It’s truly strange watching British documentaries as an American. American documentaries are so loud with constant motion and nonstop drama. I appreciate watching something that takes its time to tell the story without the need for embellishment.
It isn't that it's British. They just didn't really need to be flashy because of the content... People fighting for their lives... pretty hardcore as is
two people recieve something completely else while the others recieve the drugs. But no one knows who got what but the doctor/nurse. i believe its explained in the beginning of the video.
Be careful those drugs have severe side effects effects that allow doctors,to get away killing off whistleblowers later in off that k ow they were forced into fling along or being blamed for o get away with committing atrocities against ,minorities to suffer the same cover up by I forced treatment t and th. Blaming them and for them to to get away with to b blamed and killing them by and forcing me to do Nyerere I to palletive care to cover it up
Please help me thy are blaming me for to cover up their crimes and allow the government to,ent to blame these please people to comply and now I know they are killing off these to people and blame them for instead of rich people,to get away to comply and are know and forcing me into end of life care
I have been receiving a type of monoclonal antibody infusion every 4 weeks for the last 10 years to treat an autoimmune disease. This medication saved my life and allows me to continue surviving. The people who are willing to submit themselves to clinical trials like this are part of the reason I’m still alive, and I have so much respect for them.
My son has a number of symptoms that are autoimmune in nature rendering him at 35 unable to work and using a cane but some days unable to leave the bed. He has been given possible bur never firm diagnosis for everything from MS to Parkinsons to Meneirs to heavy metal intoxication as he shows signs of all. One of the neurologists who seemed most hopeful finding neuropathy and all the signs of his own immune system attacking his digestive and nervous systoms suggested a drug to him which was described as a chemo drug originally for cancer patients but has shown to aid patients such as he. God i wish we coyld speak to you to somehow find out if you have a similar set of issues. If so much comfort it would be while making this very important and heart wrenching decision
I also have an autoimmune disease. I am taking Telfast and Montelukast daily. If I stop, my throat gets tight and itches all over the body. I live with misery and doctors couldn't help me.
Maybe try prolonged water only fast around 10 days? Prolonged fast is the only thing that treats and cure autoimmune diseases. And then carnivore diet.
StrawberryNinja Nibbles omg you’re right. Without thinking about it, I unconsciously found myself thinking, how did they have video of these people when it was happening Lolol duh
For those of you making fun of the doctor for asking if they're okay, it's actually a very good practice. First of all, he's making sure they're still responsive. Second of all, he's trying to keep them calm. If you saw someone crack their skull open, you wouldn't start shouting "OMG ARE YOU OKAY!? OH MY GOD HE'S GONNA DIE THAT'S A LOT OF BLOOD" no, you'd say "It's going to be okay, you'll be fine." Just so you know
Raven Ryder I don’t know why Parexel claimed to have no knowledge of their responses, but the pharma doctor read in the literature supplied by Parexel that their reactions were thought to happen rarely.
I had a science teacher start our origins, universe life etc with: don’t believe everything they tell you, remember many think a supreme being, god, caused creation, others do not... in any case we don’t know how or why the universe came into being let alone having physics perfect for star formation, nuclear reactions, time, matter, all of it. That said... shall we begin.... first there was nothing, then there was a universe... any questions? Right... ok.. and we opened our books to chapter one. The Big Bang. Haha and the lesson commenced. I thought he was clever and wise and he was a great teacher. He also gave us real experiments, not cheesy ones. More dangerous chemicals and dissection, less baking soda and vinegar. Haha... break out the scalpels and Bunson burners baby.. whoops. Bang. Teacher my test tube is no more! You ok? Yeah. Had your eye wear on? Yeah. Ok... do it again but this time don’t skip step three in the directions... sorry Mr. Moss. Haha he was cool.
You believe this? They gave clinical trial medication, as a test...to humans with nothing to actually cure.. it was meant to cure leukemia....which these random people did not have
@@nanofivee I think they mean that we have lived through how the world reacted to co.v.id. Nothing will suprise me anylonger when it comes to butched up medical treatment after that.
The worst part was how quickly they dosed everyone. They first guy is in a cold sweat and writhing in pain, and while this is going on they are dosing the guys in the other room.
Julian Bell Mark R what was this drug trial for ? what the heck was the drug trial for because all those people were 100% healthy and had nothing to cure , So do you think , is it really a cure they were looking for or is it a way to make people sick to cut down the population , the government plan ?
Kristie-lee Corney This isn’t a conspiracy video. If the government wanted to cut down on the population they wouldn’t have tested the drug, they would have given it to the patient so they could die.
Shame on drug company. One guys fingers and toes fell off. They infused 8 x faster than on monkeys. These people deserve big compensation and massive apology
Big pharma doing big pharma things, and hiding behind obscure legal loopholes and endless legal battles to do whatever tf they want. It's a way too big of a business, in the hands of way too few people. They're artificially creating a lack of ADHD medication so they can jack up the prices. They claimed oxycodone is barely addictive and can be prescribed for even minor pain and injuries. They said Xanax and Lyrica are perfect risk-free options for generalized anxiety disorder. They constantly make vitally important things like epipens and insulin more expensive. They also try to invent medicine for the symptoms rather than cures. And isn't it also kinda convenient how often you need to take booster shots for this new kind of vaccine? I know it's basically a business and they need to profit, but they're building their empire on human suffering and dead bodies. The amount of greed is just overwhelming.
'Berto O. A. you never know if another person will react the same way to the medication if only one person got the trial. that’s why there’s usually more than one person getting tested
I noticed they never talked about the eighth man, I looked him up and he’s wheel chair bound and had his fingertips fall off too. How unfortunate for all of them.
He can still drive. My mother had crippling arthritis, and could not hold the steering wheel, just guide it with her palms, and turned with her elbows. He only lost the tips. Not the whole fingers. Yes, it is a tragedy he suffered. So did my mother. She still made do. Reiterate, he CAN still drive.
This is the second time I watched this video, what a horrific trial these wonderful men went through, my daughter was diagnosed with leukemia at age 10 with other complications. Without brave people like these, my daughter would not be a alive today. This Was back in 2001. My sarah is doing well today. My only child. I owe it to brave people like the ones in this document. Thank you so very much from the bottom of my heart. Thank you. Mike, from Richmond, Virginia
That's great. But everyone that I know that had leukemia and was treated for it , died. They spent years of their life receiving agonizing treatment that was meant to save them, costing thousands. They would be in remission, like they were cured, then it returned, only to kill them quickly, since their immune system was gone. RIP: Aunt Marty, Steele, Carmen.
@@lorinagosso While that is the norm, there are a few exceptions. Perhaps her young age aided her recovery. Then again they say 25% of cancers get cured all by itself (not sure if it applies to leukemia though), but I guess most don't wanna play with those odds and go for the chemo route, despite it perhaps only buying them more time and only making their early death even more likely.
@@lorinagosso leukemia in a certain group age and the type of leukemia the person has determines the rates of their survival. Simply put the older you are the deadlier it gets, children have higher survival rates and longer remission. Sorry for your loss though, seeing a loved one succumb to illness makes you feel hopeless and it's a wound that never heals even after they pass.
Well then, they now should be advocates for banning all animal testing since they know the horrors.. but they had it WAAAY better than the animals that are still being tortured
The saddest patient death I've ever dealt with was a man who had an unexpected allergic reaction to a psoriasis medication we were testing. He was a healthy guy in his early 50s. No one had any reason to believe he wouldn't be going home to his family the next day with some Christmas shopping money in his pocket. It was really a huge shock to everyone, especially his wife and kids.
That is something you should understand taking any drug, isn't it? Let alone the one that was never tested on humans, no one knows whether it is safe and that's exactly the risk they are paid for.. If it was safe (and none of the drugs are just cause of the personal reactions anyway) there wouldn't be a need in testing it..
The people are lured by money like the 50 years old man that sadly lost his life. When you are 50 YO with family of your own, it’s not advised to take a trial test. Unfortunately he probably needed the money.
Imagine being one of the ones that got the medicine and being right behind the guy showing the first symptoms. That would be terrifying. He starts screaming and you have to wait until it happens to you. Talk about a horror movie.
@@ryanblack3285 apart of the 2k, you would get in a lot of legal trouble, you signed a contract. also by the time the first severe symtphoms showed up, the drug was already administered on everybody.
To those who are interested, the reason was finally found. Fair warning: I'm neither a chemist nor a physician, so I cannot guarantee I summed it up correctly. Also, before you jump to any conclusion or think "It sounds obvious that it was bound to go wrong", I suggest looking into the reports on your own, to understand the complexity of in vivo chemistry. TGN1412 was designed to bind to the CD28 antigen of T lymphocyte cells. Those T lymphocyte come in two sub-types: "Regulatory T cells", and "Memory T cells". TGN1412 was designed/intended to stimulate the Regulatory T cells, which are the same in humans as in the monkeys. However, the Memory T cells have that CD28 antigen as well for humans, but not in the monkeys. And those cells started to emit a high amount of cytokines when activated by TGN1412. This widespread sudden and overpaced emission of cytokines is what is called cytokine storm, and the cytokines attack and kill cells. This is what is called and happens in an inflammation. In a normal functioning immune system, this should happen in direct proximity of an infected cell to kill that cell (and only a few others as collateral damage, which are easily replaced in a healthy person). But here it happened in the whole body at once, basically attacking all cells everywhere at the same time.
And isn't it ironic that the covid virus that's going around now does the same exact thing in some people, causes a cytokine storm? The monocolona antibodies since then has been perfected and is currently being used in people with covid-19 successfully. The drug is known as regeneron.
Now they use 0.1% less of the drug at 40 times slower rate of infusion then they did in that trial. So basically it was a bad calculation on their part.
I cant imagine being one of the people with the placebo... just watching and listening to everythung around you, always wondering if youre next and when its going to happen. It sounds so terrifying...
Nah. after they were the onlyone in the room it didn't happen to, Im guessing they figured out they had the placebo. But the first hour or so would've been rough, yea.
