Immunoproteasome and Thymoproteasome | Formation and Structure
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- Опубліковано 5 жов 2024
- Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases.
Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins. Proteins are tagged for degradation with a small protein called ubiquitin. The tagging reaction is catalyzed by enzymes called ubiquitin ligases. Once a protein is tagged with a single ubiquitin molecule, this is a signal to other ligases to attach additional ubiquitin molecules. The result is a polyubiquitin chain that is bound by the proteasome, allowing it to degrade the tagged protein.[1] The degradation process yields peptides of about seven to eight amino acids long, which can then be further degraded into shorter amino acid sequences and used in synthesizing new proteins.[1]
Proteasomes are found inside all eukaryotes and archaea, and in some bacteria. In eukaryotes, proteasomes are located both in the nucleus and in the cytoplasm.
Shabir, Very nice! 👏👏👏
I love 💖💙💚💜 your color scheme 🎨 with the catalytic beta subunits.
You do a superb job pulling a lot of information 📚 , compiling it 📑 , and summarizing it 📜!
Evolution 🌎🌏 was on top of its game 🏏 when it came up with the proteasome.
Thank you and stay well.
Thank you so much Dr Mike.... U know sir , i always thought of making Evolution videos but then i let it go bcz Evolution will always branch out into different ways and i won't be able to do justice ...
@@hussainbiology I don't think anyone can do evolution of the cell any good. There's nothing good in Wikipedia about it. We'd need a time machine.
@@michaeleisenberg7867 Yeah that is true.. But i was talking abt Simple Standard Evolution....
@@hussainbiology I can't even find anything concrete on how evolution of species occurs. It certainly is more than simple point mutations. Somehow large swaths of DNA change to make new proteins , new cellular processes, and new organ systems. What's going on in the nucleus to explain all that?
@@michaeleisenberg7867 To me a simple answer is the order of GOD what is going on in the nucleus. ( for me GOD is all science , for others it is only religion
Good explanation Keep it up Sir
thanks for appreciation
Sir make some videos on molecular basis of inheritance for neet / class 12th
okay sir
👏👏👏
✌️
@@hussainbiology 🤞
Superb sir
Thanks Shwetha for appreciation..
Sir are you Kashmiri
Yes Sir....
I am Hussain
Hussain too