@@csammy123 GHRP 6, Cjc 1295 and Ipam work great together. Just finished rad140 and mk677 cycle staying on peptides for few more months. I'm a hard gainer so I will always use ghrp6
I started peptides in January, 49 years old. I am on a 6 week break and will be starting again in two weeks for the remainder of the year. I can say without question recovery time, soreness, sleep all next level. It isn't comparable. During my break, I have experienced a lot more soreness and recovery from it is significantly higher.
This is for me. Gym guy, amateur bodybuilder, 51 years old. On TRT already. I’m only a couple weeks in to CJC/IPA. Hope to see results soon. Thanks for the great, informative video!
@@orion9k Well, kind of good and bad. I have noticed improvement in skin appearance. Muscularity is just now starting to see noticeable improvements. I do have sleep issues though. They may be related to other neurological issue. I started feeling lightheaded in the last couple weeks. I also have tingling in my toes, especially right side. I also felt kind of a strained feeling behind my right eye. Again, it may be unrelated to this peptide. Nevertheless, it made me pause from taking it for the last week. I started doing PT-141. I’m not sure if I’ll go back to CJC. I kind of want to since I am training for a bodybuilding event in February. So, I’m trying to determine if it was the CJC that gave me some of these wierd symptoms. It’s also concerning that the FDA recently made them unavailable to my clinic. Not sure when they’ll get them back. I may just stick with TRT and PT141 for tan and libido.
@@retroconservativeswirlerso6609 I had to stop taking CJC because the fda pulled it from my clinic for testing. I did like CJC while I was on it for a couple months. It made my skin tight and appealing. I have been on Sermorelin since then. I haven’t really noticed too much from that. Maybe better sleep. Maybe also a higher metabolism. I was 175 in November and am 158 now. I’m cutting for a show. I will probably just stay on testosterone going forward, nothing else.
This is my second time, the first time I did it, after about 30 days my cardiovascular improved tremendously. When running my heart rate would get to about 110, now, it only gets to about 80 doing the same exercise.
I’m on my 2nd cycle of this combo and I can NOT take it before bed. It makes my heart race. I don’t notice it if I’m up and going but I definitely do if I’m laying in bed. I take it right when I wake up and fast for an hour. I’m still seeing a noticeable improvement in my deep and rem sleep so no issues here. Great video!
If your heart is racing after an injection, your dosage might be too high. Do more research before you dose again, and double check your reconstitution protocols.
When I take it before bed I do notice an elevated heart rate, but, weirdly enough, it's accompanied by incredible calm and sleepiness. And I pass out instantly. On the flip side, when I take it in the morning or pre-workout it doesn't make me sleepy. I assume it's context based. Like when it's the end of the day and I'm tired, it helps me sleep. But when I'm fresh amd mentally prepping for activity, it doesn't have a sleepy impact.
What's your dosage mine is 250mcg of each cjc1295/ipamorelin, 2 hours after my last meal . I don't feel anything while I'm taking it ! How long do you cycle it ?
Same here, the chest tightness has been getting progressively worse. I haven't tried the morning. I don't know why this side effect isn't talked about more.
I’m on week 4 I have neuropathy nerve damage in my feet it helped me a lot no pain including diabetes type 2 I have dropped 25lbs I’m sleeping better recoverying a lot faster I take 500mcg (20 units) 5 days a week Cjc 1295 Dac every 4 days 500mcg too
I’m so glad to see your response about nerve damage. I have nerve damage from herniated disk. I’ve had 3 back surgeries and the nerve damage in my left leg and foot is devastating. I’m looking for something to help with the nerve pain. I hope this helps.
Is it recommended for rheumatoid and vsculaites patients? I have behcit disease and its so hard to function like normal people do, with the fibromyalgia, all bone pain and vascular?
Excellent explanation! I have to say, however, when I take it at night, I cannot sleep. It's not that my heart is racing, my mind doesn't shut down in a big way! I have no problem in the morning. God bless all!
Hi, I am wanting to start using peptide cycles but I don’t have a source for the purchase of the peptides I would like. How do you, another users purchase peptides, I mean sources? Do you get them from your doctor?
Been taking tb500/bpc 157 and instantly within the FIRST INJECTION, I noticed am way more flexible. Did not know that was a thing so I researched it and yea apparently it can help with flexibility. I went from barely being able to arch my back to going way deeper than I even imagined. No pain either which is the best part. It changed how I feel my body now. Feels younger. 38 yr btw.
Nowhere does any expert recommend to take the growth hormone peptides continuously. It is always recommended to cycle on and off. There are potential adverse health consequences, otherwise. Dosing wasn't discussed here for the blend combo, either.
Question regarding the recommended blend of CJC and Ipomorelin. I see 1:1 mg blends on most sites but i've also been told it should be 2:1 Ipomorelin to CJC. Which is it?
odd on the fasted issues. I have always been told and I tell my patients to be 90 min fasted. I also use it in myself and pts in AM and PM. fasted 90 min pre and 60 min post
On week 6 of my first go-round with CJC/Ipam and I'm starting to see the bene's, ALTHOUGH today I want to eat all the things, and I've just increased the dose by .05ml from my original .10ml .. but also Iit could be normal PMS hunger... so I'll reasses in a few days ;) I'm not at the stage to "hit the gym hard" yet, I started taking it for Peri-menopause... and associated joint pain. But I'm starting to feel the energy benefits slowly.. can't wait for the skin improvements.
How or why does a rising insulin level compete with the efficacy of CJC-1295/Ipamorelin? If the answer is too long to post here, where do I go to read about it?