I'm a former nurse and i remember hearing about this at the time. As i remember it they essentially gave all the patients the drug basically ask at once
@@imho2278no they mean the preparation was too speedily injected AND to all subjects essentially at the same time. Both are non testing- protocol bonehead moves. Amateur hour. I don't see ice packets on the beds, nor any mention, there weren't enough dialysis machines, no blood work done to rule out infection before providing immunosuppressive drugs, just a festival of silly.
@@sunandmoon139 That's not actually what it is. It's when a person experiences a decrease in symptom severity, because they believe they are receiving medication. The placebo effect does not cure illnesses, it just helps to relieve symptoms.
@@sunandmoon139 It has to do with believing that you are receiving a treatment that will make you feel better. I reccomend that you look up some examples and/or articles about it on google, as it's actually quite fascinating. There is also the nocebo effect, which is when a person believes a treatment will have negative side effects, so they end up experiencing those side effects simply because they expected to experience them. There have been trials done where one group of people is give sugar pills (though the trial participants were told it was real medication) and were not warned of any potential side effects, while the second group received the same placebo pills, but were told a list of potential side effects they might experience. The people in the second group reported experiencing those side effects at a much higher rate than people in the first group. By believing they might feel unwell, the trial participants actually caused themselves to feel sick. It really goes to show how much your mindset can effect you. This even manifests psychologically as well. For example, if you believe that you won't ever succeed, chances are you will have a lessened ability to perform tasks, low motivation, and little dedication. One of the biggest effects would be that you stop trying, and that you never actually put 100% into something. I mean, why bother putting your all into something if you are sure you will fail?? Alternatively, if you believe that you could be very successful, you would likely take way more opportunities, work harder and put more effort into things, have high motivation, and be very dedicated. These changes in behaivor have a serious effect on your life, and could actually cause someone to fail at things simply because they are convinced they aren't capable of succeeding. This is called fortune telling in psychology, if I remember correctly. I'm very guilty of doing this myself, actually. It's harder than it sounds to let go of all the negative beliefs one has about themselves and start believing in themselves all of the sudden. It's really hard, and at this point I actually fortune tell about fortune telling. I know that I do it a lot, so I end up doing it even more simply because I expect myself to. It's maddening 😂😭
@@sunandmoon139 it has nothing to do with religion if that's what you're asking, although those words can be used in a spiritual context. if that's not what you meant ignore me haha
I watched this when it first came out 6 yrs ago and let me tell you that i have never forgotten about it. It's truly haunting to think about what they went through.
Necrosis is the term for Dying tissue. This is why I think this was blood poisoning. Necrosis can occur when the blood isn't healthy enough to provide the flesh nutrition, and the cells in the tissue die.
@AL Cats They absolutely would have. It's the American way. Oh and when you write a sentence calling people stupid, make sure it isn't two sentences crammed into one.
Most of the medical trials that I've looked into ask for a commitment of 2-3 years, and specify that the patient can withdraw at any point. I've never looked into a First in Man study (now I understand that as a female, I don't generally qualify for that), though I do understand how vital that step is. Now I understand a bit better!
@@wendychavez5348actually we can now. I was in a phase 1 trial. Its for a medicine for specific heart disorder. Although I'm healthy now, I've had quite an extensive heart history. Its like being a ticking time bomb with no way of stopping it. This opportunity came about and I was all for it. Its a double blind study. Couldn't get my blood work for my syndrome until 6 months after I was done with the trial. My number actually was decreased. I know I got the drug and it works. Cannot wait until phase 2. Hoping it will be at the same hospital so I can take part.
This is astounding. I'm 24 years in remission from Leukaemia and two years of gruelling chemotherapy treatment I endured from 16 - 18. I imagine at some point each one of the toxins in the specific chemo cocktail I received were one trialled by participants equally as brave as these hero's. And I can say I wouldn't have envied what they put themselves through in doing so either! But I'm beyond grateful they did! Even given the long term ramifications I'll be dealing with from here on in, I wouldn't forsake that for the experience I had knowing what it is to be in love and the pure joy I eventually experienced in giving birth to two gorgeous and extremely precious daughters.
It's crazy when you think about the fact that healthy people took chemotherapy drugs first to see if it was safe. Knowingly taking the equivalent of a bomb going off in your system since it'll destroy everything in sight is wild
Success stories like you are exactly why I work in research. Every single cancer therapy and Alzheimer’s drug trial I hope not so see any observations or toxicity. It is always very sad when something doesn’t work as intended.
The major issue was the drug being administered to every man within minutes of one another instead of adopting a wait and see approach, which you think would be standard initially in a first in man trial. Side note: David’s family is beautiful! So happy to see that.
While that's clearly the case, it seems they still have done everything according to protocol, haven't they? At least they say that in the documentary, so it may not have been standard at the time?
@@juditmlnr you would think it’d be common sense though. A drug that’s never been given to humans before and they’re rapidly dosing everyone before any side effects are able to take effect. Live and learn, I guess. I’m just glad it wasn’t at the expense of someone’s life.
@@juditmlnrI mean technically, yes, they did everything according to protocol - but the protocol is largely determined by the entity running the trial following some standard guidelines and requirements. personally, I think the biggest problem is that this kind of reaction should not have been so unforeseen (they even acknowledged cytokine storm as a possible side effect beforehand) that they didn’t prepare for it to happen in a first-in-human trial.
@@duck3819 That is very accurate. My quack of an orthopedist gave me an unnecessary MRI, over my ankle being swollen and having pronation. It found bone bruising, JUST BONE BRUISING. It was a waste of 2hrs and $900
m3m3d_ I felt real sorry for him . He was just siting there and every one else was reacting to it. He was probably thinking that he was going to get it soon
the 2 (one in each room) who got the placebo will definately have long term mental issues from what they saw and heard..I hope they both got some great counseling...crap like that can mess your head up for life.
This is why I'm open to being involved in clinical trials! I have these conditions, and am interested in improving the care that other people with them can obtain. Like Subject #1, I understand that it's important to report anything even slightly out of the ordinary because information is vital! I wish these men hadn't suffered like this, and thank them for their sacrifice.
I'm a multiple organ transplant recipient, and on roughly a dozen medications, several of which are beyond critical to continued survival. This reminds us just how important clinical trials are, and to appreciate the sacrifice and risks those people took, to pave the way for better health and lives for all mankind. Thank you.
Here here! It's an enormous risk to participate in these trials. I've been tempted to do so for the $$$ but the thought of what *could* go wrong had held me back. You know how commercials list all those crazy side effects like diarrhea and death? That's because someone experienced that.
I found this a very interesting article. My granddaughter had a rare cancer at the age of 2 and ALL of her treatment was through international clinical trials. Part of her treatment was immunotherapy, where one of the risks was a cytokine storm because of the use of monoclonal antibodies. After nearly four years of treatment she is now five years in remission. The harsh treatments she had have left her with a variety of health problems, but she is a happy 10 year old now and very precious to our family. Whilst she has contributed to many clinical trials through her treatments, we are indebted to the children who have gone before her and may have since died of the illness or the treatment. Anyone who contributes to the advance of medicine through participating in clinical trials (of whatever stage) is making a massive contribution to the rest of humanity.
Amen. I agree. And with any trials, all precautions should be taken, and there should ALWAYS be an ESTABLISHED anecdotal plan in case of known, and especially unknown, side affects.
@@pamsam8933 the problem is that you can't know the side effects to 100% certainty in advance. You can inject them into mice and monkeys and test on human cells and determine it "might" be safe. When you are the one taking a drug that no human has taken before, nobody can predict with certainty what is going to happen, it's a big risk and they should (and almost always do) tell you that it is a risk.
The reason things like this are big stories is because of how rare events like this are. The vast, vast majority of first for human clinical trials have the worst problem of people withdrawing due to side effects. This occurs in both the cohort getting the drug and the cohort getting placebo. Multiple fatalities in a single trial is so unusual as to lead to videos like this. The risk is higher in rare illness, where there just fundamentally isn't as much data in. Even then, like in this case, actual death is exceptionally rare.
I heard about this at the time it happened and then decided the same. Your life and health isn't worth playing Russian roulette with. Even if nothing like this happens to you, you don't know what unknown long term effects might be caused.
@Poppy Mystique I'm in a study right now in the states at a place called PRA Health Sciences in Lenexa, Kansas City, Kansas My study right now is 5 days for $3,000 us
I had considered cosmetic trials, but after this there is no amount of money in the world that could make me want to participate. Just to risky for me.
I didn't have this drug, but I had a different monoclonal antibody - rituximab - and it saved my life. I had stage 4 cancer at 17 (actually, lymphoma, like was brought up in this documentary) and thiys documentary just made me feel so thankful to all of these men. Their positivity and outlooks are wonderful, too.
@@goha9218 im doing great now i do have higher risk for cancer later in life and i had a few side effect from radiation like lack of hair, stunted growth on my left side, and a few more but im fine for the most part
UA-cam, I don’t think an add for a drug trial study is the best thing to run during this video. Like seriously, I don’t think people will want to take part in a study after watching this.
Did anyone else get an ad for a company looking for medical testing subjects during this video? I couldn’t stop laughing when I saw that ad...worst use of a product placement algorithm ever lol
The fact that the doctor in charge of the trial had to scour the documents for hours after giving the drugs to find out all of the possible side effects makes me feel nauseous. As a nurse, I refuse to give a drug to a patient until I know all the important facts about it. I keep my drug guide handy at all times just in case the doc orders something I’m not familiar with, and that’s when working on the fly. With a trial you have ample time to know every single known fact found well before you even begin to search for trial participants, and then you need to be prepared for all of those effects to occur. Cytokine storm is a known possibility? Then you have staff, meds, and full treatment plan on standby just in case, and the same goes for any other potential side effect. If it’s the first time a human is receiving the drug, then you especially need to be ready for anything happen.
At 57:44, they confirm what most of us guessed. It wasn't the drug itself, but the quantity and time. The reactions of patients were like an overdose. You can't increase the concentration like that! Edit: Actually it's 47:50
@@wesleyp3024 The thing is chemo also kills things it shouldn't kill and is way more invasive and dangerous... In fact, there are still producers of vaccine-like cancer cures.
