The Bioluminescent Gaming PC

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  • Опубліковано 28 чер 2024
  • Join us in War Thunder for FREE at playwt.link/ltt Get an exclusive bonus using our link - thanks for supporting the channel!
    By genetically modifying some E. Coli we make a PC glow. Really.
    Buy Lian Li PC-O11D
    On Amazon (PAID LINK): geni.us/4YMuy8
    On Newegg (PAID LINK): geni.us/AlhysJ
    On B&H (PAID LINK): geni.us/f2MmH
    Buy MSI MPG Z590 Carbon EK X
    On Amazon (PAID LINK): geni.us/4tJq
    On Newegg (PAID LINK): geni.us/Jno2
    On B&H (PAID LINK): geni.us/DQG9Aig
    Buy Alphacool Eisball Reservoir
    On Amazon (PAID LINK): geni.us/ZHvsd
    On Newegg (PAID LINK): geni.us/aveu
    Buy Alphacool Eisbecher Helix 250mm Reservoir
    On Amazon (PAID LINK): geni.us/NqfWHX
    On Newegg (PAID LINK): geni.us/AGpY6L
    Buy Intel Core i7-11700K
    On Amazon (PAID LINK): geni.us/oJlbxe
    On Best Buy (PAID LINK): geni.us/VuDGui
    On Newegg (PAID LINK): geni.us/OteN
    Buy AMD Radeon 6900XT
    On Amazon (PAID LINK): geni.us/SiDql2H
    On Best Buy (PAID LINK): geni.us/YaFO
    On Newegg (PAID LINK): geni.us/DIfUH8
    Purchases made through some store links may provide some compensation to Linus Media Group.
    Check out Nyoka Design Labs: www.lightbynyoka.com/linustech
    Discuss on the forum: linustechtips.com/topic/13742...
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    FOLLOW US ELSEWHERE
    ---------------------------------------------------
    Twitter: / linustech
    Facebook: / linustech
    Instagram: / linustech
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    Twitch: / linustech
    MUSIC CREDIT
    ---------------------------------------------------
    Intro: Laszlo - Supernova
    Video Link: • [Electro] - Laszlo - S...
    iTunes Download Link: itunes.apple.com/us/album/sup...
    Artist Link: / laszlomusic
    Outro: Approaching Nirvana - Sugar High
    Video Link: • Sugar High - Approachi...
    Listen on Spotify: spoti.fi/UxWkUw
    Artist Link: / approachingnirvana
    Intro animation by MBarek Abdelwassaa / mbarek_abdel
    Monitor And Keyboard by vadimmihalkevich / CC BY 4.0 geni.us/PgGWp
    Mechanical RGB Keyboard by BigBrotherECE / CC BY 4.0 geni.us/mj6pHk4
    Mouse Gamer free Model By Oscar Creativo / CC BY 4.0 geni.us/Ps3XfE
    CHAPTERS
    ---------------------------------------------------
    0:00 - Say hello to the Angler Fish
    0:37 - War Thunder
    0:50 - LTT Intro
    0:58 - What is Bioluminescence
    2:04 - Intro to Genetic Engineering
    3:15 - Biotechnology, cooking show style
    4:51 - Linus playing with E. Coli
    5:44 - Test tube glowing
    7:15 - Purification feat. His-Tag
    8:30 - Glow #2
    10:56 - Filling the loop
    13:42 - The Bioluminescent Gaming PC
    14:23 - What this is actually used for
    16:22 - War Thunder again!
    17:06 - Outro
  • Наука та технологія

КОМЕНТАРІ • 4,4 тис.

  • @AYgameZ
    @AYgameZ 2 роки тому +845

    Fireflies: *look what he has to do to mimic a fraction of our power*

  • @stephenjeremy5985
    @stephenjeremy5985 2 роки тому +2214

    Ive never thought that the day would come where Linus explains DNA translation and PCR to us

    • @filleswe91
      @filleswe91 2 роки тому +108

      Yeah, usually it's been all about PCMR and RDNA talk instead.

    • @EhmJB
      @EhmJB 2 роки тому +24

      Just wait until the "Installing the Intel Cognicyte i59 BioCPU" video he releases in 2063. It's gene splicing all the way down.

    • @georgejosifidis
      @georgejosifidis 2 роки тому +1

      He just relayed the information like a parrot making noises

    • @maciejjabonski833
      @maciejjabonski833 2 роки тому +13

      Technically, he explained TRANSCRIPTION, not translation (geneticist here).
      Transcription - DNA -> RNA
      Translation RNA -> Protein

    • @TheIceThorn
      @TheIceThorn 2 роки тому +1

      @@maciejjabonski833 it's a quesiton that bohers me since very long... but since dna "evolved" from RNA, now it came to be? An error of transcription? Ther might be some sort of bacteria that has reverse rhybosomes which reverses the reaction and forms new DNA instead of RNA?
      yeah, i've already tried to find th e answer by myself or I wouldn't be asking, i swear.

  • @ajmatt
    @ajmatt 2 роки тому +1541

    As a molecular biologist I can die peacefully now listening to Linus's voice explaining cloning and bacterial transformation.

    • @TheBatracho
      @TheBatracho 2 роки тому +47

      Dude, same here, molecular biologist here and PC fan who never expected hearing Linus talk about His tags lol

    • @farhannajme7542
      @farhannajme7542 2 роки тому +5

      Samee as a marine microbiologist Linus gave a pretty good lecture there.

    • @showjjumper
      @showjjumper 2 роки тому +9

      But cut the part where he drops the eppendorf pipette 😭😭😭

    • @johnkaba2593
      @johnkaba2593 2 роки тому +5

      @@showjjumper This is where I died inside

    • @Winter_huntsman
      @Winter_huntsman 2 роки тому +2

      About to graduate with a microbiology degree in a few weeks and completely agree. It’s so neat hearing him talk about lab techniques that I learned in classes and performed in labs so much.

