Histology Of SubMandibular Gland /Mixed Salivary Gland | Salivary Gland

Salivary glands are made up of secretory acini (acini - means a rounded secretory unit) and ducts. There are two types of secretions - serous and mucous. The acini can either be serous, mucous, or a mixture of serous and mucous.
A serous acinus secretes proteins in an isotonic watery fluid.
A mucous acinuss secretes secretes mucin - lubricant
In a mixed serous-mucous acinus, the serous acinus forms a serous demilune around mucous acinus, as shown in the diagram.
The secretory units merge into intercalated ducts, which are lined by simple low cuboidal epithelium, and surrounded by myoepithelial cells.
These ducts continue on as striated ducts. These have a folded basal membrane, to enable active transport of substances out of the duct. Water resorption, and ion secretion takes place in the striated ducts, to make saliva hypotonic (reduced Na,Cl ions and increased carbonate, and potassium ions).
The striated ducts lead into interlobular (excretory) ducts, lined with a tall columnar epithelium.
The glands are divided into lobules by connective tissue septa. Each lobule contains numerous secretory units, or acini.
Sublingual glands have mainly mucous acini.
Parotid glands have mainly serous acini.
Submandibular glands have a mixture of mucous and serous acini.
Mucous acini stain more weakly than serous acini, because of the techniques used to produce the sections.

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The clinical consideration is specific for this gland or in general for salivary glands

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