The Acute Leukemias
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- Опубліковано 18 чер 2018
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Thank u very much. I get 18from 20 in med exam of hematology🎉
amazing
You are changing the history of medicine, dude!
Thank you so much 😊
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❤️💙🤍💜
Is that really a compliment?
@@heybruvv2733 Sure!
Love the dry humor and super casual attitude
Thank you 😊
I'm on my third year of being a pre-med student and whenever I can't absorb the information on the books anymore, I just go to your channel. More like I like how you approach the lessons! Just wanna say thanks!
📝 Download my handwritten notes: www.medicosisperfectionalis.com/
قناتك كنز أنا محظوظ لأني وجدتها ،بالاضافة إلى ذالك لقد درست عليك في مادة الانيميا وامتحنتها وقد صادفت سؤال لم يستطيع اغلب الطلاب حله الا انا حللته لأنك ذكرته في الشرح شكراً جزيلاً لك
😊😊🙏🙏🙏
I watched most of your hematology videos, awesome fun and simple way of explaining things that are over-complicated by books! Thank you !
Cool...I am happy to help 😊
Some people just have the gift of getting through and communicating well. You have that gift. Thankful for videos like these!!!
Thank you 🙏
50 hematology 💉 *cases* - written by me - are NOW available on www.patreon.com/medicosis/
My wife and I lost our just turned 2 year old son 7 months ago to Aml. He had MLL gene rearrangement or subtype KMT2A or 11q23. He had a translocation between chromosomes 6 and 11, t(6;11). He received cytarabine, daunorubicin, etoposide, gemtuzumab ozagamicin then mitoxNtrone and cytarabine. He relapsed after the second chemo which signified refractory Aml which had a poor prognosis. Decitabine with mylotarg was then used. He died shortly after from within 4 months of treatment. Some side effects he had were bloody nausea and diahrea. Horrible bloody mouth sores. He was in pain all over. His right eye was covered by a leukemia pool that ended up bleeding.He had a lot of liquid in his lungs which they thought was pnemonia. He ultimately died from a brain bleed within 24 hours caused we think by the chemo.
Oh!
I am so happy for u.
I am an elder sister. I have a younger sister. She has some weird symptoms. Idk what doest it mean.
1) light headed
2) tired & weakness
3) coughs and flu
4) nose bleed 1 time (gum bleeds)
just a little bit
5) today she has a unbearable pain on her teeth,ear & arms.
But I said my mom about it & she doesn’t care about it. She wanted to say I am much hypochondriac.
Basically I am so much obsessed with my sister. Maybe I love her a lot
Even after 5 years you are my teacher thank you
Thank you!
You are literally amazing thank you so much I'm studying my lab module right now !🙂
Excellent...Thanks a lot!
keep going sir :)) this is so helpful, and like I spent 20 hours trying to understand this yesterday but you made it so clear for me in less than 15 mins .. awesome content too .
So happy that I was able to help...How did you find my videos?
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well, this is the first time i comment on a video on youtube, you're amazing! thank you so much, and keep going sir.
My pleasure 😇
On my second relapse of ALL, now I finally understand what’s happening. Great video
Thank you!
I wish you a speedy recovery!
I hope everything goes well this time around. Stay strong 💕
You got this. What hospital are you going to?
My son has been diagnosed recently , my heart goes out to you . Horrible illness and aggressive treatments. Stay strong .
Have you considered "intracellular" glutathione therapy? There is a whey protein that has a precursor that raises glutathione inside the cell. That glutathione is now able to promote "monoclonal expansion" of T-cells (cd4/cd8) which places cancer cells into "negative feedback inhibition." It works amazingly will in leukemias and many other cancers.
It’s amazing how you explain this you make it easy to understand
oh gosh!!! really like your presentation!! It's interesting & funny at some points! Thank you so much ^^
Btw, may I know which software/app did you use to write these notes??
So simple to understand
Your way of explaining things is great .. finally found the best u tuber for pathology lecture ..keep it up bro
Hi
You the best,you taught easily and what’s necessary.Thank you God bless you.👌🏻🙏
I am honored:)
Thank you for your very good presentation.
thank you for this thorough video! excellent visuals!
Thank you so much 😊
Thanks a lot for making my life easier!
My pleasure 😇
Wow great overview. Very pleasant to watch too and informative. Thank you!!!
Amazing!
Thank you so much 😊
ua-cam.com/video/4TmGXQjPIEM/v-deo.html
@medicosis perfectionalis
Thank you for this amazing illustration ;keep on 👌👏
and thank you for your kind words!
"Crazy, useless, immature cancer cells" 😂
Thank you very much for all amazing infos. Can you please make more lecture about immunohematology ( blood bank) please!
Thank you ,, your videos are so informative and cool .. this helped me in my study leave alot
My pleasure 😇
Oh I can't explain how these videos are amazing thank u♥️🌸
Thank you 🙏
I honestly like the way you make life easier
Thank you ☺️
BEST explanation ever! Thank you so much!
My pleasure 😇
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Thanks a lot man
this helped a lot for my FINALS!