Right, I was initially thinking it was actually DECREASED, but I realized that they had increased it by was it 500 times?? I feel horrible that this happened truly. Been quite close a few times to participating in clinical trial research for the money. SO GLAD I WATCHED, NEED AGAIN! Edit: apparently the dose was decreased. Can you imagine if it had been the opposite??? SMH.
Wesley P Yeah it's kind of like having a voice give you an instruction, as long as the voice is still there it will still give you that instruction whether weaker or louder
I know the guys in this trial regret doing it, but I just want to tell them thank you. Because as much as that sucked they saved so many lives. Think of the consequences if this had gone for trials at st judes.
@@thygreek8076 um yeah there are cures for many forms of leukemia. What used to be a certain death sentence is now curable in up to 95% of cases, depending on the type...
In the hospital we're warlocks and witches work there witchcraft Around the ⏰ clock, there's only one great physician and he cannot fail, his name is the lord God almighty, praise God for the lamb of God.Amen.
the 1918 flu caused out of control cytokine storms. The younger you were, the stronger your immune system and the stronger your immune system was, the stronger and more out of control the cytokine storms. These caused the terrible internal bleeding.
The 2 receivers of the placebo are in my opinion entitled to damages as well, as are the staff who all were undoubtedly traumatized by witnessing this dreadful horror.
@@SaraWOanH Where does it say in the contract "risk of death"? Do you work in this field?. They would never get people by stating that fact. They Will Say it may cause side effects (like organ failure) but not death. I do see what you are saying but they picked strong healthy young men. Emphasizing death is not a priority. Also... I would never do it. My friend fell fast after being talked into a trial cancer drug by her doctor friend....sad scary and I'm not built for it. My nerves and worry are too bad...😆
My mother told me about this when it actually happened and at the time I was too young to understand the whole thing. It sounded terrifying though. I'm happy to get to see this documentary now and find out about what she told me about.
The doctors and nurses have to remain calm and clinical. Honestly alot of people react well to that as it shows everything is under control. If a doctor panics I lose all faith in his/her training. It's been proven a doctor who stays calm and collected keeps the nursing staff calm and help the patient stay calm too. They also save more lives that way.
That’s the doctors’ way of staying calm and keeping the patient calm as well. If they panic or show signs of panic, then the patient panics too. I was in the hospital for 2 months after having my lung removed and from personal experience, I can say that at first it’s a bit annoying but it slowly becomes a bit reassuring.
Sara Burke Really stupid human beings if you ask me who in their minds would allow themselves to be injected with something that they don't even really know what it is or that could potentially have deadly consequences..
I think it's a human coping mechanism to look back at a thing like this and see it for it's purpose. I have seen similar cases where people are for example enslaved but they are glad they pushed through so that they cant do it to anyone ever again. Again focusing on the purpose.
can we just give these men a round of appaluse for what they have endured that must have been really traumatising especially the guy that lost his fingers and had his foot amputated
@@williamarmstrong1017 I assure you, they would not go if they would be well informed. And what they do now with vaccine is pretty much the same! And they not have to pay for it.
I feel so bad for all the patients involved. It had to be terrifying not knowing what is happening to you or possibly going to happen due to the placebo. I hope they all received mental care for their well being. You all are courageous. We salute you for your efforts to help people get healthier. Thank you.
Guys the reason for the doctor saying “okay how are we doing?” In a calm voice is because they need to keep the patients calm, it’s worse for patients to know they are in serious danger and start panicking. They would do what the guy in the beginning was trying to do, escape the hospital.
Ellie besides the responsibility of the medical team to react calmly, they ask bcz they need the patient to tell them, in their own words, the symptoms they are experiencing. For example, the machines monitoring their heart rate couldn't tell them that the patient was experiencing an instant migraine, or the level and location of pain they were experiencing. They needed to evaluate ALL symptoms into the diagnosis, and info from the patient is critical with these sudden symptoms.
I believe they said that by the time the first patient started to writhe in his bed, they were already finishing up the last infusion. So things hadn't gotten bad enough to warrant that, in their minds. They had no idea it was about to cascade and affect everyone. But yeah, now we've changed the rules so hopefully this won't happen again.
also, one of the experts said that the dose was infused 10 times quicker than it was with the animals. Why are they omitting that fact in the final report? It looks to me that such fast infusion could have been the cause, or at least it looks highly negligent and irresponsible.
Did you read through any of the other comments? Animal trials were first, then human trials which were infused at a much faster rate than the animals. So it was definitely a bit different for the humans. Also, all the modern medicine you benefit from was brought about using the same method. Animal trials then human trials. Maybe you need to rethink things.
Tbh, it is the drug company responsible, not the doctor... Idk why everyone is blaming him. He had a job, he tried his best... I'm so sorry to the men that you had to experience that
I honestly think no one is responsible.they've tested it on mice and the mice did not show any of the probants symptoms. They also warn you and hand you a contract where they warn you that there might be some serious long term complications while testing the drug. Sure I wouldn't hope anyone was in their position and this was a very dangerous situation, however the probants knew that there might be serious complications. So in this case, no one is to blame and those who went running to their lawyer are nothing but morrons from my point of view.
@@phasorthunder1157 TBH, the speed of the injection likely had little overall change on the drastic effects. The severe reaction in people probably came from the differences in T cells between mice and humans, which was newer knowledge at the time.
This is one of my favourite documentaries. That doctor was pissing his pants no doubt. In the USA they'd be sued to the moon and back no matter what they signed.
Absolutely not..... that's an very dumb stereotype and also makes no sense considering that the pharma industry obviously have to how tk protect themselves from lawsuits. Since side effects are essential while testing....
More like: His body had a fiver, its like having a shiver when your sick. Your body muscles start moving, to warm you up, when it thinks your "to cold" or to "fight" of an intruder like a Virus or else. He felt Cold inside, but they all had a fever and the shivering, like their Body was fooled by the drug to think "your cold". I go so far to think that their bodys were Burning. In an article i read on the German Wikipedia it said that one felt like he is burning from the inside out. :3
I absolutely love a doco and I have to say this is one of the best I’ve ever seen. Absolutely terrifying experience for those involved but the changes to drug trials since have meant nothing like this should ever happen again 💗
@@ferretsnax I kind of get that, but maybe if the drug had something like cancer to fight it wouldn't have acted that way. There are so many variables when it comes to new medications that you can't really expect a drug for sick people to act normally in a healthy person.
@skxtxn m I see. So it's not just about how the drug will affect the cancer, but also the body to see if the cancer patients could even handle it. But then there leaves the question of knowing if the cancer patients could handle a drug that someone with a healthy immune system can. I understand these things need to be done to save lives, but there's just a lot about it that truly confuses me.
Cancer drug???? Giving that drug is like doing an abortion on a woman who wants children all her life. How could they be so STUPID. You are right. Give it to someone with Type 4 Cancer. They are closer to death. They had nothing to loose. Ah! SAD,
All these men seem to have such a sweet disposition and are so open about their stories and they constantly use words like “lucky” and “grateful”. It’s inspiring
But the two who were in the intensive care for longer were not speaking in it. I wonder if the guy without fingers and leg is feeling the same way, probably not. But I bet he's not allowed to speak as part of his settlement. That's why I believe these things should never be allowed to be settled outside of court. These drug compagnies can get away with almost anything without the public even knowing most of the time.
I knew a man who was working as a test person for a major German company which is called Schering. They gave him some kind of psychotropic drugs. Although he soon showed clear signs of paranoid reactions and weird habits of falling asleep in the middle of a conversation, they went on giving him these drugs. Over the next 3 months he became more and more schizophrenic and paranoid. A few days after his 21st birthday he killed himself, because he couldn't take it anymore. The doctors said his will to die must have been incredible strong, because he drowned himself in a canal although he could swim. He filled his lungs with water, he swallowed so much water that he suffocated himself. Although I have to say that he also could have said that he wouldn't do the tests anymore, I accuse the doctors who went on giving him these drugs. Since he was promised a lot of money for these tests, they could convince him to go through with these experiments. I can only recommend to never work as a test person. You never know what you get into. Although it seems to be a lot of money, it can cost your life or at least your health.
There is definitely a need for people to do human trials. Without them there would never have been a way to find cures for diseases which tormented or killed huge portions of the population. That being said, I think the big pharmaceutical companies need to seriously revamp the way that they introduce and study their drugs and mechanisms of action before human testing. The volunteers also need to carefully read exactly what they're getting into.
I was in a drug trial-it wasn't a "first in humans" trial, which would be the most risky. The new drug was for a condition that I already had. This was supposed to be a different type and more effective treatment than was already on the market. The disease is usually fatal so I was glad to be accepted into the trial. A month's worth of the drug, outside of the trial would have cost $30,000.00, and I took it for 6 weeks. I had to have my blood tested each week. One week, my test results came back w/an abnormal reading. I was called in for further testing, and fortunately, the first test result was an anomaly. I found out later that if the test results had continued to be abnormal, I would have been dropped from the trial. I don't know how they normally conduct their testing in Germany, but I know in the US, they're extremely careful, I think because we have too many lawyers here. :) Four years after the trial, and I'm still in remission, and extremely grateful.
Delighted for you Nancy, that was meant to be! So good to hear about the trials for people who have a need for the drug, glad it worked for you and you weren't crippled with debt after, fantastic really! Wish you well
Doctors are such trash. You’d hope that the people in charge of keeping you alive had even the tiniest bit of compassion, but nope, nowhere to be found in medical professionals
Maddie Trafford it’s the sad truth. Some doctors will make patients think they need surgery (which could end their life) only to get $$$. However, there are some good doctors out there.
It’s truly strange watching British documentaries as an American. American documentaries are so loud with constant motion and nonstop drama. I appreciate watching something that takes its time to tell the story without the need for embellishment.
I mean this was quite intense too.
August Break Same
It isn't that it's British. They just didn't really need to be flashy because of the content... People fighting for their lives... pretty hardcore as is
L L there’s a balance that a lot of documentaries and reality shows strike. This one hits right on the mark.
August Break omg ikr!
I can’t imagine being the person who received the fake medicine, and having to sit there, listening to all this wondering if you are next.
