMA didn’t really pop off until the 70’s and 80’s, and wasn’t made illegal until 1985.
Root beer hasn't been root beer since before the DEA existed. It was discovered in the 60's the drinking sasafras oil would cause stomach cancer.
@@ColdRacoonsa year before I was born it's as if they want me to be miserable or not
WERE GOING TO DEA'S LIST WITH THIS ONE🔥🔥🔥🔥
F**k the DEA!
I think he's long passed that 😂😂😂😂
I think most of us are long passed that. I know I am.
Again ?
Gonna? I already done been over there camping.🐄🛸
Please don't distil diethyl ether like that...
I dude from my lab turned into the ghost rider doing something similar...
he's okay, only minor burns...
But given that he was fully engulfed in flames (head to toe), it could have gone alot worse.
So, stay safe.
was your professor Hollowman ?😮
Bro has fire resistance 💀
Its ok my guy, your lab partner must have just had down syndrome if there is any real truth to that story, which I suspect there is not as you are just regurgitating armchair chemist fear mongering with little to no valid reasoning. Tell me, dont distil it like what? Huh? You trying to tell people to never distill Ether ? What should he do? Air it into the room? Splash it onto a window and lick it?
Then stop whining it only will cause minor burns and those are not a major deal.
how should it be distilled?
Let us all turn to USENET and revive the OLD WAYS:
"Old ZWITTERION, feeling especially felonious this weekend, decided to START A THREE-ALARM FIRE, and felt that there would be NO better way to do this than to isomerize some safrole."
Ok, so who's getting on nostr?
Learn gpg, crypto, and form your circle of trust.
Oh I don't have to tell you lol
@@Acceleratedpayloads It's from my favorite alt.drugs post from, my God like 30 years ago. I am not actually doing this.
@@hessex1899 I went to there a few months back for nostalgia... It's only spam for the last few years.
I wish I was capable of understanding any of this.
Lego with chemicals
I’m an 8th grade dropout and I kinda understand what he’s talking about. The safrole molecule is composed of different groups, they know how and what chemicals they need to alter each group on the molecule, and they basically remodel the safrole molecule one group at a time until it’s MDMA.
This made the 1990s such a good decade to be alive
And early 2000's
Didn’t just. What good times.
Party! I went to way too many Phish shows and many of the associated acts in the scene.
@@Mk-dm5zt best ever
Yes it created jobs for so many good DEA Agents
Molecular sieves are best used for polishing water content when you make anhydrous solvents, and they need time, like 24 hours minimum. Using them for drying the organic phase after extraction is a bit of waste of them, believe me, you won't see a big difference with such short drying between anhydrous sodium/magnesium sulfate and a mix of it with sieves.
Besides that, great chem! I love the mechanism part ;)
Keep on cooking!
When steam distilling it, I have noticed I have a TON of losses when my condenser water is too cold. I have to turn off the water occasionally let the steam creep up and melt it off. Also, it really likes ethyl acetate as a solvent. Save your ether!
I could never do these things, and don't fully understand, but I love watching videos like this and NileRed. It's fascinating.
I had no idea of anything you were saying, but couldn’t stop watching.
Same here.
Your video quality jumped up a lot man. Very well done
I watch it for the hilarious glowies humor, gets me rollin' with a lil' dimethoxy..... oh never mind. :D :D
@@billant2 LOLLLL
The synthesis for MDA is easier than MDMA from saffrole, and back when the DEA caught wind of this I believe majority of the use for saffrole was making MDA not MDMA, hence MDA is sometimes known as Sassafrass or Sally (kind of a play on Molly)
I'd heard "Sally" but that person also used "Mustang" to describe MDMA and I figured that was as deep as the name went.
@@mal2kscmustang sally
True it's mda . I've had uncle toms mda back in the 70s
@@daviddowns7552 What is the difference between the two? I am not talking chemistry here.
@@YuckFoutube-e1z mda is methylenedioxyamphetamine. While MDMA is methylenedioxyamphetamine. MDMA is like exstacy or molly. I had it a long time ago I could tell a lot of difference but MDMA supposed to be stronger I think.
