Coronavirus SARS-CoV-2 structure
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- Опубліковано 6 жов 2024
- As of March 17, there are over 180.000 people infected worldwide by the new coronavirus SARS-CoV-2, which can cause the coronavirus respiratory disease COVID-19. Recently the WHO named the outbreak a pandemic and now globally cases are rising sharply, outstripping the Chinese cases.
As the outbreak of the disease is reaching a high number of countries all over the world, the general public awareness and scientific interest are also on the rise. Currently, the virus virulence, how it is transmitted between humans and the possible treatments of the disease are being actively studied. As there is already a lot of information available, we have here gathered the known information on the molecular organization and structure of the virus, thus creating a dynamic and scientific accurate 3D animation of SARS-CoV-2!
We hope you like it! If so, please support our work by subscribing to our channel and visit our website focused on 3D animations of diverse biological processes: visual.biolutio....
Thank you!
Correction:
The video mentions that ACE2 cleaves the spike protein, however a publication published on March 5, 2020 showed that cleavage by the protease TPMSSR2 is required for priming the spike protein for viral entry: doi.org/10.101...
Thanks to Mikail Dogan, norm1124 and Levent Cavas for pointing this out!
We also apologise for referring to the hemagglutinin protein, which is of SARS-CoV. Instead SARS-CoV-2 contains a so called M Protein in the envelope. A correct Figure is here: www.ncbi.nlm.n...
Thanks to colicinK and Mike Sauder for pointing this out!
Please feel free to get in touch with us if you are interested in scientifically accurate high-quality animations. Email: office@biolution.net //
The structures used for the video can be found here:
M-protein: PDB ID 3cl4
E protein pentameric ion channel: PDB ID 5x29
Nucleocapsid: PDB ID 2GIB
Spike protein: PDB ID 5i08
Here some links with regularly updated information about the new coronavirus:
World Health Organization - WHO: www.who.int/he...
Johns Hopkins Center for Systems Science and Engineering: gisanddata.map...
American Centers of Disease Control and Prevention: www.cdc.gov/co...
#coronavirus, #covid19, #SARS
Many different drugs and therapies are being trialled and used on patients with Covid-19 and rapid progress has been made not only with vaccine developments. There are some positive results, which may be beginning to bring the hospital death toll down, but there is still a long way to go towards something a cure all. In our video we mention Remdesivir and convalescent plasma, and research has shown they are working, but here are 4 others, which have received some attention recently, we did not kow about when our video on potential COVID-19 treatments was made. Not so surpringly chloroquine is not the game changer: ua-cam.com/video/jw2OvPnx_lQ/v-deo.html
1. Dexamethasone
This is the success story - a very cheap drug, in plentiful supply around the world - that has been shown to save lives. The low-dose steroid was responsible for the survival of one in eight patients on ventilators during the Oxford University-based Recovery trial. The results were announced in mid-June and the steroid is now standard treatment for the sickest patients. The data is reliable because it comes from the biggest randomised trial of Covid-19 treatments in the world, involving almost all hospitals in the UK. Dexamethasone has been around for 60 years, so is out of patent and cheap.
2. Tocilizumab
A number of anti-inflammatory treatments are being tested to see if they can help. When the immune system responds to the coronavirus, it can cause inflammation. Tocilizumab, an antibody normally used to treat rheumatoid arthritis, is given by injection to block the inflammatory protein IL-6. Patients given the drug during the serious Covid-19 outbreak in Italy in March appeared to benefit and were less likely to end up on a ventilator or die. But the numbers were relatively small and this was an observational study, not a randomised trial set up to judge the outcomes of people with and without the drug. The Recovery trial is also investigating Tocilizumab. Roche has said that recent trials have been disappointing, but the company wants to explore other ways of using the drug.
3. Blood pressure pills
Scientists think people on medication because of their blood pressure would be well advised to stay on it. A paper from the University of East Anglia found that the risk of critical illness or death from Covid for people with high blood pressure was found to be significantly lower if they were taking angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). That does not mean those drugs would be helpful to anyone with coronavirus infection who does not suffer from high blood pressure.
4. Inhaled interferon beta
A small study from scientists at Southampton University suggests that an inhaler containing the drug interferon beta, used to treat multiple sclerosis, could be effective. The three academics behind it, who formed a spin-off company for their product in 2004, became paper millionaires when they announced the results of their trial on Covid-19 patients in July. The trial involved just 101 patients at 9 hospitals. Those inhaling the drug left hospital sooner and were more likely to recover, but the data was not published in full. Larger trials are needed.
(taken from an article published on August 24 in The Guardian: www.theguardian.com/world/2020/aug/24/six-of-the-most-promising-treatments-for-covid-19-so-far?)
Test lsd
I did not find this number for the US, but for the UK iti is about 79, so it ie entriely possible. But are you insinuating old people have no right to live, or at least you are not willing to contribute to their safety by wearing a mask? The shame should be on you!