Wait I don't get this where do they say that they were given the fake drug?
two people recieve something completely else while the others recieve the drugs. But no one knows who got what but the doctor/nurse. i believe its explained in the beginning of the video.
neither the docs nor the nurses knew, only the one who packaged them.
at 8:03
ah thats right, thanks.
Patient “am I going to die?”
Doctor “the real question is am I going to prison?”
@Kimber 10MM wtf are you talking about
@Kimber 10MM don't you understand it's just a joke , if you don't understand, Okey let me tell you it's a human thing & you need to settle up in a zoo
That’s funny
😆
It's an experimental drug, he volunteered.
I'm being treated for ovarian cancer. I cannot express my gratitude to the people who have risked their life to try to save mine
@@india1422 me too and I’m so thankful to the people and animals that helped keep me going. My very best wishes to you.
@@india1422 my thoughts and prayers🙏🏼🩷
Be careful those drugs have severe side effects effects that allow doctors,to get away killing off whistleblowers later in off that k ow they were forced into fling along or being blamed for o get away with committing atrocities against ,minorities to suffer the same cover up by I forced treatment t and th. Blaming them and for them to to get away with to b blamed and killing them by and forcing me to do Nyerere I to palletive care to cover it up
Please help me thy are blaming me for to cover up their crimes and allow the government to,ent to blame these please people to comply and now I know they are killing off these to people and blame them for instead of rich people,to get away to comply and are know and forcing me into end of life care
My best wishes to you both, and to all cancer patients. Please don't give up.
I have been receiving a type of monoclonal antibody infusion every 4 weeks for the last 10 years to treat an autoimmune disease. This medication saved my life and allows me to continue surviving. The people who are willing to submit themselves to clinical trials like this are part of the reason I’m still alive, and I have so much respect for them.
True but 😅😅😅😅
My son has a number of symptoms that are autoimmune in nature rendering him at 35 unable to work and using a cane but some days unable to leave the bed. He has been given possible bur never firm diagnosis for everything from MS to Parkinsons to Meneirs to heavy metal intoxication as he shows signs of all. One of the neurologists who seemed most hopeful finding neuropathy and all the signs of his own immune system attacking his digestive and nervous systoms suggested a drug to him which was described as a chemo drug originally for cancer patients but has shown to aid patients such as he. God i wish we coyld speak to you to somehow find out if you have a similar set of issues. If so much comfort it would be while making this very important and heart wrenching decision
I also have an autoimmune disease. I am taking Telfast and Montelukast daily. If I stop, my throat gets tight and itches all over the body. I live with misery and doctors couldn't help me.
There probably not so happy
Maybe try prolonged water only fast around 10 days? Prolonged fast is the only thing that treats and cure autoimmune diseases. And then carnivore diet.
Get this casting director a raise. All these actors look so much like the real people while also being able to actually act
I swear some of them are the actual people. Number 2 was definitely the same guy.
It’s epic bro
Best I’ve seen
Robert Gardea im aware what a re-enactment is... hence why I said props to casting director
StrawberryNinja Nibbles #mansplaining at its worst-🙄🙄
StrawberryNinja Nibbles omg you’re right. Without thinking about it, I unconsciously found myself thinking, how did they have video of these people when it was happening Lolol duh
For those of you making fun of the doctor for asking if they're okay, it's actually a very good practice. First of all, he's making sure they're still responsive. Second of all, he's trying to keep them calm. If you saw someone crack their skull open, you wouldn't start shouting "OMG ARE YOU OKAY!? OH MY GOD HE'S GONNA DIE THAT'S A LOT OF BLOOD" no, you'd say "It's going to be okay, you'll be fine."
Just so you know
lmao some doctor (well, nurse) screamed "OH MY GOD THAT'S A LOT OF BLOOD!!!" when I threw it up once, thought I was gonna die
Index III is OUT my point exactly
Raven Ryder I don’t know why Parexel claimed to have no knowledge of their responses, but the pharma doctor read in the literature supplied by Parexel that their reactions were thought to happen rarely.
*aRe YoU oKaY*
(OMG YOUR DEAD i mean) its fine ur gonna be okay:)
As a healthcare professional that works in a hospital, this is an absolute nightmare all the way around. Everyone lost in this one
and how do you feel about the covid vaccines? That experiment was forced on the world, this was volunteer
I still remember how my 6th year biology teacher warned us to never volunteer to be a guinea pig. Thank you sir.
See, I'm thankful I study chemistry, not biology or medicine. I can watch them do trials from another building, thanks.
Honey Bee 😂😂😂 that's a great teacher
I had a science teacher start our origins, universe life etc with: don’t believe everything they tell you, remember many think a supreme being, god, caused creation, others do not... in any case we don’t know how or why the universe came into being let alone having physics perfect for star formation, nuclear reactions, time, matter, all of it. That said... shall we begin.... first there was nothing, then there was a universe... any questions? Right... ok.. and we opened our books to chapter one. The Big Bang. Haha and the lesson commenced. I thought he was clever and wise and he was a great teacher. He also gave us real experiments, not cheesy ones. More dangerous chemicals and dissection, less baking soda and vinegar. Haha... break out the scalpels and Bunson burners baby.. whoops. Bang. Teacher my test tube is no more! You ok? Yeah. Had your eye wear on? Yeah. Ok... do it again but this time don’t skip step three in the directions... sorry Mr. Moss. Haha he was cool.
The FDA also recommends not being the first to take new drugs; I'd suspect only people desperate for money (poor/poverty) would/will volunteer.
@@renees1021 I don't think they normally end this badly due to prior testing on animals but yea this is also a very plausible outcome.
I've got to stop reading comments while watching documentaries. The amount of times I have to rewind is absurd.
into the mystic comment section is better than the vid
@@ethank5681 there would be no comments without the video
thanks for the reminder, i wouldve gone 10 minutes deeper without this comment
I was thinking the same... lol
I thought I had adhd or something. I always do this. Lol
This reenactment is SO WELL DONE. Holy crap.
Ikr!! I had to go back to the beginning of the video to find where it said it was reenactment I was like damnn
They found actors who look incredibly like the real people involved.
Yes. I totally forgot that it wasn´t real while watching … :D
Susan Foley are all of them actors? I straight up thought one of them (the placebo guy watching everything go down) was the actual person
You believe this? They gave clinical trial medication, as a test...to humans with nothing to actually cure.. it was meant to cure leukemia....which these random people did not have
They knew about the headache and pain and still injected the last patients. It's hard to comprehend.
@@kris2455 Yeah, you would think they would test one person, and see how they reacted, before continuing.
@@MaryDeanDotCom SAFE AND EFFECTIVE. I mean it's only killed millions....
@@jennifermarlow. this wasnt in 2024
@@nanofivee I think they mean that we have lived through how the world reacted to co.v.id. Nothing will suprise me anylonger when it comes to butched up medical treatment after that.
its very easy to believe, shareholders,pressure, company might go bust if its a failure etc.
me: oh man my knees hurt again
*watches documentary *
never mind i’m good
Joji Jo I love it 😂
Same
legit me
@@becky2322DM me, you look stunning :)
LMAO
Everyone else:
*screaming in pain*
That one dude:
*mom come pick me up im scared*
mmm
That guy would be me
@Saint Beelzebub 😭😭😭
「 Cinderblock 」 😂
Hahahahs
The worst part was how quickly they dosed everyone. They first guy is in a cold sweat and writhing in pain, and while this is going on they are dosing the guys in the other room.
Julian Bell Mark R what was this drug trial for ?
what the heck was the drug trial for because all those people were 100% healthy and had nothing to cure ,
So do you think , is it really a cure they were looking for
or is it a way to make people sick to cut down the population , the government plan ?
They should have waited way longer for each person getting injected and they should have given a way smaller dose to check how they reacted to it
@@kristie-leecorney7388 lol
@@kristie-leecorney7388 can see that you didn't watch the documentary, so you'll come up with ingenious conspiracy theories. Get out.
Kristie-lee Corney This isn’t a conspiracy video. If the government wanted to cut down on the population they wouldn’t have tested the drug, they would have given it to the patient so they could die.
Shame on drug company. One guys fingers and toes fell off. They infused 8 x faster than on monkeys. These people deserve big compensation and massive apology
Greed usually does it,the hurry to make $$$$$$$$
They got compensation and literally told you that if you had bothered to watch the documentary all the way through
@@bradenharris8718 an undisclosed amount. could've been chump change for all we know.
10x
Big pharma doing big pharma things, and hiding behind obscure legal loopholes and endless legal battles to do whatever tf they want. It's a way too big of a business, in the hands of way too few people.
They're artificially creating a lack of ADHD medication so they can jack up the prices.
They claimed oxycodone is barely addictive and can be prescribed for even minor pain and injuries.
They said Xanax and Lyrica are perfect risk-free options for generalized anxiety disorder.
They constantly make vitally important things like epipens and insulin more expensive.
They also try to invent medicine for the symptoms rather than cures. And isn't it also kinda convenient how often you need to take booster shots for this new kind of vaccine?
I know it's basically a business and they need to profit, but they're building their empire on human suffering and dead bodies. The amount of greed is just overwhelming.
Doctor: How we doing David?
David: Screams with agony and discomfort
Me when my mom wakes me up for school
flamingwolfgaming 101 disrspectful but true
Ikr
@@old-yd2kp
My bad
Doctor : seams ok to me
Everybody’s screaming in pain and the other dude’s just sitting there
He’s soooo lucky 🍀!
@@Timeless80 Haha, I was about to say that.
i would’ve hated to be him. imagine everyone around you screaming in pain... terrifying
@@dangerousbuterax6891 i'd rather be him than the ones that actually took the drug
L Frosty me too but would’ve still been scary
It makes me mad to think that the medication was administered 10 mins apart, rather than 90 mins apart. This could have only been one.
'Berto O. A. you never know if another person will react the same way to the medication if only one person got the trial. that’s why there’s usually more than one person getting tested
They just wanted to know who got the placebo.
@@birthdayplant it was never appropriately thought out and therefore that was negligence in a big way.
niyah and yet they all reacted the same way
niyah yeah and If it went that bad on one person then they wouldn’t do it on another however if one person was fine
"I was really down... the worst down" - That's such a chilling phrase.
