A New Approach to Depression | Professor Edward Bullmore | RSA Replay
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- Опубліковано 9 тра 2018
- Professor Edward Bullmore, professor of psychiatry at the University of Cambridge, visits the RSA to reveal the game-changing new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycle of stress, inflammation and depression.
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Just started reading this guys book, but I have to say, his response to the question about diet has put me off going any further with it. The question asked was a bit silly however, as the main dietary intervention for inflammation would be to remove inflammatory foods, not throw a load of Curcumin into your body, hoping it will counter act the effects of all the other crap going in. I personally have cured my own depression, anxiety, insomnia, and intrusive thoughts with a paleo/keto/low carb approach to eating. The removal of grains, milk, and refined sugars brought the most benefits. It's not about 'super foods', or what you DO eat, it's about what you AVOID.
More of this kind of thing please RSA! Excellent talk.
He mentioned the immune system has a memory like an elephant, if you had a vaccination for small pox you will have a life long immunity. My question: in a social situation that causes infliction via stress whether because of family or social isolation, what is the body inflamed against? or is the inflammation the cause of the damage? where is the physical damage that enacts an immune response? because to me it seems the immune system has a memory spanning generations and what would be the risk in tampering with it? I feel as if we are blind to the unentended consequences.
I am already depressed, suicidal, and I had to survive that introduction? WTF?
Agreed. I almost bailed out because of that intro
Still strugging badly with depression. What can we do about it?
Quite Hillary ous
Hang on in there
Christ! It’s not all about you mate. Shut up and let the man speak.
So hard to hear him. They needed to turn his microphone up.
It's extremely frustrating that the sound is so low on this recording! I'm very interested, but I'm struggling to understand what he's saying & I'm giving up at the 10 minute mark
My mind was blown listening to this. I thank you for this eye opening learning experience. Long time sufferer here.
Interesting lecture giving insight into new and exciting approach to understanding depression. I've heard before about conservation of energy hypothesis and similarity in behavioral symptoms of depression and inflammation in primates. It's great to get some extra insight. Now I'm considering picking up 'inflamed mind' book.
Excellent lecture. Appreciated.
Great info!
Professor Bullmore is a mesmerizing lecturer. I could listen to him for hours. It's sad that it's 2019 and we still don't understand depression or obesity.
I find him so boring and exhausting. dont know why!
Or Cancer
That guy in the beginning really went great lenghts to talk about him meeting Obama and Bush lol
Totally 🙄
Which makes me question if it actually happend lol
What if late onset beta amyloid accumulation is a result of eating frequency and timing that interfere with the brains natural cleansing process during sleep?
In addition to eating non-proteinogenic amino acids from plants that could be incorporated into proteins like synucleins by errors in translation, casuing an autoimmune response when erroneous amino acids are detected.
My goodness what a rambling introduction. I wonder if he read my 2016 book on brain inflammation before he delivered his 2018 presentation
It sounds almost spot on, i strugle with allergies and allergy medz usually affects my mood ec....and drops my blood pressure too. Often I have inflamation because of back cussions moved. But then I also have to admit my hormones and dna have a lot to do with it. Recently my Mom and grandma admitted they had breakdowns at 35. But could it be that my Father made me believe Im never good at anything - childhood.
I used to be on serdep, I felt like a zombi and later side effects happen like headaces and light hurt my eyes.
Currently Im on Venlor. But I do have weekly dips regarding feeling depressed.
I just started Ketamine infusion therapy for long time deep depression and inflammatory pain issues. I'm happy to say that after the 2nd infusion the depression is completely gone and pain issues mostly gone. It's been several days after the 3rd infusion and it hasn't returned. I have been depressed most of my life and it is a miracle to feel good. I have 3 more infusions to go and I see a bright future in my life. Expensive? Yes. But worth every penny! This proved to me the theory that depression is an inflammatory process.
Be warned ketamine treatment is usually temporary...U will.most likely need it continuously or find another treatment that does the same thing..i.e inflammatory inhibiting
@@paulharrisonadventuregearm5457 Yes, the doctor told me that it varies from person to person on when they need another. I am also working with my diet i.e. avoiding sugar and other inflammatory foods. I hope I'm one of the lucky ones that don't need it very often. Thanks for the post!
I hope the treatment went well for you. Be interesting to see an update!
@@sweetsweetsleep...6149 hows the ketamine going
Great to see ''temporary treatment" working. Best long term solutions are lifestyle change once a person feels better. Hence, why depression is highly linked to hereditary - we learn how to live depressed lifestyles/genetics. Intense daily exercise, diet change, relationships/meaning, and daily sun exposure have been studied to be some of the best long term solutions.
At about 43:43 a man in the audience asks about “kerkamine”. He mentions that there are cultures that eat a lot of it and it’s proven to reduce inflammation. What is this? I’m obviously spelling it wrong as I’m not getting any google results for it.
