The LDL Cholesterol Mystery: Why Low Body Fat = Higher LDL Levels
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- Опубліковано 17 чер 2024
- LDL cholesterol elevations on a low-carb diet are strongly correlated with low fat mass, a new meta analysis finds.
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Link to study: www.sciencedirect.com/science...
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----------------------------------------Show Notes-------------------------------------
0:00 Intro
0:20 There is a strong association between low to normal body mass and increases in LDL cholesterol when you go on a low carb diet.
2:25 Carb restriction tends to improve other lipid and non-lipid risk factors.
4:40 As you restrict carbs, there is an increased demand for fats that looks like hyperlipidemia.
6:00 In fasted exercise, glycogen is depleted, so ketones and fatty acids are liberated to be used for fuel.
11:51 It is normal to see an elevation in LDL cholesterol when a person with BMI of 25 or less starts a low carb diet.
14:50 LDL may be elevated from neurologic conditions, autoimmune diseases, and type 1 diabetes.
15:10 Very small LDL particles decrease with a low carbohydrate diet.
This is exactly what happened with me. Low BMI, LDL through the roof. Low Tri, High HDL.
This is me!My cholesterol is off the chart, however my triglycerides are non existent.Doctor was very concerned with my cholesterol, also said it was the lowest triglycerides she has ever seen.Im 67 year old male, carnivore.
If your HDL is high too, you’re the LMHR phenotype.
@@Valoric yes i am
Would you mind divulging your cholesterol and triglyceride values (mg/dL)?
Very skinny, very low triglycerides in the 50s, very high HDL of 112 or more, LDL of 150 or more and consistent over time. Seems to be high HDL in both parents and no heart disease. Dad died at almost 91, Mom is very healthy at 86. She was told last year that they had never seen such a high HDL in an elderly person. Hers was 120 and she is quite thin. She does not restrict carbs.
You will never have heart disease. I predict your CAC Scoring test will be zero.
Thank you, keep spreading the truth. There is a reason mainstream (corporate sponsored) media have not picked this up.
Kudos to Feldman team for bringing this information to the public papers at the sources they cannot ignore)
I gave up on tracking cholesterol about 4 years ago when I went low carb. I've never felt better and I'm never going back. Thanks for all of your coverage of the latest science!
My doctor attempted to push me on statins because of high cholestrol...despite my being a very lean, muscular, athletic 70 old...I declined...citing my triglyceride to HDL ratio of 0.5, i.e., indicating very low inflammation etc. None of the attending doctors seemed to have any knowledge or, at least, appreciation for this key marker of heart health and (low) inflammation. And when I asked for the breakdown of the lipid panel as to type of LDL I was told, 'Oh, we don't do that'.
Typical
What's you apoB--if that's high, you've got problems. HDL is not causally related to heart disease (they figured that out over a decade ago, so TG to HDL levels don't make sense).
@@karlwheatley1244 If LDL is high then APOB is high, and yeah, when there are more small particles then APOB will be relatively higher. The TG to HDL ration is a good indirect indicator for insuline sensitivity (but do your own research on this ratio). In practice people with CVD tend to have high triglycerides and low HDL.
Get a CAC Scoring test to prove your cardiovascular health is OK
@@LewisDrakePhD "Get a CAC Scoring test to prove your cardiovascular health is OK" Uhh, that DOESN'T prove your cardiovascular health is OK. In western countries such as America, almost everyone has early signs of developing heart disease by age 8, but most men have CAC scores of zero until their 40s and most women into their 60s.
People can have lots and lots of soft plaque in their arteries and still have CAC scores of zero.
Went carnivore, lost 63Lbs. Have always been athletic, and still lift heavy. I’m 61, 5’8” approx 154Lbs now. LDL went thru the roof, A1C went down to 5.4, HDL/Tris was optimal. Doc said statins, I said no. Do a CAC if worried. He said unless I take a statin he won’t do any other tests. I’m good with that. I will not be bullied, obvs he’s not really concerned.
Shucks, too bad your doctor isn't as impressed with what a genius you actually are, like the rest of us.
🤣No genius, just figured out what worked for me. thank you, though.@@HegelsOwl
@@HegelsOwlimagine spending years studying and training to be a doctor only to parrot ‘guidelines’ curated by bought-and-paid-for regulators, and never to actually make anyone healthier ever again.