I noticed they never talked about the eighth man, I looked him up and he’s wheel chair bound and had his fingertips fall off too.
How unfortunate for all of them.
Wow
Thank you for looking that up for us all!
what did you look up to find it?
Nicole Slaughter ...It mentions what happens to him right there in the video.
any link or name of the man so i could search it pls :) its very scary docu really if i could i would wish for this to never happen :(
ME, thinking I'm going to only watch 5 minutes of this and end up watching the whole thing!
Sammmme girl
This really does intrigue me .
God Is So Merciful .. Amen .
No amount of $$$$$ ... Is worth playing the , maybe , or , maybe not day !!! Which is a memory of , I'm alive !
Same! 😬
Part 1: company brings patients to trial. Part 2: patients bring company to trial.
If only it was that easy
And loose!
AppleYou Brilliant comment!
I'm sure the patients signed away any probability of liability
Uno reverse card
I’d be freaking out as soon as the first guy started to have some severe effects. Omg…
Omg. Kid was 19 and saving up for driving lessons and now he has no fingers
Gavin Haase 47:09
He lost all his toes and parts of fingers. The tips
He can still drive. My mother had crippling arthritis, and could not hold the steering wheel, just guide it with her palms, and turned with her elbows. He only lost the tips. Not the whole fingers. Yes, it is a tragedy he suffered. So did my mother. She still made do. Reiterate, he CAN still drive.
I mean he could still drive? But they didnt specifically say what exactly happen to ryan..
@@nickhiggins1091 doesn't sound safe at all. That's why in your driving test you have two hands on the wheel. Not your elbows
"No one's gonna die right?"
"Well, we'll see"
well at least he was honest
That part made me laugh so hard
"We'll see... Well... I'mean I will see. In case you, ... you know."
followed by evil cartoon villain cackle lol
yeah doctors cannot affirm things they don't know or they might be charged with lies
Placebo guy: reading his book
Guy next to him: in horrible pain
Placebo guy: *chuckles I’m in danger*
Ralph wigam
This is why I don't do trials. I did one and I had the symptoms of malaria. Never again.
Well, the entire world went trough a massive trial three-four years ago.
Did you get the vax? I hate to tell you but, you did it again 🤦🏼♂️
Lesson learned😢
@@Emsev100👍👍👍👍👍
You took the vaccination for Covid, right? That probably saved your life
They talk about how a lot of the man got back to “normal” but still one guy lost just fingers and a foot and his life was never the same
You should also watch the thalidomide documentary on youtube. ua-cam.com/video/6uizvsiaHyw/v-deo.html
Not a one of them went back to normal, their immune systems are fouled up to this day.
Yeah I wanna know more about Ryan.
And his penis. So there’s that. Pretty significant if you ask me.
@@BS-dq1kz is that true?what a shame & he was the youngest of the group, not that it would suck any less happening to any of the others.
This is the second time I watched this video, what a horrific trial these wonderful men went through, my daughter was diagnosed with leukemia at age 10 with other complications. Without brave people like these, my daughter would not be a alive today. This Was back in 2001. My sarah is doing well today. My only child. I owe it to brave people like the ones in this document. Thank you so very much from the bottom of my heart. Thank you. Mike, from Richmond, Virginia
That's great. But everyone that I know that had leukemia and was treated for it , died. They spent years of their life receiving agonizing treatment that was meant to save them, costing thousands. They would be in remission, like they were cured, then it returned, only to kill them quickly, since their immune system was gone. RIP: Aunt Marty, Steele, Carmen.
@@lorinagosso While that is the norm, there are a few exceptions. Perhaps her young age aided her recovery. Then again they say 25% of cancers get cured all by itself (not sure if it applies to leukemia though), but I guess most don't wanna play with those odds and go for the chemo route, despite it perhaps only buying them more time and only making their early death even more likely.
@@lorinagosso leukemia in a certain group age and the type of leukemia the person has determines the rates of their survival. Simply put the older you are the deadlier it gets, children have higher survival rates and longer remission. Sorry for your loss though, seeing a loved one succumb to illness makes you feel hopeless and it's a wound that never heals even after they pass.
I’m so happy for you and Sarah. I hope she loves a long successful life!
Hi Michael the world also won a precious gift then : Sarah. Please send her a hug all the way from Brasil !! She isa brave and inspiring girl ❤️🙏🏻
They all must have some form of PTSD from going through that
With a phobia of medication, needles and that i suppose
Well they nearly died that's pretty traumatic in itself
Yea thats for sure
Well then, they now should be advocates for banning all animal testing since they know the horrors.. but they had it WAAAY better than the animals that are still being tortured
Taunja Brockway but if animal testing had happend it would be different
I've watched this so many times-- the reenactments, along with the survivor's stories are so compelling.😢
Doctor: How are we doing, David?
David: *screams into the 5th dimension*
heiress of stupidity more like weirdly cut moans
I was thinking the same thing. The patient is clearly in distress and a great deal of it!!
lmfao best comment
Valincia Pruitt They ask anyways to make sure you can respond. Yeah you aren’t doing good but are you responsive?
That's what I thought.
The saddest patient death I've ever dealt with was a man who had an unexpected allergic reaction to a psoriasis medication we were testing. He was a healthy guy in his early 50s. No one had any reason to believe he wouldn't be going home to his family the next day with some Christmas shopping money in his pocket. It was really a huge shock to everyone, especially his wife and kids.
I wish I wouldn't have read this.. Now I'm sad....I could only imagine how the wife and kids felt..
That is something you should understand taking any drug, isn't it? Let alone the one that was never tested on humans, no one knows whether it is safe and that's exactly the risk they are paid for.. If it was safe (and none of the drugs are just cause of the personal reactions anyway) there wouldn't be a need in testing it..
The people are lured by money like the 50 years old man that sadly lost his life. When you are 50 YO with family of your own, it’s not advised to take a trial test. Unfortunately he probably needed the money.
This is the devils medicine now learn natural medicine.
Just him? its a lot worse than you think be hind closed doors .
Imagine being one of the ones that got the medicine and being right behind the guy showing the first symptoms. That would be terrifying. He starts screaming and you have to wait until it happens to you. Talk about a horror movie.
😩
I'd rip the IV out b4 it was my turn. Not worth 2k.
@@ryanblack3285 apart of the 2k, you would get in a lot of legal trouble, you signed a contract. also by the time the first severe symtphoms showed up, the drug was already administered on everybody.
I have a huge respect and appreciation for the people who raise their hand up for the clinical trial. I hope they stay healthy.
an hour long, slow-pace documentary, totally for free on youtube! this makes me very happy
Yus
ᴴᵃᶰˢ ᴮˡᵃᵃᵘʷ me tooo
There is hundreds of them on here they r amazing
What UA-cam was really made for
To those who are interested, the reason was finally found.
Fair warning: I'm neither a chemist nor a physician, so I cannot guarantee I summed it up correctly. Also, before you jump to any conclusion or think "It sounds obvious that it was bound to go wrong", I suggest looking into the reports on your own, to understand the complexity of in vivo chemistry.
TGN1412 was designed to bind to the CD28 antigen of T lymphocyte cells.
Those T lymphocyte come in two sub-types: "Regulatory T cells", and "Memory T cells".
TGN1412 was designed/intended to stimulate the Regulatory T cells, which are the same in humans as in the monkeys.
However, the Memory T cells have that CD28 antigen as well for humans, but not in the monkeys.
And those cells started to emit a high amount of cytokines when activated by TGN1412.
This widespread sudden and overpaced emission of cytokines is what is called cytokine storm, and the cytokines attack and kill cells. This is what is called and happens in an inflammation. In a normal functioning immune system, this should happen in direct proximity of an infected cell to kill that cell (and only a few others as collateral damage, which are easily replaced in a healthy person). But here it happened in the whole body at once, basically attacking all cells everywhere at the same time.
THANK YOU SO MUCH, it makes perfect sense to me now. Your comment is the only one in here that had the science behind what happened.
Wow a overlook that had devestating result,altho making a new drug is never easy so small things are bound to be missed from time to time
And isn't it ironic that the covid virus that's going around now does the same exact thing in some people, causes a cytokine storm? The monocolona antibodies since then has been perfected and is currently being used in people with covid-19 successfully. The drug is known as regeneron.
Now they use 0.1% less of the drug at 40 times slower rate of infusion then they did in that trial. So basically it was a bad calculation on their part.
Can we call it a Drug induced sepsis
I cant imagine being one of the people with the placebo... just watching and listening to everythung around you, always wondering if youre next and when its going to happen. It sounds so terrifying...
Yeah and he was so young at the time so it really pulls at your heart for the poor boy.
American roulette
@Addicted 2This but also guilty though. Survivors guilt
Nah. after they were the onlyone in the room it didn't happen to, Im guessing they figured out they had the placebo. But the first hour or so would've been rough, yea.
I would feel so very guilty honestly
I'm a former nurse and i remember hearing about this at the time. As i remember it they essentially gave all the patients the drug basically ask at once
No placebo?
@@imho2278no they mean the preparation was too speedily injected AND to all subjects essentially at the same time. Both are non testing- protocol bonehead moves. Amateur hour.
I don't see ice packets on the beds, nor any mention, there weren't enough dialysis machines, no blood work done to rule out infection before providing immunosuppressive drugs, just a festival of silly.
This should be a Netflix documentary
It should be that would be amazing
This could be on House MD or the good doctor
It’s better on UA-cam.
Nah, UA-cam's where it's at.
There is a indie style horror movie made based on this, wouldn’t recommend it.
everyone: throwing up, screaming
that one dude sitting: alright ima head out
Megan Khadka it’s like... i didn’t know that
He was a control/ placebo
When was that? Just so I can skip a sis is scared of sick
B lasagna
anna commanda what does that mean?
Those 2 men won a LOTTERY called PLACEBO
precious lol
@@sunandmoon139 That's not actually what it is. It's when a person experiences a decrease in symptom severity, because they believe they are receiving medication. The placebo effect does not cure illnesses, it just helps to relieve symptoms.