Source: Consensus: AI Search Engine for Research. The interaction between insulin levels and the efficacy of CJC-1295/Ipamorelin, both of which influence growth hormone (GH) and insulin-like growth factor 1 (IGF-1), is complex. CJC-1295 is a long-acting Growth Hormone-Releasing Hormone (GHRH) analog that enhances GH secretion, and Ipamorelin is a selective Growth Hormone Secretagogue (GHS) that mimics ghrelin's action to stimulate GH release. The studies I found primarily focus on the pharmacokinetic profiles, pharmacodynamic effects, and safety of CJC-1295. One study demonstrated that a single injection of CJC-1295 can lead to dose-dependent increases in mean plasma GH concentrations by 2- to 10-fold for 6 days or more and in mean plasma IGF-I concentrations by 1.5- to 3-fold for 9-11 days, with no serious adverse reactions reported (Teichman et al., 2006). Another study identified serum protein changes in response to CJC-1295, indicating potential biomarkers of GH and/or IGF-1 action (Sackmann-Sala et al., 2009). Regarding the impact of insulin on this pathway, insulin and IGF-1 share structural similarities and can interact with each other's receptors, although with different affinities. Insulin primarily regulates metabolism and has a significant role in muscle growth by stimulating protein synthesis and inhibiting protein degradation. However, elevated insulin levels can potentially lead to insulin resistance, a condition that diminishes the effectiveness of insulin in lowering blood sugar levels, which might indirectly influence the efficacy of GH and IGF-1 due to the intricate relationship between insulin sensitivity and GH/IGF-1 actions. Insulin resistance is associated with reduced GH receptor expression and impaired GH signaling, which could diminish the effectiveness of CJC-1295/Ipamorelin in promoting GH and IGF-1 release and action. Although the exact mechanisms of how rising insulin levels might compete with the efficacy of CJC-1295/Ipamorelin were not directly addressed in the studies found, the interplay between insulin, GH, and IGF-1 suggests that optimal insulin sensitivity is crucial for the full anabolic effects of GH and IGF-1. Therefore, maintaining healthy insulin levels and sensitivity could enhance the efficacy of CJC-1295/Ipamorelin in promoting GH and IGF-1 related outcomes.
Question! I'm 30yo and I'd like to start taking cjc1295 to help excelerate injury healing,liver healing, and target visceral fat, which I seem to have trouble losing do to a severe mould toxicity I had 2 years ago. I'm, 51, 58kg ( so not fat ans very muscular) am I able to just do 1 cycle of 12 weeks of just cjc1295 of 1.7ml a week and be able to maintain my results with healthy lifestyle? Or is it something you need to do many cycles of. Does it dampen yout ability to make human growth hormone after you stop taking it?
I could only get them separately here in UK so that's two needles, so not to contaminate separate vials, I've just switched to CJC-1295 DAC so don't have to daily with the Ipamorelin, I'd like to here more about that and dosages, people would like to take as little as possible with the best effects, for financial reasons and to minimise side effects.
It's absolutely fine to mix these 2 peptides, so you can simply draw up your Ipamorelin then your CJC-1295 into the same syringe before injecting. They also synergise, so they're more effective taken together.
@@tonibryant1114 No more than inserting it into the first vial. If you're concerned about contaminating one peptide with another, these 2 peptides are entirely compatible when mixed, and have no effect at all on each other's efficacy or shelf life - in fact, some labs even supply them pre-mixed in the same vial.
its flexible. generally, bpc twice a day, tb500 twice a week (though if you have a mix or prefer smaller doses, daily is sort of better but not necessary). ipa/cgc no dac also best twice a day, though once a day helps too. cgc with dac lasts much longer but much more side effects i don't recommend that one
Question: Can medications like ozempic increase aging if hunger is suppressed? It looks like hunger increases with stimulating GH. Is there a relationship?
Typically dosed at 200-400mcg daily, depending on the person and source. And we often combine peptides like CJC/Ipam with sermorelin or tirzepatide to help prevent muscle loss with weight loss. *Not medical advice, speak with your physician before starting any medications*
@robinriddle477 so can the cjc / ipam cause muscle loss?? Also I'm taking BPC157 for recovery and am looking to adding TB500 on my next order. Is it OK to take these peptides at the same time??
Would this work helping recovery from a stroke? My dad is 87 years old and has some cognitive issues and left hand not moving. Other parts have recovered. Could this help rebuild the connection to the hand and recover some short term memory loss? Thanks. I lift weights and I will be trying it.
I've been on 10mg Ipa for about a year then now Ipa 5mg / CJC 5mg for 5mo...I will say, now that I'm a year + into this peptide journey, people keep asking me what my secret is. I'm 47 and my skin is rocking. My hair is growing back. This stuff works great with topicals for hair. I'm recently single and talk to many girls in and around 30yo with no problems. I had previous experience with IPA years ago but fell off. I just got my IGF1 tested and I'm at 200...which is good, but not crazy high. So, I'm inclined to increase dose by 20%.
If I were taking CJC1295 with DAC, and Ipamorelin seperately, what would the relative dosages be? I'm of the understanding that the CJC w/ DAC is only dosed once per week, between 100-200mcg. Is that sufficient? Could I then take Ipamorelin twice per day on its own, 200-300mcg, and still achieve the same benefit of the usual blended solution without DAC? I ask for cost efficiency reasons, as the blended solution is more expensive than the individual compounds combined.
saturation dose for most (or all) ghrh or ghrp i always read 1mcg x kg weight. so i suppose 75mcg is the most cost effective dose, i am doing it 75/75mcg of cjc ipa. of course cjc no dac. using 200 300mcg for ipa is still ok because not raises other hormones , being selective. BUT once saturation dose is reached you are wasting price/performance ratio. i read that 200mcg vs 100 for example just raise 50% more. and adding other 100mcg (so 300) just adds 25% more gh. so basically injecting more = more gh but not proportional to active substance used. better MORE injections, with each the saturation dose of 1mcg x kg.
