Aside from some minor public speaking flaws, why would anyone put a thumbs down to the video? The information was great and slides were clear - thank you!
Because their the kind who probably would like to keep you on the drip feed of perpetual sickness ,and who love to treat symptoms and not focus on cure and keep you from optimum health.
Thanks Brian for your kind words. I continue to learn and as I do, I will be making more presentations and providing webinars. There is a huge learning curve here and my goal is to assimilate, digest and then inform the public as effectively and as fast as possible.
Thank you so much for making this, for people like myself who are just learning we have the MTHFR mutation (for me, both copies) then this information is hugely important and so valuable to those of us just learning about this thru a genetic test result. Cheers.
Thank you for this presentation. I have 2 double COMT and MAO A mutations and what you said about these fits me completely. I have trouble taking just simple B6's, l-carnitine or even CoQ10 without getting the severe heart palps. My docs think I'm crazy! lol I'd love to see a video from you that addresses COMT, MAO A and CBS! TY!
Excellent. Thanks for sharing this. I meant to say that some labs do not test for the 1298. If I said that none others do except for Spectracell, I was wrong. I know that LabCorp, Quest and Spectracell test for both. 23andme also tests for both plus others.
John - you could; however, you could also take a pain killer if you had a tack in your foot - or you could remove the tack. My point of this presentation is to educate people that if you reduce the burden of your methylation pathways, you may not need additional supplementation. In order to do this, you have to be committed and apply all the things I discussed. You could also supplement with some L-5-MTHF and methylcobalamin and see how you respond. If you do, check with your doctor first.
DEAR DOCTOR LYNCH, EXCELLENT PRESENTATION, DIRTY GENES, GREAT BOOK, THANX A TRILLION FOR SHARING YOUR WISDOM AND PASSION, STAYMORESTRONGER, LARRY KING ,VENICE, FL, FAN
Very interesting video. I have the homozygous mutation at A1298C. I have no mutations at 677T or my COMTs. I've been diagnosed with Small Intestinal Bacterial Overgrowth (SIBO) and Urological Chronic Pelvic Pain Syndrome (UCPPS). I maintain an incredibly detailed log of my daily supplementation and will continue tweaking things until I figure out how to solve this puzzle!
Thank You for sharing this. I am also compound heterozygous. Sharing this with my doctor, as I take many supplements and was given Folbee a few years back when I was diagnosed. Hope we can get me feeling better. I never have felt quite "right" and oldest son has Spina Bifida.
Thanks for your in-depth look at MTHFR. I and my entire family have some variation of MTHFR. With your website, this webinar, and Amy Yasko's book, I have a very clear understanding of this disorder and am teaching my doctor how to treat it as we go. :-) It has really helped me work with my clients who mostly have autism--such powerful information for parents to learn that there is a biomedical reason behind the disorder.
Hello Dr. Lynch, Thank you for this video. It has been very helpful and informative. Is there anything that you would ammend or change now based on any new findings since the recording?
It depends entirely on the person in question. Support the major junctions of both the methionine cycle and the folate cycle first. Give the cofactors in low enough doses and then titrate up slowly. P5P, B-2, Hydroxy B-12, Mg are good starting points. Methyl folate often increases anxiety because it breaks down into formininoglutamate, a glutamate metabolite. So I only recommend adding in methyl folate when the time is right, if at all. It depends on the variants and the status of those variants, as well as the expression of the variants biochemically.
metabolichealing I have both Mthfr (homozygous) and Comt mutations...Homocysteine is 43.6. Estrogen also builds up without support. Lower B12. Just started methylfolate today.... bad idea?
Hi. You mention at the beginning of the talk that other labs do not test for the 1298 gene. Labcorp tested me for both MTHFR C677T and A1298C (I am compound heterozygous) and it was almost entirely covered by my insurance. Just an FYI.
THANK YOU FOR THIS VIDEO. I have been working with my doctor taking a lot of methylated vitamin b6, 9, and 12. However my symptoms of anxiety and depression have actually immediately gotten worse. What you explained about the COMT and MAO A gives me much hope! Sounds like maybe I have too much methylfolate? I'll look into it. Thanks again!
@@angelacruz114 1. stopped taking so much methylfolate (I take about 400mcg daily now whereas before I was taking over 1000 mcg) 2. Wim hof method 3. Keto/carnivore diet 4. Exercise I’m doing amazing now 👍
Thanks much for the reply. Many variables to juggle ... I take the supps, a few times per week,in addition to a multi a few times a week. Testing seems, with continuance of problems, a must.
@05collins: I am not exactly sure where in the presentation I discuss the COMT and other SNPs; however, I do not discuss them for very long anyhow. This is mainly about MTHFR and preparing for lifestyle and dietary changes in order to reduce burden on your methylation pathways.
I have been suffering for years with no energy, fatigue, pain, etc. of course, I got the generic fibromyalgia diagnosis. I had the D23&Me done and it shows several mutant (+/+) SOD2A16V, COMTV158M, COMTH62H, VSR Taq, MTRR A66G. Then I have several (+/-) including CYP1A2 164A>C, CYP1B1 L432V, CYP2C9*2 C430T, CYP2E1*1B 9896C>G, CYP2Eq*4 4768G>A, MAO-A R297R, MTHFR C677T, MTHFR A1298C, BHMT-02, BHMT-08, CBS C699T, CBS A360A. I am desperate to know what all this means (in very layman terms please). Basically, what supplements should I take or not take. What should I eat or no eat? My family doctor looks glazed over and hasn’t told me anymore than I need Methyl B12 and L5MTHR, DHEA. I have been taking all of that for months with little to no results. I already eat clean. I am Celiac and avoid all gluten as well as allergic to dairy and I avoid all dairy. I also am allergic to corn and egg and consume neither. I have had cancer twice (thyroid) with radiation. I seem to be a medical anomaly in whatever medical situation I’m in. I was 26 when I first had cancer and it did spread to my lymph nodes. I am currently 52 and 5 years post menopausal and taking estrogen and progesterone. ANY information that can help me get out of bed, and live my life again would be greatly appreciated.
@@charlieb9144 I found a natural path that could tell me which gene means what and what supplements will work and not work with me. I am definitely feeling better but probably will never be “normal” with all i have going against me. I have several autoimmune conditions as a result of having bascially swamp water for DNA. LOL. Moving is key, although its the hardest for me because I feel useless most of the time. Like I said, I am doing better than I was for sure. Also know, that people with our “issues” are highly suseptable to mold, food allergies and environmental allergies as well. Any of those things can take us down quick. I went through extensive food allergy tests via blood tests and stool tests. I was shocked becuase of some of the allergies i had no clue of. Since I have avoided all of them, that has REALLY helped. Our immune systems can’t be in flight all the time and thats exactly what anything that triggers is does to us. Also, we are prone to leaky gut, candida, parasites, etc. all which cause brain fog, fatigue and inflammation pain. Find an LLMD (Lyme Literate Doctor) or a naturalpath knowledgable in genetics. You won’t find an MD that wants to touch any of it other than to pump you full of toxic medications that include heavy metals, protroleum and so many other things our bodies can’t handle. Good luck to you. Reach out if I can help. PS - Follow the Candida Diet for 4-6 weeks. If you find that you feel better (give it a few weeks it will be worse before better while you detox) you will know a lot of your issues are food related. Some foods you eat, you dont respong to for up to 48 hrs so its nearly impossible to figure it out on your own.❤
Hi Dr Ben, just found your video this morning I’m in the UK haven’t been well for the last couple years suffering from fatigue and high blood pressure, I sent off for a methylation test last week waiting for the results. Do you have any up-to-date videos on methylation want to learn more Regards Steve.
