No ETA right now as I will be finishing the energy metabolism course first, because right now I am getting BioOpt on its feet and the research I need to do for those two things is very similar whereas finishing the book will compete, so I need to do those things in order.
@americankulak4596 For curiosity, how long ago have you pre-ordered? I was perhaps interested in pre-ordering, yet will probably wait for the release even with if it's a slightly higher price
Hello , I absolutely love your videos and i really need a genius like you to hear my problem . i wanted to know that my hair and nails are too soft and my hair starts falling as soon as i start working out and have high protein diet and add creatine . My main sources of protein are chicken breast and whole eggs . My facial skin is awfully dry too and i am always irritated and can’t sleep . I avoid caffeine and religiously take L-arginine and citrulline malate . My vit D3 is extremely low and i am just 20 years old . What should i do ?
Need your help with lyme disease. When people take anything that kills lyme there are awful die off symptoms. Some people say to use Alka Seltzer gold to help. We "the lyme community" really need you to post something specific. Lyme is the single fastest spreading infectious disease.
don't have time to watch this yet but if lactate alkalinizes the muscles then why does baking soda help muscles under stress? I always thought because the alkaline baking soda slows down the lactic acid (lactate) from building up in the muscles.
Is there some specific reason you shortened the video but did not include a reference to your paid subscription? Or was it just by accident? Edit: I wanted to give it a rewatch but was unable to.
Could allulose potentially raise d-lactate levels? Dr. Benjamin Bikman discussed his work on how allulose greatly up regulates excretion of uric acid. This leads me to think that then d-lactate excretion would have to down regulated because of bottle-necking. No?
Chris what would happen if someone have mutation directly related to creatine synthesis because i noticed that my symptoms of "overmethylation" dissapear while suplementing with creatine and before that i tried few things like betaine,methylfolate with methylcobalamin,NAC(which didnt do anything),glycine(i couldnt tolarate that because my brain was turned off and my skin was getting really dry) those things worked for short time like 2-3 hours and then my symptoms come back and then when i suplemented with creatine i suddenlly can tolerate glycine and other things that seemed to worsen my symptoms. I dont have mthfr mutation and for me it looked like my body was overusing eveything related to methylation and wasting it in period of few hours after taking those nutrients.
I don't think it's overmethylation because creatine should increase methylation of everything except creatine. Creatine decreases glycine synthesis so that is easy to explain.
@@chrismasterjohn but isnt it true that mutation in creatine synthesis should lead to increased production of homocysteine and excess use of remethylating agents because body is in need for creatine so its forcing it but cant get enough?
my functional dr had me take 10,000mcg of methylated b12 within 10 days and now im having horrible side effects from it. i stopped taking it 5 days ago but im still having constant panic attacks, racing heart, racing thoughts, shaking, noise sensitivity etc. and its ruining my life. please tell me this will go away on its own and im not permanently damaged. i cant live like this.
@@DentalMarketingGuyit’s converted to a question contest, which is on hold but will resume in a couple of months. The format was regarded broadly by members as superior to the live Q&A and that format will not be restored.
31:50 The reaction is in fact balanced. One hydride, say, from the carbon, goes to NAD+, and the proton from phosphate goes to solution. But I do notice this lack of precision you refer to with regards to the stoichiometry of glycolysis in textbooks, especially when they abstract phosphate as ‘Pi’.
Ahh, I see your error now. That equation is not balanced. The H+ shown next to NADH is from the aldehyde group being oxidized at the top of G3P. The H on the phosphate is not balanced. You can argue, in this particular case, that the H+ from the phosphate is not stoichiometric and therefore should not be shown, but by not describing and justifying this in the text and yet depicting it in the diagram, they do nothing but sew confusion for anyone who cares about the proton balance. That H+ is not stoichiometric because it's a probability function of the pKa of the phosphate. However, the proton balance is higher than one, so leaving it out causes a serious error in the acid/base implications. Nevertheless the hexokinase, PFK, and pyruvate kinase reactions are stoichiometric and are left out of all the textbook stoichiometries.
Nonetheless I do appreciate your point about the other reactions, as I had wondered myself that protons were not being taken into account precisely with regards to the phosphates in the textbooks before watching your video. I had already figured from the pKa that in a physiological setting most of the phosphate would be H2PO4- and some HPO4(2-), but this was not sufficient in itself to have the complete picture on the acidity of glycolysis, as you have provided from your sources.
