From Lipotoxicity to Insulin Resistance: A deep dive | Will Bulsiewicz | The Proof Clips EP
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- Опубліковано 27 вер 2024
- Dive deep into the intricate world of insulin resistance and lipotoxicity. How does an excess of free fatty acids lead to metabolic disturbances? Why is the muscle cell's role in blood sugar regulation so crucial? Explore the groundbreaking research that unveils the microbiome's influence on these processes. Can walking post-meal or a high-fibre diet be the solutions we've overlooked? And what's the real impact of saturated and trans fats on insulin resistance? Join us on this comprehensive journey and discover the answers. 🤔 Ready to decode the mysteries of metabolic health?
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I love these shorter clips, much more digestible than the 2+ hour podcasts.
Same
Clean Keto is high fat (Extra virgin olive oil, Avocado oil and Coconut oil, not seed oils.) Moderate grassfed meats and eggs, high fiber from green salads and nuts (7 to 10 cups per day) supplementation and sugar free electrolytes. All fats are not equal, all proteins are not equal, and health and nutrients is the key.
@@georgelopes4589
My understanding is that all fats, olive or seed, inevitably block insulin receptors at the cell, thus inhibiting insulin signaling
similar to the way an abundance of ear-wax can interfere with sound waves reaching the eardrum-
...as a consequence, the person speaking has to crank up the volume
...likewise, the pancreas has to crank up the insulin
Natural catabolism of muscle as we age (sarcopenia) decreases the mass available to act as a sponge to mop up excess blood glucose. Because of this it makes sense that HbA1c & insulin markers rise and often remain chronically elevated leading to met syn, t2D and misc diseases of hyperinsulinemia. Yet another pathway
You mentioned Dr Taylor. He advocates for meal replacement shakes to bring weight down as quickly as possible. Would you support that (obviously opting for a plant-based product)? I am 64, 50 lbs overweight, and in a consistent state of pre-Type II per my A1C. I obviously struggle with weight even on a plant-based diet. Very frustrating!
Have you added some resistance training to your life? I have found that building some muscle while employing a plant based diet along with daily walking is a winning formula. Wishing you the best on your journey.
Im having the same Hba1c issue in post menopause. I’ve noticed muscle catabolism as I age notwithstanding I eat good amounts of protein but it occurs to me that bc muscle is a sponge for blood glucose it makes sense that the less muscle we have in aging the longer blood glucose remains elevated and over the long term this chronic elevation will affect the hba1c and insulin
Look into dr mcdougall. If you can't lose weight on the maximum weight loss plan then science needs to study you
So poly insaturated fats are not overloading the body with free fatty acids ? I would like to know what (and how) are they used for by the body ? membranes regeneration ? other ? why are they NOT stuck in the blood the same way as saturated and trans fats are ?
Sorry to be making a personal comment because I like and respect these two men's work, but I couldn't help noticing that this excessively muscly body shape has become more and more popular among men who end up looking like the Michelin Man and dare I say, fat. Men who exercise excessively to achieve this shape actually look fat to me, and often have a double chin like those in this video and don't look healthy either. What happened to the classic Greek body ideal, muscly yes, but lean rather than inflated and muscle-bound? Some of these Michelin Men don't even seem to walk properly or be able to hold their arms down in a normal way because of the excessive muscles and surely their skin becomes stretched as if they were fat instead of muscly, so if one day they stopped exercising they would become very wrinkly and flabby. I also wonder if there's some insecurity there when it comes to masculinity as this body-building really is excessive and unhealthy imo. I myself do weights and like to be toned and have some muscle definition but in a balanced way.
Great comment. I also belive in ancient-Greek (or Roman for that matter) mucle and body definition..lean and mean, not michelin😂
21:00 Yeah, polyunsaturated and saturated fats are really different, but I would worry more about using polyunsaturated. Also I would worry about my knowledge if I would put saturated fats and transfats into the same basket.
Funny hearing free fatty acids being used in place of glucose.
Can you discuss the difference between post prandial elevated triglycerides (happens after high fat meal) versus fasting elevated triglycerides? Many in the keto or low carb community consistently have low fasting triglycerides. What does one do who follows a plant based diet yet continues to have elevated fasting triglycerides? What modifications to a plant based diet have you seen that successfully lowers fasting triglycerides in those who are susceptible to such phenomena?
Keto diets promote fat adaptation- the utilization of fats for fuel. If you're using fats for fuel, you're taking them out of the blood. Low carb = low triglycerides. You can eat a low carb plant based diet.
but you are damaging your body long term by using an adaptative starving mechanism every day … just because you like animals products so much and you don’t want to live without them
I eat a mostly plant based diet low saturated fat and have low triglycerides. If you have high ones you probably still are not metabolically healthy. You are still have too much fuel, so you still need to loose some weight. I don't agree with this video fully though, there has been diabetes remission on low carb and whole food plant based. In my eyes it is the reduction of body fat that does the trick.
Is this possible to measure (calculate) calorie blood content per dL?
I wonder how this might differ between LC versus WFPB diets and individuals.
I would suggest that you increase or adjust lighting in the studio. Sometimes shadows make it look like Dr. B. has bruises on his right arm 😀
There's not a keto expert on the planet who's advocating low fiber.
What? The Keto diet relies on animal products (meat, dairy and eggs) Animal products contain NO fibre, so keto 'experts' ARE advocating a low fibre diet, by definition.
what a shame that animal products actually contains NO fiber then
@@soundstormdubai Exactly!
Why are you implying that keto diet is without fiber? That's as if I would say for example that vegetarian diet is high carb. It does not have to be.
I do not agree based on my experience. High fiber constipates me and causes my hemorrhoids' to recur.
You need to eat carbs too, it will help to keep you regular
If you ate high fiber zero way you would have constipation.
You need to drink more water when you eat more fiber.
You need to increase your fiber intake slowly. Don't go up to 30 g a day right away. Start where you are and slowly increase your plant intake slowly. Your gut microbiome needs time to adapt.
@@luluandmeowwhat he said is just opposite to what you want him to do, eat more fibre.
Ha ha they try to avoid saying high carb and instead they both are replacing with high fiber. I wonder why …
No need to wonder, “high carb” foods may also have little fiber in them, they aren’t the same, that’s why.
Twinkies are all carb and zero fiber.
Brown rice is all carb and high fiber.
"Carbs" can have wildly different fiber content and different metabolic effects.
How tf are we supposed to know if we have anything wrong with our microbiome?
If you eat like most people do, your microbiome is not likely to be optimal. Just increase your plant intake and slowly get rid of ultra processed and fast food in your diet. That will improve your health. If it doesn't, you have serious microbiome issues.
@@k.h.6991 you must of been top of your class
Follow up question. If a lower carb plant based diet will help with lower fasting triglycerides, any evidence supporting a specific increase in plant proteins and fats (except palm or coconut) with respect to carbs. Proteins tend to remain generally fixed whether plant or animal (humans have a protein satiation point?) so that would leave fats to increase. Does one get the same deleterious effects for post prandial high triglycerides with healthy plant fats?