Neuroendocrine prostate cancer

[@malinigoswami8526]

I have a few doubts.
1. Are there any cutoffs for percentage of each component to call it mixed acinar neuroendocrine tumor?
2.if only focally the tumor expresses neuroendocrine markers and is otherwise strong PSA positive, do we ignore the neuroendocrine component and call it just acinar adenoca like your second case? what about the WHO category you mentioned, when do we call it usual adenoca with neuroendocrine component?
3.small cell ca and large cell ca should not have any acinar morphology, right?

[@rajalbshahExperturologicpath]

Hi Malini. There is no cutoff. Any amount of small cell high grade NE diff is significant. Yes, if only focally the tumor expresses NE markers in an otherwise typical prostate acinar or Ductal adenocarcinoma, you ignore it. Grade it like a typical adenocarcinoma

[@rajalbshahExperturologicpath]

Pure small or large cell do not have but you can have mixed small or large and acinar adenocarcinoma

[@tinocasadeitherezo6063]

Very instructive case! Thank you very much

[@renuthomas7726]

Dr.Shah, what about NKX 3.1? Will it be negative in NEC?

[@rajalbshahExperturologicpath]

Prostate-specific markers are typically reduced or lost in expression. In my experience NKX3.1 is also reduced but the focal expression is usually retained

[@abhinavsingh8322]

Dr in this type of prostate cancer target therapy is given?

[@rajalbshahExperturologicpath]

Platinum-based chemotherapy is typically required for high-grade neuroendocrine carcinoma

[@SandhyaRamachandran]

v nice ; thank you.