Just a convention type question, is the Birgi angle the same as the Dunitz angle of 105 degrees? Thanks for the video, very claer and very informative. Cheers!
Um - I guess you mean Cram chelation? The question is slightly misleading as the nucleophile always attacks at the least sterically hindered face. The difference between Felkin-Anh and Cram chelation is the way that the transition state is set up and can have the 'apparent' effect of reversing the control. But this has nothing to do with attacking where there is the most steric hindrance. I hope this makes sense?
very good explanation sir. I am going through our model and explanation more than a week to understand 3d approach and 2d approach. now it is very clear and confident in solving crams probs. by the way can I get ur mail I'd sir. txs.
very good explanation sir. I am going through our model and explanation more than a week to understand 3d approach and 2d approach. now it is very clear and confident in solving crams probs. by the way can I get ur mail I'd sir. txs.
This is not correct. The major product should show the alcohol syn with the methyl group, not anti. You did not translate your fischer projection properly.
Thank you for your question. The answer is however correct - but you are also correct that the major product has the alcohol and methyl group syn to each other! How can this be? Well, if you look carefully you will see that the new chiral centre that I drew has the hydrogen atom in the plane; if you rotate this you will get the alcohol syn to the methyl group. This is just one way of translating Fischer projections, the textbook does it a different way. I like to show a different option so that students can 'see' the 3D methods from different perspectives. :) Good luck with your studies!
I am a French student in chemistry and I understood your explanations more easily than with my teachers . Thank you :)
Very intuitive and effective explanation.
Sir , you are doing a nice job by helping us . plz continue
So the incoming group approaching is smart.
Sir , plz uploade some videos of diastereoselective synthesis.
you really helped me to understand this easily
amazing. really got the clue, thanks for your explanation.
Thank you for the video! I was wondering where you got your molecular modeling kit from?
medical chem student here, great explanation sir
I hope u made a cram to the result
Thank you so much! So clear and precise.
thanks a lot sir...nice explanation
Just a convention type question, is the Birgi angle the same as the Dunitz angle of 105 degrees? Thanks for the video, very claer and very informative. Cheers!
It is one angle called the Burgi-Dunitz after the two people who described it. 107.5°
Best ♥️
If this was the felkin chelation model, would it attack the place where there is most steric hindrance?
Um - I guess you mean Cram chelation? The question is slightly misleading as the nucleophile always attacks at the least sterically hindered face. The difference between Felkin-Anh and Cram chelation is the way that the transition state is set up and can have the 'apparent' effect of reversing the control. But this has nothing to do with attacking where there is the most steric hindrance. I hope this makes sense?
Gareth Arnott it does! Thank you. I guess we call it felkin chelation as I'm from the uk haha! Thanks!
Great job! You explained it really well. What is the reference that you are using?
Thanks!
Thanks for the explanation, it really helped me out :)
very good explanation sir. I am going through our model and explanation more than a week to understand 3d approach and 2d approach. now it is very clear and confident in solving crams probs. by the way can I get ur mail I'd sir. txs.
very good explanation sir. I am going through our model and explanation more than a week to understand 3d approach and 2d approach. now it is very clear and confident in solving crams probs. by the way can I get ur mail I'd sir. txs.
非常感谢
Thank u alot!
Thanks a lot
This is not correct. The major product should show the alcohol syn with the methyl group, not anti. You did not translate your fischer projection properly.
Thank you for your question. The answer is however correct - but you are also correct that the major product has the alcohol and methyl group syn to each other! How can this be? Well, if you look carefully you will see that the new chiral centre that I drew has the hydrogen atom in the plane; if you rotate this you will get the alcohol syn to the methyl group. This is just one way of translating Fischer projections, the textbook does it a different way. I like to show a different option so that students can 'see' the 3D methods from different perspectives. :) Good luck with your studies!