What the human genome sequence doesn't tell you.
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- Опубліковано 21 лип 2024
- Until recently ~8% of the human genome sequence was missing. It is now sequenced - yay!
But, what information does the human genome sequence actually tell us - is it the 'book of life' as you may hear it described?
Why did it take us so long to get the full sequence, how was it done? What are the consequences or next steps now we have the full sequence.
These are just a few of the questions i raise and discuss in this video.
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TIMESTAMPS:
Intro - 00:00
What is DNA - 00:50
Complete sequence of human genome - 02:13
What doesn't DNA tell us? Genome annotation - 04:00
Why should we care? - 07:30
References:
The complete sequence of a human genome - www.science.org/doi/10.1126/s...
Stein, L. Genome annotation: from sequence to biology. Nat Rev Genet 2, 493-503 (2001). doi.org/10.1038/35080529
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "www.freepik.com/free-photos-v..."Background vector created by freepik - www.freepik.com - Наука та технологія
lol, during the editing i managed to cut out me saying "the book of life is in our hands", so just imagine i said it before i listening here 00:14
It would be so awesome if our advances in AI can give rise to a database of what every gene codes for or the function of each gene, as well as the function and structure of every protein and molecule in the body, as well as an extensive library of epigenetic triggers and modifiers.
The amount of processing power and the scale of servers required to maintain such a database and the energy consumption required would be astronomical
What practical applications does this technology have? Can it be used for reversing aging or enhancing human capabilities? I haven't viewed the video yet.
this is so randomly funny, yet still educational
Nice summary!
The program of life resides in the morphogenetic fields from which all that is material maniFests. I love this material science and it does not easily allow quantum biophysics to be easily integrated. Thanks. I really enjoy your podcasts. Thank you for the time and energy you bring to this!
Excellent video! The higher level effects from tertiary and quaternary structures, and how the DNA interacts with itself in ways we still haven't even imagined, certainly leave untold amounts of knowledge to gain. This analog nature of DNA makes understanding cellular molecular biology perhaps and endless endeavor.
Aren't there parts of the Y chromosome that are also extremely difficult to sequence? Not even the centromere and telomeres, but large parts of the rest that are extremely repetitive?
Not entirely sure about Y chromosome composition, but combining both long read sequences (high error) with short read (low error) sequencing, at least using the same approach here, is likely also now possible to sequence.
Great video!
The AAAAAAAAG joke made me laughed 🤣
Isn’t another important component whether or not a gene is expressed (epigenitics)? From what I understand, if a gene is present but not active, it doesn’t play an important role.
Its discouraging to think about the complexity and multitude of factors that make gaining control of our biology more difficult, but you have to acknowledge that the great points in this video are true. Wouldnt you say though that understand genetic processes is one of the most important areas of research for potential impact regardless?
Thanks Sheekey! I guess this means my $300 Nebula 30x full sequence wasn't exactly full.
great!
Could you say annotation is like metadata. Data that describes details of other data.
I would say yes, but genome annotation sounds cool :D
it seems although nothing major is coming in the pipeline to actually reverse/stop aging.
Just get rid of parasites and whatever causes telomere shortening? May need to pop the lenses every 80 years
Who has a runny nose at 7:56?????
it's hayfever season :(
lol, now listened back, i have no idea :D
I'm not permitted to tell you a lot...
But if I can give you a hint...
The programming of DNA molecules is more of an out of order stacking of genes over time.
Much like a program that gets updates but doesn't clear the cashe.
Hopefully this will help.
Hmmm?
@@Chris-kr7gg If you understand the implications of understanding DNA, You might understand one's reluctance to share such knowledge that is not entirely earned.
A species must emotionally mature alongside its technological development, an imbalance in this, can be catastrophic.
I care enough to help but barely wise enough to know that too much help, is no help at all.
@@eyewonder6448 where did you acquire this knowledge of DNA that you purport to know, what is your credibility ?
@@Chris-kr7gg It is not my position or care to prove something to you just to watch you destroy yourselves.. And likely me along with it.. I am not nearly as suicidal as the American society.
And don't let me stop you from following such pursuits, just try not to take the planet with you when you do.
@@eyewonder6448 how has this jumped to suicide ?
It is going to take a long time to completely understand something that was created by a genius with an IQ of about 1,000,000,000.
i have to leave your channel because of owful pronuncaition.
all of us are not a native speaker
An English pronunciation you can not hear or you are not familiar with doesn't mean "awful". You don't need to say it. I think it's about your skill of adaptation for diverse English pronunciations in reality. I am not a native English speaker, and I can hear this channel's English comfortably.
Bye!
@@IlmiMulhid ???????????? She is a native speaker. She is literally English.