C-Reactive Protein: What's Optimal? A Comprehensive Review
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- Опубліковано 24 кві 2021
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Papers referenced in the video:
The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population:
immunityageing.biomedcentral....
Bioanalytical advances in assays for C-reactive protein:
pubmed.ncbi.nlm.nih.gov/26717...
Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians:
pubmed.ncbi.nlm.nih.gov/26629...
High-sensitivity C-reactive protein predicts mortality but not stroke:
www.ncbi.nlm.nih.gov/pmc/arti...
Prospective study of high-sensitivity C-reactive protein as a determinant of mortality: results from the MONICA/KORA Augsburg Cohort Study, 1984-1998:
pubmed.ncbi.nlm.nih.gov/18156...
High sensitive C-reactive protein (hsCRP), cardiovascular events and mortality in the aged: a prospective 9-year follow-up study:
pubmed.ncbi.nlm.nih.gov/25456...
Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality: The Hordaland Health Study:
pubmed.ncbi.nlm.nih.gov/26823...
Troponin T, B-type natriuretic peptide, C-reactive protein, and cause-specific mortality:
pubmed.ncbi.nlm.nih.gov/23228...
Association between C reactive protein and all-cause mortality in the ELSA-Brasil cohort:
pubmed.ncbi.nlm.nih.gov/32102...
C-reactive protein in the prediction of cardiovascular and overall mortality in middle-aged men: a population-based cohort study:
pubmed.ncbi.nlm.nih.gov/15821...
High-sensitivity C-reactive protein and cystatin C independently and jointly predict all-cause mortality among the middle-aged and elderly Chinese population:
pubmed.ncbi.nlm.nih.gov/30592...
Seventeen year risk of all-cause and cause-specific mortality associated with C-reactive protein, fibrinogen and leukocyte count in men and women: the EPIC-Norfolk study:
pubmed.ncbi.nlm.nih.gov/23821...
High-Sensitivity C-Reactive Protein and Risks of All-Cause and Cause-Specific Mortality in a Japanese Population:
pubmed.ncbi.nlm.nih.gov/27268...
Beta2-microglobulin for risk stratification of total mortality in the elderly population: comparison with cystatin C and C-reactive protein:
pubmed.ncbi.nlm.nih.gov/18227...
Serum C-reactive protein levels can be used to predict future ischemic stroke and mortality in Japanese men from the general population:
pubmed.ncbi.nlm.nih.gov/18790...
Impact of systemic inflammation on the relationship between insulin resistance and all-cause and cancer-related mortality:
pubmed.ncbi.nlm.nih.gov/29191...
High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama study:
pubmed.ncbi.nlm.nih.gov/18403...
An epigenetic biomarker of aging for lifespan and healthspan:
pubmed.ncbi.nlm.nih.gov/29676...
DNA methylation GrimAge strongly predicts lifespan and healthspan:
pubmed.ncbi.nlm.nih.gov/30669... - Наука та технологія
I finally finished binge-watching all of your vids, they are amazing props to you Michael!! Hope more good videos are coming soon! Stay safe!
Thanks Jake Jake! I try my best to publish videos at least 1x/week, usually on Sunday mornings.
I couldn't binge watch, I barely understand them, lol
Thank you so much for your quick response. Looking forward to watching the video! Thanks for all the work you do - I’ve learned a lot.
Thank you for the work you do.
Thanks Benja Capo!
Very interesting!
thanks for all the great work compiling and making sense of all these studies.
Also agree with you on the importance of CRP
Thanks ccamire!
Mike - your videos are fantastic - keep them up. I think all your viewers would love a video that is just a video on what you eat/consume in a typical week, and why... You've obviously put a lot of thought into it, and while it is individualized for you, it would give us some insight into your food and nutrition choices and rationales. I've watched your first video on where you touch on this in the "Aging Clocks" video #1, but a video just focused on your weekly nutrition / eating / drinking would be really helpful!
Thanks B Chik. Full diet composition data is in this video (ua-cam.com/video/0Q1A4OcJlUQ/v-deo.html), but you're right, it's about time to do another! I'm blood testing in 4 days, so the corresponding diet with those results is a likely next video (or the one after that).