@@orion9k Funny you ask that. I'm thinking of trying this now instead, simply because Sermorelin is much cheaper and I could potentially dose it higher. I'm curious though if Sermorelin has the same 'cap' on it's saturation level like ModGrf(CJC). I see online many people take 200-500mcg of Sermorelin per dose, but most everyone limits their ModGrf to 100mcg. I think these are very similar peptides so it's confusing to me why the typical doses would be different. FYI.. I had great results with ipam/modgrf. I did 150mcg/100mcg doses maybe 4-5 times a week. I was very diligent about being fasted and remaining fasted. The most profound effect was the best digestion of my life and the perfect nature of my stools. Very relieving. I later tried Mk677 with CJC+DAC. The recovery was excellent but the appetite was unmanagable and my digestion was trash again (as usual). Sloppy and oily stools. I missed the perfect, dry, hard and large stools (wipe and nothing on toilet paper) of the ipam/modgrf combo. So I'm going back to the pulsatile peptide combo.
Can you take this when you take Levothyroxine. I do not have a thyroid so I don’t have any natural thyroid hormone production. They removed it because I had hyperthyroidism (graves’ disease).
Dr William Seeds says 100mcg of ipa is its saturation dose. Meaning, the body can only use that much at once. But, from what I read, many people take more. I've been doing 100mcg 3x daily.
@@user-pr5tx9ep4m saturation dose for most (or all) ghrh or ghrp i always read 1mcg x kg weight. so i suppose 75mcg is the most cost effective dose, i am doing it 75/75mcg of cjc ipa. of course cjc no dac. using 200 300mcg for ipa is still ok because not raises other hormones , being selective. BUT once saturation dose is reached you are wasting price/performance ratio. i read that 200mcg vs 100 for example just raise 50% more. and adding other 100mcg (so 300) just adds 25% more gh. so basically injecting more = more gh but not proportional to active substance used. better MORE injections, with each the saturation dose of 1mcg x kg.
That is actually the very same reason. I am on this video and re-searching all of the comments. Up above, it seems like several others have had the same thing, and a few people have switched to the morning. I am probably going to do that tomorrow morning myself as I got into these to help with sleep, and it has been progressively worse over the first two weeks of injecting. Literally will fall asleep, and my aura ring monitors, low rem, and low deep sleep. Hours of sleep or decreasing almost by the night. As long as it is on an empty stomach, I don’t feel like it hurt me any worse on sleeping if I take it in the morning, just a logistical issue at this point.
I’m curious how this might affect the elderly, my father is 85 he’s overweight he has post polio syndrome which means he can’t really walk very far without a walker and he gets out of breath fast because of previous heart failure, heart valve replacement, and he has a pacemaker
@@robinhood20233 just wondering. Apparently it doesn't help younger people much because they produce plenty of growth hormone anyway. 54 you would think it would make a difference.
Can you take casein protein at night after the shot or should you fast at night after it? would it be 30 mins to 60 mins after? or does more GH get released while you sleep if on an empty stomach? or can you take 1295+ipa then after the shot do casein so you can maximize protein synthesis over night?
I should not eat anything for 3 hours before the injection of Ipamorelin/CJC and 1 hour after. But can I take 1.5g GABA in the evening before going to bed, i.e. at about the same time as the injection of Ipamorelin or does that also influence the effect of Ipamorelin?
why doesn't Performance Medicine reply to ANY of the comments? It's only other users which mostly have more questions? I find that very poor after putting out information like Robin Riddle.
Please help Why do I have swelling for like 2 to 3 days in the injection 💉 site and itching and my stomach seems bloated I use 10units or 1 iu every night for 5 days and then sat and sun off Can I please have a proper answer or reply
What are your thoughts on CJC-1295 Ipamorelin increasing blood flow to cancer cells? You may have a small unknown cancer cell somewhere in your body and this peptide may accelerate the growth.
I take ipam with modified GRF 1-29 which is a ghrh similar to cjc but without DAC. One of the developers of CJC1295 himself prefers it wirhout the DAC. 1) you dont burn out your pituitary with pulsatile GH release with the modified grf 1-29. 2)you allow your pituitary to accumulate GH with mod grf1-29. Its like holding your piss. If you allow your body to accumulate piss, youre gonna piss out a lot. If you make your body pee all the time, youre just gonna trickle out a sorry droplet or two at a constant rate. 3) GH pulses are physiologically more natural. 4) you may develop an immune response to cjc with dac.
These growth hormone stimulators are really for people over 30 where their natural production drops off. If you start taking it at a young age where your brain is still developing I think you're taking a big risk. There are other peptides you could consider, but if you're a 17yo boy you already have SO MUCH gh, just absolutely push yourself in thr gym and get your natural production up as high as possible
With human growth hormone increase of 200-1000% more than your body is creating. Is there a point of too much human growth hormone should increase. HGH treatments from my knowledge of done too much or too high of an increase can make enlarged organs. So will this combo have any effect on your organs?
truth is these numbers are totally fake XD because i cannot give u real numbers but i read everywhere that for antiaging only purposes, is ok 100/100mcg of both peptides, pre bed. BUT for other plus like better recovery, some muscle or some lipolytic effect you have to make not 1 but 2 or 3 injections. morning, postwo, bed. and still 3 jabs i read somehow can't compare for example to 4ui of gh. could be max 3...2ui?even less? who knows.
i experimented a lot with that combo for the last 2 years, before bed,,,, not sure if its a good idea, the thing i did is lower the dosage of the ipamoralin was on 200-300mg per day 5/2 lowered it to 100mg along with mod gfr 1-29 at 100mg now no more side effects i sleep amazing and recup is awesome just turned 51 last week. GHRP2 is cheaper with lower dosage i really like it almost no appetite but too high and prolactin and cortisol is getting out of wack. For the muscle growth the vote is still out i been training for 37 years.
Ms. Robbin, do you take telemed appmnts? I just started a few things you discuss with prescription but the office I go through definitly doesn't have the attention to detail nor do they run tests to track or observe anything...
