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I appreciate your info so much. I must have 2 snips of the cc. I was on caffeine in some form since I was a kid, with cokes and chocolate, then tea, coffee, & energy drinks for the last 25 years. I was majorly affected with PMS/PMDD (irritability, OCD, anxiety, rage, hopelessness, paranoia, etc.) every month of my life and never knew it was from the way caffeine affected me. I also had other symptoms, like tinnitus, but I think my hormones were the most affected… I’ve been tired since I was 16, and just sucking down more caffeine adding fuel to the fire. My poor adenosine receptors - I sleep like a baby now, so thankful. Fortunately (I can say that now), I had a crash and I am now almost 26 months 💯 free, but I had extreme withdrawals, very similar to awful benzo suffers, but maybe not as bad, but it has not been fun. I believe I’ve been healing from the damage this drug caused me and I believe this gene mutation is why. My PMS, tinnitus, and other symptoms are practically gone. It’s amazing, but I had to go through some turmoil to get here. The quitting veterans ahead of me (there’s many of us), say it took them 3/3.5 years to completely heal and have their life back, with natural energy, and no symptoms… I feel close, but it’s been a journey for sure. Could this gene varient cause this while consuming and then the withdrawals while healing? Thank you so much 💚
Thanks, Mandy. That's really incredible news - I'm happy to hear you've been able to resolve those issues that plagued you so long. It's unfortunate you didn't run across my video on how to cut caffeine without the withdrawal symptoms, but you're through it now. I think the variant could have an effect, but there are other variants that are in other caffeine related genes that play a more direct role to what you're referring (I think it's called ADDORA or something to that degree). I don't have time to cover it at the moment, but hopefully in the future.
Good info. For years I’d said that coffee/caffeine quite often makes me sleepy and that I sometimes have a cup before bed to help me get to sleep. Yet, no one believed me. Most people I know get an energetic kick from caffeine, but I’ve never ever experienced that. Now I know I must be a very fast metabolizer. 😊
Back in the day, strong coffee got me as high as a kite!!! Now I have a tolerance, but I'm sure it impacts my sleep even many hours after. I'm sure I'm a slow metabolizer.
I have been trying to find any science behind caffeine and TRT. Before my low t I had to cut out caffeine. It’s was just too much no matter the dose. With low t I could drink 2-3 coffees feel nothing. Now I’m on TRT and one coffee had me up all night thinking ghost were in my room. Lol
Now I'm intrigued. I wonder why. I imagine the testosterone is playing a role in gene transcription (which is its normal role, so that's not a shock, but on caffeine metabolism - that's fascinating).
Maybe because t effects overall energy levels so increasing your T levels already shooted your basal energy and adrenaline levels and taking caffeine just overloads your already adequate levels of arousal
@@ozancanca9740 this is probably the answer, even though caffeine and testosterone might be different “types” of energy based on what they do in the body, there’s probably a lot of crossover in how they make you feel
In the past I could have drank 4 cups of coffee without any problems, I started to use Minoxidil and all of sudden I can barely tolerate half a cup, my blood pressure was all over the place with heart palpitations I hope i get it out of my system and go back to my normal self.
just like the comment from "hellie el". I don't know if i should quit or not. I can drink coffee and sleep whenever I want to. Last week i rode my bike for 5 hours and got a huge boost mid ride while climbing on coffee. it was so powerful. yet... it doesn't feel right to crave it as much and have a habit of making two a day at the exact same hours.
Jeez, I must have AA. Because I can down an energy drink and fall asleep within the hour. It doesn't affect me at all. I don't notice it at all unless I've had ridiculous amounts. I've gone cold turkey on the caffeine several times for various reasons and I don't get any withdrawals from it. Maybe the odd headache. My mom is the same. She used to wake up at night, not being able to fall back asleep so she'd get up, have a cup of coffee and play some solitaire and then go back asleep. We both have ADHD though so I'm not sure how that would interact with it.
At an early age i knew i had something wonkey goung on. Coffee made me sleepy, energy drinks too. I get no performance from caffeine a all. I should be considered as disabled, but whatever.