And young health adults have died from what?
When a scientist unveils every detail on the subject in a paused voice you know for sure that it really got serious.
Now we know that the real heroes are people who dedicated their whole life to science and education. These are the ones who deserves recognition.
Looking at some of the health and economic data make us feel it is pretty serious indeed.
But the stupid world will soon forget the scientists and engineers who run and sustain the world; they will turn back to praising boxers, singers and cheap instagram thots. Humanity needs to evolve into a collective reason-driven hive mind.
Voice: My name is Giovanni Giorgio. But everybody calls me, Giorgio.
Sorry, can i take this video to talk about Covid-19 in Arabic or french plz ?
Can we change the genetic material of the virous RNA and make them to fight there self
And I said, "Wait a second, I know the synthesizer
Why don't I use the synthesizer which is the sound of the future?"
And I didn't have any idea what to do
But I knew I needed a click so we put a click on the 24 track
Which then was synced to the Moog Modular
I knew that could be a sound of the future
This comment better be a jojo reference
@@Umayyadazi not at all.
A daft punk reference. ua-cam.com/video/5m4ZkEqQrn0/v-deo.html
The outbrake is sometimes we feel is due to deforestation and urbanization - due to which the viruses of animals are becoming viruses of humans as well because the gap between wildlife and humans is vanishing.
Sometimes I think Humans are also like a virus to earth :-
*Spreading Rapidly
*difficult to destroy the over population (due to machines)
*consuming resources as hell
*looking to go to another planets(kind of cells) in universe
nah
Homo sapiens, humans, are animals. These sort of viruses are zoonosis, i.e. they were initially in other animals, but now infects other species as well. In Wuhan this happened, because on a fish market they store different animals in the same cage and/or close by each other, thus the chance of viruses to become zoonosis is increased. This is not exactly because of deforestation and/or urbanization.
Are you a scientist?
Yes you are right, it is not directly related to deforestation but The exploitation of wild life is. But again as Bill Gates said More of these Virus Jumps can happen in near future. So indirectly The deforestation, defying the idea of co-existance, Not respecting wild animals and their space in earth would lead to other pandemics as well. Just my thoughts :) Stay Safe and Stay Healthy
That was another scenario virologists were fearing. But wet markets in China were always the greatest concern.
This animation is so fluid 👍
I was going to say that wow amazing animation here props to who made it should give them credit
@@chillgamer8376 thanks for the appreciation! Our graphic designer Christian Müller is a real star!
We got sick in January 10th and then my son on the 18th in Costa Rica.
I asked my health professional what was happening and he said it was a tropical flu.
Symptoms
Head ache 3 days before symptoms appeared.
Bone breaker 1st
Fever that night.
3 days of pain and discomfort.
Very dry Cough lasting 3 weeks.
3 am coughing attacks when laying down on our backs.
Dry cough, like saw dust stuck in our lungs. Nothing would come up.
It was painful.
My son 14 years old. I'm a smoker and 54 years old.
Exact same symptoms exact same cough.
Lasted about the same amount of time for us to recover.
It did notable damage to both our lungs as we had trouble breathing and doing heavy cardio afterwards.
We had morning cough like smokers cough for weeks after we recovered.
After 2 months we are both good and respitory system back to good working order.
What did we have?
I can't get a straight answer.
Well this requires a medical professional to assess.
I hope you're working on another COVID-19 related video. Your detailed explanations coupled with the animation is inspiring to learn more from such content.
Thank you for your appreciation, we are currently working on a video summarising some of the treatments currently explored for COVID19. Will be online this week I hope.
I feel so lonely in my home, no family with me🥺
This won't last forever. Stay safe my friend.
It is worth it for now, if you look at Italy.
Good! Noone to tell you what to do.
Play game pc or android dude
Dear Biolution, I congratulate you for the impressive animation. I would like you to suggest to prepare a new animation. Because there is a great need for this. As you might know, SARS-CoV-2 needs two protein from host cell: ACE2 and TMSSR2. ACE2 is angiotensin converting enzyme 2 and TMPRSS2 is transmembrane serine protease. It would be very nice if you can prepare an animation related to binding of spike protein of SARS-CoV-2 to ACE2. As you also might know that this is not enough for virus to show its effect on host. Other protein, TMPRSS2 is also needed for priming the spike protein of SARS-CoV-2. I think this could be animated and it is needed. Thanks in advance, Levent Cavas, Dokuz Eylul University, Department of Biotechnology, İzmir-Turkey
Thank you for your trust in our abilitities!
This would be quite a project, we considered to show the cleavage of spike by ACE2 and looked at the structures. Not so simple! We'd gladly do it if we can find someone to pay for this work, but for TMSSR2 not even a structure is identified yet.
