Excellent talk but I wish he didn’t scoot away from the topic of possible effects of thermal increase within the target tissue. It needs to be addressed especially within cell membranes.
I wonder if there could be an application for focused ultrasound as the thermal generator rather than a laser. By using a focused ultrasound emitter, the ultrasonic wavefront is shaped such that constructive and destructive interference results in little energy deposition until the wavefront reaches the focal point. At that point the energy is deposited and acoustic waves should be generated that then acoustic receivers would measure the magnitude and frequency of the emitted ultrasonic waves. What I don't know, since this is not my research area, is whether the pulse width of the focused ultrasound emitter is short enough and strong enough that with a similar nanosecond to maybe a microsecond pulse width that sufficient energy can be deposited at the focal point to generate sufficient emitted acoustic waves to provide the desired information about the tissue at the targeted spot. And a second issue is whether the absorption of the focused ultrasound varies depending on the tissue at the focal point such that the magnitude of the generated thermoacoustic waves is different enough so that blood, fat, muscle, and collagen can be distinguished from each other.
I think you're missing the point. The advantage of photoacoustic imaging is that it combined the specificity of optical imaging with the spatial resolution of ultrasonic imaging. It is not about getting heat into one point it's about the excitation of a specific molecule, which can not be done with ultrasound. However, there is research that shows that PA imaging can be used to monitor the heating and cooling of tissue meaning it can monitor the therapeutic use of high-intensity focused ultrasound.
When can we expect that photoscoustic imaging of whole brain will be available like mr and pet/ct? Does photoscoustic imaging has potential to find all the structures, organs and molecules in human body?
Excellent talk but I wish he didn’t scoot away from the topic of possible effects of thermal increase within the target tissue. It needs to be addressed especially within cell membranes.
Thanks for sharing, very useful
I wonder if there could be an application for focused ultrasound as the thermal generator rather than a laser. By using a focused ultrasound emitter, the ultrasonic wavefront is shaped such that constructive and destructive interference results in little energy deposition until the wavefront reaches the focal point. At that point the energy is deposited and acoustic waves should be generated that then acoustic receivers would measure the magnitude and frequency of the emitted ultrasonic waves.
What I don't know, since this is not my research area, is whether the pulse width of the focused ultrasound emitter is short enough and strong enough that with a similar nanosecond to maybe a microsecond pulse width that sufficient energy can be deposited at the focal point to generate sufficient emitted acoustic waves to provide the desired information about the tissue at the targeted spot.
And a second issue is whether the absorption of the focused ultrasound varies depending on the tissue at the focal point such that the magnitude of the generated thermoacoustic waves is different enough so that blood, fat, muscle, and collagen can be distinguished from each other.
I think you're missing the point. The advantage of photoacoustic imaging is that it combined the specificity of optical imaging with the spatial resolution of ultrasonic imaging. It is not about getting heat into one point it's about the excitation of a specific molecule, which can not be done with ultrasound. However, there is research that shows that PA imaging can be used to monitor the heating and cooling of tissue meaning it can monitor the therapeutic use of high-intensity focused ultrasound.
When can we expect that photoscoustic imaging of whole brain will be available like mr and pet/ct? Does photoscoustic imaging has potential to find all the structures, organs and molecules in human body?
31:22 visualsonic, Endra, ithera medical,