Oh dear, you just experienced the joy of playing with catechols; they oxidize and polymerize every chance they get... You're probably oxidizing a bunch of it since catechols are VERY easily oxidized in basic media and Al3+ has also been show to increase the rate of oxidation under acidic conditions. Even in rigourously deoxygenated conditions, a tiny amount of ortho-quinone impurities in you catechol coming from air oxidation can comproportionate with the catechol during the reaction and form 2 equivalents of semi-quinone radicals, which can initiate radical polymerization. This would also explain all the weirdly colored oils you observed.
This guy is probably a moron and has no idea He needs about 25 more years before he gets to being smart
Isn't it better to introduce the AlCl3 over a period of time as well? Also, the BP of the solvent matters. I believe chlorobenzene yields higher, and a good second best is DCE.
I just liked it bc I wanted to look like I understood a word of any of that
fascinating!!!
Chem is just amazing! Not sure why I can spend hour upon hour of watching videos of reactions, distillations, washing, baths, and stir bars spinning. Just brings me joy and peace for some reason. Makes me wish I had become a Chemist, and not a Cyber Security "expert".
Like the ATF, the DEA needs to be dissolved. I can't get the pain meds I need when I have stones because of their BS.
Yeah agree 100% we should make all drugs legal and regulated. Because all we got is a bunch of dead people, life wasted in prison, and lots of worse drugs then heroin like fentanyl. Legalize all drugs.
Dark web is still a thing. Plenty of opioids also are being sold" legally"
I hear you; it's stupid to have these medications and then tell people that either you don't need them ( take Tylenol) or your insurance won't cover the pain meds. I have Ankylosing spondylosis in my neck and lower back, and I have to fight for the medication so that I can function and have a "normal" life. Am I supposed to be in pain because some doctors overprescribed pain meds that have nothing to do with my disability? Don't make pain medications if the doctors are too scared to prescribe them.
The DEA doesn’t prescribe meds. If your doctor believed they would help your condition, your doc can prescribe. Advocating to get rid of the regulatory agency ignores the fact that thousands of people die from overdose every year. Is your solution really to allow free access to pain meds? I’m sorry you hate people so much….
@ other countries actually allow people to purchase their own medication such as Mexico, Canada, the Netherlands, Denmark, Sweden, just because we have an overdose situation here doesn’t mean that that is the standard way of living. People who have these issues tend to have more deep rooted mental health issues which this country is sorely lacking the ability to deal with that is why we have so many overdoses. It doesn’t have anything to do with the regulation of medication for pain that lead to overdoses. If what you’re saying was true then every country that had pain meds would have a high rate of overdose which the statistics just aren’t there.
Don't forget to download your favorite memes so that you can enjoy them whenever you want!
"memes"
@@InsanityPlusOne I love memes!
Kekistanis are persecuted for their memes. Keep posting scientific memes to keep Kekistan Free.
@@joenemeth9606based.
@@joenemeth9606I just know that your username having the word meth in it cannot be coincidence, Joe 😂
That reddish orange color was AMAZING!!!!!! If I could turn everything I own that color I would. WOW absolutely stunning!!!
Thanks Pookie. ❤
Best part of the vid :D
Pookie 😜
Yeah did you two end up rolling together on your rootbeer??
If I was 50 years younger I'd definitely study chemistry.
The older I get the more interesting the subject becomes.
You can always start at any age :)
Same!
At your older age Is best time to start. You got more money then when your young. And more resources to make a nice little lab.
at your advanced age it might be equally interesting but farmore beneficial to study biochemistry.
Chemdelic cooking up again 🔥🔥🔥
a brine wash before adding any drying agent is a good habit to build, you find most of the water is removed and you barley need to add any drying agent! also dissolving the crude material in a small amount of solvent and transferring to a vile makes for an easier transfer later on, saves washing your pipettes out and improves yield! Love your stuff dude, keep it up!
Thank you! I was following the procedure as close as possible, but a brine wash would be a good idea too!
@@chemdelicthank you. you are the best of all I know. maybe this method is simpler? can hydroxytyrozol cas 10597-60-1 be used for synthesis, please tell me about it? I think it would be a great idea to make a video about it
@@chemdelic what do you think about it?😢
@@chemdelic help me please 😢
As a gay professional chemist and drug addict for 476 years, I admire you everything about you and your video!
