Predicting Obliteration After Stereotactic Radiosurgery of Cerebral Arteriovenous Malformations

Dr. Cody Nesvick, a Neurology Resident at Mayo Clinic in Rochester, MN, shares results of his study appearing in the May 2021 issue of Mayo Clinic Proceedings where looking at 527 patients with cerebral arteriovenous malformations who were identified as having stereotactic radiosurgery from January 1, 1990 - December 31, 2014, they found the data presented demonstrates that biological effective dose is associated with likelihood of obliteration following single-session stereotactic radiosurgery, and that biological effective dose consistently outperforms margin dose in multivariate models predicting arteriovenous malformation obliteration. Inclusion of a time component may be particularly relevant for large and/or complex arteriovenous malformations that require longer treatment times, as it is increasingly understood that repair of radiation-induced DNA damage occurs in a biphasic fashion with a “fast” component occurring within 15 minutes of irradiation and a “slow” component that occurs over the course of several hours. Available at: mayocl.in/3vtQ7hQ