Negishi cross-coupling reaction

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The Negishi cross coupling reaction involves the reaction of an aryl halide (R-X) with an organozinc reagent (R'-ZnBr) in the presence of a palladium catalyst to form a biaryl (R-R'). The organozinc can be formed from a halide (R'-X). The halide is treated with either magnesium or lithium to make a Grignard or organolithium, which in turn is treated with ZnBr2 to make the organozinc. Because the organozinc is not highly nucleophilic, the Negishi coupling can tolerate many different functional groups on the biaryl product, especially on the halide coupling partner.

[@series161]

nice video! well expained! would love to hear more about the reaction mechanism of a negishi coupling.
a question: is the ZnCl2 at the end a mistake or do i miss something? Shouldn't it be ZnBr2?

[@ChemHelpASAP]

Good catch. Yes, that should be ZnBr2! There are some typos that have slipped through. For more about the mechanism (palladium cycle), see ua-cam.com/video/aEOgB0Om0c8/v-deo.html. Thanks for watching.

[@dovgov7557]

Interessing content, thanks for videos

[@ChemHelpASAP]

You are welcome. Thank you for watching.