At 215 lbs, it takes a ton of caffeine for me to feel amped up, close to a gram I’d say… however, I’ve found that I need to quit consuming caffeine 10-12 hours before bed in order to sleep at night, even with just a cup or 2 of coffee… so I’m not sure what that means for me as a metabolizer
It's exactly the same for me , I have sleepless nights if I consume caffeine past 10 AM but at the same while weighting roughtly 120 pounds , 5 foot 5 I can easily tolerate up to 1000 mg of caffeine in tablet forms on a daily basis
@@gacusrunner2004 yeah i may have been wrong about my size being a major factor. I’ve leaned down into the high 180s, it seems to take less but i can still handle quite a bit before feeling “amped”
thanks for this series on caffeine. i’m always wondering if i should quit it or not. i’d like to ask you a question about genetic testing: how useful/vital do you think it is? how much can it tell you? are the tests all the same? sorry, that’s three questions.
Never apologize for questions - always happy to chop it up when I have time. I think caffeine has more benefit than downside, assuming you metabolize it well enough. As for the genetic tests - it really depends; I think almost no one actually *needs* one, but it can be extremely helpful in understanding where you fall (in or our of the average result in studies). I'll probably create a video going into more detail based on these questions - thanks, Hellie!
thank you nic. what i wonder about is whether longtime use of caffeine actually permanently changes your physiology, making it impossible to get off it. i’ve asked google about this, but cant find an answer. it has been the most difficult thing to quit - which is why i haven’t! i think a video (or three) on genetic testing would be wonderful! (from my selfish perspective, anyway)
I hear you. It certainly isn't easy to give up. I do have a video on how to become caffeine free - step by step without getting headaches. I used the method, myself. It does change your physiology, no doubt about it, but not permanently. The effects are anchored to if you are consuming or not and your pre-caffeine physiology will return once you quit entirely for a week or two. However, you will certainly feel quite different. In that situation, I really recommend focusing on your sleep schedule to supplement being off caffeine.
@@hellie_el the addiction is definitely worse than to tobacco or social media, at least for Me. I think the habituation has something to do with neuronal expression of endorphine-receptors, but I'm not sure if I recall this correctly. look into this topic. regards.
Was curious if you adapt a high tolerance to caffeine does that decrease the impact it has on your heart rate?/ Does it still raise adrenaline to the same extent and increase heart rate? Would it also still suppress appetite to the same extent or would you need higher dose?
Great question - yes, it does decrease the impact, but to what extent that is mediated by epinephrine and to what its mediated by adenosine, I don't know.
Im still confused by the reasoning of decreased performance in slow metabolisers, especially in physical activities that require almost no attention, e.g., running. In mental tasks requiring attention, I can understand that euphoria may lead to inability of focusing on a fixed object and, therefore, decrease in the performance. Maybe there's some correlation between long lasting caffeine effects and increased sensation of fatigue?
Performance: besides metabolism type, possibly depends on if one is an endurance athlete or what type of activity. -This idea came to me from a podcast that goes in depth on details from research: Dr Bryan Saunders (researcher) interviewed on The Science of Getting Faster.
This is because the oils in coffee get converted in the liver into a sugar, which goes back to the stomach via a vein; and this sugar has a magnetism potential with water; this means that your stomach (and digestive tract) have more sugar and water coming through, which causes bowels to stimulate. It's a process called osmosis, where the sugar draws the water via a magnetic potential. As Physionic said, it happens to everyone.
First Video in this Series: ua-cam.com/video/6M3uhAcmv5I/v-deo.html
Join my Physionic Insiders Community for exclusive content (and much more!): bit.ly/PhysionicInsiders
I appreciate your info so much. I must have 2 snips of the cc. I was on caffeine in some form since I was a kid, with cokes and chocolate, then tea, coffee, & energy drinks for the last 25 years. I was majorly affected with PMS/PMDD (irritability, OCD, anxiety, rage, hopelessness, paranoia, etc.) every month of my life and never knew it was from the way caffeine affected me. I also had other symptoms, like tinnitus, but I think my hormones were the most affected… I’ve been tired since I was 16, and just sucking down more caffeine adding fuel to the fire. My poor adenosine receptors - I sleep like a baby now, so thankful.