Knowing your sexual preference really took that comment to the next level 🙄
No wonder the world laughs at your kind
NAILED IT. 😉
Clearly Lying.. No gay person's gonna start their name off as violent.. I lie.. A female with testosterone done whooped my ass for not caring what he was saying as I dropped his queer ass off from work at 5 or 6 AM.. broke my phone, and of course the cops didn't do a Fucking thing..
Your humor is exceedingly appreciated
Gay go away
this is the kind of content i want on youtube, brilliant 💯
Great video, I figured that a way to synthesize the methylene dioxy bridge had been discovered when the price of MDMA crashed 16 or so years ago. A question that could be a video possibly... my pet hamster found that dissolving street cocaine hydrochloride in room temp dry isopropanol dumped out the good salt while dissolving the contaminants. Another hamster suggested that isopropanol would react with the good salt, and my hamster found that around 60 degs C this would be the case. Luckily my pet hamster isn't into crack as such a discovery would have made a real mess of his life. Am I seeking confirmation of this method? I have no idea, I just think its fun to play around with these things and see what gives.
You should invest in TLC plates so you don't have to decide on a random reaction time. Also, a future update with an NMR or IR spectrum (former preferred but more expensive) would be desirable. The secret to good yields is (usually) purity. Pyridine looked too dirty; you could've distilled and dried it before use; AlCl3 seemed too yellow. Also, deciding upon a purification method beforehand is desirable so that messing around with different methods won't eat your yield. But still, these are just suggestions.
you sound like pro , looking for a job opportunity? :D
@@bval2201(sound of crickets)
@@bval2201I see you commented a lot on this video, especially in a rude way. Access to NMR, FTIR, GC-MS are harder to come by as a at home amateur chemist. So determining structure, impurities, etc can be more of a challenge. I am about to graduate with a B.S in biochemistry and plan to go to grad school so you’re incorrect about knowing “jackshit”. I do not go super in depth about everything as there are people who might not have that level of knowledge. I also actively study, read papers, etc. to build my knowledge but of course I still have so much to learn. Rather than just leave hateful comments, it’s more constructive to give constructive criticism. I’m not gonna block you commenting on this channel, but I want you to think about how you are presenting yourself to others.
@@chemdelic You know what..... You are right! I apologize. You are a smart guy and you are doing a great job at these videos. Something about the video triggered a memory of my past and the hate I had for the DEA agents and that was projected toward you foolishly. I see an old version of myself in the way you speak
I am a biochemical engineer, organic chemist, cosmetic chemist and product formulator. I finally clawed my way back and have several patents and a legitimate company now but almost whet to jail. I was a "big time" clandestine chemist. Undetectable PEDs for NFL teams and piperazine derivative stimulants, etc etc Think big time as metric ton quantity purchases from sinochem Jiangsu CHINA and multi 50L reactor synthesis often. Made all of the watched chemicals benzyl chloride etc and all of these chems were of my design... Totally off the radar of Fed's.... For awhile lol.
DEA made a mistake and tried to analog statute me. They said something was 10 times more powerful than meth when it was 10 times less... real idiots. Buttttt they still knocked down the front door and ruined my life.. temporarily...
Someone, not me, spent a decade of spare time designing low/undetectable chemical and bioweapons to unleash on the agents for their bullshiit to avenge. Real good stuff... next level shit. They even got all of the agents home addresses, I heard, after years of networking, I can't say how to get all these people's home addresses just in case somebody reads it and uses it, but let's just say Chance favors the prepared mind. It would have been an unprecedented reversal of fortune for some people and would have been front page news lol. But, I heard about what they were planning :) and convinced them that there's no need to avenge me. That my troubles were my own fault and not the agents. So they gave it up and I decided to make cool legal chemical business'.
So I say this as a warning, I have guys still following me 20 years later. I'm not kidding you. No they're not following me everyday but every year or so I catch dudes, most likely DEA or FBI agents, following me to see what I'm up to see if I'm staying clean or designing the synthesis of meth, MDMA or fentanyl from undetectable gas phase catylic synthesis using ethane, nitrogen and hydrogen with catalysts like Platinum, nickel, vanadium pendoxide, zeolite, chromium, molybdenum etc. :) once you buy one watched chemical they always watch you and your internet connection. They will let years go by before they arrest you so that they can build up a network of who you're working with. If you don't ever want to get caught gas phase synthesis of all materials from day one!!!!!