Thank you! 😊
Incredibly good. Packed with valuable information. Everyone should know this, but my own doctor probably doesn't even know this in detail.
Amazing video. Thank you so much.
Thanks @kevinselwa8883!
Awesome work, as always. And, nice job on presentation style to go from general to specific like that. You sparked me a few weeks ago to increase my blood testing to every 3 weeks. I'm finding there is no better motivator to stay on track with the diet and exercise than frequent, regular testing. Also, so much easier to hold everything constant and choose just one variable to play with. Chronological age of 50, Levine age of 38, Aging.AI 3.0 age of 32, Aging 2.0 age of 28 (those seems crazy low). CRP (Labcorp 0.0 - 3.0 range) 0.30 mg/L. Keep up the great stuff, Mike!
That's great, keep up the great work, and thanks, Swen!
Nice video , every time you say how low can you go I think of the Cha, Cha , slide song .
good deep dive...this makes me feel good about my usual 0.16 hs-crp and 63/70 tg/hdl readings, as i'm in my 70's..🌈
Mike have you seen any studies on diets or supplements that would help lower High-sensitivity C-Reactive proteins? Or any other therapeutic methods to affect High-sensitivity C-Reactive proteins?
I like your no nonsense, hard numbers, approach in your videos. Thank you for that!!
CRP is a marker of inflammation, so just search for the "anti-inflammatory diet", which is basically pesco-vegan whole-food diet: www.health.harvard.edu/staying-healthy/foods-that-fight-inflammation
Awesome video Michael! My two measurements so far are 0.29 and 0.36mg/L, so it looks like I can do even better. I will be sure to look up your videos on how your CRP is correlated with your food to get some ideas to try. You are doing a fantastic job with these videos! Thanks!
Thanks Neil, and those are great hs-CRP data! For me, higher blood levels of cholesterol (including HDL) are correlated with lower hs-CRP, so that's a current experiment:
ua-cam.com/video/U0nTtDmCwSQ/v-deo.html
@@conqueragingordietrying1797 , interesting since one of the things I did since the first measurement is to cut my egg consumption in 1/2 (from 12 eggs/week to 7 eggs/week). My daily cholesterol intakes for the preceding week were 630+-32mg for the first (lower) measurement and 419+-19mg for the second (higher) CRP. However, my blood levels of cholesterol were essentially the same, 177 and 175 mg/dL, respectively. I’ve heard our bodies also produce their own cholesterol, so I guess it just makes up for the loss in diet? Two data points is not enough for any confidence, of course, so I look forward to future data. As I dive down this rabbit hole, it is endlessly fascinating to me how much more nuanced nutrition is than popularly advertised.
@@neilchristensen538 We all may be different in terms of cholesterol metabolism-I've almost always had a TC < 150, and HDL ~40 (or less). So eating ~an egg/day may help with raising my blood cholesterol, which is correlated with lower hs-CRP.
I agree about the nuance-it's easy to say to cut out junk food, but on a whole food-based diet, which approach is best, and how much of each food? That's way more complicated, and fun to figure out!
@@conqueragingordietrying1797 My HDL were 76 and 78 mg/dL, respectively, so I see I average higher. It sounds like I eat more meat than you, but that is something I am playing with now too, so we’ll see where that goes. I couldn’t agree more with your statement about a whole-food diet!
My hs-CRP averages 7.5 .. can anyone please give me any information? My doctor didn’t tell me anything
Great information as always! Have you analyzed your hsCRP as it relates to your food intake over at least a few years? I'd be curious to know what you find, given the amount of data you collect about your food and the fact you don't take many supplements.
Thanks Greta Groggy! Some of that data is in this video:
ua-cam.com/video/0Q1A4OcJlUQ/v-deo.html
Just want to note that apparently quite a few much used medications are reported to lower C-reactive protein. They include statins, common blood thinners, omega-3 lipids, ACE-inhibitors (for high blood pressure). Personally happy to report hs-CRP of 0.3 while in my late sixties (and biological age about 12 years younger by the Levine blood tests). Possibly partly due to some of the above, and a modestly healthy diet, taking some supplements, while at the same time still smoking a pipe every evening when watching some movie.