Fortunately (I can say that now), I had a crash and I am now almost 26 months 💯 free, but I had extreme withdrawals, very similar to awful benzo suffers, but maybe not as bad, but it has not been fun. I believe I’ve been healing from the damage this drug caused me and I believe this gene mutation is why.
My PMS, tinnitus, and other symptoms are practically gone. It’s amazing, but I had to go through some turmoil to get here.
The quitting veterans ahead of me (there’s many of us), say it took them 3/3.5 years to completely heal and have their life back, with natural energy, and no symptoms… I feel close, but it’s been a journey for sure. Could this gene varient cause this while consuming and then the withdrawals while healing? Thank you so much 💚
Thanks, Mandy. That's really incredible news - I'm happy to hear you've been able to resolve those issues that plagued you so long. It's unfortunate you didn't run across my video on how to cut caffeine without the withdrawal symptoms, but you're through it now.
I think the variant could have an effect, but there are other variants that are in other caffeine related genes that play a more direct role to what you're referring (I think it's called ADDORA or something to that degree). I don't have time to cover it at the moment, but hopefully in the future.
A/A is what mine it. Didn't know I could look up my gene like the with 23andme
Good info. For years I’d said that coffee/caffeine quite often makes me sleepy and that I sometimes have a cup before bed to help me get to sleep. Yet, no one believed me. Most people I know get an energetic kick from caffeine, but I’ve never ever experienced that. Now I know I must be a very fast metabolizer. 😊
Back in the day, strong coffee got me as high as a kite!!! Now I have a tolerance, but I'm sure it impacts my sleep even many hours after. I'm sure I'm a slow metabolizer.
I have been trying to find any science behind caffeine and TRT. Before my low t I had to cut out caffeine. It’s was just too much no matter the dose. With low t I could drink 2-3 coffees feel nothing. Now I’m on TRT and one coffee had me up all night thinking ghost were in my room. Lol
Now I'm intrigued. I wonder why. I imagine the testosterone is playing a role in gene transcription (which is its normal role, so that's not a shock, but on caffeine metabolism - that's fascinating).
Maybe because t effects overall energy levels so increasing your T levels already shooted your basal energy and adrenaline levels and taking caffeine just overloads your already adequate levels of arousal
@@ozancanca9740 this is probably the answer, even though caffeine and testosterone might be different “types” of energy based on what they do in the body, there’s probably a lot of crossover in how they make you feel
In the past I could have drank 4 cups of coffee without any problems, I started to use Minoxidil and all of sudden I can barely tolerate half a cup, my blood pressure was all over the place with heart palpitations I hope i get it out of my system and go back to my normal self.
just like the comment from "hellie el". I don't know if i should quit or not.
I can drink coffee and sleep whenever I want to. Last week i rode my bike for 5 hours and got a huge boost mid ride while climbing on coffee. it was so powerful.
yet... it doesn't feel right to crave it as much and have a habit of making two a day at the exact same hours.
Personally, I wouldn't worry about it. I think you're only getting a benefit, but I'll post more on the topic since people seem interested.
Thanks
Jeez, I must have AA. Because I can down an energy drink and fall asleep within the hour. It doesn't affect me at all. I don't notice it at all unless I've had ridiculous amounts. I've gone cold turkey on the caffeine several times for various reasons and I don't get any withdrawals from it. Maybe the odd headache.
My mom is the same. She used to wake up at night, not being able to fall back asleep so she'd get up, have a cup of coffee and play some solitaire and then go back asleep. We both have ADHD though so I'm not sure how that would interact with it.
Mine is A/C according to 23andme. Makes sense because Im very sensitive to caffeine. Even a cup of tea will keep me up and give me hives.
Cool, you checked?
@@Physionic yes with your information
Awesome :)
Histamine
I drink organic decaf but still get a buzz and some itching….
In recent years, I consumed a lot of caffeinated beverages and now I have high blood pressure. Am I a fast or slow metaboliser?
At an early age i knew i had something wonkey goung on. Coffee made me sleepy, energy drinks too. I get no performance from caffeine a all. I should be considered as disabled, but whatever.
