Lambert-Eaton Myasthenic Syndrome - pathophysiology, signs and symptoms and treatment

"Lambert- Eaton Myasthenic Syndrome (LEMS) is a neuromuscular junction disorder that was described by Lambert, Eaton and Rooke in the 1950s.
It is a disorder of calcium voltage gated channels in the preysynaptic motor neurons. The motor neurons supply the skeletal muscles. The voltage gated calcium channel do not allow calcium influx causing reduced Acetylcholine release into the synaptic cleft and thus reduced muscle contraction. LEMS causes muscle weakness which interestingly improves with activity unlike the other neuromuscular junction disorder myasthenia gravis which manifests as muscle fatigability.
Lambert Eaton syndrome is a paraneoplastic syndrome because of its close association with small cell lung cancer. Paraneoplastic syndromes are symptoms that occur at sites distant from a tumour or its metastasis."
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[@ptrlxc]

I have a cousin who has had to deal with this for over 20 years. She really struggles when her medication comes late. Would be nice if they could degenerate the Ca gated antibodies that target this area. But LEMS is very, very rare and funding (it’s always about the funding) for research is very limited. Thank you for doing this video. It’s helped me understand more her Syndrome. Of course I’m dealing with ME/CFS myself, which has a promising direction it never had before with tryptophan metabolism issues.

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[@veravero5715]

Great info
It is any special center or clinic who is treating LEMS?

[@theartisticautist3123]

That poor rooke
Thank you for the great explanation!!

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