  • @mumble3535
    @mumble3535 2 роки тому +446

    "Yeah, I have this massive algae bloom in my tank at the moment"
    "Damn dude, are the fish okay?"
    "What? Nah dude, my rgb algae has really come into its own and its looking sick"
    I support this kind of bio engineering

    • @spamreciever4208
      @spamreciever4208 Рік тому +7

      I wanna live in the CyberPunk future where I can have a bloom of pet bio-engineered bioluminescent bacteria in my computer full time.

  • @Julian-og3ps
    @Julian-og3ps 2 роки тому +1730

    That moment where he turned on the pump was legitimetely the coolest thing I've seen in years. Made me feel like a kid going to one of these places that let you do supervised science experiments again.

    • @shadowpenguin3482
      @shadowpenguin3482 2 роки тому +24

      12:45 for anyone who wants to rewatch it

    • @fantasticparrot602
      @fantasticparrot602 2 роки тому +21

      @@shadowpenguin3482 a bit later actually for the when he turns on the pump 13:51

    • @markj9860
      @markj9860 2 роки тому +26

      I much preferred the part where he started pouring the bacteria into the spherical reservoir, that slow blue spill down the sphere is just gorgeous.
      But yes, this few minute segment is one of the greatest things I've seen in this channel.

    • @solarbirdyz
      @solarbirdyz 2 роки тому +6

      @@markj9860 YES YES YES that was AMAZING. It literally looked like an SFX shot but was real.

    • @FlyingPenguino
      @FlyingPenguino 2 роки тому +5

      "Oh god" - Alex

  • @TheHookUp
    @TheHookUp 2 роки тому +4848

    I taught AP Biology for 15 years it's sad how much better your animations are than anything teachers get access to with a textbook. This is totally not a dig because I loved the video, but If I was still in the classroom I'd 100% use this video with my students to be able to go over the hand wavy parts and have them find the couple of inaccurate/incomplete sections of the process. Science Linus gets at least a B+.

    • @volklii
      @volklii 2 роки тому +2

      ua-cam.com/video/oescB0NyejI/v-deo.html

    • @StripesOO7
      @StripesOO7 2 роки тому +144

      Exakly my thoughts with a bachelor in Biology (bachelor-thesis in genetic) . Beautiful animations that are 100x better than every old textbook but some parts are either missing or slightly wrong. But nevertheless accurate enough to be understandable and having an educational effekt on the „average“ viewer. 👍

    • @majsstenen
      @majsstenen 2 роки тому +46

      Just make sure to correct it first, that DNA repair animation ain't right :3 // Biotech engineer

    • @reyanak9818
      @reyanak9818 2 роки тому +25

      @@StripesOO7 You need a bachelors degree in spelling

    • @Kitulous
      @Kitulous 2 роки тому +131

      @@reyanak9818 don't need to be a douche in the comments. Maybe they're German, that's how they spell "effect" and the languages are pretty similar enough to mix up the words.

  • @pedroguincho6580
    @pedroguincho6580 2 роки тому +148

    Easiest like of my whole life, It’s amazing seeing Linus combining my two most loved subjects, biochemistry professionally and Tech as an hobby. What impressed me the most was how clear Linus’s explanation was of such a complex topic. Well done guys, you really outdone yourselves with this one!

    • @MoChuang343
      @MoChuang343 2 роки тому

      What kind of biochemistry do you do?

  • @filleswe91
    @filleswe91 2 роки тому +149

    More scientifically broken down videos like this please! I didn't feel like an idiot and I enjoyed the science lesson. Not just because it was Linus. Fun project, LMG!

  • @pranaygohel4630
    @pranaygohel4630 2 роки тому +761

    "Tech Tip: Don't get E. Coli"
    Yeah, that would be a good idea.

    • @BrianTeague00
      @BrianTeague00 2 роки тому +37

      Bioengineer here: The strain used in the lab is quite different from the one that makes you sick! You could drink a culture of it, and it might give you a belly-ache, but not much else.

    • @furkell
      @furkell 2 роки тому +1

      Not exactly tech, but a good tip nonetheless

    • @rwhite9994
      @rwhite9994 2 роки тому +1

      E. Coli is natural in nature and most all of us have it somewhere at any given time. The kind that makes us sick, or takes over is different. That e coli is as safe.

    • @Giangero21
      @Giangero21 2 роки тому

      what the ..... i don't think this is a coincidence

    • @emilie6466
      @emilie6466 2 роки тому

      @@DemeDemetreEscherichia Coli

  • @matiastripaldi406
    @matiastripaldi406 2 роки тому +502

    Am I actually seeing PCR, recombinant protein expression and bacterial culture in an LTT video? Is this a dream? I study biotech so this is my bread and butter, never thought you guys would venture into it. Amazing work!

    • @mycosys
      @mycosys 2 роки тому +25

      likely the most culture we'll ever get on an LTT video ;)

    • @goldcd
      @goldcd 2 роки тому

      You are - and I liked it!

    • @luxbio
      @luxbio 2 роки тому +6

      so glad you liked it! what area of biotech are you studying?

    • @FranciscoTC
      @FranciscoTC 2 роки тому +4

      As a med student who loves tech, this definitely tickled my pickle

    • @matiastripaldi406
      @matiastripaldi406 2 роки тому +4

      @@luxbio well i'm in 3rd year of university (out of 5). my uni is mostly geared towards research work (which is what I'm interested in) but it also prepares you for if you decide to go into industry (such as producing insuline for diabetes patient en masse with genetically modified E coli). After i graduate i'll probably go into research hopefully in something health or human biology related, there's a bunch of really interesting stuff popping up. Most of my professors are researchers too so they tell you about the work they're doing and it just sounds awesome to work in. But tbh molecular biology in general fascinates me so i'd be happy to work in any lab (with bacteria or eukaryotes) as long as it's not plants haha, plants are incredible but kinda boring

  • @SnifferSock
    @SnifferSock 2 роки тому +7

    2 things:
    This is sick.
    The mixing effect is good enough to replace CGI.