At 215 lbs, it takes a ton of caffeine for me to feel amped up, close to a gram I’d say… however, I’ve found that I need to quit consuming caffeine 10-12 hours before bed in order to sleep at night, even with just a cup or 2 of coffee… so I’m not sure what that means for me as a metabolizer
It's exactly the same for me , I have sleepless nights if I consume caffeine past 10 AM but at the same while weighting roughtly 120 pounds , 5 foot 5 I can easily tolerate up to 1000 mg of caffeine in tablet forms on a daily basis
@@gacusrunner2004 yeah i may have been wrong about my size being a major factor. I’ve leaned down into the high 180s, it seems to take less but i can still handle quite a bit before feeling “amped”
What genetic test service should I use to check this?
So what if you feel the affects of caffeine within 30 minutes but still get tired after 2 hours?
thanks for this series on caffeine. i’m always wondering if i should quit it or not. i’d like to ask you a question about genetic testing: how useful/vital do you think it is? how much can it tell you? are the tests all the same? sorry, that’s three questions.
Never apologize for questions - always happy to chop it up when I have time. I think caffeine has more benefit than downside, assuming you metabolize it well enough. As for the genetic tests - it really depends; I think almost no one actually *needs* one, but it can be extremely helpful in understanding where you fall (in or our of the average result in studies). I'll probably create a video going into more detail based on these questions - thanks, Hellie!
thank you nic. what i wonder about is whether longtime use of caffeine actually permanently changes your physiology, making it impossible to get off it. i’ve asked google about this, but cant find an answer. it has been the most difficult thing to quit - which is why i haven’t!
i think a video (or three) on genetic testing would be wonderful! (from my selfish perspective, anyway)
I hear you. It certainly isn't easy to give up. I do have a video on how to become caffeine free - step by step without getting headaches. I used the method, myself. It does change your physiology, no doubt about it, but not permanently. The effects are anchored to if you are consuming or not and your pre-caffeine physiology will return once you quit entirely for a week or two. However, you will certainly feel quite different. In that situation, I really recommend focusing on your sleep schedule to supplement being off caffeine.
thanks! i must view your video!
@@hellie_el the addiction is definitely worse than to tobacco or social media, at least for Me. I think the habituation has something to do with neuronal expression of endorphine-receptors, but I'm not sure if I recall this correctly. look into this topic. regards.
why do smoking-habits matter? regards.
so if someone is amped up hours later his caffeine "effectiveness" is more as a straight line than a peak and drop?
It shoots up and doesn't degrade quickly back down, so yes, the down curve is much less steep.
@@Physionic thank you
Was curious if you adapt a high tolerance to caffeine does that decrease the impact it has on your heart rate?/ Does it still raise adrenaline to the same extent and increase heart rate? Would it also still suppress appetite to the same extent or would you need higher dose?
Great question - yes, it does decrease the impact, but to what extent that is mediated by epinephrine and to what its mediated by adenosine, I don't know.
Have you found any studies that compare the health effects of coffee vs red bull preferably sugar free red bull vs plain coffee?
Unfortunately, no.
Im still confused by the reasoning of decreased performance in slow metabolisers, especially in physical activities that require almost no attention, e.g., running. In mental tasks requiring attention, I can understand that euphoria may lead to inability of focusing on a fixed object and, therefore, decrease in the performance. Maybe there's some correlation between long lasting caffeine effects and increased sensation of fatigue?
Performance: besides metabolism type, possibly depends on if one is an endurance athlete or what type of activity. -This idea came to me from a podcast that goes in depth on details from research: Dr Bryan Saunders (researcher) interviewed on The Science of Getting Faster.
i'm A/C :)
Great! :)
🤣🤣🤣🤣 i can fall asleep in 1 hour what u will tell me now
Coffee makes me poop
As it does to many, my feline friend.
This is because the oils in coffee get converted in the liver into a sugar, which goes back to the stomach via a vein; and this sugar has a magnetism potential with water; this means that your stomach (and digestive tract) have more sugar and water coming through, which causes bowels to stimulate. It's a process called osmosis, where the sugar draws the water via a magnetic potential. As Physionic said, it happens to everyone.