Thank you for this video Dr Lynch. Very interesting and informative. I have recently done the 23andme test to find out why I am so unwell and fatigued, despite adhering to a gluten free diet due to coeliac disease, and taking levothyroxine for hypothyroidism (both diagnosed 2 years ago) I got the results back last week. It has shown I am heterozygous for both the C677T & A1298C as well as VDR Taq, Mao-A, MTRR, BHMT, COMT & CBS mutations. I had already started a B-complex which includes methylfolate and methyl cobalmyn as private testing has shown deficiency in B1, B7, B9, B12, I had also started 5000mg D3 with K2, and vitamin C. I have also this week switched to a natural dessicated thyroid from levothyroxine, and have high hopes for this. As you can see, I am really trying to fix this exhaustion and get back to work and a life. My only questions about your video are that you suggest sublingual methyl B12, but I would love to know your thoughts on injections instead? I'd read that people who are not methylating properly are unable to use the B12 properly once it is in the bloodstream? Would also be worse with people with digestive issues such as myself, as sublingual may be better than tablet form, but not as useful as injections? I ask these questions because I was considering starting self injecting hydroxycobalamin (which I now know since my MTHFR results that I shouldn't take hydroxy!
Hi PSanthuff. Thanks for your comment. That's interesting. Which report was that if you don't mind me asking? I am taking methylfolate and methylcobalamin supps. I have had adrenals tested and they're ok. I am hypothyroid and have recently switched from levothyroxine to a NDT.
So..you should be working with the open medicine foundation for Me/chronic fatigue syndrome. Have you contacted them to at least share what you've found I would love for you to..it may help us!
This is a phenomenal presentation Dr Lynch, thank you. Please clarify the Folinic Acid issue, because early on in this talk you seem to say that it should not be used with MTHFR mutations and is harmful; towards the end you mention using a combination of L-5-Methylfolate and Folinic Acid for good effect. I may have misunderstood. What is your current (2017-18) view on the value/harm of Folinic Acid in MTHFR? Thank you :)
I'm confused about folinic acid. AT around 45:00 you say to give methylfolate and NOT folinic acid. But then around min 54:00 you say its a good idea to combine folinic acid and methylfolate.
Nikoleta - I do not think there is much info to write specifically on the A1298C MTHFR mutation. I think a paper on just MTHFR is good - but not 1298 specifically. There is not enough data to show it is even causing much of an impact. The C677T is definitely showing issues. I keep looking though..
Dr Ben, you certainly can't expect your normal person to understand this? It seems impossible if you don't have a dr to work with. I have found a great dr.
I’d really like to know if you have associated some of this with children who have developed body odor at a very young age. My autistic son has had very stinky armpits since he was 7 or 8. I have ordered your strategene test for myself and will also order for my kids if I have a mutation. I’m so glad I ran across one of your videos that made me dig deeper.
How is the mutation of MTHFR determined? I have seen on the Estimated Genotype Frequencies Values of C/C, C/T and T/T, can you explain what they stand for? thank you
Maria Gertrudis Colorado Sorry a bit late here: www.geneticlifehacks.com/mthfr/ You can go to that site and compare your results to see what mutations You have. Or You can pay a website to do it for You for about $15.00 bucks some times free a good site is: promethease.com/ You can also pay for a direct test of the gene: www.lifeextension.com/lab-testing/itemlc100045/mthfr-comt
I have Hashimotos and a single copy MTHFR C677T mutation. My heart races and I continue to have heart palpitations for an hour after a B12 injection. B12 supplements bother me as well. I have been on the GAPS diet for 5 months, have taken probiotics for years, have taken many of the supplements for years that you recommend, am on Nystatin and NatureThroid. Does my B12 problem make any sense?
You mentioned several times "uncooked leafy greens" - what do you specifically mean by this? When I think of leafy greens I think of kale, collards, chard, spinach... all of which are best cooked. Thanks!!
Thank you for this presentation! Please could you tell me if it is safe for me to take Lmethylfolate even though have elevated folate levels? My B12 level is way too low also - should I supplement with both?
Im not sure I understood the relationship between A1298C with COMT and MAO A, and if what you meant is that taking methylfolate would have the contrary desired effect in my case: I have homozygous mutations on thoseones (MTHFR A1298C and COMT V158M and COMT H62H and MAO A R297R).
Hi I M - it really depends. This video was made years ago and is when I was first starting in this area. Dirty Genes book is the best and most up to date resource and one that I highly recommend everyone start with . You can get it here on Amazon - amzn.to/2EmtTmn or any bookstore. Homozygous SNPs doesn't mean anything really - not until you see how you score using the quizzes in the Dirty Genes book. This way you can see real time if these genes are causing you problems or not - and if so - how to support them.
I have homozygous MTHFR, the -70% one..... and also COMT. Homocysteine of 43,6. Many health issues/symptoms. Just started L-methylfolate today. B12 is on the low end though, and I know I am a FUT2 non secretor which I think affects how much B12 I can actually use? I am not very knowledgeable on this... But how do I know for certain I have enough B12 to be taking only methylfolate? My doc knows I get bad side effects from B12 so maybe they want to see how this goes first. I also have the COMT and am scared I might get the anxiety issues etc?
Hi Ben,Im homozygous for cbs, hetero for mthfr 1298 but also hetero for comt, mao, bhmt and quite a few others as well. Actually on the Sterling variant report it showed I was homozygous for a couple of mthfr's but with no specific number assighned. My problem is that like many I did great with methylfolate/methylcobalamin at first but then my head started blazing on fire and falling out not matter how much I took of it! I read that straight hydroxycobalamin may be better tolerated for CBS upregs so I tried that( but without the methylfolate) and the same thing has happened.Matter of fact Ive been on a supplement protocol for digestion for two months and seems that all of a sudden now anything I take like even betaine hcl ( I suppose methyl donors are at play here somehow) causes the same thing so I dont know what to do.Should I back off everything and perhaps just start with a little molybendum for the CBS and slowly work up to methylfolate/coblalamin? Problem is that it seems I cant tolerate anything but yet in order to heal I have to be able to tolerate something so I am very frustrated. Any input you might have Id greatly appreciate. Btw great video and not too hard to understand for us layfolks as well.Thanks! (: ps just read a comment below,perhaps I will try supplementing with a small amount every three days..
What can a person do if they are already on medication for schizophrenia and they know one of there patients have MTHFR C677T? Living in a small rural town that doesn’t have doctors who can help with this.