@@bval2201 schizophrenia is a hell of a drug, children
A safrole total synthesis? We came a long way from digging in dirt for the forbidden soda chem. ❤
I have many sassafras trees at my house when is the best to harvest roots
In the fall when the tree has dropped leaves, and is putting energy into the roots. Or so I've read.
The best kind of not-illegal.
Also thanks for reminding me of where I'd previously heard of Myristicin and Piperine, now I don't have to look those up. Leave those parts of the video in IMO.
5:26 Chemdelic casually chilling next to the reaction with safety tshirt&shorts
Almost as good as the OSHA approved safety squint
my suggestions consistently show me content that probably puts me on a few list
Hamilton throwback. I miss him so much. You know because of PiHKAL and TiHKAL i have tried over id say 70 different "experiences" 😉
2:38 is he holding one of the books?
For me, only owning Trachsel's "Psychedelic Chemistry", i never had made anything out of the book, but learned a lot about reactions and proceeder and had a few good laughs.
@@goiterlanternbase oh no sir but it was a guidance of what to purchase from some email vendors lol
It sure would have been neat to have been in Shulgin's study group...
Sasha and his wife are so cool. I had those books for years. Great reference books, great stories.
I made the allylcatechol with IBX (for demethylation of eugenol), which I generated with 2-iodobenzoic acid and Oxone. When the IBX is spent, you can just filter it out and recycle it with more Oxone :)
For the later step, I used caesium fluoride + DCM and a PTC.
I've looked into eugenol, I have a few little toothache bottles that are 85%. I was thinking about doing exactly what you did here and stopping. No manufacturing charges for me thanks!
Eugenol can also be extracted from cloves via steam destillation pretty easily
@@blubberbernd2347 yep, the toothache stuff is just clove oil.
@blubberbernd2347 the hard part there is isolating the pure eugenol from the clove oil (which contains trace amounts of other aromatics)
That Hamilton Morris video is a great one.
It irritates me greatly that I'd need to import sassafras oil (for culinary use... the amounts I'd use are so small that any illicit use would be infeasible in any case). Birch oil is available but a very poor substitute. The DEA would regulate carbon atoms if they could...
Fun story: I once trolled the DEA by asking them about the legalities of buying street meth and converting it into pseudoephedrine because I objected to the identification demand (the pharmacy fills my (actual) narcotics prescriptions without batting an eye.. go figure). They responded humorlessly that since I'd need to possess the methamphetamine I'd be breaking the law. I replied "OK; I won't help you get meth off the street, though you obviously can't do your job yourselves" -- I won't say it's connected, but since this exchange I am "randomly" selected for secondary airport screening much more than statistically plausible.
Just bring extra flowers and candy for them .
They LOVE that shit .
You "Asked the DEA...?" What does that even mean?
@@MemphisGRIZ901 I emailed them, asking what I related. They responded humorlessly, also by email. I refuse to show identification for something ostensibly OTC. Fortunately I seldom need decongestants.
Sounds like making a mountain out of a mole hill. Showing ID takes 2 seconds. Raising dea and transportation authority and whoever else eyebrows with your email seems to be more disruptive to you (eg secondary holds on flights where you also need to show same ID). Ps of course they don't respond with sarcasm or memes, it's in writing from federal employee and is about you purchasing and posessing meth
@@SoulDelSol I derived more amusement* than aggravation, and any time they waste fruitlessly investigating me is time not spent on mischief.
As to it being a molehill, I refer you to slippery slopes and standing on principle.
---
* One can certainly argue that I'm easily amused. Guilty as charged.
I have 6 years of chemistry schools behind me, and wanted to go study chemistry in 7 months.
Was doubting it alot recently tho, this video showed me how great chemistry really is again. Thank you for that you potentially changed my life with that
The channel with the most downloaded videos
I would never synth something from youtube lol but this is still interesting to learn how you started the process, anything in theory with the chain you want could make something else
4:55 that was out of pocket but very factual
You and Nile make me wish I’d taken chemistry so much. Tom from E/F just makes me hope a snake never gets him in the shed.
bro critical thought this entire process by not just digging up sassafras root
15:11 I’ll be waiting for that next vid🤣( as a kid I’ve seen the process 😅 , but I’m curious about how a veteran chemist brick turns out)😂
Rolling on sass is the cure for depression.