It's curcumin. Found in turmeric, turmeric is considered an anti-inflammatory agent amongst a lot of other things. I don't know much about it but feel free to research more. I feel like if this was true, then the people who had turmeric in their diet, they would experience depression much less. India is the country that consumes the most turmeric and I don't believe they are any less depressed than the rest of the world.
Curcumin isn't easily absorbed by the body and there has been no science to prove that curcumin is beneficial at all really. Same with turmeric in general. pubs.acs.org/doi/abs/10.1021/acs.jmedchem.6b00975. Wouldn't hurt to try it but I wouldn't bet on it either.
I have never found Indians to be particularly happy or healthy people, though many have very bad diets and are overweight.
An inspiring introduction. Every Psychiatrist, Doctor, Therapist and person suffering with Clinical Depression should be made aware of this ground-breaking work.
If supported by further research, this could be one of the most significant breakthroughs in Psychiatry seen in the past 50 years. Depression, (not to be confused with the normal emotion of “sadness”) is one of the most widespread forms of disability of our times. Sadly, and I say this as both a therapist and a sufferer, the illness is often hard to treat with either “therapy” or standard antidepressants.
The inflammatory model brings together what is observed biologically and socially in terms of traumatic childhood events and ongoing life stressors (which via increased inflammation) may act as triggers for depression. It is also commendable that professor Bullmore has acknowledged the possible role of the Microbiome as another contributory factor in terms of fuelling inflammation.
Dr Bullmore’s presentation was clear, extremely measured and cautious. Nevertheless, like him, I hope this will lead to new treatments and diagnostic criteria within a generation or so.
Thank you Professor Bullmore for the work you are doing.
inflammation of the blood is mostly caused by bad diet that is mucus forming food, meat and dairy products and basic junk food, what do you think of that!
@@healthyone100 what's your point ,,,
@@garysimone4977 mucus filled blood puts pressure on the brain and causes brain disease's only fastings, strict vegan diet, exercise, fresh air, water and sunshine can cleanse the blood and take pressure off the brain, all disease start in the colon toxic waste from an unnatural foods is the cause, it takes a lot of work and patience to cleanse the blood!
@@healthyone100 that's a great way to live . , what would be a good fast protocol
@@garysimone4977 Thanks its the only way to maintain a healthy body,i've been on this regime for 37 years, its never to late to improve your health!
Very interesting talk. They need derivatives of Wellbutrin.
I applaud the fact that the lecturer owned up to being an employee of GSK.The lecturer seemed unaware that the malaise that frequently accompanies illnesses has been recognised and documented by doctors for many, many decades. Over the last couple of decades though, malaise has been rebranded as depression thereby opening up a vast new market for GSK et al. However from this lecture we can glean that the effectiveness of antidepressants on these patients is underwhelming - probably because most do not have a depressive illness. I do agree that the new technique of investigating the activity of genes and correlating it to unwellness and its improvement is fascinating in its potential and may yield effective interventions. And like some commenters, I would not be surprised if diet (including avoiding refined sugar) is discovered to be very important.
Thanks for your excellent comment. I agree. You might have interest in some of my videos and my book on brain inflammation
@@DrAlexVasquezICHNFM yes psych. Meds are posion as more and more studies are showing. BIG pharma will not go down without a fight
Volume is a struggle on this video.😑
FIND OUT WHAT YOUR CAUSE IS..IS IT SITUATIONAL YOUR SURROUNDED BY NEGATIVE INPUT..IS IT A BRAIN MALFUNCTION ...GET A BRAIN SCAN..GUARD AGAINST HARMING THE SELF FEELINGS CHANGE AND YOU ARE OF GREAT VALUE AND LOVED BY SOMEONE...REACH OUT TAKE A PROACTIVE APPROACH...
I'm shocked to see he has no knowledge on nutritional compounds, such as curcumin. There is a large body of quality evidence to support anti-inflammatory effects of curcumin - specifically interleukin-6 and COX-2. I don't doubt something like curcumin would significantly impact the microbiome but it's hard to imagine Ed wouldn't have a basic understanding of curcumins mechanism of actions beyond this. It could be used for his kind of interests, just as the engineer suggested... This very example is why we are so far behind in understanding key elements needed to draw accurate conclusions. I haven't read his book yet and was very excited about it but seeing this leaves me reluctant to say the least.
Avery mayheim. Yes lots of evidence see my post above.
But I am not shocked he's not aware of this and dismisses it.
That is the problem establishment doctors are not aware of this, not trained this way and don't think this way. Virtually all of the functional medicine doctors or train that way and stumbled upon diet nutrition for treatment and cure diseases in the years of their practice
What's the cause of inflammation at such a young age? And what about existential depression? would that cause the inflammation?
I think existential depression is just a symptom of depression itself. Once you're out of it, think about those big questions again and you'll probably see them as just curious doubts and totally able to think and stop think about them at will. As a person battling with a really awful depression, I'd like you to believe me, it is just a symptom and hopefully, you'll see what I'm talking about.