What do I do? I have both MTHFR and COMT. I don’t know where to start. I also have CIRS due to toxic mold exposure. I feel overwhelmed and hopeless. Help!
The 'protocol' for 1298 is the same for MTHFR 677. The information on the internet saying 1298 is more related to biopterin while 677 is more related to cardiovascular issues is not supported by research.
How is MTHFR 1298 involved in BH2 -> BH4 conversion? Would appreciate comments on the following. 1) MTHFR 1298 is an SNP on the MTHFR gene which encodes the MTHFR enzyme only. 2) MTHFR enzyme is not involved in BH2 -> BH4 conversion 3) Even if methyl folate is required for the BH2 -> BH4 conversion that does not make the 1298 SNP any special. Similarly, the 677 SNP would make the conversion hard because of deficiency on MethylFolate. Is there anything wrong with the above points? Thanks in advance!
Hi Dr Ben I have just finished listening to your presentation understanding I will need to listen again and again. I am a nurse in Cairns Qld diagnosed 1298 MTHFR and had my daughter tested 677 for her. My son nothing (Asperges Syndrome aged 12 though???) I have access to mycobalamin injections and am being supplemented inadequately, I need guidance in supplementing Chloe, I have emailed MTHFR persons in Australia but am not connecting can you pls help put us on the right path as I have limited access to MTHFR doctors, at the practice where I work they think I have two heads! Im confident I have the neurotransmitter deficiency as I cannot stop taking Valdoxan otherwise within a short space of time life goes very pear shaped and I develop depression symptoms. My daughter is on her 6th cycle and the heavy bleeding, migraines and PMS plus anxiety has only been reduced slightly with LMII plus activated B6 supplementing....I need real guidance please. My email for frequent contact or ease of contact is chersy1@bigpond.com. Kind regards Cher
Dr. Lynch? I'm homozygous 1298. my daughters 3 and 1yrs old, they are compound heterozygous. Diagnosed today, what's your view on the smarty pants multivitamin for kids, has a little owl on it, comes in a red bottle and green bottle for added fiber? is it any good?
Those of use with 2 double COMT mutations are advised to limit foods with Tyrosine & Phenylalanine as they contribute to the overload of dopamine. These are found in high amounts in all protein sources - all meats, poultry, fish, most nuts, many legumes, and much dairy (which I'm reactive too so avoid anyway). We are also to restrict foods with Quercetin which takes care of a lot of healthy colorful veg & fruit! Just having learned this I'm worried about my basically Paleo diet - what on earth should I eat? I'm sad to say I just left Seattle after 6 years and nobody sent me to you...what a missed opportunity - I just learned of you down here in SoCal! I have intractable debilitating CFS (fatigue) and have worked with many elite naturopaths in Seattle while I lived there, doing lots of expensive experimental treatments which maybe luckily I can no longer afford! Just got the genetic testing 2 yrs ago but nobody really did anything with it. If you have recommendations for diet I'd be so grateful. Thank you for your work!
I think he would probably tell you to buy his book, "Dirty Genes," which I just did. It has numerous recipes correlated to specific mutations, which will help you to know what to eat with COMT mutations.
I am so confused. New to this area so please excuse my ignorance. I have had huge problems with my estrogen levels (high oestrogen dominance) and low levels of serotonin. Does this suggest a COMPT/ MAO variation. Also if this is the case Methylfolate might do more harm than good, yet I see the highest doses of Methyl-Folate being prescribed for depression i.e. 5mg+?
When you measure trace minerals in blood what do you request? For example to measure zinc, I have been told only rbc zinc is accurate and not serum zinc. Is this true? Thank you, Carol Doroshow, M.D.
so if my child is Homozygous A1298c with a comt (val,met) should she not be taking methylfolate? my other child is heterozygous c677t with comt (val,met) and my other is A1298c and c677t no comt test done yet but homocysteine is around 10ish . Hemotologist wouldn't test homocysteine in the child with heterozygous c677t ( she said it wasn't relevant) two of my kids can barely attend school. any ideas?
I have mercury toxicity for 7 years, and I've been chelating via the Cutler Protocol for almost 2 years without any real improvements. Glutathione is extremely important for detoxification of heavy metals. I suspect that those who have acquired heavy metal toxicity through dental amalgams do not have the inherent ability to naturally detox them - leaving the metals to accumulate over time. An inability to create glutathione as mentioned at the 45 minute mark might play a role in this.
Does anyone really know if those ionic detoxing foot baths work? Maybe the better quality ones? It seems that the metal arrays rust coloring the water brown/orange. Supposedly this is normal and water turns darker color with the feet, but how healthy is it to soak your feet in rust water?
they do not work...I purchased a $$$ unit and ran the water / 1 tsp salt combo and the array(NO FEET)..and you got it..the water started to turn rust colored. Then I ran it with my feet in it...same color rust. its Baloney
bob marchant The child gets one gene from each parent. So if you have only positive genes and the other parent has only negative genes, the child will inherit one positive, one negative.
When testing your B12 level, labs should be testing at the molecular level? Is there a certain name for this test? I too have MTHFR and I am always tired!!! What makes it worse is that I have trouble sleeping. Any suggestions would be appreciated! Also, I have Factor V Leiden and Factor II; what are the chances my siblings have this?
So why is the genetic testing benificial if it doesn't actually indicate what genes are being expressed? Wouldn't a mthfr pathway be better? Don't know if there are any pathway test s for the other genes... we need phenotype testing.
Thank you very much for a very informative lecture! Ive had DNA test done & confirmed that I have 677TT variation. My NP puts me on quick silver glutathione 2x2 pumps/day, plus Thorne B Complex #6. Now I am not sure if I should continue taking glutathione. As you said my homocysteine is not affected, it’s at normal range 8.4 (rr 5-15.9). I am also taking Thorne NAC. Your insight will be greatly appreciated!🙏
I was just tested and found out I'm C677T homozygous. I've read through a lot of the stuff on mthfr.net (thank you!) and I'm confused - can 677Ts experience the neurological problems mostly attributed to 1298? I've been suffering with anxiety, depression for years, and most recently diagnosed as adult ADD, brain fog. My memory stinks too. My Dr. is starting me on a regimen of Methyl Protect (B12 Methylcobalamin, B6 P5P, TMG, 5-MTHF, Riboflavin). Also, if I'm homozygous, does that mean my brother inherited the EXACT same mutation?
+Irv Stern I have the same exact question regarding C677T and mental health problems!! I am homozygous for C677T but wildtype for 1298, yet my main symptoms are anxiety, insomnia, fatigue and brain fog. I am going to ask my doctor next time I see him to see what he says. Regarding your brother, it's possible for him to have any combination (homo, hetero or wildtype). It depends on what genotype your parents are...let's say both of them are heterozygous for C677T. Their children would have a 25% of being wildtype (no mutation), 50% being hetero, and 25% for homozygous (like you). But if they are both homo or one is homo and one is hetero, then the chances of their children inheriting the mutation increases. I'm wondering the same thing about my siblings.