@@biolution are you a team or an outsider? how can i help? albertogallardas@gmail.com
@@albertogallardas1864
They are not A-Team
Not ACE2 but TMPRSS2 protease cleaves the S protein. ACE2 is the primary receptor.
You are right, the text under the vid is now pointing this error out! Thanks for pointing this out.
+ACE2 docking
+TMPRSS2 Schnitt
+Polymerase
Danke für das Video
thanks!
I really hope you guys get more views. Amazing animation!
thanks for your appreciation, we hope so too!
wow! moorrrreeeeeee... make us an animation documentary which goes into detail about the complete mechanism from a to z my friend we need it thanks.
Yea, like where's the detail?
Researchers underestimate the public. Also secrecy = profit.
Thanks for your encouragement, we would love to do this. But these vids are an enormous amount of work and we really need someone to financially support us to take on such an enormous task with many challenges
@@biolution call Bill Gates. He's *loaded*.
thanks for the tip. He is also quite busy I hear...
heh hehe, yes i understand, but at the same time its also the best time to make it. i can chip if there would a funding. but it wont be so much but if we have enough people it might be possible. theres allot of parts we can use from this video
Very nice presentation, I sure people appreciate video better if you'll put russian and spansish subtitles.
We will have Spanish soon and are grateful if you do a Russian version. We opened the vid up for community contributions in subtitles and translations.
Hard to believe this is a year ago. jeez and its still going
more than a year, even!
I believe there are options for prevention and treatment that entail two possible approaches: We know the primary avenue of attack are the lungs, and once in, they attach by means of the spicules or "spikes". Their primary target or "receptor" are the ACE-2 or angiotensin-converting enzymes, same as that of SARS-CoV, on the epithelial cells of the lungs. Right there is one strategy for a form of intervention using nebulized or detached bonding receptors, akin to chelators or in fact serpins, serine protease inhibitors.
Beside Remdesivir, Pyridone type inhibiting compound 13b will likely emerge as promising along these lines within the body. This compound disables the sars-cov-2 cleavage enzyme on the attachment spikes. Since this is a papain-like enzyme, the inhibitor will not affect the human serine enzymes, like trypsin, amylase, etc.
It could be used externally as well to attach aerosolized virii and they'll be inactivated even if they are inhaled.
Another approach is in terms of direct digestion of the virus by hydrolases like amylase, trypsin, chymotrypsin and lipase. Intramuscular injections of amylase and trypsin were proven to resolve malaria very effectively by Lambelle in the early part of the 20th c. The ratio of amylase to trypsin was 2:1, and was well tolerated. His paper is available as a pdf. While malaria is not a virus, the process of infectant inhibition of native enzymes taxing the whole system is akin and the strategy of bolstering it is rational.
It is worthwhile to also research the potential of external nebulized colloidal silver in air systems and bound to fiber masks, as an effective means of external denaturing the virus. As for inhaled nebulized colloidals, I am not aware of its possible utility or risk one way or the other.
Paper on Compound 13b:
science.sciencemag.org/content/early/2020/03/20/science.abb3405.full
For structure of viral components, also see:
www.sciencedirect.com/science/article/pii/S0092867420302622
I am afraid Dr. Lambelle's article is not available in pdf, but a transcription I did of it is still available at a mirror of my old website:
robertcathey.wordpress.com/the-utility-of-enzymes-in-malaria-by-f-w-lamballe-m-b-major-royal-army-medical-corps/
Lambelle, F. W. (1913). Journ. R.A.M.C., Vol. XXI, p. 660.
John Beard's letter to Nature re Dr. Lambelle's work. (The transcriptionist at Nature misspelled Lambelle as "Lamballe".)
www.nature.com/articles/092060c0
Thank you for sharing your excellent scientific insights, we are currently working on a vid on potential treatments, including convalescent place, soluble ACE2, protease inhibitors and remedesivir. Once it is only we would like to have your opnion!
and did you see the work by Rolf Hilgenfeld and colleagues on a protease inhibitor: science.sciencemag.org/content/early/2020/03/20/science.abb3405
@@biolution : That is the first link in my original comment, so yes. 😉
ah, yes!
Practically all cases happened after 2019 so would it not be more useful to call it Coronavirus Disease 2020 (COVID-20)?
It was isolated in 2019 and this determines the name. This makes sense as in the past without advanced sequencing molecular definition was laboursome and lengthy. Calling it after the number of infections makes little sense, as this is something we only know later.
Lawrence No, the virus started in the middle of November.
Very informative, thanks. Though I suggest a less distracting background music, or even no music at all.
I have to disagree
tastes are just so different, can't get it right for everybody unfortunately.
cezarius are you disgreeing with the informative or the choice of music?
@@biolution what i meant to say was that I enjoyed the music. I'm sorry for the misunderstanding.