@@HegelsOwlHope you're having a better day, today! 😉
Perfect timing!
My husband had blood drawn recently. He had switched to a carnivore diet after being on a low-carb, zero processed food diet for 7 years.
His triglycerides had cut by a 3rd from 90 to 60 his ldl went up from 60 to 90. His doctor panicked and wanted him on statins, despite the fact his overall cholesterol was 190...I told the dude no thanks 😂
I'm going to send his office this video link...
His doctor panicked at an LDL of 90? Most consider under 100 optimal
Oh, that's a great idea. He'll think you're really intelligent that you found a UA-camr who says, "It's not true -- so there!"
@@jimg6970 It's not the number itself, but the fact his LDL increased by 50% from his previous number that most likely caused his doctor to panic.
90 LDL is low. Maybe there was a third digit missing. I wish mine was that low.
He went from unhealthy to healthy. Low LDL is correlated with illness.
Thank you so much for covering our research, Mike. As you know, it's been a long journey... but I can definitely see the LEM really picking up speed now. We hope to have a number of upcoming experiments to better test key components mechanistically.
@realDaveFeldman Please help me understand why your high-fat diet experiment made your LDL cholesterol tank. How much animal fat does your regular diet contain?
Thank you for your research. I have LDL as high as almost 400. TG 80, HDL 80. BMI 22 🤣🤣
Same thing happened, went low carb, LDL went up 180, triglycerides down to 50, HDL up to 70, total cholesterol 280, lean athletic feeling great. Before this my total cholesterol was always about 180, and I didn't feel as good as I do now. I'll keep my higher healthy cholesterol !
Same for me, doctor wants me to take statin. She told me to "eat less fat, please"
So basically if you are fat adapted and using fat for fuel, LDL will increase as required by the body, and as in the Havard study you could drop this LDL back down by eating sugary biscuits OR statins. So this LDL stuff looks like a nothing burger just to flog statins.
Well said.
BUT, the increase only occurred in people who were on a no/low carb diet. One of the likely reasons is there was very likely an increase in the consumption of animal protein to compensate for calories/energy. BTW, I’m a fan of animal protein. However, I understand the importance of carbs.
Great video Mike. I loved when at 17:41 you said "if you are really worried about your LDL, you can ask your doctor for a statin and I am sure Peter Attia would agree with that" 😅. I love the latest research on LDL and the work done by Dave Feldman as well to help us understand this marker, which as you said, when all your risk markers are improving, one isolated one should not be a cause of concern. The latest OREO experiment I feel is sending a clear message to the medical community showing how that isolated and considered risky marker can be reduced by following an unhealthy carbohydrate diet. Maybe LDL is not so bad after all. Maybe one day they will recognize it.
worrying about cholesterol is a monumental waste of time.
Not if you’re obese.
@@chrisburton3571 If you are obese there is a plethora of things u should be focusing on instead of that. like what garbage you are stuffing down your face.
My BMI is 20.2, waist circumference 28”, low body fat, workout 🏋🏼♀️ 4x a week ….. and I’m 67 yes old.
LDL is 168
HDL 105
Triglycerides 40
According to new studies on long lived people, it looks like LDL is protective!
Beautiful numbers!
I think its a source of testosterone too.
The whole fat makes you fat, and fat makes your heart attack, its all sus, imo.
Yes congratulaions! Please see this paper - it is free to download: The LDL Paradox: Higher LDL-Cholesterol is Associated with Greater Longevity
Huge THANK YOU for adding a little more clarity and insight to this contentious issue. There is so much conflicting info, even from the best intentioned folks, let alone those driven by questionable motives. Most of us are just trying to wade through the BS and make good decisions for our health. Thanks for helping with that!
This confirms my since long time theory that these lipids is just a fat/energy transportation system. With less glucose in the blood stream you need to transport more triglycerides and cholesterol so the LDL is needed for that. If you have plenty of fat deposits you will start to burn off that fat turning it in to ketones so you would expect less increase in LDL. Pure logic!
These study breakdowns are very helpful guiding me to optimal health. Thank you!!!
I have never had my cholesterol levels checked. I’m 66 and still kicking it.