  • @Cobyc5150
    @Cobyc5150 2 роки тому +10

    I want more science lectures from linus, he's surprisingly really good at explaining everything. He uses some very easy to understand examples.

  • @PetePeteRepeat
    @PetePeteRepeat 2 роки тому +552

    Linus, get your team to do some research and create an LTT Lab Coat, with elastic sleeve cuffs, and quick-release snap buttons... as a Chemist, I would 100% buy one

    • @hellowill
      @hellowill 2 роки тому +14

      Reminds me of his older videos, around 2013, when he would wear a lab coat for PC builds

    • @Aviyara
      @Aviyara 2 роки тому +18

      Quick-release snap buttons, three pockets (with the pen subdivision on the chest pocket) and in-garment "cable management" loops for threading wired earphones. Forget buy them, I'd preorder them and pay up front.

    • @volklii
      @volklii 2 роки тому

      ua-cam.com/video/oescB0NyejI/v-deo.html

    • @Jeffmylife
      @Jeffmylife 2 роки тому +6

      As not a chemist, I also would 100 percent buy one

    • @ron200088
      @ron200088 2 роки тому +1

      Now that they have the technology, they could also create their own brand of bioluminescent "RGB" coolant. ;)

  • @damustermann
    @damustermann 2 роки тому +522

    Linus DNA tips - really cool that you guys go into a lot of detail about the background of this.

  • @sullychow4123
    @sullychow4123 2 роки тому +16

    Never expected LTT to go all Thought Emporium but love it. More of this whenever you guys can please.

  • @MiddleofKnowhere
    @MiddleofKnowhere 2 роки тому +82

    Please keep spotlighting initiatives like this with sustainable and environmentally friendly products. The tech industry is probably one of the most wasteful from materials for the actual product to the packaging (all that plastic!). It's something that ought to change and some companies have been doing better I've noticed.

  • @ln1721
    @ln1721 2 роки тому +330

    this is just upgraded RGB and i love it

    • @gliderman9302
      @gliderman9302 2 роки тому +4

      Ikr? But it adds style points tho

    • @basil127
      @basil127 2 роки тому +11

      eco friendly rgb

    • @brodyenli
      @brodyenli 2 роки тому +8

      More like upgraded B

    • @subboytris8946
      @subboytris8946 2 роки тому

      RGB 2.0 HAS BEEN RELEASED

    • @paulgray1318
      @paulgray1318 2 роки тому +4

      We're just getting used to 4 wire RGB controller's and now they want to add DNA controllers - in the 60's you made your own colours :).

  • @NathansWargames
    @NathansWargames 2 роки тому +297

    Linus, we need a legit LTT Lab Coat for when we're doing computer "science" like this.

  • @thecomfyshirt
    @thecomfyshirt 2 роки тому +4

    It SO beautiful!!!! I wish it was practical to actually have on of these. This is why I love LTT. Today I learned about chemistry on a PC building channel. What a great vid!

  • @CsTvInc
    @CsTvInc 2 роки тому +8

    truthfully, I love it when they head out and meet up with companies with cool ideas and goals. these are some of the best type of videos

  • @ThisIsTechToday
    @ThisIsTechToday 2 роки тому +4619

    If only science class was this exciting when I was in grade school, lol

    • @doggoonus1414
      @doggoonus1414 2 роки тому +1

      ua-cam.com/video/H-BuXc18fQI/v-deo.html

    • @desmanbotts4244
      @desmanbotts4244 2 роки тому +6

      Thats crazy because I learn about rna and dna last school year.

    • @dadsfriendlyrobotcompany
      @dadsfriendlyrobotcompany 2 роки тому +11

      @@desmanbotts4244 it gets even crazier. I got my degree in genetics and genomics

    • @experimental0000
      @experimental0000 2 роки тому +1

      Little show called Bill Nye the Science Guy

    • @markscheuerman7962
      @markscheuerman7962 2 роки тому +2

      What grade school is going to be able to afford pcr equipment?

  • @xanthosjason9530
    @xanthosjason9530 2 роки тому +334

    Bioluminescent bacteria: *exist*
    Linus: "slap that sh*t in a computer!"

  • @bkrc123
    @bkrc123 2 роки тому +5

    Thank you for giving nyoka labs recognition. Will be following their progress.

  • @FriendBe
    @FriendBe 2 роки тому +2

    This is pretty amazing ngl. The applications for something like this has me pretty excited for the future.

  • @thanhvinhle2893
    @thanhvinhle2893 2 роки тому +862

    Linus holding biology chemicals.
    Everyone: nervous sweating

    • @kemalardaayar
      @kemalardaayar 2 роки тому +21

      conspiracy theorists: oh shit L virus is coming!

    • @clydemasterson1129
      @clydemasterson1129 2 роки тому +14

      Next week: Can Linus power a gaming PC with a Tesla Coil???

    • @cyber_hacker
      @cyber_hacker 2 роки тому +4

      @@kemalardaayar are you talking about that L-vid-2021 (aka. Linus video 2021)

    • @kemalardaayar
      @kemalardaayar 2 роки тому +1

      @@cyber_hacker oh

    • @zerumsum1640
      @zerumsum1640 2 роки тому +3

      even though i knew it'd be lab bacteria that are (relatively) harmless, I still cringed when he said it was e-coli. We get examples all the time of why Linus is a bad guy to pass dangerous/fragile things.

  • @YeahRightMCD
    @YeahRightMCD 2 роки тому +435

    A whole video on environmentalism-meets-technology?
    Keep em coming, big guy.