Glad it helped!
Thank you for make it so simple
My pleasure...Best of luck to you!
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Thank you so much for these videos!
ua-cam.com/video/4TmGXQjPIEM/v-deo.html
THANK YOU 🙏 MORE POWER❣️GOOD LUCK 🍀
Hello! I'd like to thank you for this vedio .
I want to ask , do you allow to take a screenshot of the vedio?!
Thanks alot.
You know what is attractive, its your voice😁😁
Thank you ☺️
Very nice explanation ....
Thank you 🙏
Your videos are fantastic, thanks 💜
My pleasure 😇
ua-cam.com/video/4TmGXQjPIEM/v-deo.html
What an amazing effort..👏👏
Thank you 🙏
Amazing explanation👌thank you so much
My pleasure 😇
youre the best teacher ever!!!
Thank you!
excellent video....
great explanation..!!
Thanks a ton!
This is a very good explanation. It is my assessment that your presentation covers the symptomology of the disease process and current medical practices to correct the symptoms.
I am intrigued to understand the actual disease process occurring in/at the bone marrow level. Some questions I have are what hormone cascades/signaling hormones are involved in the negative feedback loop of the bone marrow. Is there pathology in the negative feedback loop?
What is actually occurring in the marrow to produce these immature blast cells? We understand the presentation of the disease well but with is the pathology as it relates to the bone marrow? Heavy metal deposition causing ROS and altering mitochondrial function? Are “forever chemical” depositing in the marrow and cause risk for cellular disfunction. Perhaps a severe acute stress response or chronic stress due to interpersonal relationships, or work could leave someone particularly vulnerable to relapse? I have so many questions.
Blood cancers don’t start a tumor growths/mass development. What is occurring in the marrow? Is there tumor development in the marrow of dysfunctional marrow cells?
Does the diseased marrow spread to other marrow containing bones?
you are the best. i cant believe u dont have many views yet.
Thanks a ton! You made my day! Please help me by sharing! Thanks in advance!
@@MedicosisPerfectionalis sure
Thank you so much!
Fantastic videos sir. Thank you for these. Really really helpful. ♥️♥️♥️♥️♥️♥️
Awesome 👏
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that ALL drawing at testicles at 7:33 is perfect 😂
best explaination so far
Thank you so much 😊
you are great thank u so much
You are very welcome! Thank you for watching!
Hi
I’m a retired HemOnc RN who has recently beenndiagnosed with LCH, aka:
Langerhans Cell Histiocytosis
Can you address a segment to this chameleon like disease?
TIA
one question tho, why doesn't it matter where wo do the biopsy? if the clonal cells haven't metastisized yet, they should be limited to one bone and only one bone no?
That was so helpful
Thanks 😊
1:07 Hey! Don't neutrophiles stem from the same cells that make up monocytes, rather than other granulocytes?
I told everyone
Be drunk and then study you will know medicine easily
You are donerrrreerrrr♥️
Thank you very much doctor
My pleasure 😇
can you recap the video content? I need it for the upcoming lesson
Why does infection increase in leukemia (high WBC)? Due to dysfunction of WBC
Friend diagnosed with AML and he is almost 61. Was low in ferritin for a while. Anemic. Pretty healthy guy.. except I guess not.
Amazing!
I have a question, in acute leukemias, there are high number of blasts but does that translate to a high total white count? or leukopenia?
and in chronic leukemia, I assume that it would be leucocytosis?
In acute leukemias there is neutropenia but WBC count is high due to blasts(as they enter blood stream).And in chronic leukemias there would be leukocytosis.
can AML spread to lymph node and cause lymphadenopathy?
informative video. Loved it
Thank you so much 😊
You are awesome🥺. Thank you so much
My pleasure 😇
awesomeeee explanation
you're the best keep going🔥🔥🔥🔥
Appreciate it, brother!
This was really good
Thank you 😊
I had a friend get diagnosed with AML in November 2010 and pass away from it in January 2011. It is so rapid and aggressive.
Was it caught late?
@@maryjohns7968 no she only began showing “mild” symptoms maybe 3 months(?) prior to diagnosis. At the time of diagnosis however her condition was bad. Very high relentless fever, very pale, weight loss, no energy, bruises everywhere… I’ve never seen a disease like this.
thank youuu so much
ThanQ man ,l luv u💜
can you please just give me the definition of monoclonal?? you are the best ..
Monoclonal: Originating from one entity (from one cell)...Think of it as plants originating from a common root.
The auer rods in AML are in the cytoplasm right?
Yup 👍
hello, first i would like to say thankyou for your amazing videos. second i would like to ask regarding wbc count, i dont understand how it can be increased wbc or decreased
Cancer doesn't follow rules!
Your absolutely the best I like ur videossss
Thank you so much 😊
Can you please help me by sharing?
Medicosis Perfectionalis yeah sure I’ll, any other thing u want me help u in?
That’s more than enough...Thank you so much!
Now, do you want any help from me?
Thanks!