@@cezariusus7595 thanks for your clarification. We appreciate your feedback!
this video its going to help me a lot whit my online clases
glad to hear it!
Coronavirus is not a joke don’t make it a meme it’s serious
The animation is amazing 👏 this video made me feel how amazing life is
Thank you!
2600 years back Loard Buddha has discribed in Buddism that what kind of flesh is most dangerous and harmful also not to eat
1. Human Flesh
2. Elephants Flesh
3. Lion Flesh
4. Tiger Flesh
5. Leopard Flesh
6. Reptiles Flesh
5. Bears Flesh
7. Dog Flesh
8. Horse Flesh
9. Cats Flesh
10 Fox Flesh
In buddism discribes very clearly that when the people starts to eat these flesh then the human being would be facing to many critical deceases like virus and cancers.that doesn't mean that other flesh are good.but Loard Buddha's teaching and philosophy is about 100% non cruelty and harmless practices for every live being and even the nature.Loard Buddha's teaching is every being has a right to live and nobody has a right to kill others.when the people kill animals,people collect sins and curses in their solves also may cause and result for accidents,deaths,disabilities or punishable incident.after the death they will be born as animals and invisible devils lives and may suffer for millions of years.untill the humans realize this reality,the entire world will face to many critical and horrible disaters in the future.May triple gem bless you 🙏🙏🙏❤️The Buddism is not a religion.it's a philosophy.it's discribes practice of the supreme power of " Nibbana " (Quite birthing) and the reality of the world and the universe.modern technology or any religion can never defeat it and those are discribe and contains only 0.00001 of what buddism has revealed.that's why even Albert Einstein had predicted that in 2050 the main religion in the world would be Buddist philosophy.it has no rules and regulations or restrictions like in other religions.any one can follow or leave Buddism 🙏
Celebrities and Famous Characters those who have converted in to Buddism 🙏
.gio, soccer (football) star for Italy
Mario Balotelli, soccer (football) star for Italy
Fabien Barthez, soccer (football) star for France
Orlando Bloom, English actor
Kate Bosworth, American actress
David Bowie, musician, writer, actor
Abby Brammell, American television and stage actress
Jeff Bridges, American actor
Jackie Chan, actor
Tisca Chopra, Indian actress
John Cleese, actor, writer
Leonard Cohen, Canadian singer/songwriter/poet
Combat Jack, hip hop music attorney and executive
Penelope Cruz, Spanish actress and model
Manuel De Peppe, Italian actor, musician, songwriter, producer
Patrick Duffy, actor
George Dvorsky, Transhumanist, futurist
William Ford, Jr., Executive Director of the Board at Ford Motor Co.
Boy George, British singer-songwriter
Richard Gere, American actor
Allen Ginsberg, poet
Philip Glass, composer
Herbie Hancock, musician
Dan Harris, American journalist, anchorman Nightlinenews show
Goldie Hawn, actress
Hermann Hesse, Noble Prize winning author
bell hooks, author
Kate Hudson, actress
Michael Imperioli, American actor
Phil Jackson, Basketball coach of the NBA's Los Angeles Lakers
Charles R. Johnson, Writer, academic, artist, philosopher, Black American literature scholar
Angelina Jolie, American actress, humanist activist, Goodwill Ambassador for the UN Refugee Agency
Steve Jobs, CEO of Apple Inc.
Ariya Jutanugarn, professional golfer
Jack Kerouac, author, poet, painter
Miranda Kerr, Australian supermodel, one of Victoria's Secret Angels
K.D. Lang, Canadian singer
Jet Li, Chinese martial artist, Hollywood actor
Jennifer Lopez, actress, singer
Courtney Love, American singer-songwriter
George Lucas, American filmmaker, director of Star Wars
Naima Mora, fashion model
Alanis Morissette, Canadian singer-songwriter
Maya Soetoro-Ng, university professor, sister of U.S. president (Barack Obama)
Ellison Onizuka, U.S. Air Force colonel, NASA astronaut
Kenneth Pai, Chinese-American writer
Sarah Jessica Parker, actress, producer
Victor Pelevin, novelist
Brad Pitt, actor
Ron Reagan, talk show host, son of former U.S. president (Ronald Reagan)
Keanu Reeves, American actor
Alex Rodriguez, American baseball player
Mehmet Scholl, soccer (football) star for Germany
Steven Seagal, American actor and aikido expert
Wayne Shorter, American jazz saxophonist and composer
Russell Simmons, Entertainment and Fashion Mogul
Sting, English singer-songwriter, lead vocalist of The Police
Oliver Stone, film director
Sharon Stone, American actress, producer, and former fashion model
George Takei, American actor, "Sulu" on Star Trek
Uma Thurman, American actress
Thuy Trang (1973-2001), Vietnamese American Actress
Tina Turner, American singer-songwriter
Alice Walker, author (Color Purple and others)
Marcia Wallace, American actress
Naomi Watts, British-Australian actress
Dennis Weaver, actor
Ming-Na Wen, Chinese American Actress
David Woodard, American businessman
Tiger Woods American Golfer
Elaine Wynn, Wynn Resorts, charities
Steve Wynn, CEO of Wynn Resorts Limited, Las Vegas
Adam Yauch, American musician, director, producer, Beastie
Michelle Yeoh, Malaysian actress
Mark Zuckerberg, Facebook CEO, philantropist
Buddhist politicians
Bill Clinton, U.S. President (1993-2001)
Colleen Hanabusa, U.S. Congresswoman (2011- ) from Hawaii
Mazie Hirono, U.S. Congresswoman, (2007-2013) and U.S. Senator (2013- ) Democrat from Hawaii
Hank Johnson, U.S. Congressman, (2007- ) Democrat from Georgia
Eric Lubbock, United Kingdom, elected member of the House of Lords
Rosa Parks, U.S. Civil Rights activist
Travel Tec & Tours Sri Lanka "He is ALLAH , the one . ALLAH , to whome the creatures turn for their needs . He begets not , nor was He begotten , and there is none like Him"
TL;DR
this virus came from Pangolins though, didBuddha say nothing about them?