    • @pdabrowski4831
      @pdabrowski4831 2 роки тому +11

      Linus already has more going on in the environmentalism space than most tech reviewers/creators, there's been a good amount of highlighting sustainable packaging in their unboxings and his recent serious investment in the right-to-repair campaign with Framework Laptops shows a commitment to the future.

    • @YeahRightMCD
      @YeahRightMCD 2 роки тому +4

      @@pdabrowski4831 You're not kidding. Most tech content creators realistically don't do enough to push the efficiency side of progress, as much as the *RAW POWER* side of the coin.
      P.s. A+ power move investment on framework. Right to repair, and Wu Tang, are for the children.
      P.p.s. #$_& a full landfill *throws up fake gang sign thing, or whatever*

    • @volklii
      @volklii 2 роки тому

      ua-cam.com/video/oescB0NyejI/v-deo.html

  • @DrivenKeys
    @DrivenKeys Рік тому

    Perfect reservoir for this, and great camerawork. Absolutely amazing developments. Keep making these videos.

  • @mirrorsandstuff
    @mirrorsandstuff 2 роки тому +3

    This is one of the neatest projects the LTT team have come up with recently and I really hope whoever led the project's research is proud of themselves. The organic chemistry was well explained and the level of detail was at the right level whilst still being engaging.

  • @marcosmedia7463
    @marcosmedia7463 2 роки тому +411

    Linus: We make PC that glow
    War Thunder: This is worth a sponsor

    • @tomasalmeida2940
      @tomasalmeida2940 2 роки тому +2

      Nah but is a minor detail

    • @haydenw8691
      @haydenw8691 2 роки тому +1

      Good thing you can block sponsors now. Makes the videos much better.

  • @HattertheThird
    @HattertheThird 2 роки тому +52

    This PC lures in gamers with its pretty lights to prey on their free time

  • @kristycyw
    @kristycyw Рік тому +2

    That was an impressive summary of DNA transcription, translation, RNA transcriptomics, PCR and genetic engineering

  • @thekraken8him
    @thekraken8him 2 роки тому +2

    This has got to be the most interesting PC build I've ever seen. What a creative idea, and great execution. The Techquickie style explanation of the DNA reactions was an excellent touch.
    Also, 9:47 should be the thumbnail for this video.

  • @thethoughtemporium
    @thethoughtemporium 2 роки тому +1827

    Nyoka's stuff is so cool. I've seen their stuff go by a lot in the various bio groups. It's a neat idea for sure, though hard to say if they'll be successful. Don't get me wrong, the idea is clever, but scaling biotech is really really hard. Take it from someone literally trying to scale up a lab scale biotech project to industrial scale. It's very much non-trivial, even if the idea is very simple. Also the claim you can drink it is mega sus. And they will need a huge amount of certification that there is no contamination of the live genetically modified organisms in the liquid or it would be a felony to dump it down the sink. The EPA would be furious. And if it's just a lysed ecoli suspension it'll always smell awful. So ya, they've got some stuff to address.
    Also, I really hope those were "stunt" pipettes, cause those are expensive and dropping them like that will wreck them.
    Edit: They replied and clarified that they've already addressed all this, and this was just the demo version, so nvm I guess. Glad they're further along than I realized! Never gonna complain about more cool biotech companies doing cool stuff.

    • @timfallonphd3085
      @timfallonphd3085 2 роки тому +70

      Yep, I totally agree on the difficulty of implementation of bioluminescence! Biology is a whole different ballgame from tech, as you well know! And yeah, dropping the pipettes not ideal but in my experience not too bad. Every biologist should know how to calibrate / validate their pipettes & do it whenever they have a suspicious fall like this.

    • @ScreenNameLmao
      @ScreenNameLmao 2 роки тому +51

      My fav biotech youtuber in linus comments? Is this a crossover episode

    • @thethoughtemporium
      @thethoughtemporium 2 роки тому +121

      After what I just spent on pipettes, there's no way I'd throw them around like that. But that's just me. I do have a cheap chinese set though that are specifically for shots like that where you want to joke around. But I film bio stuff all the time. I assume for them the publicity of this video outweighs concerns about pipette calibration though, so w.e. To each their own.

    • @timfallonphd3085
      @timfallonphd3085 2 роки тому +45

      ​@@thethoughtemporium Not to worry, I'm sure Linus is working on a follow up video about calibration of that dropped pipette right now! Right Linus?? Linus? Haha but more seriously: people get all up in arms about mistreating instruments - either pipettes, or things several orders of magnitude more expensive like LC-MS instruments. IMO, minor mistreatment and yes occasionally breaking them is part of the natural learning process, so my philosophy is scientists should be comfortable with pushing the envelope, potentially breaking things, & evaluating when they need to be fixed & how to fix things, and not be afraid if they did break something to ask for help. I can understand in self supported research that changes the equation a bit as each dollar available is more precious due to the limited funding sources, but at least in science education I lean towards the response being "that's okay, let's see what happened". Or at least that is what I tell myself to feel better about when I accidentally drop my pipettes :)

    • @matiastripaldi406
      @matiastripaldi406 2 роки тому +4

      @@thethoughtemporium i thought the same, was really surprised to see the team handling expensive lab equipment. But i guess they're within budget

  • @EclipsaMyrtenaster
    @EclipsaMyrtenaster 2 роки тому +189

    "Haha. I made you guys watch a Science lecture disguised as a computer video."
    That ticks off two things on my list.

  • @rusinsr
    @rusinsr 2 роки тому +1

    Love these sorts of videos! Really interesting and different from the usual stuff :D

  • @Auroric
    @Auroric 2 роки тому +4

    This is so rad! Stoked to see Nyoka getting some good exposure, would love to this take off

    • @luxbio
      @luxbio 2 роки тому

      Thanks Auroric! How had you heard of us??

  • @fireaza
    @fireaza 2 роки тому +467

    It was very brave of the staff to hand Linus their expensive scientific equipment to hold, knowing what might happen.