I'm 59 and I haven't been to a 'white coat doc' since 2010. I'm a health coach (nutrition,strength,flex,detox,age well) for 22 years....I would NEVER go to a 'doc' for a health checkup... it's laughable.
Good study review! Thanks!
Nice one! Learned something new about low-carb diets and LDL. 💪
I was listening to Dr Baker talk to Mark Bell about this and it was really really interesting
Thank so much for being a truth teller ❤
THANKYOU for this, your talking about me. Also answered questions I've been looking for.
So important. Thank you! 💪🙌
Very, very good presentation!
Very clear.
Thank you.
Watching the numbers! I like it. Great explanation ✔
No longer worried about mine which is 224, Im 183cm and 78kg, lean and mean.......and healthy too apparently 😁
Same as me, on keto and cholesterol 280
Mean😂
@@saintjulien9707 haha, theres an old phrase "lean, mean fighting machine" 😁
Same here , never been better
You'll pay later at 60. Cholesterol matters.
great grasp of the material
Good information!👍
Same happened to me. When I was very lean and low carb my LDL was very high, but my triglycerides extremely low.
It was a well made video with a very helpful information.
Such great information once again.
I would love to hear how your mom's doing she's around my age. I'm wondering if you could do a follow-up video on her.😊
I was just looking for videos like this, had some labs yesterday that showed some high cholesterol, even though I'm very lean right now. I've been under eating from being lazy with cooking, and most of what I've been eating in the days before my lab was meat/eggs/dairy. Was encouraged to do a "Heart Healthy Diet", but was fairly familiar with the fact that LDL isn't a great indicator in cases like mine.
I'll keep up with what I'm doing, and if my doctor bothers me about it, I'll try putting forward this study.
Have been very low carb/keto for 1 year. What started off as a way to help heal from IBS and autoimmune issues turned into a way of life for me. I dropped the menopause weight that had crept on the year before, healed my gut (no more chronic diarrhea🙌), gallbladder and feel so much better. My insulin and C peptide are low, tris high and HDL low but the only thing my doc ever mentions is the raise in Cholesterol and LDL that has happened. I was worried at first but after watching a lot of great videos, like this one, I’m not so worried anymore and will keep doing what I know my body loves!
I LITERALLY had this discussion about my lab LDL bloodwork this year vs last year at my physical this morning!! I said I was eating less carbs, more meat, and running/exercise more (but hardly excessively.) All my ratios are fantastic as well. She was like can’t you eat less meat? to which I responded - I’m not doing that. My hdl, triglycerides, etc were perfect. No genetic predispositions to coronary diseases etc either.
I'm one of those with low body fat and high LDL. I presume it's because of low Vitamin D. If I remember correctly Dr.J.Kruse had mentioned. Cholesterol needs to be hit with UVB to produce vitamin D. If it doesn't, it just get circulating. I live in the UK and my LDL has been high for 10+ years and my BMI is 17-18.
Interesting. Before winter hit, I was routinely getting at least 1 hour of sunbathing a day as well as taking vitamin D. My latest bloodwork taken in late Sept showed my Vitamin D at 69.5, HDL at 62, VLDL at 14 and LDL at 170. I consider myself a LMHR but my LDL is lower than your typical LMHR. I've gone from 197 lbs to 157 following Dr. Eric Berg's keto with intermittent fasting.
This is interesting - my vitamin D was showing low this year in conjunction with my LDL increase. I haven’t been out a lot in the sun or supplementing as much - never made the correlation…
I have suspected that i am a LMHR for a few years now. Good video Mike, thanks.
You see the oreo study? Who needs a statin when they can use a pack of oreos if really worried about cholesterol. I'm happy sitting at over 200 on low carb 😊
Would you also be happy sitting at over 500?
@@amfohr got some friends who work out daily also on low carb and around 400 doing fine.
@@amfohrit is each person's individual body that functions differently. We are not all the same cut with a cookie cutter pattern and doctors should not treat us as such. Oreos can kill you yet make you have good readings on doctors tests. Does that make sense?
This happened to me when I had my values drawn 2 years ago. I am 6’1 with 19BMI. LDL higher than ‘normal’, but Trigs and vLDL was low and HDL was high. Funny, I was already going in for a blood draw tomorrow and I expect the same. Glad I caught this video.