You’re very welcome 😊
actually, how its become thrombocytopenia when ALL occurs? i thought it only influence lymphopoiesis lineage so it will never disrupt any platelet count.. please explain me doc :(
Hyper-production of WBC lineage will "crowd out" other cell lines such as platelets and RBCs leading to thrombocytopenia and anemia respectively.
Hi! i am studying in (Medical Laboratory Technology 4years program) currently i am in 2nd year
Hematology is include in my subjects, next month my annual exam will be start
i watch the Leukemia videos
there are a lot concepts are missing which i need
i need your help
Thank you sir.
my teacher ileen😂 watches your video's No more headaches.
var caught😁
Thank you so much 😊
Hahaahah i can't breathe 😁
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I'M DRINKING LEMONADE
Enjoy 😉
Based on physical examination that include age etc
How can u differentiate
AML & ALL
It's very difficult to differentiate between them based on the physical exam alone, we almost always need a bone marrow biopsy, peripheral smear, immunohistochemistry and flow cytometry. Based on age, ALL patients are usually (not always) younger. ALL is associated with Down syndrome, so you will see clinical features of Down's. AML-M3 subtypes has some specific characteristics such as DIC, AML-M5 has oral mucosa involvement.
Thank you Very much that was very helpful!!! I’m just abit confused about whether WBCs are raised or low in acute leukaemia?
If they are raised then why are they more susceptible to infections?
WBCs could be any number in case of leukemia...They could be less than 10,000, more than 100,000 or anything in between.
The reason why there could be infections is that these WBCs are malfunctioning, even though they might have a high number.
Number and function are 2 different things!
@@MedicosisPerfectionalis perfect this makes sense thank you !!
My pleasure 😇
Thank you man! I hope you enjoy your lemonade too 😂
Very helpfull👌
Glad to hear that!
Amazing 👍
Thanks!
Bro do a picture lecture of aml classification I got confused
O my God dude! You are awesome!!!!!! 😃😍
Thank you 😊
Excellent
Thanks 🙏
Thank you 👌👍
My pleasure 😇
you are the best,,, keep going
Thank you 🙏
Medicosis perfectionalis. 👏👏👏❤️❤️❤️❤️❤️
there is squeaky weird noises in the background when I play this. strange.. nevertheless great vid as always!!! Thank you so much Medicosis i love you!
Thank you so much for your honest feedback!
I wish I could better understand what is going on with me. They found out I had MDS for years that was masked by me having colitis for years. Some of the same in CBC tests are the same. Then suddenly after my colon was removed I came down with AML. All bone marrow biopsy showed I had MDS that progressed to AML. Lone of the mutations were bad. Chemo bought me all the way to cytogentic remission last Sept. Things went great until an adrenal test when I had to stop anything steroid for 5 full days. I started feeling sick, it didn't do away. In hospital the bone marrow showed my AML back with one catch. I have isolated 20q12. Percentage of bone marrow is 86%. Red cells, platelets, and B cells are low. Everything else is normal. Whites are slightly low but not dangerous. Doctors have never seen this. Nothing is documented. They gave me 6 to 8 weeks to live. Now that is up in the air when CBC just before giving me blood showed my platelets went from 30 to 70, Now the doctor doesn't know what will happen other than it will kill me. blast levels in marrow are 20%. Peripheral bone smear marrow smear show 5%. Blasts in blood 0.5%. Blasts in marrow are atypical with slight left shift. What is the world is this and how long do you think I will have to live.
How are you
May you be healed of this cancer!
Can you please explain the mechanism of Dic in acute leukemia :")
Please watch my video titled: “DIC”.
brilliant
Thank you 😊
Every time I study these topics I end with forgetting them all in the early morning hope this time is different
Thank you alot
If continuous cell division exposes the folate deficiency Anemia than there should B12 deficiency Anemia and Iron deficiency Anemia too right ?? Or is there any other mechanisms in it, plz explain if you know
Sorry, I didn’t understand the question...Can you phrase it in other words, please?
@@MedicosisPerfectionalis At 8:17 you were explaining about Lab in Acute lukemia. Due to rapid cell turnover nd continuous cell division, sometimes there can be Folate deficiency causing Macrocytic Anemia......so my question is B12 or Iron deficiency Anemia can also occur right ? Bcuz those things are important in cell division or is there something else causing only folate deficiency Anemia.... hope you got my question 😅
Yes! You’re absolutely correct! B12 deficiency will be the last to appear because the liver store it for years.
@@MedicosisPerfectionalis these things are easy to discuss on paper but in clinical diagnosis it must be hard to determine specific pathology 😐😓😕
Yup
when lukemia metastasize into the lymphnodes will it be called lymphoma?
Yes
You are amazing
Thank you 😊
Simplified greatly
Thanks!
I have a question, why is the WBC count can be low in AML (
Not always!
We can’t rule out a leukemia based on the WBC count alone.
Medicosis Perfectionalis Okay now its clear to me! You are the best! ;)
Thank you so much 😊
very good video
Thank you so much 😊
Can you please help me by sharing?
@@MedicosisPerfectionalis i shared your videos to all my classmates !!
Legend❤