Government wants control through chaos, confusion, ignorance, poverty and sickness. Live your life how you want and move through the system like a high agency individual
Uh oh! You put the double bond in the wrong place silly goose! That olefin is gonna substitute in the terminal carbon if you react it with HBr! Now you'll have to reflux it with potassium tert-butoxide over molecular sieves to scooch it over, then you can substitute at the alpha position 😊
I saw the thumbnail and thought “IS THIS WHAT I THINK IT IS!!???” Hell yes it is!
DEA loves this substance, gives them something to do and funding.
Great stuff!!....had a thought....if sticky product gets stuck in pipettes....maybe find a way to plug the end of the pipettes and gently warm them in an oil bath.
spoken like a gent well in touch with his inner junkie desperation 🙏🏼😆
@@DezyFlores lolol....after a second read of my words, it DOES sound like that...but i assure you...I was only thinking about yield..i got to be an official olde pharte by NOT putting chemicals in me ;)
I like how ur chemical sus rating seems to go. Fails vibe check, ur getting a fine, ur getting a friendly visit, ur losing ur front door and ur gonna jail. Its kinda educational without feeling like ur learning. Really enjoy ur style of content.
Actually that's just the YT comments sections hyperbolic impression of the reality of the law. What he's doing is perfectly legal. Safrole is regulated on a quantity basis for purchase. Possession is same/similar. Homie made like 3ml
@Skunkhunt_42 yeah he said it was legal just sus. I just thought it was funny how he described it.
We goin to the federal prison with this one 🗣️🗣️
Aluminum chloride doesn't directly demethylate the methoxy group in eugenol. Instead, aluminum chloride could facilitate the electrophilic aromatic substitution of the allyl group but not directly remove the methoxy group.. Also the formation of the methylenedioxy bridge (methyleneation) typically requires a different reagent, such as formaldehyde and a strong base (e.g., sodium hydroxide) or a specific methylene transfer reagent like dichloromethane in the presence of a base like K2CO3 can work but usually in different conditions.
Poorman chemist is my hero
🐐
Ehhh.... on a slightly different kick, you can just use sesame seed oil to make sesamol, which is actually better for some synthesis then Saffrole.
The easiest way is to simply heat the oil in air until it hits it's smoke point and the sesamol begins to naturally accumulate in the oil.
You don't see DCM as a reagent that often!
My grandma grew up drinking sassafras tea. She also died of gut cancer
Based on the memes and jokes in this video, I'm concerned about you too, Pookie. I've diagnosed you with Ligma. Algorithmic Psychosis has taken hold. Dont let the psyops get you.
Ligma is a curable nutritional deficiency. The most common cure is the liberal consumption of deez nuts. Please suck.... err, _seek_ a nutritionist.
Love the Sticky Buddy Dub voice over!
NOW GET OUT OF MY HOUSE!
How many precursors can I watch be made with zero chemistry experience before I wind up on a watchlist? 🤔 can’t recreate any of this but it’s mad fun to watch 🤷🏽♂️
pretty sure the search itself is where it starts lol
Anything that in any way could possibly destabilize their control will not be tolerated
i heard about natural ingredients for rootbeer flavor being banned and that all commercially sold rootbeer is artificially flavored. though it said the fda claimed the ingredient was banned for allegedly being carcinogenic. i see now the real reason is for the potential to make hallucinogenics
yea and the legal crap is probbaly more toxic! weed ILLEGAL NOT ALLOWED< wait got GMO toxic weed now APPROVED!, clot shot APPROVED life saving drug DENIED. i bet the elite scum have access too all the banned stuff masses are nto allowed. now i wonder if there is bootleg rootbeer.
Yessir, that ol' Sunset Sassparilla
0:45 Looks like a Frog with a missing leg 😅 On that point: Is it possible to get another propanol chain on the bottom right with some chemist-magic?
Yep, all this over my head, I have no need of safrole either. I was thoroughly entertained. Now I want a fuzzy root beer float😊
1:40 He saw the left hand bottom corner...
I got spooked when i saw you just standing in the reflection of the round bottom glass
NileRed slightly evil variant
DarkNile
This explains why MDA has a root beer smell
Root Beer🔥🔥🔥
What an excellent accent you do at 5:38. Sounds like a cross between mid-Atlantic and New England. Classy!