@@hogassassin5307 oh that’s awesome! Same here. I was on it for 2 and a half months and bpc157 but then I ran out and didn’t have funds to buy more so I’ve been off couple months now. Bummer cuz you can really start to see results around 6 months or so
I just ordered IPAMORELIN , IM NEW TO THIS , BUT I BOUGHT IPAM 2MG , MY THOUGHTS WAS THE EVERYDAY DOSAGES ? WHATS THE MINIMUM AMOUNT OF A DOSAGE ? AND IS ONCE A NIGHT SUFFICIENT ? FUNNY ABOUT THE NAME TOO , I WAS TRYING TO SPELL IT AND I BROKE IT DOWN TOO IPAM LOL TO REMEMBER. I'D APPRECIATE IF YOU CAN HELP ME OUT TY
Your dose is too high most likely, are you cycling 5 days of 2 days off, that’s one of the reasons for this type of cycling instead of continuous for 3 months.
My concern is no long term studies to show increasing malignancy rates.. anyways Im on my day 14 - will take it 6 months straight - 5 day on 2 days off.
@@Ridindirty808 First vial is done by yesterday. Gained 5lb pure lean muscle, dropped body fat 3%. Never looked this muscular in my entire life. I will give 2 week break then do the second 2-month cycle.
After taking this for 6 months I started getting an allergic reaction after injecting. My hands and feet itch badly and I feel like my face wants to swell up even though visually it doesnt. This lasts for about 30 minutes and is impossible to sleep when this happens. Is there a way around it?
Would be nice if you guys could spend at least SOME time on the safety of this completely new treatment. Apart from efficacy, safety is most important. Any health risks? Cancer risk? Any human research? Appreciated.
without dac i think is that one. with dac i think you take once a week, and i heard dont eat 2 hours before and dont eat 30 min. and people say before bed
Im 48 and using cjc1295 ipam and ghrp6. I feel amazing 20 years younger. 👍👍👍
Why ghrp6 over Ipamorelin?
@@csammy123 GHRP 6, Cjc 1295 and Ipam work great together. Just finished rad140 and mk677 cycle staying on peptides for few more months. I'm a hard gainer so I will always use ghrp6
@@csammy123 I'm a very hard gainer. So I use it to eat more
@@somethinglikethat212same here 💪🏻 appetite boost is tremendous with ghrp6 and no prolactin or any other sides at normal to moderate dosages.
Where did you buy it ?
I started peptides in January, 49 years old. I am on a 6 week break and will be starting again in two weeks for the remainder of the year. I can say without question recovery time, soreness, sleep all next level. It isn't comparable. During my break, I have experienced a lot more soreness and recovery from it is significantly higher.
This is for me. Gym guy, amateur bodybuilder, 51 years old. On TRT already. I’m only a couple weeks in to CJC/IPA. Hope to see results soon. Thanks for the great, informative video!
Have you seen anything yet? Hope everything going well.
@@orion9k Well, kind of good and bad. I have noticed improvement in skin appearance. Muscularity is just now starting to see noticeable improvements. I do have sleep issues though. They may be related to other neurological issue. I started feeling lightheaded in the last couple weeks. I also have tingling in my toes, especially right side. I also felt kind of a strained feeling behind my right eye. Again, it may be unrelated to this peptide. Nevertheless, it made me pause from taking it for the last week. I started doing PT-141. I’m not sure if I’ll go back to CJC. I kind of want to since I am training for a bodybuilding event in February. So, I’m trying to determine if it was the CJC that gave me some of these wierd symptoms. It’s also concerning that the FDA recently made them unavailable to my clinic. Not sure when they’ll get them back. I may just stick with TRT and PT141 for tan and libido.
How’s the results five months later?
@@retroconservativeswirlerso6609
I had to stop taking CJC because the fda pulled it from my clinic for testing. I did like CJC while I was on it for a couple months. It made my skin tight and appealing. I have been on Sermorelin since then. I haven’t really noticed too much from that. Maybe better sleep. Maybe also a higher metabolism. I was 175 in November and am 158 now. I’m cutting for a show. I will probably just stay on testosterone going forward, nothing else.
@@retroconservativeswirlerso6609he died because of the peptides I went to his funeral
This is my second time, the first time I did it, after about 30 days my cardiovascular improved tremendously. When running my heart rate would get to about 110, now, it only gets to about 80 doing the same exercise.
Aren't you afraid, if you stop it, your heart rate may go up even higher?
I’m on my 2nd cycle of this combo and I can NOT take it before bed. It makes my heart race. I don’t notice it if I’m up and going but I definitely do if I’m laying in bed. I take it right when I wake up and fast for an hour. I’m still seeing a noticeable improvement in my deep and rem sleep so no issues here. Great video!
I do that as well, then I hit the gym after
If your heart is racing after an injection, your dosage might be too high. Do more research before you dose again, and double check your reconstitution protocols.
When I take it before bed I do notice an elevated heart rate, but, weirdly enough, it's accompanied by incredible calm and sleepiness. And I pass out instantly.
On the flip side, when I take it in the morning or pre-workout it doesn't make me sleepy. I assume it's context based. Like when it's the end of the day and I'm tired, it helps me sleep. But when I'm fresh amd mentally prepping for activity, it doesn't have a sleepy impact.
What's your dosage mine is 250mcg of each cjc1295/ipamorelin, 2 hours after my last meal . I don't feel anything while I'm taking it ! How long do you cycle it ?
Same here, the chest tightness has been getting progressively worse. I haven't tried the morning. I don't know why this side effect isn't talked about more.
I’m on week 4 I have neuropathy nerve damage in my feet it helped me a lot no pain including diabetes type 2 I have dropped 25lbs I’m sleeping better recoverying a lot faster I take 500mcg (20 units) 5 days a week Cjc 1295 Dac every 4 days 500mcg too
Have you been dieting?
I have the same issues just wondering how long you have been taking it before you saw the weight loss and relief with the nerve damage?
@@CAPTALISM i would recommend OMAD/intermittent fasting to further boost gh
I’m so glad to see your response about nerve damage. I have nerve damage from herniated disk. I’ve had 3 back surgeries and the nerve damage in my left leg and foot is devastating. I’m looking for something to help with the nerve pain. I hope this helps.