    • @ikonikian475
      @ikonikian475 2 роки тому +5

      How is it brave? He's rich. He breaks it he buys it lol

    • @zatoichi188
      @zatoichi188 2 роки тому +8

      PCR machine ain't that expensive, and once you have the actual engineered organism you can you usually produce buckets of it for pennies. The expensive bit is the actual engineering.

    • @highping5137
      @highping5137 2 роки тому +2

      @@ikonikian475 do you know how much money it takes to make a business he probably only has 50% more money than the averege person so he would be broke if he broke one

    • @Jawad.1
      @Jawad.1 2 роки тому +1

      Nothing 'might have happened'. Linus knows what he does. He's one of the most intelligent and responsible people I've ever seen.

    • @joetownsend6325
      @joetownsend6325 2 роки тому +1

      @@highping5137 he has a business and assets, to say he would be broke because he loses the money in his pockets is patently false. It simply means he can't buy a new car until next week.

  • @lecuyermarcandre
    @lecuyermarcandre 2 роки тому +141

    As an immuno and microbiologist, this is by far the best content ltt could have produced. Great vulgarisation of the scientific principle behind it as well. I would like twice if I could.

    • @dkofkloveeqisgreat6123
      @dkofkloveeqisgreat6123 2 роки тому +4

      virologist and molecular biologist here, this might help some begin to understand how mRNA vaccines work as well. Tip of an iceberg but a start. other than that is there a version of these products that has both molecules stable before and after binding that can reveresed by say the application of heat. so in the cool part of the loop they bind and emit light but on the addition of heat dissacociate ( pass through heat block over chip), rinse repeat. i guess it depends on how stable the protein or capable of refolding after the techicaly heat denaturing. awesome work either way and shows molecular biology/ bio chemistry off well, in way lots can see and understand. ahh beer and now i cant stop thinking grr

  • @keithvassallo
    @keithvassallo 2 роки тому +1

    This was one of the best and most interesting LTT videos I’ve seen in a long time! Well done and give us more!

  • @dkursada
    @dkursada 2 роки тому +1

    It was such a fun episode, legit props for the explanation w/ great animations! As someone long time PC enthusiast who's just started studying biotechnology, this video is such an eye opener for me, for the bioluminescent gaming PC is such a cool demonstration of what happens when you bring knowledge of two seemingly distinct subjects together with a fun idea or two. What you do doesn't always have to be practical. A PC with glowing water cooling is just plain awesome. It's good getting to know Nyoka Design Labs folk, too. They're doing awesome work with reusable and longer-lifespan material!
    p.s: Linus Biotech Tips lol, I could get used to this. Would be such a fun channel

  • @mindgame112
    @mindgame112 2 роки тому +167

    As someone wo used to work in Molecular Biology: Linus dropping the pipet: SHIT now you need to recalibrate it...

    • @mayanksoni2399
      @mayanksoni2399 2 роки тому +15

      forget recalibration, my lab ones would just shatter and break

    • @MitgliedT5
      @MitgliedT5 2 роки тому +11

      If we broke a pipette in the lab, we had to go to the professor and pay for a new one ourselves, depending on the situation.

    • @arksy8703
      @arksy8703 2 роки тому +3

      @BIG ASS you will never be a real woman, 48% yourself

    • @Spork0
      @Spork0 2 роки тому

      @@arksy8703 its a robot btw. not a real person

    • @ilodabomb
      @ilodabomb 2 роки тому

      Dropped so many pipettes in my life... recalibated a whopping number of 0 pipettes 😄

  • @argon552
    @argon552 2 роки тому +266

    As a microbiologist that specializes in bioinformatics, this was one of the best colabs and video that LTT ever produced. Well done guys

    • @StripesOO7
      @StripesOO7 2 роки тому +6

      Nice to see someone else doing the same thing. I am still studying but switched after my bachelor thesis in molecular biology/genetics to bioinformatics as my master 😅👋

    • @argon552
      @argon552 2 роки тому +2

      @@StripesOO7 in that case cheers 🤘

  • @Swordsmanjan
    @Swordsmanjan 2 роки тому +9

    As a biochemist working in enzymology I truly enjoyed this episode. Great job everyone, both for the entertaining content and the high degree of scientific accuracy. Seeing educational content like this is great!

  • @jessterbal
    @jessterbal 2 роки тому

    Great collaboration, please do more like this!!!! Thanks!!!

  • @okabehakaze6416
    @okabehakaze6416 2 роки тому +354

    As a molecular biologist that builds computers as a hobby, I just wanna say this build looks awesome

  • @DVMJon
    @DVMJon 2 роки тому +340

    I LoL'd literally. When I realized Linus was giving an actual lecture in polymerase chain reaction (PCR) 😂

    • @Grocel512
      @Grocel512 2 роки тому +16

      Linus next week: "Let's overclock and water cool a PCR machine." **shows live Covid-19 samples** "This will be our benchmark!"

  • @WendtKyle
    @WendtKyle 2 роки тому

    This and the Framework laptop video from a day or two ago are a new and really awesome direction for this channel.

  • @madhazza64
    @madhazza64 2 роки тому +4

    I really enjoyed this! I love science, Linus delivers things so well and I honestly wasn’t bothered at all that computers were hardly involved. I’d super appreciate more videos of this style thrown into the regular mix more often ☺️☺️

  • @DerekMorrelli
    @DerekMorrelli 2 роки тому +81

    Having a bachelors in biology and a masters in chemistry, this is possibly my favorite video I've seen from LMG. Great job at explaining the scientific process, pretty much as simplified as you can get and still describing the process accurately. You've just made RGB obsolete!

  • @optillian4182
    @optillian4182 2 роки тому +113

    Linus really woke up one day and said "hmm yes I'm gonna put glowing germs in a computer".

    • @optillian4182
      @optillian4182 2 роки тому +5

      @CHIYOKO Begone, bot.