@@Yassinehadiri When USA was bombing on muslims,where was Allah.? Allah is not a god.he was the father of Nabi who killed thousands of people to spread islam world wide
@@biolution Buddha has nothing explained about each and every virus.his teaching is path to supreme enlightenment.but he has explained publicly about world disasters and the end of the world.
Muito explicativo! Obg.
Thanl you!
i almost went on a trip to mexico to see my fam right before we got the lock down order. i almost got stuck with my fam. but we decided it would be better to stay. if we just decided to go and deal with the consequences, i would be surrounded by my awesome family, which would have been the best thing to have happened to me in this situation. i love my family.
Thanks
Thanks for the video, it helped me alot in my quest for its cure
You can’t cure a virus. There’s vaccines to prevent it.
There is a summary out on the molecular architecture of SARS-CoV-2, which shows all we know about the virus so far: www.sciencedirect.com/science/article/pii/S0092867420311594
I just got covid 19 and it's getting worse every day! Btw good video! Hope people are safe.
hope ypu have had your vaccine and you will get well soon!
Excelente explicación. Creible y didáctica. Mi enhorabuena.
Gracias!
So how does Moderna intend to inhibit the spike proteins interaction with the ACE-2 receptors?
Moderna explores a lipid nanoparticle (LNP)-encapsulated mRNA vaccine encoding for a prefusion stabilized form of the Spike (S) protein. THis is expected to generate an immune response against he spike protein, resulting in antibodies blocking the interaction between spike and recptor ACE2. see our vid on potential COVID-19 therapies ua-cam.com/video/jw2OvPnx_lQ/v-deo.html
Why did you stop there? Show how it infects a human cell. Geeez!
Thanks for your trust in our abilities and the encouragement. Happy to go for the second part, once we get it funded. If you have a few thousand € to spare send them over! (and no revenue on ads will not even get close to cover production costs)
But i l studied in my local news paper recently it was attached in London on February.17. 2013 .and one death also reported on that day.it happened in
Queen Elizabeth hospital Birmingham
How chloroquine comes into picture? where it is binding?
Chloroquine, like other drugs (ie remdesivir) potentially inhibit replication of the virus in the cells. Some people think chloroquine works by altering the pH in the lysosomes, but the mechanism is unknown. It is not presumed to bind the virus.
Providing soluble ACE2 could prevent entry of the virus.
Chloroquine makes the cell permeable to zinc... and zinc is very important in inhibiting the viral replication
Chloroquine inhibits SARS-cov-2 because it binds to ace2 receptors on human cells, therefore preventing the virus from attaching itself and infecting the cell.
@@dr.brindha Would it not be easier to starve the body of Arginine? Hence starving the virus of essential ingredient for replication.
Paul Freedman I don'T think this is the proposed mechanism of chloroquine
English caption please, sometime too noisy here, so I need to read text
I came after the events of 2 days ago
Thank you, very detailed!
there is more to come soon!
What do the purple and white bits attached to spiral RNA strand represent?
nucleocapsid proteins package and condense the RNA genome
The quality of Russian products is famous for its quality and safety, Russia has many scientists who are excellent in biology, chemistry and genetics, they are also very reputable, experienced in pharmaceutical production. In opposition to Russia, Chinese pharmaceuticals are of very bad and toxic quality.
There is a lot of feedback from the people about the accidents of western countries, while the Russian vaccine first with good and safe prevention features is pressured by the US.
Russian researchers famously performed very well even under the communist regime, despite sometimes difficult conditions. Clearly after the dissolution of the Warsaw pact Russian science was hit hard with many well educated academics leaving the country.