Great, informative video! I loved listening to both of you!
Is it recommended for rheumatoid and vsculaites patients? I have behcit disease and its so hard to function like normal people do, with the fibromyalgia, all bone pain and vascular?
Excellent explanation! I have to say, however, when I take it at night, I cannot sleep. It's not that my heart is racing, my mind doesn't shut down in a big way! I have no problem in the morning. God bless all!
For this reason I've split up my intake : ipa in th morning, cjc in evening
Hi, I am wanting to start using peptide cycles but I don’t have a source for the purchase of the peptides I would like. How do you, another users purchase peptides, I mean sources? Do you get them from your doctor?
Been taking tb500/bpc 157 and instantly within the FIRST INJECTION, I noticed am way more flexible. Did not know that was a thing so I researched it and yea apparently it can help with flexibility. I went from barely being able to arch my back to going way deeper than I even imagined. No pain either which is the best part. It changed how I feel my body now. Feels younger.
38 yr btw.
Nowhere does any expert recommend to take the growth hormone peptides continuously. It is always recommended to cycle on and off. There are potential adverse health consequences, otherwise. Dosing wasn't discussed here for the blend combo, either.
Well what are they…. Gh has to be taken long term. As a pro bodybuilder I take it all year round non stop.. i fell super human
u can do literally 6 month cycles with these
Hi everyone in Australia here, great video by the way excellent!!
I’m having trouble finding cjc 1295 ipma in Australia
Google Phyx
Question regarding the recommended blend of CJC and Ipomorelin. I see 1:1 mg blends on most sites but i've also been told it should be 2:1 Ipomorelin to CJC. Which is it?
It’s 1:1
odd on the fasted issues. I have always been told and I tell my patients to be 90 min fasted. I also use it in myself and pts in AM and PM. fasted 90 min pre and 60 min post
how does she feel about Sermorelin in conjunction with ipamorelin?
On week 6 of my first go-round with CJC/Ipam and I'm starting to see the bene's, ALTHOUGH today I want to eat all the things, and I've just increased the dose by .05ml from my original .10ml .. but also Iit could be normal PMS hunger... so I'll reasses in a few days ;) I'm not at the stage to "hit the gym hard" yet, I started taking it for Peri-menopause... and associated joint pain. But I'm starting to feel the energy benefits slowly.. can't wait for the skin improvements.
Hey! Can I ask your age? I am 31 and considering it
Does this help arthritis?
What about it effect on fasting blood sugar ?)
How or why does a rising insulin level compete with the efficacy of CJC-1295/Ipamorelin? If the answer is too long to post here, where do I go to read about it?
Source: Consensus: AI Search Engine for Research.
The interaction between insulin levels and the efficacy of CJC-1295/Ipamorelin, both of which influence growth hormone (GH) and insulin-like growth factor 1 (IGF-1), is complex. CJC-1295 is a long-acting Growth Hormone-Releasing Hormone (GHRH) analog that enhances GH secretion, and Ipamorelin is a selective Growth Hormone Secretagogue (GHS) that mimics ghrelin's action to stimulate GH release. The studies I found primarily focus on the pharmacokinetic profiles, pharmacodynamic effects, and safety of CJC-1295.
One study demonstrated that a single injection of CJC-1295 can lead to dose-dependent increases in mean plasma GH concentrations by 2- to 10-fold for 6 days or more and in mean plasma IGF-I concentrations by 1.5- to 3-fold for 9-11 days, with no serious adverse reactions reported (Teichman et al., 2006). Another study identified serum protein changes in response to CJC-1295, indicating potential biomarkers of GH and/or IGF-1 action (Sackmann-Sala et al., 2009).
Regarding the impact of insulin on this pathway, insulin and IGF-1 share structural similarities and can interact with each other's receptors, although with different affinities. Insulin primarily regulates metabolism and has a significant role in muscle growth by stimulating protein synthesis and inhibiting protein degradation. However, elevated insulin levels can potentially lead to insulin resistance, a condition that diminishes the effectiveness of insulin in lowering blood sugar levels, which might indirectly influence the efficacy of GH and IGF-1 due to the intricate relationship between insulin sensitivity and GH/IGF-1 actions. Insulin resistance is associated with reduced GH receptor expression and impaired GH signaling, which could diminish the effectiveness of CJC-1295/Ipamorelin in promoting GH and IGF-1 release and action.
Although the exact mechanisms of how rising insulin levels might compete with the efficacy of CJC-1295/Ipamorelin were not directly addressed in the studies found, the interplay between insulin, GH, and IGF-1 suggests that optimal insulin sensitivity is crucial for the full anabolic effects of GH and IGF-1. Therefore, maintaining healthy insulin levels and sensitivity could enhance the efficacy of CJC-1295/Ipamorelin in promoting GH and IGF-1 related outcomes.
how new is CJC-1295 Ipamorelin?
Question! I'm 30yo and I'd like to start taking cjc1295 to help excelerate injury healing,liver healing, and target visceral fat, which I seem to have trouble losing do to a severe mould toxicity I had 2 years ago. I'm, 51, 58kg ( so not fat ans very muscular) am I able to just do 1 cycle of 12 weeks of just cjc1295 of 1.7ml a week and be able to maintain my results with healthy lifestyle? Or is it something you need to do many cycles of.
Does it dampen yout ability to make human growth hormone after you stop taking it?
I could only get them separately here in UK so that's two needles, so not to contaminate separate vials, I've just switched to CJC-1295 DAC so don't have to daily with the Ipamorelin, I'd like to here more about that and dosages, people would like to take as little as possible with the best effects, for financial reasons and to minimise side effects.
Where do you get them from in the UK?
What is the difference between the DAC vs not DAC ?
It's absolutely fine to mix these 2 peptides, so you can simply draw up your Ipamorelin then your CJC-1295 into the same syringe before injecting. They also synergise, so they're more effective taken together.
@@adammaximuswilkinson5601 so when you insert your needle into the 2nd vial, aren't you contaminating it?