Hello, I am writting to write a paper in MTHFR A1298Cmutation and i have great difficultly finding info. I was wondering if you could help me out since whenever I google for info I keep getting into your sites... Thank you in advance!
Dr. Lynch, one condition you don't have listed here is EHS. My life has been shut down by wifi proliferation. I can't be near anything wireless, and now strong emf fields make me ill too. I have been looking at MTHFR as a most likely aspect to my suffering. I am very motivated and already have covered most of your steps for great health. What so you think about EHS sufferers? Do you think this could be a methylation issue? Thanks! BTW- All doctors here have wireless offices so I cannot go to see them---
I have noticed when electricity goes out ringing and vibration stops.. Always thought it was odd. Reminds me of how one of my dogs could tell if it was going to rain 2 hrs ahead, sometimes 3.
Please can you advise if there is a birth control pill that is suitable for people with MTHFR 677 homo. I have been reading many sites that say not to take any birth control at all but teenagers need it and I thought I read that one was being developed or was already developed that would suit. Thank you.
Dear Mo, Teenagers 'need' sex = LIE/Deception. Live based on morals, values, principles. I beg you, never let a boy 'talk you into' ever giving him any physical part, place, or touch! Please, CHERISH your 'womanhood' as the most gift it is! Remain 'pure'. Command 'respect'! ANY boy/man of any age that tries to be physical with you has ZERO RESPECT FOR YOU! I implore you to RESPECT YOURSELF enough to stand proud and say 'hands off'! Your future 'peace; as a 'LADY' demands it! Every female can claim being 'woman'. To be a 'Lady' must be earned! With much love, Neecie
Hello Doctor. when I face a problem. My body trembles, my heartbeat increases, and I feel difficult to speak. ..Do you recommend supplement to treat my condition..Please help my age 40 years
If you suffer from an MTHFR defect, chances are you are severely deficient in Glutathione, the body's "master antioxidant". The methylation cycle is responsible for helping synthesize this remarkable antioxidant. If you suffer from an MTHFR defect you should look into supplementing Acetyl Glutathione in order to fortify your immune system.
Looking at the prevalence of MTHFR gene in European, Asian and Indigenous Americans, and relatively low incidence in Africans, it looks like something that we might have acquired from the neanderthals?
Why are all those health conditions so prevalent ? Too bad he did not list vaccinations as culprits. He views GMO foods and vaccinations as an underlying cause of these problems.
I am always tired if I don't take stimulants.. such as coffee, guarana and others. I am positive on the A1298c gene, but only on one strand. Still I am dong everything right, and followed all the advice I could conjure on the internet regarding this mutation, but still.. I am tired and feel lethargic through the day... Nothing helps. I have no candida, do not drink, and have a healthy diet without milk or glutten etc. Why is it so difficult to feel energetic? I am so fed up. I am at a loss... Please give me more leads I can follow. I have exhausted all avenues :(
get tested for hypothyroid: TSH should be between .33 to 2.00, don't go by obsolete ranges given by some labs that set the top of the range at 4 or higher. If my TSH is higher than 1.5 I am exhausted.
A doctor suggested my daughter get tested for this. She started having seizures 2011 and been to two Neuro they don't know what's going on. How does MTHFR and seizures have a connection?
Maybe. Many people with methylation problems will get sick taking taking MethylFolate and methylcobalamin. They need to detox with molybdenum and take hydroxocobalamin first then go very slowly with methylfolate. Some can take the methyl directly and be helped immediately. To determine if you are mutated, you go to 23andme.com to get your genetic test. that can take 3 or 4 weeks to get back. it costs around $100. Next go to geneticgenie.org and run it thru methylation analysis. Donate $10. Optionally you can also go to MTHFR.net and go to Sterlings app to select order reports. This gives a more extensive SNP list if you want. It costs $30. The geneticgenie methylation analysis report will get you your basic methylation results. Look for anything that has +/+ (bad) or +/- (less bad) . -/- means ok. Go to phoenixrising.me. Someone put together a document on how to interpret you results. SNPs Interpretation Guide 8-24-2014. There are 3 other documents. You can find a MTHFR doctor at seekinghealth.org/physician-directory/?action=search&dosrch=1&q&listingfields[1]&listingfields[10] to get further testing. For anxiety, I recommend trying Taurine and Magtein. Don't take GABA or L-Theanine since it may displace the protective taurine.
Aside from some minor public speaking flaws, why would anyone put a thumbs down to the video? The information was great and slides were clear - thank you!
Because their the kind who probably would like to keep you on the drip feed of perpetual sickness ,and who love to treat symptoms and not focus on cure and keep you from optimum health.
All people everywhere should be taught this in school as a standard.
Thanks Brian for your kind words. I continue to learn and as I do, I will be making more presentations and providing webinars. There is a huge learning curve here and my goal is to assimilate, digest and then inform the public as effectively and as fast as possible.
As a student of biochemistry with the MTHFR mutations, I appreciate this video greatly. Thank you for explaining the pathways.
I feel like I've just found a gold bar! This information is so helpful. Thank you so much Dr. Lynch!
We test babies on so many genetic diseases at birth with the PKU. This should be one of them.
Love the "important point here in case you're zoning out." :) Thank you Dr. Lynch!
Thank you so much for making this, for people like myself who are just learning we have the MTHFR mutation (for me, both copies) then this information is hugely important and so valuable to those of us just learning about this thru a genetic test result. Cheers.
Thank you for this presentation. I have 2 double COMT and MAO A mutations and what you said about these fits me completely. I have trouble taking just simple B6's, l-carnitine or even CoQ10 without getting the severe heart palps. My docs think I'm crazy! lol I'd love to see a video from you that addresses COMT, MAO A and CBS! TY!
Frau Dr. Christina Ronchi sagte aktives B 6 ganz langsam einschleichen.
Anfangs eine halbe Tablette über den Tag verteilen. 💊
Excellent. Thanks for sharing this. I meant to say that some labs do not test for the 1298. If I said that none others do except for Spectracell, I was wrong. I know that LabCorp, Quest and Spectracell test for both. 23andme also tests for both plus others.
Thanks so much for putting this on youtube!!!
I think this guy’s knowledge has evolved since then
a wee bit. ;)
John - you could; however, you could also take a pain killer if you had a tack in your foot - or you could remove the tack. My point of this presentation is to educate people that if you reduce the burden of your methylation pathways, you may not need additional supplementation. In order to do this, you have to be committed and apply all the things I discussed. You could also supplement with some L-5-MTHF and methylcobalamin and see how you respond. If you do, check with your doctor first.
DEAR DOCTOR LYNCH, EXCELLENT PRESENTATION, DIRTY GENES, GREAT BOOK, THANX A TRILLION FOR SHARING YOUR WISDOM AND PASSION, STAYMORESTRONGER, LARRY KING ,VENICE, FL, FAN
thank you! and you're welcome!