Great presentation
Well explained
Thank you 🙏
I know 2 co-workers. Super skinny, both from China, eating very healthy. They both have super high cholesterol levels. Based on their situation, I start to think that cholesterol is not necessarily a bad thing. The high cholesterol is probably there to compensate their low body fat in order for their body to function properly.
Thank you
Thanks buddy
I am also going through low carb diet with intermittant fasting. Looking forward to higher LDL as my reward. ❤
When I went low carb, triglycerides went way, way down and HDL went up. Total cholesterol is a bit high so am pondering how to handle the PCP. She thinks it is too early for statins, thank goodness.
There is no good reason to take statins. The drug companies quote *relative* risk reduction (of heart attack etc) and not *absolute* risk reduction. So, for eg, if my risk of having a heart attack is 2% before taking a statin, and 1% after taking a statin, the drug companies will say that my risk of having a heart attack has been reduced by 50%. In reality, it has been reduced by 1%. The absolute risk reduction figures are miniscule . Also, statins are implicated in many negative health outcomes - diabetes to name just one.
this proves even more that LDL has nothing to do with heart attacks
Seems like it all comes down to metabolic fitness. Bad Cholesterol, meat, fat and salt were all scam science in the end by religious zealots.
I was pretty worried about the VLDL. I got bloodwork done when I was doing True OMAD diet with only meat and veggies like kale and avocado. I had been keto for about 4 months. Started out not fasting, went from 16/8 down to 2 meals a day, eventually ended up doing 1 meal. I was around 10%bf. Pretty lean and very muscular. My HDL was low, LDL was high, triglyceride were high and VLDL was also very high. So was my cholesterol particularly count. I had no answers for that.
I wish you had included a link to the article either in the description or the video.
Thhankyou.
Always walk away smarter from your podcasts. Thank you.
This is also what anabolics that have fat burning properties, like Anavar and Masteron also increase LDL. Many BBs freak out about their LDL while taking these.
Interesting. Also, I noticed her ALT and AST were also high, I'm guessing this was triggered by the workout too?
Some of us with high fat have high ldl too, but not the 600 it was on keto thank god!
Dr Ford Brewer, 4 years ago, was talking about the various research pointing out that the triglyceride ratio is what really matters.
Ketogenic diet now for 5years. I'm 18.5 bmi LDL 160 HDL 94 Triglycerides 54 LP-IR
I don't understand why 129 grams of carbohydrate is considered 'low'
Wow so glad I found your video
My LDL is 201 and my HDL is 113 my triglycerides 59. My A1c 5.4
Exercise weight lifting and cardio my doctor wants me to take drug for cholesterol
Always had this problem I thought something was wrong with me
the labs that you displayed showed high liver enzymes. Does this same fasted exercise increase those as well?
It may also be interesting to know if LMHR individuals … over time … develop above avg arterial deposits?
So basically, the cholesterol story we've been told is oversimplified, without doing due diligence.
No, they lied. I read the medical journals on LDL, HDL and cholesterol.
It would be nice if any of these things anywhere looked at people with a higher BMI but low body fat...
To get to a "normal" BMI, I'd have to have a limb amputated or something.
My question is whether the keto diet itself might not be solely responsible for the spike in cholesterol levels that some people experience when they begin this diet. It's possible that the increase in LDL cholesterol is more attributed to the higher intake of saturated fats, which often accompanies a keto diet. By replacing some of these saturated fats with other options like olive oil and including fiber-rich foods such as avocados, you can potentially mitigate this rise in LDL cholesterol.
The blood work you discussed, was the liver enzymes very high? Fatty liver ??
Where can I get a copy of this study? My Dr appointment is soon and I'd like to give her a copy. Thanks
If your dock is big Pharma, she won’t care about the study at all.
BMI 16, as LMHR, what I do to make my primary doctor happy is to eat more Quinoa for 2 weeks before my blood work, and this decreases my LDL to a less alarming range (still elevated though) 😂
I've never put much value in the BMI chart because it's just height and weight. Muscle is heavier than fat per amount. Two people can have a weight of 150 lbs and height of 5' 5", but one be fat and one be lean. Am I missing another chart or way of measuring that takes this into account? I'm 20 BMI, but I don't believe that reflects my health.
