What Are Chronic Neutropenic Disorders?

Julia Warren, MD, PhD, Associate Professor of Hematology at the University of Pennsylvania and Hematologist at Children's Hospital of Philadelphia, gives an overview of chronic neutropenic disorders.
Chronic neutropenic disorders are blood disorders characterized by low levels of neutrophils. These disorders are associated with increased risk of recurrent and/or severe infections. The most common forms are chronic idiopathic neutropenia, cyclic neutropenia, and severe congenital neutropenia. The current management strategy for chronic neutropenia is long-term treatment with injectable granulocyte colony-stimulating factor (G-CSF).
As Dr. Warren explains, the reduction in neutrophils makes persons more susceptible to severe infections, as well as a plethora of symptoms that can develop, including mouth sores, fatigue, and gastrointestinal problems.
Recently, positive results of a phase 1b trial evaluating mavorixafor in across patients with chronic neutropenic disorders were presented at the most recent American Society of Hematology Meeting & Exposition (ASH 2022).

[@cindystlon]

What do you think about benign ethnic neutropenia? Which test needs to be done to get this diagnosis?

[@aigredouxx]

complete blood count

[@cmmvgr2]

My son is 8 months old and has chronic idiopathic neutropenia , BMB was good it did show fibrosis in bone marrow, he’s done a neutropenia panel and bone marrow panel . Now we’re doing a WES. Hoping we get some answers . He did have 7 mutations in his bone-marrow failure syndrome panel of unknown significance. So we’re just waiting for mines dads and his genetic testing