In contrast Chinese science has a very different tradition and is organised completely differently. Nevertheless the advances Chinese research institutions have made in the last decade are enormous and there is much to watch out for in the future.
this is super informative thanks
thank you!
It doesn't take much to know that it is a biological weapon.
It doesn't take much to know who owns the patents.
Even more scary is that something this lethal just arises spontaneously. Most scientists (including me) did not even understand the lethal potential of this virus. Certainly would not have planned it this way.
Coivd: this is not my final from
It looks beautiful to me somehow.
ZELENG ZHUANG for me it looks like I may throw up soon 🤢🤮
Beautiful but painful
Wow....
After doing numerous research on the web , I found an interesting article dating back to 1918.
When the Spanish flu killed an estimated 50 million people , nurses found out that by taking patients outside when the temperature was warmer , patients got better . This telling me that the virus needs colder temperature to survive ...
There are other ways to explain this. Viruses are certainly sensitive to UV Radiation. Certainly best way to protect yourself is vaccination.
@@biolutionohh really.. vaccines.. okay but it turns out that you’re either lying or not very good at understanding vaccines after all the latest info about the vaccines should make you feel ashamed or suicidal wouldn’t you think. ! But money matters and fuck the rest of us… dam you bastards
hello, what is the infection mechanism?
There are Receptors on the cell surface, which bind the spike protein. There might be other accessory Receptors and cleavage of the spike contributes to the infection.
The spike proteins bind to the ACE2 receptors present on human cells. This happens with astonishing efficiency.
Why is it so hard to find the SIZE of the molecule of this virus??
About 120 nm is the diameter of the virus
Does Any one know the size of the Virus in NM?
125 nm as judged by EM
Excuse, Can I use the your covid animation to my video? I will tag you in my description box or give a credit title in my video? Thank you😊
Thank you for your interest, but sorry, no you cannot. You are welcome to use our video for teaching and any other non commercial purpose without changing it.
Pretty cool video
Soothing music
thank you, corona is bad enough as it is. A bit of calming musc felt appropriate.
The cure for humanity....Beautiful..
Within 25 days we received more than 200 k views and many positive comments: thank you so much for your encouragement and interest!
Check also our second vid on potential therapies for COVID19: ua-cam.com/video/jw2OvPnx_lQ/v-deo.html
How do you make this videos?
@biolution .. don't know whether my idea is correct or not however just look into this about covid-19 vaccination . Coronavirus has outer wall with protein and it got mutated based on situation in this case can we encapsulate the entire Corona virus wall including protein to avoid replication of virus as well as secure our cells.
YOu are right in principle, but modern genetic engineering and molecular biology have many advanced tricks up their sleeve, which makes them claim they can generte a vaccine with 18_24 months!
So is soap and water sufficient in killing the virus or must we use hand sanitizer also after washing our hands? Also I know this virus is airborne, so will we all have to start wearing masks too?
Soap is sufficient to inactivate the virus. Look in our coronavirus playlist for an explanatory vid. If infected people wear simple masks, it prevents from spreading the virus in little droplets.
Just wondering... If thoose spikes are reason that virus can attach to human cell receptors can some medicine be used to destroy thoose spike proteins in virus so they cant attach anymore?
there are approaches aimed at this, antibodies from convalescent patients would most likely bind to spike proteins and prevent interaction. Another approach would be providing soluble receptor ACE2
@@biolution good to know. Thanks
Unbelievable animation quality😍😍
Thank you! But check out our second video, the virus is significantly improved ua-cam.com/video/jw2OvPnx_lQ/v-deo.html
I heard that some coronavirus strains cause the comman cold so why is this SARS-COV 2 strain more serious than its cold causing cousins?thanks in advance.
Also the other coronaviruses can cause severe respiratory tract infections, but it is much rarer. Somehow the SARS, MERS and SARS-CoV-2 appear to evade the immune system more eficiently. Their virulence may be to do with the receptor ACE2, which serves as a protease in angiotensin signaling. This appears to impede the response to the virus further. The more benign coronavirsues do not use ACE2.
Can i take this vidéo to talk about corona in french or arabic ?
Maybe you can make French and Arabic subtitles for us? For non-commercial uses we provide permission, as long as you use the vid without changes and acknowledge biolution as copyright holder.
@@biolution i would like to subtitle your videos , but how can i contact you ?
@@amelyagoub6062 We have opened up the community contributions for subtitles. You click below the video on the three ... and select add translations. We would be very grateful!
Arabic and french memes intensifies
Excellent!!
Danke schön.
Freut uns, wenn es gefällt!
What is the diameter of SARS COV 2?
Menia Virus.
They should call it that.