Very interesting video. I have the homozygous mutation at A1298C. I have no mutations at 677T or my COMTs. I've been diagnosed with Small Intestinal Bacterial Overgrowth (SIBO) and Urological Chronic Pelvic Pain Syndrome (UCPPS). I maintain an incredibly detailed log of my daily supplementation and will continue tweaking things until I figure out how to solve this puzzle!
how to see if you have SIBO?
there is some discussion at 43:50... for COMT and MAO A in relation to 1298
Thank You for sharing this. I am also compound heterozygous. Sharing this with my doctor, as I take many supplements and was given Folbee a few years back when I was diagnosed. Hope we can get me feeling better. I never have felt quite "right" and oldest son has Spina Bifida.
Thanks for your in-depth look at MTHFR. I and my entire family have some variation of MTHFR. With your website, this webinar, and Amy Yasko's book, I have a very clear understanding of this disorder and am teaching my doctor how to treat it as we go. :-) It has really helped me work with my clients who mostly have autism--such powerful information for parents to learn that there is a biomedical reason behind the disorder.
Hello Dr. Lynch,
Thank you for this video. It has been very helpful and informative. Is there anything that you would ammend or change now based on any new findings since the recording?
How would you supplement someone with a MTHFR polymorphism and a COMT mutation?
It depends entirely on the person in question. Support the major junctions of both the methionine cycle and the folate cycle first. Give the cofactors in low enough doses and then titrate up slowly. P5P, B-2, Hydroxy B-12, Mg are good starting points. Methyl folate often increases anxiety because it breaks down into formininoglutamate, a glutamate metabolite. So I only recommend adding in methyl folate when the time is right, if at all. It depends on the variants and the status of those variants, as well as the expression of the variants biochemically.
metabolichealing I have both Mthfr (homozygous) and Comt mutations...Homocysteine is 43.6. Estrogen also builds up without support. Lower B12. Just started methylfolate today.... bad idea?
Hi. You mention at the beginning of the talk that other labs do not test for the 1298 gene. Labcorp tested me for both MTHFR C677T and A1298C (I am compound heterozygous) and it was almost entirely covered by my insurance. Just an FYI.
THANK YOU FOR THIS VIDEO. I have been working with my doctor taking a lot of methylated vitamin b6, 9, and 12. However my symptoms of anxiety and depression have actually immediately gotten worse. What you explained about the COMT and MAO A gives me much hope! Sounds like maybe I have too much methylfolate? I'll look into it. Thanks again!
What did you end up doing? Lowering your dose? What was the outcome? How are you now?
@@angelacruz114
1. stopped taking so much methylfolate (I take about 400mcg daily now whereas before I was taking over 1000 mcg)
2. Wim hof method
3. Keto/carnivore diet
4. Exercise
I’m doing amazing now 👍
Thanks much for the reply. Many variables to juggle ... I take the supps, a few times per week,in addition to a multi a few times a week. Testing seems, with continuance of problems, a must.
@05collins: I am not exactly sure where in the presentation I discuss the COMT and other SNPs; however, I do not discuss them for very long anyhow. This is mainly about MTHFR and preparing for lifestyle and dietary changes in order to reduce burden on your methylation pathways.
"Are they chewing or being a snake" LOLOLOL! I laughed pretty hard over that. It struck me funny.
I have been suffering for years with no energy, fatigue, pain, etc. of course, I got the generic fibromyalgia diagnosis. I had the D23&Me done and it shows several mutant (+/+) SOD2A16V, COMTV158M, COMTH62H, VSR Taq, MTRR A66G. Then I have several (+/-) including CYP1A2 164A>C, CYP1B1 L432V, CYP2C9*2 C430T, CYP2E1*1B 9896C>G, CYP2Eq*4 4768G>A, MAO-A R297R, MTHFR C677T, MTHFR A1298C, BHMT-02, BHMT-08, CBS C699T, CBS A360A.
I am desperate to know what all this means (in very layman terms please). Basically, what supplements should I take or not take. What should I eat or no eat? My family doctor looks glazed over and hasn’t told me anymore than I need Methyl B12 and L5MTHR, DHEA. I have been taking all of that for months with little to no results. I already eat clean. I am Celiac and avoid all gluten as well as allergic to dairy and I avoid all dairy. I also am allergic to corn and egg and consume neither.
I have had cancer twice (thyroid) with radiation. I seem to be a medical anomaly in whatever medical situation I’m in. I was 26 when I first had cancer and it did spread to my lymph nodes. I am currently 52 and 5 years post menopausal and taking estrogen and progesterone.
ANY information that can help me get out of bed, and live my life again would be greatly appreciated.
Hi, did you find any solutions? I'm in a similar position. Hope you are doing better
@@charlieb9144 I found a natural path that could tell me which gene means what and what supplements will work and not work with me. I am definitely feeling better but probably will never be “normal” with all i have going against me. I have several autoimmune conditions as a result of having bascially swamp water for DNA. LOL. Moving is key, although its the hardest for me because I feel useless most of the time. Like I said, I am doing better than I was for sure. Also know, that people with our “issues” are highly suseptable to mold, food allergies and environmental allergies as well. Any of those things can take us down quick. I went through extensive food allergy tests via blood tests and stool tests. I was shocked becuase of some of the allergies i had no clue of. Since I have avoided all of them, that has REALLY helped. Our immune systems can’t be in flight all the time and thats exactly what anything that triggers is does to us. Also, we are prone to leaky gut, candida, parasites, etc. all which cause brain fog, fatigue and inflammation pain. Find an LLMD (Lyme Literate Doctor) or a naturalpath knowledgable in genetics. You won’t find an MD that wants to touch any of it other than to pump you full of toxic medications that include heavy metals, protroleum and so many other things our bodies can’t handle. Good luck to you. Reach out if I can help. PS - Follow the Candida Diet for 4-6 weeks. If you find that you feel better (give it a few weeks it will be worse before better while you detox) you will know a lot of your issues are food related. Some foods you eat, you dont respong to for up to 48 hrs so its nearly impossible to figure it out on your own.❤
Hi Dr Ben, just found your video this morning I’m in the UK haven’t been well for the last couple years suffering from fatigue and high blood pressure, I sent off for a methylation test last week waiting for the results. Do you have any up-to-date videos on methylation want to learn more Regards Steve.
Is Niacin still something to avoid with the 677TT..? And would that include other forms of B3..nicotinic acid, nicotinomide etc…? Thanks so much!
Thank you for this presentation!
Thank you for this video Dr Lynch. Very interesting and informative.
I have recently done the 23andme test to find out why I am so unwell and fatigued, despite adhering to a gluten free diet due to coeliac disease, and taking levothyroxine for hypothyroidism (both diagnosed 2 years ago)
I got the results back last week. It has shown I am heterozygous for both the C677T & A1298C as well as VDR Taq, Mao-A, MTRR, BHMT, COMT & CBS mutations.
I had already started a B-complex which includes methylfolate and methyl cobalmyn as private testing has shown deficiency in B1, B7, B9, B12, I had also started 5000mg D3 with K2, and vitamin C. I have also this week switched to a natural dessicated thyroid from levothyroxine, and have high hopes for this. As you can see, I am really trying to fix this exhaustion and get back to work and a life.
