Good morning sir, this is udhayakanth I am working in analytical research and development, currently l am developing a polor molecule , drug name is tranexamic acid tablets, I am getting placebo interference, name of the placebo is magnesium sterate , using YMC AQ column, mobile phase is sodium phosphate with 0.23% SLS and pH is 2.5 , I tryed with different column and chromatography conditions I can't separate the peak , I changed column, mobilephase PH, SLS concentration, flow rate adjustment, temperature adjustment, it is not separating, I need your suggestion sir...
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Highly valuable content 👍
Thank you Sir its very useful and unique
Hello sir, can I get the link of starting part of this video.
Thanks and best regards
Do you have any hplc method development case study
Good morning sir, this is udhayakanth I am working in analytical research and development, currently l am developing a polor molecule , drug name is tranexamic acid tablets, I am getting placebo interference, name of the placebo is magnesium sterate , using YMC AQ column, mobile phase is sodium phosphate with 0.23% SLS and pH is 2.5 , I tryed with different column and chromatography conditions I can't separate the peak , I changed column, mobilephase PH, SLS concentration, flow rate adjustment, temperature adjustment, it is not separating, I need your suggestion sir...
Find out pka value of your drug and magnesium stearate and change pH according this, or Add ACN in your m.phase to change RT of both
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