@@tonibryant1114 No more than inserting it into the first vial. If you're concerned about contaminating one peptide with another, these 2 peptides are entirely compatible when mixed, and have no effect at all on each other's efficacy or shelf life - in fact, some labs even supply them pre-mixed in the same vial.
But what is the recommended amount for daily use? for the 10mg (NODAC) 45 age
Sounds good but no explanation about where to buy or how to apply it? She’s talking about micro dose but they sell 10mg. No mcg
What if I’ve been taking it for two weeks and I don’t notice improve sleep? I also don’t get that flush feeling at night
So if your on this blend along with bpc157&tb500 should the latter be taken in the am and cjc ipam in the evening?
its flexible. generally, bpc twice a day, tb500 twice a week (though if you have a mix or prefer smaller doses, daily is sort of better but not necessary). ipa/cgc no dac also best twice a day, though once a day helps too. cgc with dac lasts much longer but much more side effects i don't recommend that one
Is it true that the FDA has banned pretty much all peptides? they are becoming hard to get...
Yes
There’s alot of money made off of sick and injured people.
Bpc157 is prescribed though
Question: Can medications like ozempic increase aging if hunger is suppressed? It looks like hunger increases with stimulating GH. Is there a relationship?
Where can I find doasge info? Also can you stack with Tirzepatide for cutting?
Typically dosed at 200-400mcg daily, depending on the person and source. And we often combine peptides like CJC/Ipam with sermorelin or tirzepatide to help prevent muscle loss with weight loss.
*Not medical advice, speak with your physician before starting any medications*
@robinriddle477 so can the cjc / ipam cause muscle loss?? Also I'm taking BPC157 for recovery and am looking to adding TB500 on my next order. Is it OK to take these peptides at the same time??
@@lloydy2644that’s the exact stack recommended to me
Would this work helping recovery from a stroke? My dad is 87 years old and has some cognitive issues and left hand not moving. Other parts have recovered. Could this help rebuild the connection to the hand and recover some short term memory loss? Thanks. I lift weights and I will be trying it.
I've been on 10mg Ipa for about a year then now Ipa 5mg / CJC 5mg for 5mo...I will say, now that I'm a year + into this peptide journey, people keep asking me what my secret is. I'm 47 and my skin is rocking. My hair is growing back. This stuff works great with topicals for hair. I'm recently single and talk to many girls in and around 30yo with no problems. I had previous experience with IPA years ago but fell off. I just got my IGF1 tested and I'm at 200...which is good, but not crazy high. So, I'm inclined to increase dose by 20%.
Where did you get out
@@zaksnow6895 a functional medicine doctor would be willing to prescribe this in many cases
Wait, you mean mcg not mg
10 mg? You are on way way way way way too much.
@@foopus I think they met milligrams because 10 mcg would be nothing. And 10 mg is insane.
Where can I get this from in the UK?
If I were taking CJC1295 with DAC, and Ipamorelin seperately, what would the relative dosages be?
I'm of the understanding that the CJC w/ DAC is only dosed once per week, between 100-200mcg. Is that sufficient?
Could I then take Ipamorelin twice per day on its own, 200-300mcg, and still achieve the same benefit of the usual blended solution without DAC?
I ask for cost efficiency reasons, as the blended solution is more expensive than the individual compounds combined.
saturation dose for most (or all) ghrh or ghrp i always read 1mcg x kg weight. so i suppose 75mcg is the most cost effective dose, i am doing it 75/75mcg of cjc ipa. of course cjc no dac. using 200 300mcg for ipa is still ok because not raises other hormones , being selective. BUT once saturation dose is reached you are wasting price/performance ratio. i read that 200mcg vs 100 for example just raise 50% more. and adding other 100mcg (so 300) just adds 25% more gh. so basically injecting more = more gh but not proportional to active substance used.
better MORE injections, with each the saturation dose of 1mcg x kg.
@@realista182 what about Sermorelin & Ipamorelin together? Know anyone who done this combo?
@@orion9k Funny you ask that. I'm thinking of trying this now instead, simply because Sermorelin is much cheaper and I could potentially dose it higher. I'm curious though if Sermorelin has the same 'cap' on it's saturation level like ModGrf(CJC). I see online many people take 200-500mcg of Sermorelin per dose, but most everyone limits their ModGrf to 100mcg. I think these are very similar peptides so it's confusing to me why the typical doses would be different.
FYI.. I had great results with ipam/modgrf. I did 150mcg/100mcg doses maybe 4-5 times a week. I was very diligent about being fasted and remaining fasted. The most profound effect was the best digestion of my life and the perfect nature of my stools. Very relieving.
I later tried Mk677 with CJC+DAC. The recovery was excellent but the appetite was unmanagable and my digestion was trash again (as usual). Sloppy and oily stools. I missed the perfect, dry, hard and large stools (wipe and nothing on toilet paper) of the ipam/modgrf combo. So I'm going back to the pulsatile peptide combo.
Need to find dosage or 1295/DAC and IPAmorelin
What do you guys think of just cjc1295 without dac on its own
Can you take this when you take Levothyroxine. I do not have a thyroid so I don’t have any natural thyroid hormone production. They removed it because I had hyperthyroidism (graves’ disease).
Hi there, if you are already doing hgh subcutaneous, should you stop that before starting this peptide blend? Or ok to do it together?
Has anyone take this with Enclomiphen ?
Great information. thanks. what is the dosage?
Dr William Seeds says 100mcg of ipa is its saturation dose. Meaning, the body can only use that much at once. But, from what I read, many people take more. I've been doing 100mcg 3x daily.