    • @yknx4
      @yknx4 2 роки тому

      He is running out of new things to put into computers

  • @nihouma11
    @nihouma11 2 роки тому

    This looks so cool, have to watch later, but keep up the amazing videos!

  • @SparklySpencer
    @SparklySpencer 2 роки тому

    This was a fantastic video, and I hope you have more like this in the future

  • @occasionalglory5261
    @occasionalglory5261 2 роки тому +438

    Linus: "Traditional glow sticks are full of toxic material."
    Me: *Starts having flashbacks to cutting open glow sticks and smearing it on my face as a kid*

    • @willy.c
      @willy.c 2 роки тому +39

      I remember well biting into one and having the liquid shit in my mouth to scare my friends...p

    • @aarontimm
      @aarontimm 2 роки тому +18

      bruh WHAT

    • @hpsmash77
      @hpsmash77 2 роки тому +5

      tf!!!

    • @Soosss
      @Soosss 2 роки тому +8

      i used to bite into them like an idiot

    • @t_y8274
      @t_y8274 2 роки тому +25

      One part carcinogen, one part high concentration peroxide. Yum!

  • @joosts4085
    @joosts4085 2 роки тому +183

    These videos are such an amazing lesson in disguise. The amount of people that now know about this that otherwise wouldn't hear about this for months or years is amazing and will hopefully boost this kind of research.

    • @timfallonphd3085
      @timfallonphd3085 2 роки тому +4

      I totally agree. The type of reach this video has is incredible! Millions of people learning about bioluminescence! So great!

    • @Haskellerz
      @Haskellerz 2 роки тому +4

      LTT in 2030, we are gaming on the latest Ryzen 90000 bacteria processor attached to 1000 TB permanent DNA storage

    • @TheBackyardChemist
      @TheBackyardChemist 2 роки тому +2

      @@Haskellerz DNA tape drive. Retains data integrity for 10 000 years at -80 °C.

  • @vk.7165
    @vk.7165 2 роки тому +1

    This was one of the most interesting videos in a while, really fun and informative, and also gives a shoutout to hard working scientists. If you can, do more of things like this :)

  • @MakDemonik
    @MakDemonik 2 роки тому +1

    As a student of Biotechnology I have to say you did a great job of simply yet effectively explaining the whole process of cloning genetic material via the PCR method and how the entire bioluminescence process works. (You could have just mentioned that each cycle gives you orders of magnitude more material - doubling it every time - than just having "more" in general)
    Loved the video.

  • @Ulandos
    @Ulandos 2 роки тому +951

    7:12, Linus deciding whether or not he's holding a condom or E.Coli

    • @trailfork7815
      @trailfork7815 2 роки тому +46

      I'm still bothered that it looked like a used condom

    • @pepkin88
      @pepkin88 2 роки тому +55

      linus sex tips

    • @randomblock1_
      @randomblock1_ 2 роки тому +5

      4:52

    • @adityadivine
      @adityadivine 2 роки тому +1

      Me who never got a chance to use it.
      Ahh life sucks

    • @106640guy
      @106640guy 2 роки тому +2

      COOOOM

  • @mullokakkarin
    @mullokakkarin 2 роки тому +249

    I actually really appreciate as ex Lab worker, that once in a while you make science videos. We actually need more people to get people interested in the science topic and also influencers to put more emphasis on importance of science... I believe that even those 'once in a while videos' can cause some changes for better in that field. (Believe me or not but scientists are in many cases underpaid, and they do not want to invest more than 10-15 years of gaining knowledge to not earn enough to live like a human)

    • @TheKeKApex
      @TheKeKApex 2 роки тому +1

      imagine if we put the ability to regrow limbs in humans, how many amputee's we can help alone. along with other things that can be cured with designer viruses. it's wild it's even a debate to keep pushing on this.

    • @volklii
      @volklii 2 роки тому +1

      ua-cam.com/video/oescB0NyejI/v-deo.html

    • @wobblysauce
      @wobblysauce 2 роки тому

      While YT is good and all, more people in Science is not a bad thing.

  • @carnotit
    @carnotit 2 роки тому

    this vid is awesome! congratulations linus for bringing such great content.

  • @jora9655
    @jora9655 2 роки тому

    I absolutely adore how you give us the background knowledge to understand how bioluminescence works and even how the gene manipulation involved functions. You're a tech channel, but you have such a broad horizon. Love it!

  • @20quid
    @20quid 2 роки тому +175

    I love how he's holding a model of a tardigrade when he's explaining how they get the genetics from a crustacean and put it in a bacteria, neither of which are tardigrades.

    • @Kuli24000
      @Kuli24000 2 роки тому +5

      Nervous laugh.... yeah that.

    • @la24dogg21
      @la24dogg21 2 роки тому

      Lmao I knew I would learn form someone here

    • @paigewhitehead2157
      @paigewhitehead2157 2 роки тому +14

      yeah we didn’t have a model of those on hand! We brought our tardigrade in the hopes it would make it on screen - it was hand made by someone on our team 😆

    • @benezzy
      @benezzy 2 роки тому +1

      I was waiting to see when the tardigrade Linus was holding was gonna be talked and it just never happened lol😂

    • @tomrl6674
      @tomrl6674 2 роки тому +3

      @@paigewhitehead2157 tardigrades are pretty cute

  • @Verlisify
    @Verlisify 2 роки тому +1331

    Ok this is one of the coolest things I have ever seen and exactly what I imagined the future would be like

    • @botted1193
      @botted1193 2 роки тому +5

      deez

    • @an456pop3
      @an456pop3 2 роки тому +5

      nutz

    • @LightningSquad
      @LightningSquad 2 роки тому +1

      I uploaded my Face Reveal...