@@sunandmoon139 It has to do with believing that you are receiving a treatment that will make you feel better. I reccomend that you look up some examples and/or articles about it on google, as it's actually quite fascinating. There is also the nocebo effect, which is when a person believes a treatment will have negative side effects, so they end up experiencing those side effects simply because they expected to experience them. There have been trials done where one group of people is give sugar pills (though the trial participants were told it was real medication) and were not warned of any potential side effects, while the second group received the same placebo pills, but were told a list of potential side effects they might experience. The people in the second group reported experiencing those side effects at a much higher rate than people in the first group. By believing they might feel unwell, the trial participants actually caused themselves to feel sick. It really goes to show how much your mindset can effect you. This even manifests psychologically as well.
For example, if you believe that you won't ever succeed, chances are you will have a lessened ability to perform tasks, low motivation, and little dedication. One of the biggest effects would be that you stop trying, and that you never actually put 100% into something. I mean, why bother putting your all into something if you are sure you will fail?? Alternatively, if you believe that you could be very successful, you would likely take way more opportunities, work harder and put more effort into things, have high motivation, and be very dedicated. These changes in behaivor have a serious effect on your life, and could actually cause someone to fail at things simply because they are convinced they aren't capable of succeeding.
This is called fortune telling in psychology, if I remember correctly. I'm very guilty of doing this myself, actually. It's harder than it sounds to let go of all the negative beliefs one has about themselves and start believing in themselves all of the sudden. It's really hard, and at this point I actually fortune tell about fortune telling. I know that I do it a lot, so I end up doing it even more simply because I expect myself to. It's maddening 😂😭
@@sunandmoon139 it has nothing to do with religion if that's what you're asking, although those words can be used in a spiritual context. if that's not what you meant ignore me haha
Comment war
I watched this when it first came out 6 yrs ago and let me tell you that i have never forgotten about it. It's truly haunting to think about what they went through.
@@Poorsha88 and maybe still are…
Same and here we are, watching it again
His fingertips fell off!! They weren't even amputated! Imagine just laying there watching your fingertips FALL OFF!!! I feel so bad for those men...
@jorge rodi Ohhhhh I'm dumbbbb
I got so freaked out!!
Bruh
@jorge rodi please use your inside voice
Necrosis is the term for Dying tissue. This is why I think this was blood poisoning. Necrosis can occur when the blood isn't healthy enough to provide the flesh nutrition, and the cells in the tissue die.
@jorge rodi Capital letters means you're shouting. So low your voice 🤗 and be caring.
If this would have happened in America, they would have been stuck with the medical bill as well.
@@Tyler-zw4kq just because a law suit is won doesn't mean they ever see the money
big facts. good ole american health“care.”
Lol accurate
@AL Cats They absolutely would have. It's the American way. Oh and when you write a sentence calling people stupid, make sure it isn't two sentences crammed into one.
@AL Cats I don't know . you tell us. How do you.
My first Chemo infusion took over 13 hours to complete. These men were given a full infusion in 10 minutes...That is crazy!
How are you doing? I hope you are doing well. I sincerely mean that.
@@sabitrakhadka8397 wtf is wrong with you
@@gg-sc6gy 1st time internetting?
@@kungfreddie yeah i made it 29 years and never once did I discover it until today
@@sabitrakhadka8397 swedish
This is probably why clinical trials span a few months rather than a few days
Even the placebo dosing is done over a month these days.
Most of the medical trials that I've looked into ask for a commitment of 2-3 years, and specify that the patient can withdraw at any point. I've never looked into a First in Man study (now I understand that as a female, I don't generally qualify for that), though I do understand how vital that step is. Now I understand a bit better!
unless you are in a global scamdemic and they are virtually forcing everyone on the planet to partake
@@wendychavez5348actually we can now. I was in a phase 1 trial. Its for a medicine for specific heart disorder. Although I'm healthy now, I've had quite an extensive heart history. Its like being a ticking time bomb with no way of stopping it. This opportunity came about and I was all for it.
Its a double blind study. Couldn't get my blood work for my syndrome until 6 months after I was done with the trial. My number actually was decreased. I know I got the drug and it works.
Cannot wait until phase 2. Hoping it will be at the same hospital so I can take part.
@@wendychavez5348 could you please elaborate on why you cannot qualify for it?
This is astounding. I'm 24 years in remission from Leukaemia and two years of gruelling chemotherapy treatment I endured from 16 - 18. I imagine at some point each one of the toxins in the specific chemo cocktail I received were one trialled by participants equally as brave as these hero's. And I can say I wouldn't have envied what they put themselves through in doing so either! But I'm beyond grateful they did! Even given the long term ramifications I'll be dealing with from here on in, I wouldn't forsake that for the experience I had knowing what it is to be in love and the pure joy I eventually experienced in giving birth to two gorgeous and extremely precious daughters.
It's crazy when you think about the fact that healthy people took chemotherapy drugs first to see if it was safe. Knowingly taking the equivalent of a bomb going off in your system since it'll destroy everything in sight is wild
Success stories like you are exactly why I work in research. Every single cancer therapy and Alzheimer’s drug trial I hope not so see any observations or toxicity. It is always very sad when something doesn’t work as intended.
Not brave but stupid. Usually people in need of money.
Your life is worth so much more than money!
No to pharma.
Congrats to you, and I hope you live to see 103 😊
Best re-inactments I've ever seen. Usually SOOO cheezy
Dana Ashlie British do it better
@natalie L Same but that's mostly because I am British.
Dana Ashlie i agree plus the faces are quite identical too. i didnt realized it was just reenactment for the first 10 mins lol
I honestly though it was actual footage
So true !
Patient: No one is going to die right?
Doctor: Who's your favorite Avenger? Just wondering..
Patient: I prefer DC
Doctor: yeah im just gonna give you another dose
😂😂
I don't feel so good doctor
I like how these reply’s are taking the joke in so many different ways
HA
The major issue was the drug being administered to every man within minutes of one another instead of adopting a wait and see approach, which you think would be standard initially in a first in man trial. Side note: David’s family is beautiful! So happy to see that.
While that's clearly the case, it seems they still have done everything according to protocol, haven't they? At least they say that in the documentary, so it may not have been standard at the time?
@@juditmlnr you would think it’d be common sense though. A drug that’s never been given to humans before and they’re rapidly dosing everyone before any side effects are able to take effect. Live and learn, I guess. I’m just glad it wasn’t at the expense of someone’s life.
@@juditmlnrI mean technically, yes, they did everything according to protocol - but the protocol is largely determined by the entity running the trial following some standard guidelines and requirements. personally, I think the biggest problem is that this kind of reaction should not have been so unforeseen (they even acknowledged cytokine storm as a possible side effect beforehand) that they didn’t prepare for it to happen in a first-in-human trial.
@@junk_DNA The doctors were not prepared for anything to go wrong. Common sense says you should be prepared for ANYTHING when testing an unknown drug!
@@Courtneyemily91yeah but how longbdoyou wait and see 10 min 10 days you know
In the U.S the hospital would of have tried to charge you for your stay
Facts.
You are right, and they would have charged 3,000 a night.
You just nearly died because of us...
Give us $30,000
@@duck3819 That is very accurate. My quack of an orthopedist gave me an unnecessary MRI, over my ankle being swollen and having pronation. It found bone bruising, JUST BONE BRUISING. It was a waste of 2hrs and $900
donte ray damn right they would have
That one guy just sitting there on the bed was horrified.
I feel terrible knowing the mass pain they were going through.
m3m3d_ I felt real sorry for him . He was just siting there and every one else was reacting to it. He was probably thinking that he was going to get it soon
I would feel guilty for Being tho One Who got the placebo
crumch
Are you him (Looking at your profile pic even though I know it's just Arin
the 2 (one in each room) who got the placebo will definately have long term mental issues from what they saw and heard..I hope they both got some great counseling...crap like that can mess your head up for life.
If you don't want ads, skip to the end and replay it will make the ads go away. You can thank me later.
YOU ARE A GOD
@@sarina2364 or install an addblocker, no adds anywhere!
You right, I gotta get on that. Thanks!
thanks.
A prophet like you comes along every 200 years or so. Thank you for this gift. The gift of this knowledge.
Must have been horrifying for the placebo patients to have been surrounded by everyone around them succumbing to ebola-like complications
documentary: shows up in my recommended
me: aight ok guess i’m staying up another hour
claudia There is no sleep when there is UA-cam 😆
It is nice when the algorithm works.
Me rn
claudia same!!
claudia 4:42 here
Everyone: puking, screaming, dying
That one guy: okay think imma head out ✌️
@Jimo National ok boomer
@Jimo National ok snow roach
@Jimo National and this is a problem because...
@@harssamoanlal2947 kip
@Jimo National apespeak isn’t a real word either 💀 what a mong
This is like watching a horror movie but every detail actually happened
Ikr, it makes it WAYYY scarier... obviously
@@LiterallyEly honestly this scared me more than any horror movie ever has
As someone with auto immune disease its heros like this that risk their lives that give me the medicine I need to survive.
@@ItzBrittKneeBish ❤️
This is why I'm open to being involved in clinical trials! I have these conditions, and am interested in improving the care that other people with them can obtain. Like Subject #1, I understand that it's important to report anything even slightly out of the ordinary because information is vital! I wish these men hadn't suffered like this, and thank them for their sacrifice.
I'm a multiple organ transplant recipient, and on roughly a dozen medications, several of which are beyond critical to continued survival. This reminds us just how important clinical trials are, and to appreciate the sacrifice and risks those people took, to pave the way for better health and lives for all mankind. Thank you.
I work for a clinical research organization and I always thank our volunteers
Liver transplant recipient here 👋
Here here! It's an enormous risk to participate in these trials. I've been tempted to do so for the $$$ but the thought of what *could* go wrong had held me back.
You know how commercials list all those crazy side effects like diarrhea and death? That's because someone experienced that.
This was malpractice in testing.
@@gemmawatson1879 me too
I found this a very interesting article. My granddaughter had a rare cancer at the age of 2 and ALL of her treatment was through international clinical trials. Part of her treatment was immunotherapy, where one of the risks was a cytokine storm because of the use of monoclonal antibodies. After nearly four years of treatment she is now five years in remission. The harsh treatments she had have left her with a variety of health problems, but she is a happy 10 year old now and very precious to our family. Whilst she has contributed to many clinical trials through her treatments, we are indebted to the children who have gone before her and may have since died of the illness or the treatment. Anyone who contributes to the advance of medicine through participating in clinical trials (of whatever stage) is making a massive contribution to the rest of humanity.