I've heard some people say that hacking blood biomarker-based composites of biological age are correspondingly easy to hack-just take metformin to lower glucose, and other medications that can reduce CRP. However, that doesn't consider the effect of those meds on the other 7 biomarkers, and I wouldn't assume that the net effect would be positive.
Very interesting thanks !! All 3 last CRP test came like that
There seems to be a significant discrepancy between the hs-CRP values of the subjects in this study (n=6,060) when compared to the subjects in the Kumar et al 2020 study "Glutathione Restoration Improves Hallmarks of Ageing in Older Adults", where the Young Adult (20-30yo) group (n=8) had an average hsCRP of 2.5 ng/ml while in the older (70-80yo) group (n=8) the average was 4.8ng/ml. Maybe the small sample size in Kumar et al is the explanation?
2.5 ng/mL = 2.5 micrograms/L, which is 1000x smaller than all the studies that reported mg/L. I'd bet that Kumar's units are wrong, that their units are actually micrograms/mL, which is equal to mg/L.
I love all your videos. Could you make a video on reducing other kinds of inflammation such as Homocysteine & Nf-Kb.
Thanks Zulkifli Curran. Homocysteine may be sooner rather than later, as I'm measuring that again on Wednesday. NFK-B will be later on the list...
@@conqueragingordietrying1797 thank you very much for the response. Also please show us strategies to reduce these nasty inflammations markers.
@@zulkiflicurran94 There aren't any RCTs that have reduced CRP from ~1 to < 1 mg/L, but
in my data, higher blood levels of cholesterol, which is relatively easily impacted by diet, is correlated with lower hs-CRP:
ua-cam.com/video/U0nTtDmCwSQ/v-deo.html
@@conqueragingordietrying1797 thank you very much for responding to my request. I hope the videos you create will get many likes and surely all your videos will be beneficial for many people out there. How about another marker for heart disease, endotoxins? You happen to know how to eradicate it too?
Thanks @@zulkiflicurran94! I also have videos on LPS, for ex.,
ua-cam.com/video/NGrYzOKGBXA/v-deo.html
Great video thanks! Statins lower crp are you tempted to take one to keep crp low? David sinclair does.
Ha, nope. My last hs-CRP measurement was 0.26 mg/Lin March 2021. Here's how I'm manipulating hs-CRP:
ua-cam.com/video/U0nTtDmCwSQ/v-deo.html
Statins side effects, damaging mitochondria , destroying coenzyme Q10, selenium...
Fish oil keeps my CRP 0.6 at age 69.
My CRP and Complement C3 are constantly high/above normal. What specialist should I be seeing?
Great work! I am toast lol. Mine is high- so what are the top 3 strategies to lower? I already exercise 6-7x/week, eat lo carb.
Thanks Kent. I can't say what will work for you, but a major focus of this channel is to encourage others and track their own data in an effort to find out what causes what.
On my last few blood tests the lab didn’t provide the exact CRP value but just reported less than 1.0. I would like them to provide the actual values
It's likely that you got the CRP test, not hs-CRP. If it's hs-CRP, you'll have a numerical value...
So the takeaway from all this is to avoid inflammation if you want to extend your lifespan and presumably also your healthspan. What actions can we take to achieve that? I'd nominate eliminating visceral fat and low-level infections. Does fasting reduce inflammation and CRP? ISTR that one theory was that chronic infection with chlamydia pneumoniae was a cause of CVD. So perhaps the CRP level is a proxy for various things that are damaging our health from obesity to infections by bacteria and viruses. Do the studies on centenarians speculate on the reasons for the low CRP in those populations eg robust immune systems, diet, low stress?
The actions that we can take may have inter-individual variability, but in a previous video, higher levels of cholesterol are correlated with lower hs-CRP in my data:
ua-cam.com/video/U0nTtDmCwSQ/v-deo.html
I only have CRP data. Is there any rule of thumb for the conversion of CRP to hs-CRP?
Unfortunately not. The hs-CRP test is measured differently from standard CRP, which isn't as good to detect very low levels.