Coronavirus is about 125 nm as judged from electronmicrographs. Human hair ranges from 18 to 170 micrometer in diameter. A cell is about 10-15 micrometer diameter. So the diameter of the virus is 1000 times smaller than very thin human hair or 100 times smaller than a cell.
@@biolution ty
biolution and still can do damage to us .... can’t believe it
How are the spikes of SAR-Cov 2 different from SARS-Cov?
They are almost identical but the SARS-CoV-2 spike protein cleavage site comprises several arginines, making it an excellent substrate for many host proteases. Therefore TPMRSS2 is the presumed protease priming SARS-CoV-2, which is not implicated in SARS-CoV.
@@biolution where is the M membrane glycoprotein in this model
@@biolution Since this virus is arginine dependant for reproduction, wouldn't arginine starvation be an effective method of combating the virus in early stages?
*Now make a video featuring PRIONS*
thanks for your trust in our abilities. Good idea. We have a video online on Parkinsons, which is caused by aggregates of alpha-synuclein.
@@biolution :)
Y using proteases will not break down the protein membrane and denature it
some proteases are extremely specific and bind only in a certain way to cleave in precise position. Many of these proteaes are involved in processing signalling molecules (like ACE2 for angiotensin) and maturing proenzymes.
Zidovudine prevents corrona virus?
DNA heeft toch altijd een on\off switch.
Evolution - What Darwin Never Knew - NOVA Full Documentary HD
Good video
thank you!
It's time for the technology to do the rest
Help, we need
7 billion
devices to stop pandemics
Desired
Cost: Less than a penny a test
Time: 30 seconds a test
Location: Anywhere small machines, maybe cell phones
Conformation: Cross check machines
Upgrades over internet
Current
Time: 45 min
Cost: $32
Location: Lab
Conformation: complicated
The music is disturbing
THe virus also!
Please i need structure quimic of covid-19 can someone help me please
What?
@@biolution chemical composition of covid-19 please:(
@@biolution specific because i hav the translate, don't understand the video, i speak spanish, can help me please?
Is it circular ARN?
no!
How many electrons belongs to this virus? Thanks
too many to count!
The RNA of the virus is Negative or Positive?
positive-strand, meaning the genome can be translated right away and there is no need for its own replication machinery to be brought in from the vial particle.
How do masks work if viruses are so small?
First of all, viruses do travel in droplets, which are much bigger than individual viruses. Secondly the material of the masks is like a maze which provide adhesive surface, to which viruses can stick.
@@biolution but what about all the air and droplets that go out the sides, top and bottom of the mask?
reducing the risk by filtering out a percentage is still better than nothing, and when you breath in these droplets will be filtered out.
@@biolution but wouldn’t my glasses fogging up every time I wear a mask indicate that droplets are not being captured ?
humidity fogging up your glasses is due to individual water molecules, not droplets.
Studies report that there are people who have more ace2 "ECA" receptors in 1 cell phone than other people and that some drugs help to increase the amount of ace2 in cells, for more than 20 days I have been wondering why the virus has so much aggression against these people who have high blood pressure or make use of vessel dilators, most medicines are produced from snake venom. My question is this: could this medication be causing an excessive number of ACE2 receptors in the cells of these people, facilitating the uncontrolled multiplication of this virus. It is quite a coincidence that the Ace2 Receptor produces enzymes just to control blood pressure. I would very much like an infectious disease specialist to study the amount of ACE2 "ECA" in the cells of infected people or those who use drugs to control blood pressure. I thank you for the video and I await your response or from people who study this area. I'm brazilian.
Can a disease cure another disease
Bacteriophages work well against bacterial infections. But there is no virus to directly attack another virus, that has to be done with a retrovirus that infects a number of healthy cells, and then hijacks them to produce antibodies for the actual virus ravaging the body. I am not a virologist, so I might not be 100% right on this.
what’s the shape
Sars-Cov 2 really has HE protein? I dont think so.
sorry, you are right. The comments mention this error already!
I have understood nothing.
sorry to hear this! not even with the German subtitles?
@@biolution Well, I wanted to know how it works, incubation time, time of being sick, all known symptoms, maybe some simple to understand pics of how it behaves in the body and what it does there.
@@Marauder1981 sorry we could not meet your expectations. I like to check this @who www.who.int/health-topics/coronavirus
@@biolution it doesn't work with me
We are very happy that György Keserü used this video to present his research for the "Celebration of Hungarian Science" of the "Hungarian Academy of Sciences", an event which due to the corona pandemic was held online with a series of virtual presentations avaibale online: ua-cam.com/video/iz6z6KDcAC0/v-deo.html
Quran 2.26 Allah does not shy away from making an example of a mosquito and what is above it. As for those who believe, they know that it is the Truth from their Lord. But as for those who disbelieve, they say, "What did Allah intend by this example?" He leads astray many thereby, and He guides many thereby; but He misleads thereby only the evildoers.