Amen. I agree. And with any trials, all precautions should be taken, and there should ALWAYS be an ESTABLISHED anecdotal plan in case of known, and especially unknown, side affects.
The posh doctor interviews between creepypasta-like reenactment scenes is such a mood
@@pamsam8933 I I IC think ⁹I 99
@@pamsam8933 the problem is that you can't know the side effects to 100% certainty in advance. You can inject them into mice and monkeys and test on human cells and determine it "might" be safe. When you are the one taking a drug that no human has taken before, nobody can predict with certainty what is going to happen, it's a big risk and they should (and almost always do) tell you that it is a risk.
The reason things like this are big stories is because of how rare events like this are. The vast, vast majority of first for human clinical trials have the worst problem of people withdrawing due to side effects. This occurs in both the cohort getting the drug and the cohort getting placebo. Multiple fatalities in a single trial is so unusual as to lead to videos like this. The risk is higher in rare illness, where there just fundamentally isn't as much data in. Even then, like in this case, actual death is exceptionally rare.
Who else watched this, and immediately decided to never participate in a clinical trial? 🤯🧐
I heard about this at the time it happened and then decided the same. Your life and health isn't worth playing Russian roulette with. Even if nothing like this happens to you, you don't know what unknown long term effects might be caused.
Sarah Vela I have participated In one! Nothing happened to me thank goodness lol
Where did you participate in your study at ?
@Poppy Mystique I'm in a study right now in the states at a place called PRA Health Sciences in Lenexa, Kansas City, Kansas
My study right now is 5 days for $3,000 us
I had considered cosmetic trials, but after this there is no amount of money in the world that could make me want to participate. Just to risky for me.
Calling People fighting for their lifes and suffering trough a lot of pain "Elefant Man" shows just how disguting humanity can get.
I didn't have this drug, but I had a different monoclonal antibody - rituximab - and it saved my life. I had stage 4 cancer at 17 (actually, lymphoma, like was brought up in this documentary) and thiys documentary just made me feel so thankful to all of these men. Their positivity and outlooks are wonderful, too.
i know its been 6 months since you posted it but im a 2 time lymphoma survivor myself but do you remember if you had hodgkins or non-hodkgins lymphoma
Wow at such a young age how are you doing now ?
@@goha9218 im doing great now i do have higher risk for cancer later in life and i had a few side effect from radiation like lack of hair, stunted growth on my left side, and a few more but im fine for the most part
Are you dead now?
@@theyracemesohardchair i wish
UA-cam, I don’t think an add for a drug trial study is the best thing to run during this video. Like seriously, I don’t think people will want to take part in a study after watching this.
Pilar Tromacek 😂😂😂😂😂
2 months later and I got the add too!
ye THIS TOTALLY HAPPENED...
Yea UA-cam has no humanity or morality left. Google is probably run by Skynet
XD still gonna, because someone got to be the one to do it
Did anyone else get an ad for a company looking for medical testing subjects during this video? I couldn’t stop laughing when I saw that ad...worst use of a product placement algorithm ever lol
yes, it was about 10min to the end of the video.(P.S I laughed too don't feel bad)
i got leggings ads like 5 times not kidding
That's priceless
that would be funny but scary at the same time
i did..and I thought the same..i was also thinking maybe a lawyer ad would have been better!
All those symptoms seems extreme and scary.Sounds like a nightmare
It's crazy to think that they didn't have an emergency protocol in place. That doctor was scrambling to find any other doctor.
That dr was probably just a pawn on a larger chess board.
You can't plan for unexpected reactions
Very poorly administered trial for sure. Why inject them all at once??? Pathetic!!!
@@nasramohamed no he called for the other doctors because he didn't know what to do.
@@Abdi-libaax read the comment before replying the obvious jeez
The acting in this reconstruction is incredible !!
Alana this isn’t a act this is real I hope you know that!!
@@alexischang5929 yeah it is. These are actors they don't even look like the actual people?
Alexis Chang I know the story is real but the reconstruction of the events isn’t real!
As a cancer treatment patient I understand the importance of drugs being administered at a slow rate.
I hope you get well and go into remission forever.
Hope you are doing better
It's basically poisonous nuclear waste they're dumping in people's bodies.
Cladrabine 7 day IV infusion slow I know it
That's because you don't know the great physician, the lord god almighty.Amen.
The fact that the doctor in charge of the trial had to scour the documents for hours after giving the drugs to find out all of the possible side effects makes me feel nauseous. As a nurse, I refuse to give a drug to a patient until I know all the important facts about it. I keep my drug guide handy at all times just in case the doc orders something I’m not familiar with, and that’s when working on the fly. With a trial you have ample time to know every single known fact found well before you even begin to search for trial participants, and then you need to be prepared for all of those effects to occur. Cytokine storm is a known possibility? Then you have staff, meds, and full treatment plan on standby just in case, and the same goes for any other potential side effect. If it’s the first time a human is receiving the drug, then you especially need to be ready for anything happen.
How it's supposed to be
You're a great healthcare professional - thank you for your caution and everything you do to improve lives.
At 57:44, they confirm what most of us guessed. It wasn't the drug itself, but the quantity and time. The reactions of patients were like an overdose. You can't increase the concentration like that!
Edit: Actually it's 47:50
@@wesleyp3024 The thing is chemo also kills things it shouldn't kill and is way more invasive and dangerous... In fact, there are still producers of vaccine-like cancer cures.
Right, I was initially thinking it was actually DECREASED, but I realized that they had increased it by was it 500 times?? I feel horrible that this happened truly. Been quite close a few times to participating in clinical trial research for the money. SO GLAD I WATCHED, NEED AGAIN!
Edit: apparently the dose was decreased. Can you imagine if it had been the opposite??? SMH.
@@wesleyp3024 WOW. These poor chaps.
@Fab Elger I meant at the London trial. They used too much, too fast.
Wesley P Yeah it's kind of like having a voice give you an instruction, as long as the voice is still there it will still give you that instruction whether weaker or louder
I know the guys in this trial regret doing it, but I just want to tell them thank you. Because as much as that sucked they saved so many lives. Think of the consequences if this had gone for trials at st judes.
Which lives are you talking about? There's no cure for leukemia.
ThyGreek they mean the lives of other test subjects I think
@@hevbushnell4013 Yeah that makes more sense.
ThyGreek yes there is? People are being cured from it every day.
@@thygreek8076 um yeah there are cures for many forms of leukemia. What used to be a certain death sentence is now curable in up to 95% of cases, depending on the type...
“It is now recommended that high risk trials take place in a hospital with an intensive care unit”
Excellent work, gentlemen...
In the hospital we're warlocks and witches work there witchcraft Around the ⏰ clock, there's only one great physician and he cannot fail, his name is the lord God almighty, praise God for the lamb of God.Amen.
Nosha Dean lol keep up with that attitude😂 I really hope you don’t have any children that need real medical attention
@@jowenmick8507 says the unrepentant sinner.Amen.
@@noshadean787 How do YOU know he is unrepentant of his sins?
@@B_Bodziak I didn't say i knew,but this is certainly what someone who's unrepentant would say,this can also apply to me and you.Amen.
the 1918 flu caused out of control cytokine storms. The younger you were, the stronger your immune system and the stronger your immune system was, the stronger and more out of control the cytokine storms. These caused the terrible internal bleeding.
After trial: here’s your two grand. Don’t spend it all at once!
patients: we are dieing here
Actually two thousand pounds converts into $2,562.91
Definitely deserved a lot more. As in 5,000,000,000 for each person effected by the drug physically
James Only r u mad? If a person died there they would have to only pay from 100k - 2-3M €
James Only that’s why they have u sign all ur rights away before the test :)
patients: puking, fainting, screaming in pain
doctors: *Don't stop administrating the drug*
Mhm
😥
doctors: its working its working..infuse more drug
Ahhhh, the benefits of knowing more in the name of science
Ya what's that?
The 2 receivers of the placebo are in my opinion entitled to damages as well, as are the staff who all were undoubtedly traumatized by witnessing this dreadful horror.
You do know they willing signed up for this, knowing that there could potentially be a risk of death right?
Nope
Agreed.
@@SaraWOanH Where does it say in the contract "risk of death"? Do you work in this field?. They would never get people by stating that fact. They Will Say it may cause side effects (like organ failure) but not death. I do see what you are saying but they picked strong healthy young men. Emphasizing death is not a priority.
Also... I would never do it. My friend fell fast after being talked into a trial cancer drug by her doctor friend....sad scary and I'm not built for it. My nerves and worry are too bad...😆
Sounds like an inside job done by a lone crazy scientist.
My mother told me about this when it actually happened and at the time I was too young to understand the whole thing. It sounded terrifying though. I'm happy to get to see this documentary now and find out about what she told me about.
16:07 How the doctor sees the patient squirming in pain and then causally asks, "How are we doing David?"
The doctors and nurses have to remain calm and clinical. Honestly alot of people react well to that as it shows everything is under control. If a doctor panics I lose all faith in his/her training. It's been proven a doctor who stays calm and collected keeps the nursing staff calm and help the patient stay calm too. They also save more lives that way.
Lol made me spit out my dasani.
Kenna Martin dasani water? We have that in suriname
shevon gibson. Dasani flavored water. I drink them everyday!
That’s the doctors’ way of staying calm and keeping the patient calm as well. If they panic or show signs of panic, then the patient panics too. I was in the hospital for 2 months after having my lung removed and from personal experience, I can say that at first it’s a bit annoying but it slowly becomes a bit reassuring.
these guys are really great human beings to look back on the trial so positively.
They don't have a choice but to look on it positively. They know how brutal life is, it's in their eyes.
It’s like labour, you never really remember how painful it is.
Sara Burke Really stupid human beings if you ask me who in their minds would allow themselves to be injected with something that they don't even really know what it is or that could potentially have deadly consequences..