Hi Michael, Im 64, do a mixture of running and strength. My hs-CRP is 0.6. The fasting blood sample was taken 14hrs after a big stength and condition session. Would that have impacted results?
Hey Stuart, it can. To test that experiment, you can take a full rest day the day before the test. But that will only be 1 measurement-ideally you'd need data for no rest day vs taking a rest day to see how much/if that affects next-day hs-CRP.
I have had CRP test, but not the more sensitive hs-crp after inflammation mostly in my wrists and fingers. Since this video mostly talks about hs-crp I was wondering if you could shed some light on my crp results. My level is at 27.4, but after taking the test I read that NSAID’s can affect the results (lowering). I took 800mg of ibuprofen 3 hours before the blood draw, so not only do I want to know if 27.4 could be pointing to an autoimmune disorder, and how much of a factor the ibuprofen should be considered.
Hi Linda Capra, do you have more test data for CRP? 27.4 mg/L is very high...
You need more subscrubers!
Ha, thanks Pavel, there's no rush, I plan on making these videos for a long, long time!
Sir my hcrp report is 3.6 give medication
I had my hs-CRP measured & it came back as 0.13. amaze!
0.13 mg/dL or mg/L? If it's mg/L, that's great! If it's 0.13 mg/dL, it can be improved...
@@conqueragingordietrying1797 mg/L but this was a single test. & I know they had to ship my blood across the country in a coolbox to get to the lab. So hmm, can it be trusted? A prior test for CRP was 1.3mg/L from the same guys.
My value of 0.75 (0-5) was already low...never heard of 0.4 or lower, really.
@@pramuanchutham7355 As shown in the video, there's published data that even lower than that, 0.3 or less may be optimal.
@@conqueragingordietrying1797 could you suggest ways to reduce hs-crP further? I already take daily folate, PQQ, Astaxanthin, NAC, Glutathione reduced, tocotrienols, C & D3...
Details are great, but can you make some “big picture” videos?
Sure bkinstler, like this?
ua-cam.com/video/G5zXa4DLvjY/v-deo.html
I was less than .2 the last time measured at 49. This is probably due to an anti-inflammatory diet. However, I wonder if there are some negatives from very low inflammation. Don't some of the benefits of exercise come from a hormetic reponse to exercise induced inflammation? Query whether an anti-inflammatory diet would suppress some exercise induced inflammation and thereby reduce the hormetic response?
Interesting question. We do know that some supplemental vitamins can blunt the response to exercise, as for foods, I think it's unlikely but cannot be excluded at this point.
Does anti inflammatory diet reduce CRP?
@@acousticmotorbike2118 Given that CRP is a marker for inflammation, I would guess so
Does sleep deprivation increase hscrp value sir?? Past 2 months i didn't sleep well, took hscrp test it came 3.65 is it high sir??
Mine was higher too.
My CRP level has been high over the normal range for over 12 years. And no diagnosis for any autoimmune disease. Strange. Do you know the possibilities? I have fatigue problems
Sorry to hear that-I offer blood test consults on Patreon, which may be of interest.
I am 60 and my CRP was recently measured as .02. Actually, it is always very low. Is it too low? Now I am worried.
Where is the evidence that CRP close to 0 is bad for health?
What cause CRP to elevate and how to reduce it? Could it be infection or low antioxidants intake cause elevation of CRP?
Lots of stuff impacts it-the challenge (and fun) is learning what impacts it within each person. For me, hs-CRP is higher on the day after exercise. In terms of diet, see this video:
ua-cam.com/video/G5zXa4DLvjY/v-deo.html
My crp levels were through the roof when at 41, I had thoracic outlet syndrome, clots from wrist to neck and both lungs, crazy!
My hs-crp high sensitive cardio CRP averages 7.5 and I’m 40. What can I do? I’m really worried. I’ve done several in a row, weeks apart. I never had the test til this year. What can it mean? Most of my blood work other than a couple of liver enzymes and being pre diabetic and taking Metformin is normal. Help! I take multivitamins and some supplements. But nothing specific for that. Help
Hey @SingingAesthetician, sorry to hear about your hsCRP.
