Dantrolene & Calcium Channel Blockers (CCBs)

[@dryaminivs7852]

I was looking for Malignant hyperthermia and this gave me a wholesome understanding.

[@physiopathopharmaco4190]

Thanks for the feedback!

[@jamesgriffitts5652]

Thanks Brother Baker, coming in clutch!

[@hussain55019]

Your passionate voice and loving way of teaching.

[@hussain55019]

Sir please clear my confusion what i understand is that in skeletal muscle the CR RyR1 is activated mechanically by DHP receptors in T tabules while in cardiac and smooth muscle calcium has to enter the cell and then combine to the receptor of ST to release Calcium.Am I right?

[@collho]

This was such a clear and succinct explanation. Fantastic

[@sashahanna3792]

Excellent video!

[@radio-teb2018]

great explanation. Thank you :)

[@minzzal]

Awesome, thank you
fukcing lecturer in my school doesn't say anything in terms of the antagonistic actions
and told us to find

[@AMWE-gh7ti]

Informative...

[@Ukjackie73]

Hi, I really love how you have done your video, especially the patho section - is there any chance I can use from 1.47 - 1.59 on Dantrolene for my uni assignment please? I can't get my powerpoint animation to work :(

[@禿頭叔叔]

Thanks dude！
My teacher didn't tell me so much details!

[@physiopathopharmaco4190]

You’re very welcome thanks

[@rubbers3044]

Why does giving a calcium channel blocker with dantrolene leand to hyperkalemia?

[@physiopathopharmaco4190]

Decreases calcium inside cells so more calcium in the ECF which corresponds to blood levels so there are higher levels in the blood Also the combined action may inhibit the Na/K pump so again more K+ in the ECF which again corresponds to higher blood levels