My only questions about your video are that you suggest sublingual methyl B12, but I would love to know your thoughts on injections instead? I'd read that people who are not methylating properly are unable to use the B12 properly once it is in the bloodstream? Would also be worse with people with digestive issues such as myself, as sublingual may be better than tablet form, but not as useful as injections?
I ask these questions because I was considering starting self injecting hydroxycobalamin (which I now know since my MTHFR results that I shouldn't take hydroxy!
Hi PSanthuff. Thanks for your comment. That's interesting. Which report was that if you don't mind me asking? I am taking methylfolate and methylcobalamin supps.
I have had adrenals tested and they're ok. I am hypothyroid and have recently switched from levothyroxine to a NDT.
Do you feel better on NDT? How many grains do you take? Sounds good. I used Nutrahacker too but don't really know how to interpret the results.
So..you should be working with the open medicine foundation for Me/chronic fatigue syndrome. Have you contacted them to at least share what you've found I would love for you to..it may help us!
This is a phenomenal presentation Dr Lynch, thank you. Please clarify the Folinic Acid issue, because early on in this talk you seem to say that it should not be used with MTHFR mutations and is harmful; towards the end you mention using a combination of L-5-Methylfolate and Folinic Acid for good effect. I may have misunderstood. What is your current (2017-18) view on the value/harm of Folinic Acid in MTHFR? Thank you :)
I think he mentioned folic acid being harmful, not folinic acid. The two different.
I'm confused about folinic acid. AT around 45:00 you say to give methylfolate and NOT folinic acid. But then around min 54:00 you say its a good idea to combine folinic acid and methylfolate.
Great presentation!
Nikoleta - I do not think there is much info to write specifically on the A1298C MTHFR mutation. I think a paper on just MTHFR is good - but not 1298 specifically. There is not enough data to show it is even causing much of an impact. The C677T is definitely showing issues. I keep looking though..
Dr Ben, you certainly can't expect your normal person to understand this? It seems impossible if you don't have a dr to work with. I have found a great dr.
Excellent presentation, thanks much. Wonder why I woudn't just take a supplement just in case I had the mute ?
I have homogeneous 1298c, and homogenous COMT V158 + H62H. Is it not a good idea to supplement with the methyl folate then??
I’d really like to know if you have associated some of this with children who have developed body odor at a very young age. My autistic son has had very stinky armpits since he was 7 or 8. I have ordered your strategene test for myself and will also order for my kids if I have a mutation. I’m so glad I ran across one of your videos that made me dig deeper.
How is the mutation of MTHFR determined? I have seen on the Estimated Genotype Frequencies Values of C/C, C/T and T/T, can you explain what they stand for? thank you
Maria Gertrudis Colorado Sorry a bit late here:
www.geneticlifehacks.com/mthfr/
You can go to that site and compare your results to see what mutations You have.
Or You can pay a website to do it for You for about $15.00 bucks some times free a good site is:
promethease.com/
You can also pay for a direct test of the gene:
www.lifeextension.com/lab-testing/itemlc100045/mthfr-comt
I have Hashimotos and a single copy MTHFR C677T mutation. My heart races and I continue to have heart palpitations for an hour after a B12 injection. B12 supplements bother me as well. I have been on the GAPS diet for 5 months, have taken probiotics for years, have taken many of the supplements for years that you recommend, am on Nystatin and NatureThroid. Does my B12 problem make any sense?
You mentioned several times "uncooked leafy greens" - what do you specifically mean by this? When I think of leafy greens I think of kale, collards, chard, spinach... all of which are best cooked. Thanks!!
The bitters, too eg dandelion and arugula.
Is this protocol still valid and if so what products do I get. I looked on the site and am having a hard time matching products.
Thank you from Germany 🇩🇪
Thank you for this presentation! Please could you tell me if it is safe for me to take Lmethylfolate even though have elevated folate levels? My B12 level is way too low also - should I supplement with both?
Carol - depends on the nutrients. Yes, zinc and magnesium, for example, RBC levels are best.
Great video - but at the very end it cuts to another video for one of his products without wrapping up.
Im not sure I understood the relationship between A1298C with COMT and MAO A, and if what you meant is that taking methylfolate would have the contrary desired effect in my case: I have homozygous mutations on thoseones (MTHFR A1298C and COMT V158M and COMT H62H and MAO A R297R).
Hi I M - it really depends. This video was made years ago and is when I was first starting in this area. Dirty Genes book is the best and most up to date resource and one that I highly recommend everyone start with . You can get it here on Amazon - amzn.to/2EmtTmn or any bookstore. Homozygous SNPs doesn't mean anything really - not until you see how you score using the quizzes in the Dirty Genes book. This way you can see real time if these genes are causing you problems or not - and if so - how to support them.
Can you point us to a good recent video about A1298C homozygous data?
I have homozygous MTHFR, the -70% one..... and also COMT. Homocysteine of 43,6. Many health issues/symptoms. Just started L-methylfolate today. B12 is on the low end though, and I know I am a FUT2 non secretor which I think affects how much B12 I can actually use? I am not very knowledgeable on this... But how do I know for certain I have enough B12 to be taking only methylfolate? My doc knows I get bad side effects from B12 so maybe they want to see how this goes first. I also have the COMT and am scared I might get the anxiety issues etc?
Hi Ben,Im homozygous for cbs, hetero for mthfr 1298 but also hetero for comt, mao, bhmt and quite a few others as well. Actually on the Sterling variant report it showed I was homozygous for a couple of mthfr's but with no specific number assighned. My problem is that like many I did great with methylfolate/methylcobalamin at first but then my head started blazing on fire and falling out not matter how much I took of it! I read that straight hydroxycobalamin may be better tolerated for CBS upregs so I tried that( but without the methylfolate) and the same thing has happened.Matter of fact Ive been on a supplement protocol for digestion for two months and seems that all of a sudden now anything I take like even betaine hcl ( I suppose methyl donors are at play here somehow) causes the same thing so I dont know what to do.Should I back off everything and perhaps just start with a little molybendum for the CBS and slowly work up to methylfolate/coblalamin? Problem is that it seems I cant tolerate anything but yet in order to heal I have to be able to tolerate something so I am very frustrated. Any input you might have Id greatly appreciate. Btw great video and not too hard to understand for us layfolks as well.Thanks! (:
ps just read a comment below,perhaps I will try supplementing with a small amount every three days..
What can a person do if they are already on medication for schizophrenia and they know one of there patients have MTHFR C677T? Living in a small rural town that doesn’t have doctors who can help with this.
What do I do? I have both MTHFR and COMT. I don’t know where to start. I also have CIRS due to toxic mold exposure. I feel overwhelmed and hopeless. Help!
Why did the video stop mid talk? And what does tapering up on methylfolate mean? Should i increase, and if so, by how much and hw ofen?
So, what's the protocol for 1298 as described at 41:00? Still no answer on your website as far as I can tell.