    • @raulll95
      @raulll95 2 роки тому +5

      Just think having the Bioluminescent liquid inside the PC and having the Glow paint on the PC case - ua-cam.com/video/Y_OIK2IBqXE/v-deo.html . The effects from TRON movie are not far from having day to day near us

    • @Denofu
      @Denofu 2 роки тому +7

      cringe

  • @nolanmanning3749
    @nolanmanning3749 2 роки тому

    I love this and hope it takes off to reach multiple millions of views! Would love to see more demo type videos

  • @acrythm8316
    @acrythm8316 2 роки тому

    Wow. This looks amazing, love the video man!

  • @benjaminkocsis2983
    @benjaminkocsis2983 2 роки тому +134

    As a researcher in a microbiology lab, I am so happy LTT made this video. He did a pretty good job of explaining pcr in lamens terms. I didnt expect to see the wonders of microbiology shared by a tech channel but I am very glad they did.

    • @volklii
      @volklii 2 роки тому

      ua-cam.com/video/oescB0NyejI/v-deo.html

  • @zackriehl8079
    @zackriehl8079 2 роки тому +125

    "I will not be making any *AHEM* unscheduled visits to the bathroom." - Linus. This implies the existence of SCHEDULED bathroom visits. Hmmmmm

    • @sphrcl.
      @sphrcl. 2 роки тому +6

      Bro someone copied this exact comment word for word and they got a lot more likes than you because they have a check mark next to their name

    • @zackriehl8079
      @zackriehl8079 2 роки тому +4

      @@sphrcl. oh well. As long as I'm the og, I don't care.

    • @stefa4013
      @stefa4013 2 роки тому

      I mean on work days I have set times I go to the bathroom so yeah you can totally schedule them

    • @cubeventure
      @cubeventure 2 роки тому +3

      @@zackriehl8079 i respect that you don’t care

    • @clared5812
      @clared5812 2 роки тому

      @@sphrcl. why does it matter, internet points are completely meaningless

  • @andresleon-vargas3603
    @andresleon-vargas3603 2 роки тому

    This was awesome. Great job explaining the science, not an easy task. I'm studying bioengineering in school right now and find this type of content particularly interesting and fun.

  • @AD-de2sl
    @AD-de2sl Рік тому

    love the fact that you give great ideas a chance on your channel ! :)

  • @devinou-programmationtechn9979
    @devinou-programmationtechn9979 2 роки тому +56

    Linus : "Minor details like our sponsor : war thunder ..."
    War Thunder : "Am I a joke to you ?"

  • @DrNarf
    @DrNarf 2 роки тому +49

    LTT, you're laying the groundwork for producing better, higher quality, educational videos than McGraw-Hill when it comes to Biochemistry.
    If you need someone with an MS in Biochem, lmk because, yeah. Awesome work. We need more content like this. I already enjoy your "tech longer". Go full send.
    Keep at it, bro.

  • @zen1647
    @zen1647 2 роки тому

    Bloody amazing video. Loved it!

  • @kehnxii
    @kehnxii Рік тому

    This is the first time I have ever seen this pop up on recs and I love it

  • @FranciscoTC
    @FranciscoTC 2 роки тому +70

    If you want to do this at home you'll only need:
    *200 dollar variable volume pipette*

    • @timfallonphd3085
      @timfallonphd3085 2 роки тому +10

      There is always Ebay :) Rather than a variable volume pipette, a standard medicine dropper, releases about 20 to 50 microliters per drop - more than enough accuracy to do this type of experiment at home.

    • @zechsta28
      @zechsta28 2 роки тому +5

      you could use a thin straw as long as you make a good estimate on the volume. a bikewheel as centrifuge, and pots and pans with different temp water in them for the thermalcycler (Its gone take a while though getting your sample from pot to pot 40+ times)

    • @timfallonphd3085
      @timfallonphd3085 2 роки тому +5

      @@zechsta28 Yep! I think there are lots of ways to make this work at home, without the "professional" equipment, just have to get a bit creative. After all, biologists in the 1800 - early 1900s had pretty crude tools but were able to figure out a huge amount of stuff!

    • @kehrnal
      @kehrnal 2 роки тому +1

      Also if you used the centrifuge he showed, you'd be spinning small amounts of that culture all day long... Not 10 min

    • @adamengelhart5159
      @adamengelhart5159 2 роки тому

      At least the column is only five cents?
      Oh, wait. I think I might have that confused with something else. :-/

  • @DamnCyrus
    @DamnCyrus 2 роки тому +77

    That shot of the reservoir lighting up was so fucking good, hope those people get the work done to make the bio-luminescence usable in the future

  • @shriramvenu
    @shriramvenu 11 місяців тому

    this was a really entertaining and educational video. keep it up guys!

  • @becomealex
    @becomealex 2 роки тому

    I'm barely one-third of the way to the video and this is the best video I Feel you've ever produced! I'm loving the whole science aspect of this and I'm really looking forward to the science lab! Congratulations on all your success! Continue being excellent and may the Everlasting Computer Gods be with you through all your endeavors!

  • @jordanm2984
    @jordanm2984 2 роки тому +31

    As a biology undergraduate and a PC enthusiast, this is one of the coolest videos you guys have released!

    • @Aepus
      @Aepus 2 роки тому

      That pipette technique tho

  • @Slinder14
    @Slinder14 2 роки тому +39

    We did a bioluminescence experiment in my bio lab a few years ago. To me it’s one of the coolest things in nature, and bringing it to a pc is amazing. Awesome video

    • @doggoonus1414
      @doggoonus1414 2 роки тому

      cool r6 clip ---> ua-cam.com/video/H-BuXc18fQI/v-deo.html

    • @luxbio
      @luxbio 2 роки тому

      we so agree. what kind of experiment did you use bioluminescence for?

  • @burkfivesix
    @burkfivesix 2 роки тому

    Loved this science focused video and how you applied the science to your own application.

