why does the DNA only gets gut between histones? What prevents it from beeting cut at the curled around parts? Also Thank you for these awesome videos!
That is a great question. As DNA is replicated - or transcribed - nucleosomes dissociate from the DNA and reform behind the polymerase. There's a lot going on at the replication fork and the transcription bubble!
Though they make room for other proteins to bind directly to the DNA, the rest of the DNA is still bound up in nucleosomes. Chromatin remodeling is very dynamic.
Finally all DNA level structures well explained! No others videos like this one.
One of the most useful videos on this topic!
Thank you. I'm glad it helped.
I can't thank you enough for these videos!!!!!!!
I very glad they are helpful.
I have no words to thanks you
You are save my life
This is quality content!
The only video that helped. Thanks a lot. :)
I’m glad you found it helpful!
Thank you so much for this video! It helped me soooo much.
Glad you found it helpful.
Can you please tell us how all histone intract to each other in octamer and how h1 is bound
why does the DNA only gets gut between histones? What prevents it from beeting cut at the curled around parts?
Also Thank you for these awesome videos!
That is a great question. As DNA is replicated - or transcribed - nucleosomes dissociate from the DNA and reform behind the polymerase. There's a lot going on at the replication fork and the transcription bubble!
Tq
Dr. LeBlanc,
When MAR proteins attach and allow formation of radial loop domains, is the nucleosome still present or is it just DNA?
Though they make room for other proteins to bind directly to the DNA, the rest of the DNA is still bound up in nucleosomes. Chromatin remodeling is very dynamic.
Nucleosomes are present! The loop domains are made with the 30 nm fibers which contain nucleosomes.
wow thank u
Glad it helped.
In which book , are these lectures ?
i seriously wish you were my professor
Well, I guess I am! Good luck!