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What is the proteasome?
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- Опубліковано 7 чер 2017
- Cells are constantly building proteins to perform all kinds of different tasks inside a cell. But that also means that it can get quite crowded inside the cell, so it needs to get rid of proteins that are no longer needed. In a previous video, we've shown you how ubiquitin tags are attached to these unwanted proteins, flagging them for destruction.
In this video, we're going into a bit more detail about how that destruction actually works, by looking at the cell's big protein shredder: the proteasome.
Our video about ubiquitin: • What is ubiquitin?
References:
- Huang et al. Nature Structural & Molecular Biology (2016)
- Koehler et al. Molecular Cell (2001)
- Beck et al. PNAS (2012)
- Unverdorben et al. PNAS (2014)
- Aufderheide et al. PNAS (2015)
- Schweitzer et al. PNAS (2016)
- Wehmer et al. PNAS (2017)
These videos should have millions of views!!!
this is so cool!! on an unrelated note, proteosomes kinda remind of a paper shredder :)
That’s so cool 🎉
This video are part of my class, I hope they help me to pass my quiz this coming Monday.
So did you pass your quiz?
I am in nursing school 2nd semester
@@elyssavelasquez4351 Good luck
I have an exam after an hour 😩
This video made me feel hungry, I started thinking of noodles😅 Otherwise, it's a cool illustration.
this is the coolest video ever!!!!
SubhannAllah!
You make great videos :)
This is dope. Nice.
Gorgeous, Good job
This video is so cool!
Sir, if the beta rings are the one that act as a chopper? What is the regulatory part doing? Is it that the regulatory part chops off the ubiquitination, and beta rings convert it to individual amino acids?
The regulatory particles recognize and bind the ubiquitin (chain) and cleave it from the substrate
How does ubiquitin itself get recycled? Is there another signalling molecule for that or how does that work?
THANK YOU!!!
Where do you get this animation from? :)
I would need them too!!!
Can you do a video about Cullin-RING Ligases
beautiful
What are the alpha subunits doing again?
annoying and distracting bg sound