@@ariellucas7755 it's like they said, every drug has to go in a first in human trial. You have a family member who's life was saved?
I think it's a human coping mechanism to look back at a thing like this and see it for it's purpose. I have seen similar cases where people are for example enslaved but they are glad they pushed through so that they cant do it to anyone ever again. Again focusing on the purpose.
can we just give these men a round of appaluse for what they have endured that must have been really traumatising especially the guy that lost his fingers and had his foot amputated
!!!
For their Stupidity for taking a few bucks?
@@williamarmstrong1017 I assure you, they would not go if they would be well informed. And what they do now with vaccine is pretty much the same! And they not have to pay for it.
@@cica8427 For a elegal mrna vaccine?
@@cica8427 💯
I feel so bad for all the patients involved. It had to be terrifying not knowing what is happening to you or possibly going to happen due to the placebo. I hope they all received mental care for their well being. You all are courageous. We salute you for your efforts to help people get healthier. Thank you.
David: *rolling around in agony*
Doctor: How we doing David?
Edit: It's at 16:08
David ' yeah a bit unsettled. Yourself?'
It’s to see if they can talk or respond
Probably could have asked a different question
Plot Twist...Dr HabibiStein knew all along what was going to Happen!
Thanks guys for all of the likes, greatly appreciated
Guys the reason for the doctor saying “okay how are we doing?” In a calm voice is because they need to keep the patients calm, it’s worse for patients to know they are in serious danger and start panicking. They would do what the guy in the beginning was trying to do, escape the hospital.
Ellie Arnold to keep them calm like you said and to test if they can properly respond to the question still
Ellie besides the responsibility of the medical team to react calmly, they ask bcz they need the patient to tell them, in their own words, the symptoms they are experiencing. For example, the machines monitoring their heart rate couldn't tell them that the patient was experiencing an instant migraine, or the level and location of pain they were experiencing. They needed to evaluate ALL symptoms into the diagnosis, and info from the patient is critical with these sudden symptoms.
That’d work opposite for me
Hard to believe all infusions were not stopped once first patient demonstrated such severe symptoms.............
I believe they said that by the time the first patient started to writhe in his bed, they were already finishing up the last infusion. So things hadn't gotten bad enough to warrant that, in their minds. They had no idea it was about to cascade and affect everyone.
But yeah, now we've changed the rules so hopefully this won't happen again.
I agree
They still have to test the drugs though..
also, one of the experts said that the dose was infused 10 times quicker than it was with the animals. Why are they omitting that fact in the final report? It looks to me that such fast infusion could have been the cause, or at least it looks highly negligent and irresponsible.
Mara Ram, yes, it was administered 10 times quicker, BUT it was also a 500x smaller dose.
You realize this is the kind of torture and abuse that they put live animals every single day , right?
Did you read through any of the other comments? Animal trials were first, then human trials which were infused at a much faster rate than the animals. So it was definitely a bit different for the humans. Also, all the modern medicine you benefit from was brought about using the same method. Animal trials then human trials. Maybe you need to rethink things.
Tbh, it is the drug company responsible, not the doctor... Idk why everyone is blaming him. He had a job, he tried his best... I'm so sorry to the men that you had to experience that
Agreed
Exactly. He was just there to inject them and make sure they were ok. It was completely out of his control
I honestly think no one is responsible.they've tested it on mice and the mice did not show any of the probants symptoms. They also warn you and hand you a contract where they warn you that there might be some serious long term complications while testing the drug.
Sure I wouldn't hope anyone was in their position and this was a very dangerous situation, however the probants knew that there might be serious complications.
So in this case, no one is to blame and those who went running to their lawyer are nothing but morrons from my point of view.
But they injected humans with the drug much more faster then was done on previous testing on animals.
@@phasorthunder1157 TBH, the speed of the injection likely had little overall change on the drastic effects. The severe reaction in people probably came from the differences in T cells between mice and humans, which was newer knowledge at the time.
This is one of my favourite documentaries. That doctor was pissing his pants no doubt. In the USA they'd be sued to the moon and back no matter what they signed.
They were
Dover McManus you’re right! No matter what you have a patient sign they can still sue!
@@kriss8499 your execution of responsibilities is always subject to question and judgment...
Absolutely not..... that's an very dumb stereotype and also makes no sense considering that the pharma industry obviously have to how tk protect themselves from lawsuits. Since side effects are essential while testing....
Not as much with vaccines.
17:20
Testimony: “Shivering with cold, but I wasn’t cold.”
Actor: “I’m cold.”
Riptide27 he felt cold but his temperature was fine
Riptide27 I get this all the time.
he was cold on the inside but didn't feel it on the outside
More like: His body had a fiver, its like having a shiver when your sick. Your body muscles start moving, to warm you up, when it thinks your "to cold" or to "fight" of an intruder like a Virus or else. He felt Cold inside, but they all had a fever and the shivering, like their Body was fooled by the drug to think "your cold". I go so far to think that their bodys were Burning. In an article i read on the German Wikipedia it said that one felt like he is burning from the inside out. :3
I think a few of you guys are taking this comment too seriously. It was just something I found funny when I watched it.
I absolutely love a doco and I have to say this is one of the best I’ve ever seen. Absolutely terrifying experience for those involved but the changes to drug trials since have meant nothing like this should ever happen again 💗
I'm so confused as to why cancer drugs would be tested on people who don't have cancer.
to see if this is what's going to happen
Me too..
@@ferretsnax I kind of get that, but maybe if the drug had something like cancer to fight it wouldn't have acted that way. There are so many variables when it comes to new medications that you can't really expect a drug for sick people to act normally in a healthy person.
@skxtxn m I see. So it's not just about how the drug will affect the cancer, but also the body to see if the cancer patients could even handle it. But then there leaves the question of knowing if the cancer patients could handle a drug that someone with a healthy immune system can. I understand these things need to be done to save lives, but there's just a lot about it that truly confuses me.
Cancer drug???? Giving that drug is like doing an abortion on a woman who wants children all her life. How could they be so STUPID.
You are right. Give it to someone with Type 4 Cancer. They are closer to death. They had nothing to loose. Ah! SAD,
All these men seem to have such a sweet disposition and are so open about their stories and they constantly use words like “lucky” and “grateful”. It’s inspiring
But the two who were in the intensive care for longer were not speaking in it. I wonder if the guy without fingers and leg is feeling the same way, probably not. But I bet he's not allowed to speak as part of his settlement. That's why I believe these things should never be allowed to be settled outside of court. These drug compagnies can get away with almost anything without the public even knowing most of the time.
If everyone recovered I think they’d all be complaining, but they seem basically ok compared to the other guys so they lost the right to complain
I do like the one patient’s comment about understanding that the very drugs used to save him, all had to undergo ‘first man’ testing process...
@@benanders4412 Big Pharm is plain evil. They give us a disease and then act like we should be grateful for a cure.
@benanders4412 ❤ Very Well Said!!
I knew a man who was working as a test person for a major German company which is called Schering. They gave him some kind of psychotropic drugs. Although he soon showed clear signs of paranoid reactions and weird habits of falling asleep in the middle of a conversation, they went on giving him these drugs. Over the next 3 months he became more and more schizophrenic and paranoid. A few days after his 21st birthday he killed himself, because he couldn't take it anymore. The doctors said his will to die must have been incredible strong, because he drowned himself in a canal although he could swim. He filled his lungs with water, he swallowed so much water that he suffocated himself.
Although I have to say that he also could have said that he wouldn't do the tests anymore, I accuse the doctors who went on giving him these drugs. Since he was promised a lot of money for these tests, they could convince him to go through with these experiments.
I can only recommend to never work as a test person. You never know what you get into. Although it seems to be a lot of money, it can cost your life or at least your health.
If this is true, it's very sad.
There is definitely a need for people to do human trials. Without them there would never have been a way to find cures for diseases which tormented or killed huge portions of the population.
That being said, I think the big pharmaceutical companies need to seriously revamp the way that they introduce and study their drugs and mechanisms of action before human testing.
The volunteers also need to carefully read exactly what they're getting into.
I was in a drug trial-it wasn't a "first in humans" trial, which would be the most risky. The new drug was for a condition that I already had. This was supposed to be a different type and more effective treatment than was already on the market. The disease is usually fatal so I was glad to be accepted into the trial. A month's worth of the drug, outside of the trial would have cost $30,000.00, and I took it for 6 weeks.
I had to have my blood tested each week. One week, my test results came back w/an abnormal reading. I was called in for further testing, and fortunately, the first test result was an anomaly. I found out later that if the test results had continued to be abnormal, I would have been dropped from the trial.
I don't know how they normally conduct their testing in Germany, but I know in the US, they're extremely careful, I think because we have too many lawyers here. :) Four years after the trial, and I'm still in remission, and extremely grateful.
Symbolsysteme why blame the medical staff. It was his choice. Nobody forced him.
Delighted for you Nancy, that was meant to be! So good to hear about the trials for people who have a need for the drug, glad it worked for you and you weren't crippled with debt after, fantastic really! Wish you well
It made me so happy at the end when I saw David with his children ❤
A lesson learned
Watching this in lockdown, quarantine coronavirus.
Same here😐
Yeah
yup 4/2/20
So what,everyone is in lockdown.
me too
Patient 1: *Writhing in pain*
Doctor: “How are you doing sir?
Doctors are such trash. You’d hope that the people in charge of keeping you alive had even the tiniest bit of compassion, but nope, nowhere to be found in medical professionals
It's to attempt to make the patient think it's ok and the doctor also needs to know if he's responsive
Maddie Trafford it’s the sad truth. Some doctors will make patients think they need surgery (which could end their life) only to get $$$. However, there are some good doctors out there.
he needs to check if he’s responsive and trying to make him calm
the 2 people who got injected with the placebo where so lucky
How hard is it to know the word “were” exists?
Maddie Trafford that was 2 months ago and people make mistakes
@@maddietrafford1225 oh get a life
DaisyV. Wolf хаха какво се случва
eh not exactly they probably have survivors guilt
Gosh, that was... unexpectedly harrowing. I'm so relieved that everyone made it out alive. I hope they go on to live full, happy lives.
No not really