It’s all AI💀
@@chemdelic - "AI" as in "All In". ;D The glowies can't believe this while scrambling to ban more sh*t. lol Anyway, you've got a great sense of chemical humor. :)
Sounds like Jaboodydubs voice
@@chemdelic Is it the Jaboody dubs voice? I thought i was gonna hear a dubbed video for a sec!
If cartels used your methods, they would have gone bankrupt by now)))
Are these precursors expensive or something? What makes this one less profitable I'm curious
A lot of steps, a lot of reagents and solvents, a lot of time, low yield, which will give you, after 3 more steps ....i guess, just 2 pills.
they've really adapted in the last decade ish. always have, but man kudos to them. they watched breaking bad & knew they could up their game. so they did.
now they really are converting shit into shit they convert into more shit to make the shit they was originally set out to produce 😂 but they wouldn't be if it wasn't still wicked profitable.
2:57 IT TRULLY IS!!! Pretty much SHREDDED MY PTDS!
Safrol is THAT DIVINE!
Its Ketone SMELLS LIKE A MEDOW FINE,
Its Amine IS…A GIFT FROM ABOVE!!!
“Stranga Are the Ways of the Lord!”
When I heard that I NEVER IMAGINED THAT
a way TOWARD HIS LOVE & GRACE
FITS IN Fishscale like
BITTER
Crystaline Substance!!!😊
Only One True God CAN BE THAT AWESOME & THAT HUMBLE at THE SAME TIME! ❤❤❤
Dude, you're the greatest!!
Really hyped for the nextr video
Thank you YT for adding me to a watchlist instead of adding content to my watchlist.
My immediate reaction to 0:46... "Aww... It's cute. Like a mouse with a crooked tail!"
That blue color was gorgeous
I have no idea what you just did but I really enjoyed watching it stoned 🤣
Nice job! I thoroughly enjoyed this! You are a great chemist! Thank you!
Good to see someone paid attention in Chemistry class... I was just here for the Root-beer recipe....
AW YEAH BENZINE IS BACK BABY
So close to one of my favorite chemicals. Even got the structure tattooed on my arm, amongst a few other great chemicals.
I have no background nor interest in this at all. YT just decided to autoplay it. But I actually found it very interesting and watched the whole thing. Good job.
Well, you truly learn something every day!
Pete 🏴
Stockport England.
You can just do the whole thing in DCM
Start with the eugenol dissolved in DCM, add the AlCl3 (fresh anhydrous), acidify with HCl, reflux with excess DCM and either NaOH and phase transfer catalyst (fabric conditioner) or use DMSO (faster higher yield)
Vacuum still the product
20 years ago I would have been in love with you this is something I really wanted to try when I was younger. Out of necessity I've been doing a mindless job for the last 20 years. I've completely lost the knowledge and the skill.
Use vacuum distillation for chems like these. Add s little penut oil and perlite to start. Your saffrole will be a very refractive water clear liquid.
All I have to say is living in Tampa from 97 to 2002 was insane
You are trolling the DEA i like it
we makin it into the rave with this one ‼️‼️🗣️🗣️🔥🔥🔥
Idk if safrole itself might be a good flavoring agent for a fun food project.. I've been thinking about good smelling but probably never considered as spice plants like kavakava and sassafras. I think a marshmallow infused with the leaf aroma of either kava plant or even sassafras leaf into a marshmallow or souffle or even marshmallow souffle pancakes with either or both aromas I fused into it or them might be devilishly delicious. And where are THOSE jellybeans???
12:59 Safrol can EASILY BE PURIFIED by FREEZING it and REMOVING IT THAT WAY…either from Essential Oils or Most Solvents INCLUDING ETHER! ;-)
Weird username
This video was great🤣 do ya work with isoquinalins?🤔
I truly love chemistry humor 😂😂😂
Talk about your film setup/color grading! Your stuff looks great!
OMG. Damn you had me LMAO!!!!! Freaking loved it
I’d like to see you make triclosan. Since it’s been banned from soaps, it may be a fun project.
Dear chemdelic: love your videos. If you make dph you should make dextromethorphan
6:04 this is called the lobster reaction right?