In my data (32 tests), a relatively lower calorie intake is significantly associated with lower hsCRP, so that might be a good start.
I wouldn't cut intake below body weight maintenance, though-the common though of cutting 500 calores/day is too much. From my experience, smaller calorie cuts over a long period of time are easier to maintain.
@@conqueragingordietrying1797 thank you so much. Have you ever heard of anyone having levels that high? Does it mean I have heart damage or another illness? Are there any supplements and medications or specific foods I should try? If I had an autoimmune disease would that raise cardio hs-CRP? I’m wondering if I should have more blood tests etc!
Bicor means strongest marker right?
Nope, it means "bivariate correlation"
Is there an inverse correlation between c-reactive proteins and sirtuins? Are their treatments that lower CPR?
I haven't looked into the CRP-sirtuin link, but I will.
In terms of lowering CRP, higher blood cholesterol levels are correlated with lower CRP in my data. For example see 7:13 in this video:
ua-cam.com/video/U0nTtDmCwSQ/v-deo.html,
@@conqueragingordietrying1797 Thanks Michael. From your other video there might be a Goldilocks region of cholesterol. I read that Niacin is a statin that has a positive impact on high cholesterol. But I would like to learn more on all of this. Good topic.
@@Earwaxfire909 I agree that there's a Goldilocks zone for cholesterol, the key is discovering it. A CAC scan is on my to do-list for lates this year, which can help with that.
I've used high-dose niacin to reduce Lp(a), which it did (and improved HDL, TGs), but it doubled my liver enzymes, so fix 1 problem but make another worse. Also though, there's likely an optimal intake range for niacin in that regard, too.
@@conqueragingordietrying1797 I read that non-flush niacin is bad for the liver. But also read that niacin by itself is OK. Is any of this true?
@@Earwaxfire909 I don't think it's that simple, and comprehensive blood testing, beyond CVD risk factors and liver enzymes, can help answer that question.
How do you reduce CRP?
Causation is difficult to prove, but in my data, a relatively higher turmeric intake is significantly correlated with lower CRP:
ua-cam.com/video/46_Xkj9xQug/v-deo.html
How about a video on how to lower Hs-CRP or what works the best?
I looked for RCTs that reduced CRP from > 1 to < 1 mg/L, and it looks like there aren't any studies for that. If anyone finds a study that accomplished that, please put it in the comments!
In my data, higher blood levels of cholesterol, including HDL are correlated with lower hs-CRP, so that a current experiment:
ua-cam.com/video/U0nTtDmCwSQ/v-deo.html
@@conqueragingordietrying1797 not sure about how much but these studies suggest moderate vitamin C reduces creactive protein and hs creactive. Vitamin C blood levels also correlated with HDL. And in animals supplementation with vitamin c appears to increase albumin. pubmed.ncbi.nlm.nih.gov/18952164/
www.dovepress.com/effect-of-vitamin-c-on-inflammation-and-metabolic-markers-in-hypertens-peer-reviewed-fulltext-article-DDDT
Given the linear reduction in mortality up to 100 micromole, and the fact some sources appear to say people have even achieved 500 micromole levels with oral vitamin c, one wonders if such higher doses would further reduce creactive.-"Glycohaemoglobin and ascorbic acid"
"plasma ascorbic acid (AA) frequently is positively correlated with high-density-lipoprotein (HDL) cholesterol and inversely related to total cholesterol" www.sciencedirect.com/science/article/abs/pii/104727979400041Q
vitamin c supplementation albumin animals.
www.researchgate.net/figure/Effect-of-three-levels-of-vitamin-C-on-albumin-concentration-g-d_fig1_281893103
@@diamond_s Thanks Diamond S, these are interesting insights. I average more than 1000 mg of dietary C/d, but yet my HDL average is ~45, and there isn't a significant correlation between them in my data. My C intake is not significantly correlated with albumin either, but maybe that's true for others.
@@diamond_s While it's good that VitC reduced CRP in one of those studies, note the reduction from ~15 to to ~8 mg/L. At least based on my data, that correlation may not be significant at far lower starting CRP concentrations (< 1mg/L).