@@iagocorreia2458 Yes I am sorry you are correct and I was in error. It seems their approach is to add in the H to the PO4 here when they need it as a means to balance NAD+ 2 e- + 2 H+ --> NADH + H+ but otherwise ignore it. For example in pyruvate kinase they make the H show up out of nowhere because they don't need to relate it to the overall stoichiometry. Now that I think about it, they are basically just reverse engineering the balancing of the overall stoichiometry, simply because the overall stoichiometry is some kind of untouchable canon of glycolysis.
Is all this math based on in vivo? I have a hard time believing it really works that neatly in an individual. Since I haven't seen the proof on a real working muscle, i think there is going to be an update to this one day .
There is in vitro and in vivo research cited. I don’t know what you mean by “neatly.” What specifically do you expect to be messier in an exercising human?
@@chrismasterjohn there are many ways to explain this without going so fast and showing that your an expert try teaching to people who want to learn instead of showing off
There are different levels of discussion to be had. If a video is not at the level you are looking for, that is neither a reason for you to be offended nor any basis of responsibility for the creator to make a separate video at the level you are looking for.
@@chrismasterjohn so glad you care so much maybe you should turn the comments off so you don’t have to be trouble to do anything to help others. Just keep being you and showing off.
@@rcfyr6I’m sorry for making you feel like I don’t care about helping people at your level. I make a lot of different content at different levels, but I can’t make every video be for everyone. I’ll make easier videos on this topic but to be honest the tldr is “making lactate yourself is alkalinizing while taking lactate is not” and this is for people who want to understand why that is true, which requires going into chemistry.
The king is back 👑
Great to know that you are back, Chris. And with a very interesting topic (as usual). ❤
As always, great video. Hey Chris any idea when the book will be released? Appreciate all the knowledge.
No ETA right now as I will be finishing the energy metabolism course first, because right now I am getting BioOpt on its feet and the research I need to do for those two things is very similar whereas finishing the book will compete, so I need to do those things in order.
@@chrismasterjohn really cool. 😎 keep up the amazing work. Our health depends on it.
@americankulak4596 For curiosity, how long ago have you pre-ordered?
I was perhaps interested in pre-ordering, yet will probably wait for the release even with if it's a slightly higher price
Great information for us Chris about this mith. Thank you for share.
After long time you're back on UA-cam, welcome back!!
Hello , I absolutely love your videos and i really need a genius like you to hear my problem . i wanted to know that my hair and nails are too soft and my hair starts falling as soon as i start working out and have high protein diet and add creatine . My main sources of protein are chicken breast and whole eggs . My facial skin is awfully dry too and i am always irritated and can’t sleep . I avoid caffeine and religiously take L-arginine and citrulline malate . My vit D3 is extremely low and i am just 20 years old . What should i do ?
Good work, Brother in Christ ☦️
Need your help with lyme disease. When people take anything that kills lyme there are awful die off symptoms. Some people say to use Alka Seltzer gold to help. We "the lyme community" really need you to post something specific. Lyme is the single fastest spreading infectious disease.
don't have time to watch this yet but if lactate alkalinizes the muscles then why does baking soda help muscles under stress? I always thought because the alkaline baking soda slows down the lactic acid (lactate) from building up in the muscles.
No, it reacts with the protons to make CO2 and water.
Is there some specific reason you shortened the video but did not include a reference to your paid subscription? Or was it just by accident?
Edit: I wanted to give it a rewatch but was unable to.
Could allulose potentially raise d-lactate levels? Dr. Benjamin Bikman discussed his work on how allulose greatly up regulates excretion of uric acid. This leads me to think that then d-lactate excretion would have to down regulated because of bottle-necking. No?
Chris what would happen if someone have mutation directly related to creatine synthesis because i noticed that my symptoms of "overmethylation" dissapear while suplementing with creatine and before that i tried few things like betaine,methylfolate with methylcobalamin,NAC(which didnt do anything),glycine(i couldnt tolarate that because my brain was turned off and my skin was getting really dry) those things worked for short time like 2-3 hours and then my symptoms come back and then when i suplemented with creatine i suddenlly can tolerate glycine and other things that seemed to worsen my symptoms. I dont have mthfr mutation and for me it looked like my body was overusing eveything related to methylation and wasting it in period of few hours after taking those nutrients.
I don't think it's overmethylation because creatine should increase methylation of everything except creatine. Creatine decreases glycine synthesis so that is easy to explain.