@highintensityhealth Thank you, I have been looking for an explanation of this, and I fit the parameters. Now, my most recent blood panel showed high glucose at 109. Why, is there any explanation for this? (Triglyceride is 74)
Doctor wants to put me on Statin because my Calculated LDL is high since I do low carbs, medium protein, high fat. My triglycerides is low 55 though.
My ldl was 203. Low triglycerides high HDL. I declined statin. I had just went back on keto three weeks before my appointment and I lost 25 pounds. My new doctor never asked me anything. 😂
Yup, my LDL is 250 when doing keto. I have 10-14% BF and 20.5 BMI. Im a bit worry, but decide to not take statin.
We need more studies about this. CMIIW, as I know people who live long (80++ yo), tend to have high cholesterol.
So maybe Cholesterol indicate protective mechanism in niece case???
What would the bodyfat percentage be like for this group? Because my BMI is between 29-30 but I have a low enough bodyfat to see my abs. So would I be a likely hyper responder, or would my body be able to use more glycogen? 🤔
What is your advice as I am on a low carb diet because I have diabetes. I also have CVD and raised LDL is not good for me. I am also on statin drug.
Do you have any data on whether a keto/low saturated fat diet raises LDL as much as a keto/high saturated fat diet?
So I'm 5'11'' 170 lbs athletic frame and was on a moderate protein and maybe 200-300 gram carbohydrate diet in the form of mostly healthy carbs and my vLDL was around 16 and LDL was about 139. I went low carb and upped my protein intake with healthy organic meats with all meat coming from grass fed cattle from a local farm along with pork and organic chicken. In the process my body composition began to change slightly over the next several months. Clothing fit the same, but the scale increased to 175 lbs along with gaining more definition around my core due to fat loss. In fact, I'm a little more chiseled all around and probably look the best aesthetically than I ever have in my life. I currently have a sprinter's physique and many are blown away that I'm 48 and surprisingly walking a ton and 2-3 15-20 min workouts a week focusing on varied pushups, pullups and hexbar deadlifts have gotten me to this point...simply put it's been MUCH easier than expected. It feels as if I've done nothing and yet my body has changed drastically. But, love story short, going low carb my vLDL graduallly went up to as high as 44 from 16. My LDL went up from 139 to 165ish. Also, I should note, before my triglycerides would be around 80-90 but during this low carb journey it did go up to 140-170ish. I'm guessing the increased saturated fat might be the cause? Interesting though seeing that I appear to align with this video presentation with regard to LMHR. Anyway, great vid.
But, you’re overlooking the increased intake of animal protein (with fat) and how that impacts your numbers. Regardless of how healthy the animal ate, it still has fat and increased intake will play a role. I suspect the control groups for the data traded carbs for increased animal protein. That has to be factored into the equation.
Struggling to see the part of any of these "lipid model" papers that deal with CVD risk association with LDLc
you mentioned “transient” increase in LDL being not a cause for concern for low carb and low bmi individuals. is a sustained hi LDL under these condition be detrimental then? is an eventual subside of the hi LDL be expected during low carb diet?
What about low bmi, high cholesterol, low triglycerides, high ldl and high oxidized ldl? Is higher oxidized ldl something that is just a given when you have high ldl?
Can you do wbc on low fat people! Is there a link? The difference between obese and thin maybe?
My LDL was 100 HDL 36 and Triglycerides 45. A little worried with such a low HDL. I do everything you are supposed to do to have high HDL. Not sure what to do or look for
New, now past, doc wanted me on a statin for 6.7 LDL (250). The rest of my blood test showed everything within parameters. Am my right weight and zero carb but she didn’t know any of this research. How many just blindly take meds when not needed?
So, BMI 29.9, 73 year old female, fasting glucose 84, on keto/low carb 3 years (mostly), exercise regularly, and I have a triad profile! Not lean but LDL 188, Trig 62, HDL75. Any one else like this? Luckily, my MD is ok with this and no pressure to take statins and she is supportive of keto.
Yes, I am similar. Ldl 259, Hdl 46,Trig 38. BMI 30.