@@user-pr5tx9ep4m Thank you for replying
@@user-pr5tx9ep4m saturation dose for most (or all) ghrh or ghrp i always read 1mcg x kg weight. so i suppose 75mcg is the most cost effective dose, i am doing it 75/75mcg of cjc ipa. of course cjc no dac. using 200 300mcg for ipa is still ok because not raises other hormones , being selective. BUT once saturation dose is reached you are wasting price/performance ratio. i read that 200mcg vs 100 for example just raise 50% more. and adding other 100mcg (so 300) just adds 25% more gh. so basically injecting more = more gh but not proportional to active substance used.
better MORE injections, with each the saturation dose of 1mcg x kg.
My Dr - 20 IU at night, 5 nights a week for 6 months.
Can these be used at the same time as Tirzepitide?
Yes
Very beneficial it’s called stacking
Thanks Performance Medicine!!!
Hey Guys, What do I do if I've had adverse effects...can't sleep wide awake. Please help. Thanks
That is actually the very same reason. I am on this video and re-searching all of the comments. Up above, it seems like several others have had the same thing, and a few people have switched to the morning. I am probably going to do that tomorrow morning myself as I got into these to help with sleep, and it has been progressively worse over the first two weeks of injecting. Literally will fall asleep, and my aura ring monitors, low rem, and low deep sleep. Hours of sleep or decreasing almost by the night. As long as it is on an empty stomach, I don’t feel like it hurt me any worse on sleeping if I take it in the morning, just a logistical issue at this point.
@@MattVirtualRuns12 Did you switch? Any better results?
Can you please do a video on Tesamorelin/ Ipamorelin? 🙏
that is a much better combo though much more expensive (the tesa part is $$$). much better overall! less side effects like awake at night
There are 100s or available peptides and only about a dozen that target high and igf1
true ehehehe . she said most peptides do this...
I thought the exact same thing…. It’s definitely not even close to a “majority of the peptides” lmaooooo
@@matthewdecloedt1323 true
I’m curious how this might affect the elderly, my father is 85 he’s overweight he has post polio syndrome which means he can’t really walk very far without a walker and he gets out of breath fast because of previous heart failure, heart valve replacement, and he has a pacemaker
yes, it does... but, it's gradual increase unlike hgh, which can shoot it into the stratosphere.
Do some research on peptides there’s several that help with cardiovascular, dementia, healing the liver. All sorts of different peptides.
Can this speed up cancer cells?
How bad is water retention?
I try this both peptides but i feel nothing and a dont sleep better or deeper. From CJC-1295 i feel heart beating and opposite of sleepy.
How old are you?
@@innocentbystander8038 I'm 54. Why?
@@robinhood20233 just wondering. Apparently it doesn't help younger people much because they produce plenty of growth hormone anyway. 54 you would think it would make a difference.
So this is a question for the audience. Will any of these peptides actually cause insulin resistance given that growth hormone is that play?
Good question…I wonder about that too.
Can you take casein protein at night after the shot or should you fast at night after it? would it be 30 mins to 60 mins after? or does more GH get released while you sleep if on an empty stomach? or can you take 1295+ipa then after the shot do casein so you can maximize protein synthesis over night?
Better skip the protein and you don't need the protein to grow muscle overnight.
You need to be fasted for 2 hours before the shot, and for an hour after.
I developed lupus and hypertension after taking CJC ipam
After how long of being on them?
I should not eat anything for 3 hours before the injection of Ipamorelin/CJC and 1 hour after. But can I take 1.5g GABA in the evening before going to bed, i.e. at about the same time as the injection of Ipamorelin or does that also influence the effect of Ipamorelin?
reputable places to get peptides?
P sciences
amino usa
I experienced severe dizziness.. is that common? What would cause this?
why doesn't Performance Medicine reply to ANY of the comments? It's only other users which mostly have more questions? I find that very poor after putting out information like Robin Riddle.
Can I take cjc1295/ipamorelin nasally rather than needles I know it’s less bio just wonder if it’s safer and possible
Please help Why do I have swelling for like 2 to 3 days in the injection 💉 site and itching and my stomach seems bloated I use 10units or 1 iu every night for 5 days and then sat and sun off
Can I please have a proper answer or reply
Ipa+tesma+cjc how's this combination ?
As a beginner. Never took peptides weighing 95kg but looking to get under 90kg, how much should i take and how often?
but does it induce cancer?
What are your thoughts on CJC-1295 Ipamorelin increasing blood flow to cancer cells? You may have a small unknown cancer cell somewhere in your body and this peptide may accelerate the growth.
Do you have recommended reliable sources for purchase?
What about as a nasal spray with this combo?
I take ipam with modified GRF 1-29 which is a ghrh similar to cjc but without DAC.
One of the developers of CJC1295 himself prefers it wirhout the DAC. 1) you dont burn out your pituitary with pulsatile GH release with the modified grf 1-29.
2)you allow your pituitary to accumulate GH with mod grf1-29. Its like holding your piss. If you allow your body to accumulate piss, youre gonna piss out a lot. If you make your body pee all the time, youre just gonna trickle out a sorry droplet or two at a constant rate.
3) GH pulses are physiologically more natural.
4) you may develop an immune response to cjc with dac.
I thought the blend is with out the dac unless you get the cjc-1295 dac there’s 1295 without dac
Can I take it at 17 without fear of more side effects than water retention and headaches
These growth hormone stimulators are really for people over 30 where their natural production drops off. If you start taking it at a young age where your brain is still developing I think you're taking a big risk. There are other peptides you could consider, but if you're a 17yo boy you already have SO MUCH gh, just absolutely push yourself in thr gym and get your natural production up as high as possible
I split the dose, half in morning and half at night.
hello all, love peptides but, where are you all getting them ?? most importantly
P sciences
Can peptides replace hrt/trt????
No
I have 2mg cjc1295. How much waterndo I mix with ?
If you add 2ml of water, then in an insulin syringe with 40 lines, five lines will mean a dose of 100 micrograms.
Can type 1 diabetics take advantage of this?
Damn i just ordered 12 weeks of sermorelin/ipamorelin blend
Wish I did cjc/ipa
Where did you get it can’t find that combo
@anamshaikh1497 not the end of the world. Still a solid stack. I did just IPA foe years and it was great
Please explain dosage....