@@chrismasterjohn but isnt it true that mutation in creatine synthesis should lead to increased production of homocysteine and excess use of remethylating agents because body is in need for creatine so its forcing it but cant get enough?
my functional dr had me take 10,000mcg of methylated b12 within 10 days and now im having horrible side effects from it. i stopped taking it 5 days ago but im still having constant panic attacks, racing heart, racing thoughts, shaking, noise sensitivity etc. and its ruining my life. please tell me this will go away on its own and im not permanently damaged. i cant live like this.
Sugar Alkohol and natural gas
Hey I bought the webinars program for a year but I'm not sure what to do because I think it's cancelled
It’s a subscription, so you can resubscribe. Either way this is free for a week.
@@chrismasterjohn right I'm saying I bought it but I read that the q and a webinars are cancelled after I paid. Is it being restored?
@@DentalMarketingGuyit’s converted to a question contest, which is on hold but will resume in a couple of months. The format was regarded broadly by members as superior to the live Q&A and that format will not be restored.
Ok cool I look forward to it. Glad to hear you're returning@@chrismasterjohn
I got out something better the different chemical process behind the way we breath
31:50 The reaction is in fact balanced. One hydride, say, from the carbon, goes to NAD+, and the proton from phosphate goes to solution. But I do notice this lack of precision you refer to with regards to the stoichiometry of glycolysis in textbooks, especially when they abstract phosphate as ‘Pi’.
Every textbook correctly balances the proton in the NADH reaction. None of them balance hexokinase, PFK, or pyruvate kinase.
Ahh, I see your error now. That equation is not balanced. The H+ shown next to NADH is from the aldehyde group being oxidized at the top of G3P. The H on the phosphate is not balanced. You can argue, in this particular case, that the H+ from the phosphate is not stoichiometric and therefore should not be shown, but by not describing and justifying this in the text and yet depicting it in the diagram, they do nothing but sew confusion for anyone who cares about the proton balance. That H+ is not stoichiometric because it's a probability function of the pKa of the phosphate. However, the proton balance is higher than one, so leaving it out causes a serious error in the acid/base implications. Nevertheless the hexokinase, PFK, and pyruvate kinase reactions are stoichiometric and are left out of all the textbook stoichiometries.
This is the reaction Lehninger wrote:
C3 H5 O3 PO3^(2-) + H PO4^(2-) + NAD+ = C3 H4 O4 (PO3^(2-))2 + NADH + H+
Definitely balanced.
Nonetheless I do appreciate your point about the other reactions, as I had wondered myself that protons were not being taken into account precisely with regards to the phosphates in the textbooks before watching your video. I had already figured from the pKa that in a physiological setting most of the phosphate would be H2PO4- and some HPO4(2-), but this was not sufficient in itself to have the complete picture on the acidity of glycolysis, as you have provided from your sources.
@@iagocorreia2458 Yes I am sorry you are correct and I was in error. It seems their approach is to add in the H to the PO4 here when they need it as a means to balance NAD+ 2 e- + 2 H+ --> NADH + H+ but otherwise ignore it. For example in pyruvate kinase they make the H show up out of nowhere because they don't need to relate it to the overall stoichiometry. Now that I think about it, they are basically just reverse engineering the balancing of the overall stoichiometry, simply because the overall stoichiometry is some kind of untouchable canon of glycolysis.
Is all this math based on in vivo? I have a hard time believing it really works that neatly in an individual. Since I haven't seen the proof on a real working muscle, i think there is going to be an update to this one day .
There is in vitro and in vivo research cited. I don’t know what you mean by “neatly.” What specifically do you expect to be messier in an exercising human?
I really wish you could explain this in a little less complicated way
It's part of a course, start at the beginning if you want to understand it.
@@chrismasterjohn there are many ways to explain this without going so fast and showing that your an expert try teaching to people who want to learn instead of showing off
There are different levels of discussion to be had. If a video is not at the level you are looking for, that is neither a reason for you to be offended nor any basis of responsibility for the creator to make a separate video at the level you are looking for.
@@chrismasterjohn so glad you care so much maybe you should turn the comments off so you don’t have to be trouble to do anything to help others. Just keep being you and showing off.
@@rcfyr6I’m sorry for making you feel like I don’t care about helping people at your level. I make a lot of different content at different levels, but I can’t make every video be for everyone. I’ll make easier videos on this topic but to be honest the tldr is “making lactate yourself is alkalinizing while taking lactate is not” and this is for people who want to understand why that is true, which requires going into chemistry.