The 'protocol' for 1298 is the same for MTHFR 677. The information on the internet saying 1298 is more related to biopterin while 677 is more related to cardiovascular issues is not supported by research.
How is MTHFR 1298 involved in BH2 -> BH4 conversion?
Would appreciate comments on the following.
1) MTHFR 1298 is an SNP on the MTHFR gene which encodes the MTHFR enzyme only.
2) MTHFR enzyme is not involved in BH2 -> BH4 conversion
3) Even if methyl folate is required for the BH2 -> BH4 conversion that does not make the 1298 SNP any special. Similarly, the 677 SNP would make the conversion hard because of deficiency on MethylFolate.
Is there anything wrong with the above points?
Thanks in advance!
Is (all?) this information in the book Dirty Genes..?
Because a lot of things pass by here that are not even in his PowerPoint...
Hi Dr Ben
I have just finished listening to your presentation understanding I will need to listen again and again. I am a nurse in Cairns Qld diagnosed 1298 MTHFR and had my daughter tested 677 for her. My son nothing (Asperges Syndrome aged 12 though???) I have access to mycobalamin injections and am being supplemented inadequately, I need guidance in supplementing Chloe, I have emailed MTHFR persons in Australia but am not connecting can you pls help put us on the right path as I have limited access to MTHFR doctors, at the practice where I work they think I have two heads! Im confident I have the neurotransmitter deficiency as I cannot stop taking Valdoxan otherwise within a short space of time life goes very pear shaped and I develop depression symptoms. My daughter is on her 6th cycle and the heavy bleeding, migraines and PMS plus anxiety has only been reduced slightly with LMII plus activated B6 supplementing....I need real guidance please. My email for frequent contact or ease of contact is chersy1@bigpond.com. Kind regards Cher
Dr. Lynch? I'm homozygous 1298. my daughters 3 and 1yrs old, they are compound heterozygous. Diagnosed today, what's your view on the smarty pants multivitamin for kids, has a little owl on it, comes in a red bottle and green bottle for added fiber? is it any good?
I love this !!! I have Ehlers Danlos Syndrome & also P450 cytochrome pathway problems …is That linked to MTHFR which I think I have too ? Anybody ?
No
Dr. Lynch,
What does it look like clinically when a patient does not tolerate multivitamins well?
Thanks!
Those of use with 2 double COMT mutations are advised to limit foods with Tyrosine & Phenylalanine as they contribute to the overload of dopamine. These are found in high amounts in all protein sources - all meats, poultry, fish, most nuts, many legumes, and much dairy (which I'm reactive too so avoid anyway). We are also to restrict foods with Quercetin which takes care of a lot of healthy colorful veg & fruit!
Just having learned this I'm worried about my basically Paleo diet - what on earth should I eat?
I'm sad to say I just left Seattle after 6 years and nobody sent me to you...what a missed opportunity - I just learned of you down here in SoCal! I have intractable debilitating CFS (fatigue) and have worked with many elite naturopaths in Seattle while I lived there, doing lots of expensive experimental treatments which maybe luckily I can no longer afford! Just got the genetic testing 2 yrs ago but nobody really did anything with it.
If you have recommendations for diet I'd be so grateful. Thank you for your work!
Where did you get that info telling you to avoid those things? Just curious. Hope you find your answers !
I think he would probably tell you to buy his book, "Dirty Genes," which I just did. It has numerous recipes correlated to specific mutations, which will help you to know what to eat with COMT mutations.
I live in London England.
Where do I get one of these test pls,
I am so confused. New to this area so please excuse my ignorance. I have had huge problems with my estrogen levels (high oestrogen dominance) and low levels of serotonin. Does this suggest a COMPT/ MAO variation. Also if this is the case Methylfolate might do more harm than good, yet I see the highest doses of Methyl-Folate being prescribed for depression i.e. 5mg+?
What was the Electrolyte solution that you suggested?
When you measure trace minerals in blood what do you request? For example to measure zinc, I have been told only rbc zinc is accurate and not serum zinc. Is this true? Thank you, Carol Doroshow, M.D.
What type of green leafy veggies do you recommend is best for the mtfr gene mutations?
Organic
Why aren't Drs looking into any of these issues I've had to look this problem up myself.
no incentive to resolve underlying issues when medications are the primary focus
so if my child is Homozygous A1298c with a comt (val,met) should she not be taking methylfolate?
my other child is heterozygous c677t with comt (val,met) and my other is A1298c and c677t no comt test done yet but homocysteine is around 10ish . Hemotologist wouldn't test homocysteine in the child with heterozygous c677t ( she said it wasn't relevant)
two of my kids can barely attend school. any ideas?
I need a good doctor to help me I have mthfr and I need treatment
I have mercury toxicity for 7 years, and I've been chelating via the Cutler Protocol for almost 2 years without any real improvements. Glutathione is extremely important for detoxification of heavy metals. I suspect that those who have acquired heavy metal toxicity through dental amalgams do not have the inherent ability to naturally detox them - leaving the metals to accumulate over time. An inability to create glutathione as mentioned at the 45 minute mark might play a role in this.
Hey Doc just watch on of the videos you made with someone.. and found you here. Any thoughts on supplements that have greens in them?
greens can be great - as long as they're tested for things like arsenic and lead
Does anyone really know if those ionic detoxing foot baths work? Maybe the better quality ones? It seems that the metal arrays rust coloring the water brown/orange. Supposedly this is normal and water turns darker color with the feet, but how healthy is it to soak your feet in rust water?
they do not work...I purchased a $$$ unit and ran the water / 1 tsp salt combo and the array(NO FEET)..and you got it..the water started to turn rust colored. Then I ran it with my feet in it...same color rust. its Baloney
Can I pass the double gene mutations c667t onto my son if his father is negative I HAVE THE double gene mutations c677t
bob marchant The child gets one gene from each parent. So if you have only positive genes and the other parent has only negative genes, the child will inherit one positive, one negative.
When testing your B12 level, labs should be testing at the molecular level? Is there a certain name for this test? I too have MTHFR and I am always tired!!! What makes it worse is that I have trouble sleeping. Any suggestions would be appreciated!
Also, I have Factor V Leiden and Factor II; what are the chances my siblings have this?
The methylfolate even at 100mcg daily makes me very sick. Depressed, confused, histamine reactions to some foods.
So why is the genetic testing benificial if it doesn't actually indicate what genes are being expressed? Wouldn't a mthfr pathway be better? Don't know if there are any pathway test s for the other genes... we need phenotype testing.
+Kyle A If you are homozygous for C677T or A1298C those pathways are going to be compromised.
yes - right - that is why I made this - go.strategene.org/genetic-analysis/ - it combines pathways and genetics
Thank you very much for a very informative lecture! Ive had DNA test done & confirmed that I have 677TT variation. My NP puts me on quick silver glutathione 2x2 pumps/day, plus Thorne B Complex #6. Now I am not sure if I should continue taking glutathione. As you said my homocysteine is not affected, it’s at normal range 8.4 (rr 5-15.9). I am also taking Thorne NAC. Your insight will be greatly appreciated!🙏
I was just tested and found out I'm C677T homozygous. I've read through a lot of the stuff on mthfr.net (thank you!) and I'm confused - can 677Ts experience the neurological problems mostly attributed to 1298? I've been suffering with anxiety, depression for years, and most recently diagnosed as adult ADD, brain fog. My memory stinks too.