How long you should cycling for ?
I'm on my 2nd month and thinking doing 6 months! 5 days on 2 off ?
I was told 4 months on, 1 month off. 5/2
With human growth hormone increase of 200-1000% more than your body is creating. Is there a point of too much human growth hormone should increase. HGH treatments from my knowledge of done too much or too high of an increase can make enlarged organs. So will this combo have any effect on your organs?
truth is these numbers are totally fake XD because i cannot give u real numbers but i read everywhere that for antiaging only purposes, is ok 100/100mcg of both peptides, pre bed. BUT for other plus like better recovery, some muscle or some lipolytic effect you have to make not 1 but 2 or 3 injections. morning, postwo, bed. and still 3 jabs i read somehow can't compare for example to 4ui of gh. could be max 3...2ui?even less? who knows.
How much is this product ???
Where y’all buy it from ?
i experimented a lot with that combo for the last 2 years, before bed,,,, not sure if its a good idea, the thing i did is lower the dosage of the ipamoralin was on 200-300mg per day 5/2 lowered it to 100mg along with mod gfr 1-29 at 100mg now no more side effects i sleep amazing and recup is awesome just turned 51 last week. GHRP2 is cheaper with lower dosage i really like it almost no appetite but too high and prolactin and cortisol is getting out of wack.
For the muscle growth the vote is still out i been training for 37 years.
Sounds like a massive overdose. Supposed to be .3mg a day, not 300.
Ms. Robbin, do you take telemed appmnts? I just started a few things you discuss with prescription but the office I go through definitly doesn't have the attention to detail nor do they run tests to track or observe anything...
Yes! Email April@performancemedicine.net Thank you!!
So will it work for type 1 diabetics
I'm type 1 and this combination hasn't messed with my glucose. It's great!
@@hogassassin5307 oh that’s awesome! Same here. I was on it for 2 and a half months and bpc157 but then I ran out and didn’t have funds to buy more so I’ve been off couple months now. Bummer cuz you can really start to see results around 6 months or so
How about a link to get some? Im kinda unsure whos legit.
Umbrella labs look them up they 💯 legit I’ve been using their stuff for a while now.
@@lou861000 any bad effects from cjc ipa
Amino asylum if in USA
I just ordered IPAMORELIN , IM NEW TO THIS , BUT I BOUGHT IPAM 2MG , MY THOUGHTS WAS THE EVERYDAY DOSAGES ? WHATS THE MINIMUM AMOUNT OF A DOSAGE ? AND IS ONCE A NIGHT SUFFICIENT ?
FUNNY ABOUT THE NAME TOO , I WAS TRYING TO SPELL IT AND I BROKE IT DOWN TOO IPAM LOL TO REMEMBER.
I'D APPRECIATE IF YOU CAN HELP ME OUT TY
Why are you yelling? LoL...Might as well buy the 5mg to 10mg. Will the 2mg help, sure, but you're just dipping your toe in the water.
Where did you buy it from?
I’ve noticed a lot of water retention
Your dose is too high most likely, are you cycling 5 days of 2 days off, that’s one of the reasons for this type of cycling instead of continuous for 3 months.
Got a reliable source for your recommended peptides?
A lot of med spas off them
Does Ipamorelin have the same side effects as regular HGH which can trigger tumor growth?Because thats the reason I never used HGH
Both elevated İGF-1
What about the side effects?
My concern is no long term studies to show increasing malignancy rates.. anyways Im on my day 14 - will take it 6 months straight - 5 day on 2 days off.
hows it goin so far
@@Ridindirty808
First vial is done by yesterday.
Gained 5lb pure lean muscle, dropped body fat 3%. Never looked this muscular in my entire life. I will give 2 week break then do the second 2-month cycle.
Where did you order from?
@@DrMattViolingreat progress!!
Do you take this daily?
Can anyone recommend where to order? Thank you!
Peptide science
Where's a good place to get the dissolvable CJC-1295 Ipamorelin tablets?
What’s the best to lose weight?
dose ?
Growth, hormone releasing hormone is actually released by the hypothalamus and on the pituitary. I think they’re trying to say
Mk677 or CJC/Imp? Which is better?
That's what I want to know
mk677 would be more aggressive, more of a gainer.@@sharkclub1
Both + insulin
Anyone with experience using Sermorelin & Ipamorelin together?
What time in the day are you supposed to take it?
Right before you go to sleep . Can’t eat for at least an hour or 2 before
@@lip91688 *2-3 hours before
@@ChrisWolfe31 the standard is 1-2 hours. Depends, 3 hours is obviously better, but he can get away with 90min
@@returnfreedom OK, I'm new to this. I was just going off of what the video said, thanks for correcting me
Did you even bother to watch the video??
If you take this is the morning would drinking a black coffee no cream no sugar mess it up?
After taking this for 6 months I started getting an allergic reaction after injecting. My hands and feet itch badly and I feel like my face wants to swell up even though visually it doesnt. This lasts for about 30 minutes and is impossible to sleep when this happens. Is there a way around it?
Benadryl
I’m looking at ipamorelin nasal spray from pure rawz 50mcg a spray , so 2 sprays before bed
The clinic I contacted said the CJC one is $1,700.00 a month! Definitely not for my budget.
its like $400 for a couple months supply in a lot of clinics. Shop around.
It is cost around $500 . Shop around
@@burimkurtishi9678 Thanks for that 😀
Would be nice if you guys could spend at least SOME time on the safety of this completely new treatment. Apart from efficacy, safety is most important. Any health risks? Cancer risk? Any human research? Appreciated.
I have with the growth hormones. It could also make other things grow like potential cancers, in your body.
Gratefully Educational & Great Show 👍
So did I hear correctly that you inject 5 times a day? And don't eat 2 to 3 hours before injecting?
5 days a week before bed on empty stomach
without dac i think is that one. with dac i think you take once a week, and i heard dont eat 2 hours before and dont eat 30 min. and people say before bed