wow , great explanation . For medical students or doctors preparing for their USMLE this is the best explanation , as it simplifies the cycle present in First Aid , Thanks Alot .
Thank you sir!!! U did a great job. I have a question though,why can't the muscle just transport it as glutamte? Since already glutamate is also an amino group carrier?
You are most welcome Samantha Gonah. Yes alanine is the predominant amino acid secreted by the muscle compared to glutamate or glutamine. The reason for this is skeletal proteolysis will go on at increased levels during catabolic states (negative nitrogen balance). During this time there will be increased cortisol, increased glucagon which will increase proteolysis in the muscle and gluconeogenesis in the liver. Formation of alanine provides return of carbon skeleton pyruvate to live from the muscle so that glucose can be synthesized. Glutamate in the liver will be undergo transamination with ALT to make alanine which is secreted into the blood to bring back pyruvate to the liver. The other fate of glutamate is it is used to fix NH4 by glutamine synthetase to make glutamine and glutamine is released into the blood. So overall, there is a selective advantage is there for the body to secrete alanine from muscle compared to glutamate. I hope this helps.
Muscle protein can be sometimes be broken down to provide energy. Briefly describe this process and state under which physiological condition it takes place? Skeletal muscle. Amino acids undergo transamination reaction -Amino acids - alpha ketoglutarate- alpha Keto-acids - Glutamate. Alpha Keto-acids undergo energy metabolism to give energy to the tissue. How? Hope you can help me ?
Fasting beyond 24-hrs leads to peak in gluconeogenesis and the predominant substrate for gluconeogenesis at that time is alanine. Alanine comes mainly from skeletal muscle, skeletal muscles can start to break when insulin level drops which can happen in prolonged fasting, lack of insulin which could initiate skeletal muscle breakdown like how you see in type 1 diabetes patients. Coming to your second question, alpha-ketoacids like pyruvate, alpha-ketoglutarate can enter into TCA cycle to generate energy.
wow , great explanation . For medical students or doctors preparing for their USMLE this is the best explanation , as it simplifies the cycle present in First Aid , Thanks Alot .
You are most welcome. I'm glad that this video has simplified the concept for you and you were able to grasp it.
Beautiful concept explained in a very lucid manner. Thanks a ton, sir!
Superb sir🤟
What about Glutamine cycle? Isnt it also transported in the lever for Desamination? Helpful video though, thanks
+Stelios Lysiotis : yes it is.
sir yours all videos are so helpful .. tanq
You are most welcome.
Thank you sir, the video had helped me lots! the confusions are all gone now! thank you so much once again! :)!!
Your most welcome. I'm glad this video has helped you. Kindly SUBSCRIBE for regular updates and SHARE with your friends.
Thank you sir v well explained. Just wonder from where does the oxaloacetate apear in the liver to become aspartate
You are most welcome. In the mitochondria.
excellent video sir
Thank you
Great explanation!!
Thank you. Best wishes.
nice video sir... this explains exactly Pg 82 of First aid018
this video was very helpful thank you so much!
Your very welcome. I'm Glad my video helped you.
Thank you sir!!! U did a great job. I have a question though,why can't the muscle just transport it as glutamte? Since already glutamate is also an amino group carrier?
You are most welcome Samantha Gonah. Yes alanine is the predominant amino acid secreted by the muscle compared to glutamate or glutamine. The reason for this is skeletal proteolysis will go on at increased levels during catabolic states (negative nitrogen balance). During this time there will be increased cortisol, increased glucagon which will increase proteolysis in the muscle and gluconeogenesis in the liver. Formation of alanine provides return of carbon skeleton pyruvate to live from the muscle so that glucose can be synthesized. Glutamate in the liver will be undergo transamination with ALT to make alanine which is secreted into the blood to bring back pyruvate to the liver. The other fate of glutamate is it is used to fix NH4 by glutamine synthetase to make glutamine and glutamine is released into the blood.
So overall, there is a selective advantage is there for the body to secrete alanine from muscle compared to glutamate.
I hope this helps.
@@DrMungli Wow!!
Very usefull
Thanks a lot sir..
Just Subscribed
Muscle protein can be sometimes be broken down to provide energy. Briefly describe this process and state under which physiological condition it takes place?
Skeletal muscle. Amino acids undergo transamination reaction -Amino acids - alpha ketoglutarate- alpha Keto-acids - Glutamate.
Alpha Keto-acids undergo energy metabolism to give energy to the tissue. How?
Hope you can help me ?
Fasting beyond 24-hrs leads to peak in gluconeogenesis and the predominant substrate for gluconeogenesis at that time is alanine. Alanine comes mainly from skeletal muscle, skeletal muscles can start to break when insulin level drops which can happen in prolonged fasting, lack of insulin which could initiate skeletal muscle breakdown like how you see in type 1 diabetes patients.
Coming to your second question, alpha-ketoacids like pyruvate, alpha-ketoglutarate can enter into TCA cycle to generate energy.
@@DrMungli Thank you so much .
In which medical college you teach?
I teach in University of Medicine and Health Sciences, St Kitts. www.umhs-sk.org
thank you very much this was very helpful :)
Thanku that was helpful
excellent !! thx sir
+hicham tijari : thank you, I'm glad this video has helped you.
Thank you so much
tq sir
+nithin rao :Thank you. I'm glad this video helped you.
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