Cyclosporine in Dermatology - Drug, Mechanism of Action, Use, Side-effects

Hi. With this video, we will discuss the use of Cyclosporine in dermatology and be better prepared for treating our patients. This video is directed towards dermatologists and is not at all advisory for non-medical personnel.
Introduction - 00:00
Pharmacology - 02:07
Mechanism of Action - 07:03
Use - 11:30
Use in Psoriasis - 17:35
Contra-indications - 25:08
Adverse effects - 31:14
Drug interactions - 49:31
Additional Points - 53:03

[@trader_dryogeshkumar]

Awesome lecture sir

[@sabhderma]

Thanks and welcome 😁

[@aye_puniya]

Thank you sir 👌

[@sabhderma]

Thank you so much 😊

[@m.koushikreddy6677]

Thank you sir🙏🙏

[@sabhderma]

You are most welcome 🤗🤗

[@shivanibhandari1009]

Plz make a detailed video on oral isotret also. Thank you

[@sabhderma]

Yes I will. Let me just finish a few topics in venereology.

[@NehaYadav-eh7mp]

Sir what's the difference between rotational and sequential therapy other than that , ki we use acitretin or biologicals in sequential and metho in rotational, as both will have a transition phase right when we are introducing metho or acitretin and tapering cyclo

[@sabhderma]

That's a good question! See, rotation or sequential therapy has nothing to do with the type of drug that you use. Rotational therapy means that you go from drug A to drug B to Drug C after a certain amount of time so that each individual drug has minimal side effects, and body has time to recover from the side effect of each drug used. In sequential therapy, the drug used matters. Some drug are faster acting, or they will act better in a certain type of psoriasis, and act faster, while some drugs are good for maintenance and can be used in sequence when the disease is stable. I hope this answers your question. Let me know if it doesn't.

[@CA-and-doctor-couple]

@@sabhderma sir please suggest where can we read in detail about both types. Also my teacher asked why cyclosporin stops showing effects in few patients, is it due to the tachyphylaxis. Thankyou

[@ojasdhotre2054]

Sir please do video on apremilast 🙏🙏

[@sabhderma]

Surely, in due time 😊

[@sunilkumargautam6905]

Hi sir i am suffered for genital lichen planus dermatologist introduced cyclosporine 100 mg a day(single dose) for 3 day in a week (for two week)
I am really scared about the adverse side effects like malignancies and kidney related problem .
My question is how long cyclosporine safe to take

[@sabhderma]

Hi, thank you for your query. Regarding the duration of cyclosporine treatment, your dermatologist will be able to answer it better. Malignancies and kidney issues are known but rare. You treating dermatologist will surely be looking for them; but in the doses you described, they would be rarest of rare. I hope this answer helps. Do let me know if any further clarification is required.

[@sunilkumargautam6905]

​@@sabhdermathanks sir for responding sir currently my dermatologist tap off elergy medicine ( ebastine 20mg and LCZ 5 mg) but continue with methotrexate 20 mg (once in a week followed by folic acid twice a week) and with cyclosporine 100 mg (3 times in a week ) for another 2 weeks..
I am scared and freaking out about health effects of cyclosporine reading research papers on internet... Kindly guide me sir... How common are malignancies in cyclosporine treatment

[@tushar1618]

Any information about interactions between cyclosporine and hydroxychloroquine

[@sabhderma]

Thank you for asking this question. Hcqs may increase blood levels of cyclosporine, so we would need to keep an eye on the kfts and lfts, and the possible side effects. However, on a cursory literature search, i could not find any significant interactions between these two drugs.

[@tushar1618]

@@sabhderma thanks a lot sir

[@magadimaguda4493]

How to safely transition from cyclosporine to methotrexate in pustular psoriasis

[@sabhderma]

That is a nice question. I would suggest to first control the disease activity with cyclosporine, and then introduce mtx in lower doses, like 7.5mg a week. Then in phase 2, gradually build up mts while decreasing cyclosporine doses and taper off in 1-2 months, making sure the patient doesn't have a flare. Although personally, i would just manage the pustular psoriasis on cyp only, and taper off when the disease is cleared. 😊

[@yashwanthkumard5217]

Where can we get this ppt

[@sabhderma]

The ppt that I use is expanded in the video. So the video has more data and information. The ppt is only available on request to tier 1 premium members of the channel. 😊