I've heard of people on Keto lower their LDL by cutting added oils, and lowering their Sat fat intake as much as possible.. Unfortunately food is going to taste like cardboard with spices, unless you are okay mentally with your numbers.
@Drgluee there was a lecture on YT by Paul Mason where he claims that dietary cholesterol has no affect on blood cholesterol. (don't know if it's true). Cutting down on oils and fats means you will have to add something else to keep your calories? More protein/carbs might not be a good idea for keto. Also oils (olive, macadamia) have no cholesterol?
What I understood - LDL goes up because we use fat as primal energy source in absence of sugars so more of it is produced by liver for energy. And if a person is lean and exercise, more of it is produced to keep them going?
@@universanima I never mentioned dietary cholesterol, but dietary does boost it temporarily and won't hurt you in the long run as long as it isn't constant intake. But, yes LDL and Tris can go up if fat is the primary energy source. Exercising regularly can reduce the numbers, the only issue is, it isn't universal. Fortunately for me, increasing my exercise time and intensity does lower my LDL and tris quite a bit, but other people may not have the same level of benefits..
@@Drgluee Thank you! Will increase my exercise. Hope it will help a bit. Don't want my LDL to go up even more.
Lost 40lbs on low carb. HDL doubled. Triglycerides dropped in half. Cholesterol and LDL didn't change a tick.
Odd - BMI 20, LDLC 60 (apoB 66) - there again .. plant based ... helps.
How exacty does LDL (of any size) get through the endothelial cell wall? All of them are far too big to get through the ion channels 🙂
My total c is 349/ ldl 281/ HDL 47/ triglycerides 51. 2 years ago it was 203/143/56/98x glucose down to 80. Was 105. A1c 4.9 was 5.1. 8 weeks on carnivore. Down 30 lbs. bp normalized . Skin disorders cleared up
Wish this was known when I got my life insurance, my rate went up because of my "high" LDL
I am 55 on keto, triglycerides, hdl normal and ldl and total choleserol little higher.
I don’t Most doctors want to admit that they got a lot wrong.
Lost 20 Kg in the past 2 years and I feel at my best physically and MENTALLY on a low carb diet and since then my LDL is higher. Some docs have wanted me to start medication but I refuse as all other factors are perfect. My current doctor “blames” the diet and my “thick” hemoglobin and iron rich blood on this high-ish number.
With an elevated LDL will you automatically have a high ApoB and Lipoprotein A?
Although my crummy GP is still trying to shove ozempic on me, at least she is not worried about LDL going from 100 to 125. Trigs 45. Anyways keep it up. Doctors are trash at nutrition and prevention. Garbage
A majority of life insurance companies will not write a policy for anyone over a certain LDL threshold. Beyond a fast and avoidance of exercise before bloodwork, is there anything that a LMHR individual can do that may temporarily drop LDL?
Yes, the oreo study showed that by adding in more carbs will lower LDL. The study used oreos so it had a "clickbait" quality to gain as much attention as they could to this phenotype, but it was also stated that the same result of lowering LDL could be achieved by eating bananas.
Eat carbs for a week, don’t fast, don’t exercise. I lost my insurance because I got my bloods done mid keto weight loss and the day after a sprint run. Lipids were mad.
Don't exercise *heavily* and eat plenty of animal fat.
How lean is lean? Im female. My BMI is 27.4 but my DEXA scan says 20.3% body fat. LDL 146, HDL 70, triglycerides 45mg/dl. I'm not exactly low carb though.
The problem with the study is that severe exercise will raise LDL especially if your exercise is in the top 5 per cent and severe low carb even at bmi 31.
Mine is 352. ldl 223. Triglycerides 90. Hdl 105. Ratio 3.5. My Doc says I’m fine.
That’s cool. But let’s not overlook the central question … are we certain this isn’t still harmful?
One can achieve all of these benefits while maintaining a moderate to high carb diet.
The message for me is if it doesn’t hurt you then adding a few healthy carbs is a good idea. Nobody knows if high LDL in this group is dangerous or not. You can lower visceral fat blood sugar body fat and inflammation on a carb inclusive diet. It’s all about the calories. Low carb and fast weight loss depresses you thyroid and that slows LDL clearance. Nick’s studies show this thyroid effect.