My Dr. is starting me on a regimen of Methyl Protect (B12 Methylcobalamin, B6 P5P, TMG, 5-MTHF, Riboflavin). Also, if I'm homozygous, does that mean my brother inherited the EXACT same mutation?
+Irv Stern I have the same exact question regarding C677T and mental health problems!! I am homozygous for C677T but wildtype for 1298, yet my main symptoms are anxiety, insomnia, fatigue and brain fog. I am going to ask my doctor next time I see him to see what he says.
Regarding your brother, it's possible for him to have any combination (homo, hetero or wildtype). It depends on what genotype your parents are...let's say both of them are heterozygous for C677T. Their children would have a 25% of being wildtype (no mutation), 50% being hetero, and 25% for homozygous (like you). But if they are both homo or one is homo and one is hetero, then the chances of their children inheriting the mutation increases. I'm wondering the same thing about my siblings.
+Ariel Hall 677TT*
Hello,
I am writting to write a paper in MTHFR A1298Cmutation and i have great difficultly finding info. I was wondering if you could help me out since whenever I google for info I keep getting into your sites... Thank you in advance!
Thank you for what you do!
Awesome video!
I wish I would've seen this in April 2012.
I will follow up with you shortly..
Dr. Lynch, one condition you don't have listed here is EHS. My life has been shut down by wifi proliferation. I can't be near anything wireless, and now strong emf fields make me ill too. I have been looking at MTHFR as a most likely aspect to my suffering. I am very motivated and already have covered most of your steps for great health. What so you think about EHS sufferers? Do you think this could be a methylation issue? Thanks! BTW- All doctors here have wireless offices so I cannot go to see them---
I have noticed when electricity goes out ringing and vibration stops.. Always thought it was odd. Reminds me of how one of my dogs could tell if it was going to rain 2 hrs ahead, sometimes 3.
Please can you advise if there is a birth control pill that is suitable for people with MTHFR 677 homo. I have been reading many sites that say not to take any birth control at all but teenagers need it and I thought I read that one was being developed or was already developed that would suit. Thank you.
Dear Mo, Teenagers 'need' sex = LIE/Deception. Live based on morals, values, principles. I beg you, never let a boy 'talk you into' ever giving him any physical part, place, or touch! Please, CHERISH your 'womanhood' as the most gift it is! Remain 'pure'. Command 'respect'! ANY boy/man of any age that tries to be physical with you has ZERO RESPECT FOR YOU! I implore you to RESPECT YOURSELF enough to stand proud and say 'hands off'! Your future 'peace; as a 'LADY' demands it! Every female can claim being 'woman'. To be a 'Lady' must be earned! With much love, Neecie
drnails
Hate to break it to you, but we're going balls deep Dr Nails
Hey Doc, Couldn't a person correct the Electrolyte Deficiency (micro-nutrient)with just using an Unprocessed Salt ?
What are your opinions on the covid vaccine and mthfr or other gene mutations?
Effect of covid vaccine on people with mthfr.
The very last thing written on this video said vaccines not recommended.
Hello Doctor. when I face a problem. My body trembles, my heartbeat increases, and I feel difficult to speak. ..Do you recommend supplement to treat my condition..Please help my age 40 years
Try magnesium
@@TheShumoby thank you
If you suffer from an MTHFR defect, chances are you are severely deficient in Glutathione, the body's "master antioxidant". The methylation cycle is responsible for helping synthesize this remarkable antioxidant. If you suffer from an MTHFR defect you should look into supplementing Acetyl Glutathione in order to fortify your immune system.
GlyNac is the best for glutathione
Looking at the prevalence of MTHFR gene in European, Asian and Indigenous Americans, and relatively low incidence in Africans, it looks like something that we might have acquired from the neanderthals?
is this still teh case that no more than 1 mg of L-methylfolate in a capsule in 2019?
Why are all those health conditions so prevalent ?
Too bad he did not list vaccinations as culprits. He views GMO foods and vaccinations as an underlying cause of these problems.
ua-cam.com/video/l7g7IcZ95-A/v-deo.html - do vaccines cause autism - great point -
I am always tired if I don't take stimulants.. such as coffee, guarana and others.
I am positive on the A1298c gene, but only on one strand. Still I am dong everything right, and followed all the advice I could conjure on the internet regarding this mutation, but still.. I am tired and feel lethargic through the day... Nothing helps. I have no candida, do not drink, and have a healthy diet without milk or glutten etc. Why is it so difficult to feel energetic? I am so fed up. I am at a loss... Please give me more leads I can follow. I have exhausted all avenues :(
get tested for hypothyroid: TSH should be between .33 to 2.00, don't go by obsolete ranges given
by some labs that set the top of the range at 4 or higher. If my TSH is higher than 1.5 I am exhausted.
Do you omit only gluten or wheat altogether?
A doctor suggested my daughter get tested for this. She started having seizures 2011 and been to two Neuro they don't know what's going on. How does MTHFR and seizures have a connection?
i take 1,5 mg of Methylfolate . And my anxiety is much better ! I didnt get testet . But does that mean I have MTHFR mutation ???
Maybe. Many people with methylation problems will get sick taking taking MethylFolate and methylcobalamin. They need to detox with molybdenum and take hydroxocobalamin first then go very slowly with methylfolate. Some can take the methyl directly and be helped immediately.
To determine if you are mutated, you go to 23andme.com to get your genetic test. that can take 3 or 4 weeks to get back. it costs around $100. Next go to geneticgenie.org and run it thru methylation analysis. Donate $10. Optionally you can also go to MTHFR.net and go to Sterlings app to select order reports. This gives a more extensive SNP list if you want. It costs $30. The geneticgenie methylation analysis report will get you your basic methylation results. Look for anything that has +/+ (bad) or +/- (less bad) . -/- means ok. Go to phoenixrising.me. Someone put together a document on how to interpret you results. SNPs Interpretation Guide 8-24-2014. There are 3 other documents.
You can find a MTHFR doctor at seekinghealth.org/physician-directory/?action=search&dosrch=1&q&listingfields[1]&listingfields[10] to get further testing.
For anxiety, I recommend trying Taurine and Magtein. Don't take GABA or L-Theanine since it may displace the protective taurine.
u r amazing!!!!!!!!!!!!!!!!!!!!!!!!
I have both gene mutations.
I do not understand any of this. Thank you.
Carnauba wax? Great for polishing the car, lol.
There's a lot of hype about Nicotinamide Riboside having a lot of health benefits... But iif it soaks up a lot of SAMe that doesn't sound good. .
Maybe - maybe not. Most likely - no.
Lol, another gigantic scam
Yes, dna is a scam. We should be ok with better foods and less vaccines I am sure, that is the real scam.