Full Workflow on Computer Aided Drug Design | Dawn of Bioinformatics

#বায়োইনফরমেটিক্সে_হাতেখড়ি
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Welcome to this comprehensive tutorial on Computer Aided Drug Design (CADD), In this video, we will explore the full workflow of computer-aided drug design, which is a critical process in modern drug discovery and development. Computer-aided drug design involves the use of computational methods to design, develop and optimize potential drug molecules, and has become an indispensable tool in the pharmaceutical industry.
We will start by introducing the basic concepts of drug discovery and drug design, including the different stages of drug development and the importance of computational techniques in the process. We will then delve into the key techniques used in computer-aided drug design, including molecular docking, molecular dynamics simulations, virtual screening, hit identification, ligand database, ADME-Tox prediction, computational chemistry, pharmacophore modelling, and structure-based drug design.
We will walk through the entire drug design workflow, from the initial target identification and lead discovery to the optimization of the lead compounds through iterative cycles of design, synthesis, and testing. We will explore how different computational techniques are used at each stage of the process and highlight the strengths and limitations of each approach.
In this video, we will cover the following topics:
Introduction to Computer-Aided Drug Design
Target Identification
Protein structure determination and preparation
Ligand database searching and selection
Virtual Screening
Molecular docking
ADME-Tox prediction
Molecular Dynamics Simulations
MM/PBSA Analysis
PCA Analysis
Throughout the video, we will provide examples of successful drug design projects that have utilized computer-aided techniques, including de novo drug design and structure-based drug design. We will also discuss the importance of integrating experimental data with computational predictions to improve the accuracy and reliability of the design process.
By the end of the video, viewers will have a comprehensive understanding of the techniques, methods, and workflows involved in computer-aided drug design. Whether you are a researcher, student, or just interested in the field, this video will provide valuable insights into the exciting world of computational biology and drug discovery.

[@masudurrahman1593]

ড্রাগ ডিজাইনের ওয়ার্কফ্লো নিয়ে,বাংলায় এতো ডিটেলস ভিডিও সত্যি অবিশ্বাস্য।

[@dawn_of_bioinformatics]

Thank you so much...❤️

[@nirjonatania6090]

Clearly bujte pereci.. Khub valo viya ❤❤

[@Science21199]

Thank you so much

[@dawn_of_bioinformatics]

Welcome..

[@TFL1600]

Such a great and helpful video for us..
"Keep on" ❤❤

[@dawn_of_bioinformatics]

Thank you, I will..✌🏻✌🏻❤️❤️

[@merrylynsundae3865]

Kindly asking you use english. Your impact has reached so many different countries, you just can’t imagine

[@dawn_of_bioinformatics]

I’ll try 😍

[@kanizfatemachhowa2701]

Thank you Vaiya 🌸, it's very informative and helpful

[@dawn_of_bioinformatics]

You are most welcome..😍

[@alriyadhasan4176]

ধন্যবাদ ভাইয়া ,এতো সুন্দর ভিডিও উপহার দেয়ার জন্য।❤❤

[@dawn_of_bioinformatics]

Thank you so much.. 😊😊

[@shahriarsajal9549]

Which tool are you used to design this slide?

[@mehedihasan-gy2ce]

its a totally informative video vai

[@dawn_of_bioinformatics]

Thanks for watching

[@sunzidahmed5594]

Beautiful and Excellent

[@dawn_of_bioinformatics]

Thank you so much..😍😍

[@kstanik8426]

Grateful to you vai

[@dawn_of_bioinformatics]

Many many thanks😍

[@kstanik8426]

want more video vai

[@pandobchakma8480]

Thanks bhaya

[@dawn_of_bioinformatics]

Ok, I'll try

[@masudurrahman1593]

Informative ❤

[@dawn_of_bioinformatics]

Thanks 🙂❤️

[@ZerinSultanaLira]

Great Work,,,,😍

[@dawn_of_bioinformatics]

Thanks ✌️

[@user-ze6nx8vm4q]

vaia, ei kaajgulu ki laptop diye kora jabe?
naki computer must laagbei?

[@dawn_of_bioinformatics]

Laptop diye e kora jabe, sudhu simulation er jonno computer lagbe

[@mdamanat3611]

Make a video on PCA analysis...

[@dawn_of_bioinformatics]

I'll try...😊

[@tanjimulsafat8169]

MD simulation ta tahole korbo kivabe?

[@johirislam8174]

hlw as far I understand the CADD, I explain it there ,first i prepared protein and after that i prepared the ligand of interest related to that protein. Then performed virtual screening . After virtual screening best ligand were docked through Auto dock vina. Then pre clinical trial of my particular drug of interest . But in where I should perform the QSAR?

[@dawn_of_bioinformatics]

It’s another method brother,, I’ll try to upload video on it..🙂

[@johirislam8174]

great . Do you mean QSAR will be utilized on ligand based drug design r8? And one think to know, in virtual screening we will do docking for all the possible ligand with the receptor. So why do we need another docking after virtual screening?@@dawn_of_bioinformatics

[@johirislam8174]

in virtual screening we will do docking for all the possible ligand with the receptor. So why do we need another docking after virtual screening?

[@merrylynsundae3865]

Is there a free autodick vina app? Please kindly share link, as I could not find a free one

[@offline.mehedi]

Molecular docking er jonno Autodock4 r pyrx er kaj ki same?

[@dawn_of_bioinformatics]

Pyrx muloto autodock vina e use kore,, eta just easy to use

[@minhaz7074]

cadd এর জন্য লিটারেচার রিভিউ এর জন্য কোন কোন জার্নাল ফলো করতে পারি?

[@dawn_of_bioinformatics]

Onek gulo journal ase .. apni journal flow na kore specific topic focus kore google scholar e paper gulo porle hoyto valo hobe

[@niloy.hawladar]

💛

[@kazimohammedrokanuddin2387]

🎉

[@dawn_of_bioinformatics]

❤️

[@shandhi5391]

Bhaia, where can I get more in depth information on this topic? Any books you suggest or do you know of any video series on UA-cam?

[@dawn_of_bioinformatics]

You can follow my facebook page

[@abbasibrahim9435]

আরেকটু ভাল অডিও হইলে ভাল হইত

[@dawn_of_bioinformatics]

Recently microphone neye hoyese er porer video gulor audio valo hobe ..😊

[@hmmoniruzzaman3500]

Mashaallah..may Allah bless you. Brother, how to contact with you?

[@dawn_of_bioinformatics]

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