@@conqueragingordietrying1797 what I'm thinking is the chart on your other table showed linear ACM reduction up to 100micromole measure as far as the chart goes, it is conceivable part of that reduction is by lowering CRP, which could further continue at blood levels of 200micromole or more.
My reading has been at 8.7 for the last 1.5 years.. I'm 50 yo woman on hrt. My doc didn't suggest for any follow-up
My CRP is 10.1 and I am on transdermal estrogen and oral progesterone. I was wondering if the HRT increased the value? i mean CRP not hsCRP.
I'm 68 and last hsCRP was 0.3
If that's 0.3 mg/L, that's great! Or, is it 0.3 mg/dL? If so, it can be improved...
I've just done a 3-4 month carnivore diet and my C Reactive Protein has leapt from 0.6 mg/L to 10.
That said, everything else from thyroid to lipids improved.
What do you make of that? 🤔
I'd figure out what you can add to lower hsCRP...
@@conqueragingordietrying1797 thanks very much for the quick response. Any idea what? I take many rational points from carnivore but am wary of ideology so hard to find what that may be amongst the community zealots 🤷
Mine is 7.75 mg/Litre and I’m 32
I am 41 yrs old and my hs-CRP was 0.85 mg/L
That's good, but as I show in the video, there's published evidence that as close to 0.2 or less is optimal.
@@conqueragingordietrying1797 I am overweight but losing it, dropped 13 lbs. I have been working on getting my gut health tho I sometimes slip up. I have been eating lots of sweet potato and asparagus lately. If I shrink the fats cells I am hoping to bring my CRP down. I just had the test so in a couple months after I have lost some more weight I hope it will be better.
Good luck @@joshuagenes!
@@conqueragingordietrying1797 Thanks.
Does anyone have consistent hsCRP numbers above 30? Besides me? With no other significant issues in their blood tests or metabolic panels?
Hi Athena Rice, your hs-CRP is > 30 mg/L?
@@conqueragingordietrying1797 yes. 33 in December and 36.2 I think in March (after I did a gluten challenge).
I’m done with my celiac testing (negative for genes and antibodies) so I’ve completely quit eating gluten (specifically wheat).
@@conqueragingordietrying1797 I just don’t know that I can find anyone with high hsCRP numbers like mine. CRP maybe, nut not hsCRP, which was what they did for my test.
@@alr293 Yes, that's definitely high.
Such a bad marker to follow for aging and all-cause mortality. High sensitivity and very low specificity. so many things will bring up your hsCRP including vigorous exercise. So many variables. I suppose there are a small sub-set of people in might be useful to follow.
Hard disagree, but what would you suggest instead?
We don't actually have a biomarker for all-cause mortality. We have biomarkers for ASCVD and IR. When you pick a lab that has an arms length list of thing things that will elevate it will inherently have a low specificity, that's just a fact. Just like a D-dimer has a low specificity for a pulmonary embolism. CRP has very little clinical utility other than for PMR, Temporal Arteritis, maybe also for following cellulitis and other inflammatory conditions already diagnosed. Using it for all-cause mortality predictor as one marker really?🤔@@conqueragingordietrying1797
Oh we don't actually have biomarkers for all cause mortality. I see you're not a clinician. I really don't need to educate you on the clinical uses of CRP and epidemiology. @@conqueragingordietrying1797
Why did my normal test have me at 4.1 if it starts at 10 and goes to 1000??
Are you asking about CRP?
@@conqueragingordietrying1797 Yes, thank you. I know there are two tests. High Sensitivity CRP and CRP. I have not gotten the results back for the High Sensitivity CRP yet, but my regular CRP test result is 4.1. Also, on my result paperwork it says 4.1 is within normal range with a "
@@atomic_poppy Based on the data in the video, the reference range is outdated. As low as possible (0) for CRP may be optimal.
@@conqueragingordietrying1797 Maybe do a new video if all of this is outdated - as it's quite confusing. Neither range is correct in this video. You say close to zero, but a zero isn't even possible looking at this. This says 10 is the lowest.
@@atomic_poppy None of the data in the video is outdated-the reference range is outdated. Close to 0 is possible, I've seen it both anecdotally and in papers referenced in the video.