  • @radspiderjackson
    @radspiderjackson 2 роки тому

    cool intro breakdown, i didnt have to skip thru to the good stuff

  • @MrWestonO
    @MrWestonO 2 роки тому +123

    "Alex, you had ONE JOB."
    *proceeds to list 5 jobs*
    Edit: yes guys i know this was a joke but its still funny

    • @Tosti_bakker
      @Tosti_bakker 2 роки тому +17

      I think that was the joke

    • @duatchol7710
      @duatchol7710 2 роки тому +1

      I’m completely lost as to whether you got the joke or not, lost in internet translation I guess

    • @MrWestonO
      @MrWestonO 2 роки тому

      @@Tosti_bakker well ye

    • @MrWestonO
      @MrWestonO 2 роки тому +2

      @@duatchol7710 i did

  • @balintmajor5416
    @balintmajor5416 2 роки тому +51

    Linus speaks like he knows what is he speaking about, he is a very good actor.

    • @Emma_madison
      @Emma_madison 2 роки тому +2

      Well it all about putting up a show

  • @SkySweetie
    @SkySweetie 2 роки тому +1

    Thank you for including how we can have fun and maintain the ground we stand on! Appreciate the full perspectives on reusable tech and safe tech.

  • @fishingtherapy5959
    @fishingtherapy5959 2 роки тому

    Idk how I missed this video. I watch nearly everything you guys do. My apologies you waited on my view for so long. Great content! I was tickled pink

  • @floofthefops
    @floofthefops 2 роки тому +40

    Am I the only one that absolutely loves when Linus goes to explore what other companies are doing? These videos are always very cool and usually talk about stuff I would never hear about otherwise. The episode about quantum computing was absolutely fascinating to me.

  • @spongerglory
    @spongerglory 2 роки тому +65

    The whole Anglerfish bit in the beginning won a “like” from me!

    • @timfallonphd3085
      @timfallonphd3085 2 роки тому

      Fun fact! The type of bioluminescence (in terms of the luciferase and luciferin) is different from both the types linus showed here: Firefly (yellowish green glow) and the Marine copepod Gaussia (blue glow)

  • @dontaskiwasbored2008
    @dontaskiwasbored2008 2 роки тому

    This is wildly out of scope for this channel and I love it.

  • @kwerboom
    @kwerboom 2 роки тому

    Cool and informative video. This is interesting technology. The in depth explanation of the science behind the technology was informative and appreciated.

  • @tywer1297
    @tywer1297 2 роки тому +28

    *gets safety glasses last* “safety first, ladies and gentlemen”

    • @mattjc
      @mattjc 2 роки тому

      Proceeds to roll up sleeves and leave labcoat unbottoned, leaving the most likely areas of exposure unprotected

  • @jackgotgamez
    @jackgotgamez 2 роки тому +39

    I bet with a lot of those “glow sticks” and the luminescence you could actually make yourself a diy glow in the dark lightsaber from Star Wars.

    • @oMega-sm1eg
      @oMega-sm1eg 2 роки тому +2

      Then it will be pretty heavy since it's filled with water, and not retractable of course. Now some excellent-looking lightsabers already exist using diffusion of a beam of LED light to light up the entire retractable blade.

    • @nickthemage2052
      @nickthemage2052 2 роки тому

      I feel like LEDs, a toggle switch, and a sanded plastic tube (to make it opaque) would be lighter and far cheaper lol

    • @oMega-sm1eg
      @oMega-sm1eg 2 роки тому

      @@nickthemage2052 Yes, that's what cheap sabers are, a LED strip in the middle and plastic outside. It's not retractable though, thus not a true lightsaber but a fluorescent lamp with color, attached to a handle

    • @nickthemage2052
      @nickthemage2052 2 роки тому

      @@oMega-sm1eg yes I’m aware.

  • @Locke567
    @Locke567 2 роки тому

    I just came here to tell Andy what a fantastic job he did, absolutely bang on in difficult lighting.

  • @TilmanBaumann
    @TilmanBaumann 2 роки тому

    That's the quality computer content I can't here for nice work

  • @muhammadanwaril6872
    @muhammadanwaril6872 2 роки тому +50

    keep it coming, Linus. environment-friend techs, repairable techs, things will eventually get better. hopefully.

    • @eisenklad
      @eisenklad 2 роки тому +1

      Linus should get Solar and possibly Wind power on his home

  • @Dangineering
    @Dangineering 2 роки тому +59

    I have a degree in molecular biology and I am surprised that I got to watch a LTT video where you explained PCR and column chromatography rather well!

  • @aceofspades3763
    @aceofspades3763 2 роки тому

    W video. Honestly, this is the COOLEST thing I have seen in years. I want to rewatch it over and over lmao

  • @chrisashih5142
    @chrisashih5142 2 роки тому

    Great explanation of bioreactors! I think the balance of detail and hand-waving is perfect for a wide range of audiences for the given time constraint. This type of stuff is what got me into molecular biology in the first place, and I hope that anyone who finds inconsistencies is tempted to go find out the fuller explanation for themselves!

  • @MiraiKishi
    @MiraiKishi 2 роки тому +20

    Linus: "You had one job, Alex." *Proceeds to list off many tasks*

  • @kelvinnkat
    @kelvinnkat 2 роки тому +16

    "I will not be making any unscheduled visits to the bathroom"
    Does that mean that he schedules his bathroom visits in advance?

    • @CallanElliott
      @CallanElliott 2 роки тому +1

      You'd generally want to take your toilet breaks before a shoot, I'd reckon.

    • @kelvinnkat
      @kelvinnkat 2 роки тому

      @@CallanElliott Timing something is different from scheduling it.

  • @Cubulation
    @Cubulation 2 роки тому +1

    Wow, this was actually a very decent overall description of PCR.

  • @MarcusBS
    @MarcusBS 2 роки тому

    thank you for this! its fun to learn, and i want a ocean computer with some thing like this!