Cheers.
what a legend
More statements than questions in the Q&A
7:19
Thank you!
Thank you
Does any depressive here find that sleep deprivation alleviates their symptoms?
for me is worst if i don't sleep
Absolutely
Yes. I was sleeping every other day (+ 2 hr nap) for a few months, and it was great for my mood.
But it eventually wreaked havoc on my body. My eyes especially. And your memory is borked 1/3 of your waking hours.
I say do it occasionally as a shock treatment, but don't try to make it a maintenance med.
He didn’t answer the questions on diet! That was the most interesting bit
It's at 46 minutes.
Please adopt yoga practices in daily life and watch videos of U.G. Krishnamurti. Good luck.
Is This man aware of an addressing in his thinking a major part glutamine and astrocyte brain cells have on mental diseases both physiologic and genetic??
Someone with inflammation idiopathic in severe clinical problems as a child Who became depressed and had eating disorders Mikhail Peterson
apparently the interviewer interviewed a couple presidents - show off
The depression whisperer
I don't care about life anymore it's just an endless pointless battle
Ny City - i fear i agree with you....i mean, who else prays for a planet killing asteroid or other such cataclysm? ffs...
I feel the same.
Agreed
Wherever you and whatever you are doing, you should move somewhere where it is cheaper to live and start doing something interesting.
hey man, RELAX, talk to a therapist and say everything you need to say to him. You'll find that solutions generally are there, you just cant appreciate them because of your current state. You'll be ok!
Hola
anyone on here heard of DUTCH TEST to test neuro transmitters in brain
Yes! I just ordered one for my mom, excited to get the results
What causes inflammation? - Processed food, high sugar intake, lack of exercise/seditary lifestyle, and stress..so the high tech, urban lifestyle most people live now. The most effective solutions shown by long term mental health providers? -Get outside everyday for sunshine, daily intense exercise, whole food diet, no processed sugar, healthy relationships. Mostly 'free" but require lifestyle change and access to a clean environment. Medication does not cure depression.
Depression due to potential fraud
Stress issues due to potential fraud
Inflation due to potential fraud
All diseases due to potential fraud
All social issues and economic issues due to potential fraud.
What is the solution for this matter?
potential fraud
I know the cure! No I really do!
We could have easily done without the introduction and its political hints.
Any one who submits to psychiatric drugs and benzos have just been sentenced to HELL.
Life is inherently stressful... how do you eliminate stress from life? It's a contradiction to the inevitable survival struggle.
Some people experience more stress than others.
Some people can handle more stress than others... you can't simply takeaway stress.
Stop being weak
Nietzsche said that that what doesn't kill you makes you stronger. I don't think that he fully understood the autoimmune system or indeed many things. What does it mean to be really strong or healthy as opposed to more resistant to specific threats?
incompoter ´
That’s one way to compound people’s depression….by bringing to our minds, B.H.Obama.
Yes yes yes, you met Obama, the fake Nobel peace prize, SO WHAT. 🙄 Tedious intro, just shut up and let the man speak!
Excellent talk. Introducer is most irrelevant, flippant, and just plain goofy MC I've ever seen for a serious talk. His intro and questions are asinine. Prof Bullmore was exceedingly gracious.
Carnivore Diet,Exercise,Sleep.
After a lifetime spent consuming toxins, propaganda, and porn what would you expect. Love the stuff on SOC this smells too much like GB PR loads of much better presentations by Michal Schwartz...tooth ache :-/
Fraud word is very very dislike in world society to everyone,if everyone do dislike it,why is main purpose and focus in the world society. Why you create the confusion to everyone?
Who picked the guy doing the introduction?
Such a shame considering the distinguished intellectual speaker that was presenting.
Quack. Ridiculous excuse for science. Might as well say you have no bloody idea at all but glaxo will hopefully make a mint from the posters.
Yes, Big Pharma pays me £100 for every post on UA-cam - easy money!
I have experienced clinical depression for 25yrs. I think this man is definitely on to something. I can feel inflammation within myself, literally. My brain literally feels sore, and my body leaden. Also, when I try a high dose of an anti inflammatory such as ibuprofen, I notice my mood changes.
I am intending to go on a trial of his as soon as possible.
I would just like to take this moment to point out that the only video you have uploaded is from someone claiming to be God, who said that salvation could be achieved through worship of him.
Hardly a quack...
who is this fake Jordon Peterson british knock-off ?
Happiness is a choice
Shows how little you know
Easily said.
Is it a choice akin to sexual orientation? Can you describe how you personally decided this? Is diabetes a choice? How did you decide to have or not have this illness? Why do you think some people choose to have it? Is being poor a choice? Can you describe the process by which you chose your parents, place of birth, & genetic makeup?
not for people with depression
What a stupid, uninformed comment.