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There is a peculiar phenotype of thinness called constitutional thinness, which is described in scientific literature. It is defined by a state of non-pathological low body weight stable over time, in which from early childhood these people remain in the lowest percentiles adjusted for age, sex, etc. They are people with a normal caloric intake but exhibit resistance to weight gain despite the obesogenic environment of the modern world. In 2019, an in-depth study was carried out on this peculiar phenotype, in which people with said phenotype and people with normal weight were brought together and white adipose tissue was compared and studied in both groups. The results were that evidently the adipocytes of these particular thin people were noticeably smaller than the control group, they contained a greater number of mitochondria, which translated into a greater oxidation of fatty acids but also surprise in the synthesis of triglycerides. In the blood, the lipids were balanced, with no evidence of hypertriglyceridemia, so they are healthy people. In addition, not only was there an increase in mitochondrial number but there was elevated activity of the electron transport chain. The scientists did not find the presence of the uncoupling protein as a possible explanation for the energy expenditure in these people. We also wanted to see if there was a greater oxidation of lipids in the skeletal muscle, but in neither of the two groups were there differences in the oxidative capacity, which is why the study postulates that the increased lipid metabolism in these thin people is specific to adipose tissue. white, but not of mitochondrial biogenesis. The study ends by stating that mitochondria are key to local adiposity and could be a target for better treatments for obesity. I present this phenotype of constitutional thinness, I have a BMI that fluctuates from 16.3 to 17.5 at most. I was always like this, since I was little I moved through the lowest percentiles. The interesting thing for me is that it is as if the white adipose tissue of us constitutionally thin people is atypical since it is assumed that white tissue does not contain many mitochondria, but ours demonstrates the opposite. Quite curious What do you think? The study can be found as follows. Low body weight in humans is associated with high mitochondrial activity in white adipose tissue. I recommend that you read it. It's interesting.
With all of our histology videos we explain the principle concepts of histology while integrating them with other subjects such as biochemistry, physiology, and anatomy. We believe this style of teaching makes the histology more relevant and easier to learn. Additionally, the USMLE and other exams will ask you questions that require integration of knowledge across multiple subjects.
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Join our channel's membership to gain exclusive access to our histology lab videos which compliment our histology video course. The lab videos walk through histology slides and help with identifying staining patterns, cells, tissue types, high yield structures, and organs. Click the Join button above or this link: ua-cam.com/channels/oQx83m4hrKAHRX7ZqeRRHg.htmljoin
I learnt and understood it all
your presentation skills are really effective, this was really helpful :)
Thank you so much for that feedback. Much appreciated. So glad you found the video helpful!
There is a peculiar phenotype of thinness called constitutional thinness, which is described in scientific literature.
It is defined by a state of non-pathological low body weight stable over time, in which from early childhood these people remain in the lowest percentiles adjusted for age, sex, etc.
They are people with a normal caloric intake but exhibit resistance to weight gain despite the obesogenic environment of the modern world.
In 2019, an in-depth study was carried out on this peculiar phenotype, in which people with said phenotype and people with normal weight were brought together and white adipose tissue was compared and studied in both groups.
The results were that evidently the adipocytes of these particular thin people were noticeably smaller than the control group, they contained a greater number of mitochondria, which translated into a greater oxidation of fatty acids but also surprise in the synthesis of triglycerides.
In the blood, the lipids were balanced, with no evidence of hypertriglyceridemia, so they are healthy people.
In addition, not only was there an increase in mitochondrial number but there was elevated activity of the electron transport chain.
The scientists did not find the presence of the uncoupling protein as a possible explanation for the energy expenditure in these people.
We also wanted to see if there was a greater oxidation of lipids in the skeletal muscle, but in neither of the two groups were there differences in the oxidative capacity, which is why the study postulates that the increased lipid metabolism in these thin people is specific to adipose tissue. white, but not of mitochondrial biogenesis.
The study ends by stating that mitochondria are key to local adiposity and could be a target for better treatments for obesity.
I present this phenotype of constitutional thinness, I have a BMI that fluctuates from 16.3 to 17.5 at most.
I was always like this, since I was little I moved through the lowest percentiles.
The interesting thing for me is that it is as if the white adipose tissue of us constitutionally thin people is atypical since it is assumed that white tissue does not contain many mitochondria, but ours demonstrates the opposite.
Quite curious
What do you think?
The study can be found as follows.
Low body weight in humans is associated with high mitochondrial activity in white adipose tissue.
I recommend that you read it.
It's interesting.
informative , thank u
Thank you! So glad you found the video helpful.
where are the practice questions
Really useful. And im not even in bio
Thank you so much. So glad you found the video helpful!
this is histology but you're explaining biochemistry
With all of our histology videos we explain the principle concepts of histology while integrating them with other subjects such as biochemistry, physiology, and anatomy. We believe this style of teaching makes the histology more relevant and easier to learn. Additionally, the USMLE and other exams will ask you questions that require integration of knowledge across multiple subjects.
nice
Thank you for your comment. So glad you found the video helpful!