What is the proteasome?

Cells are constantly building proteins to perform all kinds of different tasks inside a cell. But that also means that it can get quite crowded inside the cell, so it needs to get rid of proteins that are no longer needed. In a previous video, we've shown you how ubiquitin tags are attached to these unwanted proteins, flagging them for destruction.
In this video, we're going into a bit more detail about how that destruction actually works, by looking at the cell's big protein shredder: the proteasome.
Our video about ubiquitin: • What is ubiquitin?
References:
- Huang et al. Nature Structural & Molecular Biology (2016)
- Koehler et al. Molecular Cell (2001)
- Beck et al. PNAS (2012)
- Unverdorben et al. PNAS (2014)
- Aufderheide et al. PNAS (2015)
- Schweitzer et al. PNAS (2016)
- Wehmer et al. PNAS (2017)

[@goxdie000]

These videos should have millions of views!!!

[@asmiamsi1786]

this is so cool!! on an unrelated note, proteosomes kinda remind of a paper shredder :)

[@Juiciverse]

That’s so cool 🎉

[@elyssavelasquez4351]

This video are part of my class, I hope they help me to pass my quiz this coming Monday.

[@Abo-Al-Loze]

So did you pass your quiz?

[@elyssavelasquez4351]

I am in nursing school 2nd semester

[@Abo-Al-Loze]

@@elyssavelasquez4351 Good luck
I have an exam after an hour 😩

[@daddley9776]

This video made me feel hungry, I started thinking of noodles😅 Otherwise, it's a cool illustration.

[@mohamedadawee4120]

this is the coolest video ever!!!!

[@QWERTY-qe1fj]

SubhannAllah!

[@FMOTLGWU]

You make great videos :)

[@maxwamsley]

This is dope. Nice.

[@ahmedmahmoud-vf9ey]

Gorgeous, Good job

[@nzadventurefamily3728]

This video is so cool!

[@Alchemist_171]

Sir, if the beta rings are the one that act as a chopper? What is the regulatory part doing? Is it that the regulatory part chops off the ubiquitination, and beta rings convert it to individual amino acids?

[@BOBI2111]

The regulatory particles recognize and bind the ubiquitin (chain) and cleave it from the substrate

[@slapperorange]

How does ubiquitin itself get recycled? Is there another signalling molecule for that or how does that work?

[@gabyfridman7475]

THANK YOU!!!

[@burcusatelier]

Where do you get this animation from? :)
I would need them too!!!

[@zombieraccoon1653]

Can you do a video about Cullin-RING Ligases

[@sammmysam1291]

beautiful

[@MingeTheAllKnowing]

What are the alpha subunits doing again?

[@bigjapko3139]

annoying and distracting bg sound