ان الله لا يستحى ان يضرب مثلا ما بعوضة فما فوقها
فاما الذين أمنوا فيعلمون انه الحق من ربهم واما الذين كفروا فيقولون ماذا اراد الله بهذا مثلا
يضل به كثيرا ويهدى به كثيرا وما يصل به الا الفاسقين
Sorry, I don't get the connection to our vieo?
Is it bad that I want to bite into it?
löwenzahn bite ? It’s ugly it looks like crap 🤮🤮🤮
@@armeniancrusader301 No, it looks like a chocolate truffle.
Wow, you guys even know how it looks like, then why bothering doing a pcr test to identify it,
The pcr test is not fit for purpose the inventor said so himself . But i guess you being sarcastic . This is brainwashed echo-chamber by the looks of the comments
@ajith0306 Well, just knowing what it looks like (and this is just an artist's impression using the known protein structures of the surface proteins) will not help you to diagnose with a PCR test.
Viruses are so small, you need an electron microscope to see them.
A PCR test is fast and reliable.
@@biolution They never truly isolated the virus. The pictures are taken from cell cultures where you can see lots of cell debris. Telling which one is the virus is pure guessing.
Hijacks cellular machine, dude don't tell me it's trying to turn us into zombie like thing
Nope, it is just trying to replicate and spread. This is what it is built for. Killing is not its goal, an unfortunate collateral damage from its point of view.
@@biolution built for, you means someone built it?
@@kaisebastian1640 These intricate nanomachines self-assemble without any divine intervention.
@@kaisebastian1640 No. Scientists have already figured out it is not engineered. There's a whole article on the internet about it. Confirmed by multiple labs.
Corona virus is stronger than 3.2% ALC/vol beer but weaker than the good ol Tequila virus 😂 😝 nothing like a quarantine with out cuevo lololol
In spanish :/
Please generate the subtitles...
@@biolution biolution hello. I work in a Public radio and TV broadcasting service in Mexico. Is it possible for us to use this video across our platform? Most of our audience don't speak English so I was thinking on making the voice over narration in Spanish.
In case you are ok with that, I would appreciate the original script, that way with the help of our awesome scientist experts in here, we can make it with no errors.
Thanks in advance.
Here's the link to the channel of our station.
ua-cam.com/users/canal3morelos
Or search for IMRYT
@@dave2520 please contact us under STEFAN.GRUENERT(AT) biolution.net and we will provide you with a written permission, if you comply with certain conditions. Thanks for your interest.
It's such a grotesque looking thing
The effects of it are even more grotesque....
Could I ask if this virus reproduces by lytic/lysogenic cycles or does it reproduce by normally how influenza like virus behaves
Gpe
Most viruses of higher eukaryotes do not show a strict separation between lytic and lysogenic cycles, as they lack the capacity to incorporate into the host genome. SARS-CoV-2 has not been reported to integrate and therefore cannot follow a "lysogenic cycle".
@@biolution Thank you. I see. Regarding the current vaccines, I was concerned about how mRNA vaccines are able to be accepted into the cells without being degraded by ssRNA or miRNA complexes. Do you have any idea or thoughts on that? thanks
@@harinachiappansubramanian9206 rna vaccines are chemically modified to make them more stable in cells.
@@biolution I see. Thank you :)
Uuuuuhm SARS-CoV-2 does NOT have the hemagglutinin-esterase protein. Also, the M membrane glycoprotein is missing in this model. How dare you call this a cientifically accurate animation? :p
Sorry abou this error, you are absolutely right, the m-protein is mislabeled.
No this is not the structure of a cow bullet willow.
neither is it the structure of goat's cheese.
will my Windows Defender anti virus keep us safe?
Certainly stop corona from infecting your hardware, but how would this help you?
@@biolution lol...At least I won't get it from the 'net.
@@davidcraig9779 certainly no chance of contracting coronavirus from surfing sleazy sites... 😉
@@biolution ty, I'll test that...lol
We should call it by its real name
SARS cov 2
World called it covid19 to avoid people remembering the 2004 SARS
SARS-CoV-2 is the virus which causes the disease COVID-19 just like HIV causes the disease AIDS.
Im now a doctor but is this actually made by a bat soup?
The ebola was really different
Nope, there is still some uncertainty about Pengolins, but almost certainly tehre was an feline between the bats and humans.
Some people saying it man maid is it true?
nope, it jumped from a currently still not identified species (some favour Pangolins, but their is some doubts about this) from bats. check this explanation why this virus is so deadly: ua-cam.com/video/y5_g_pjf0eE/v-deo.html
What is the size of covid19's genome?
The Virus SARS-CoV-2 has almost 30,000 bases of RNA genome, COVID19 is the disease!
@@biolution from 1 person?
@@SubmissionArmwrestling don't get your question?
I look in my recommendation and all video is about coronavirus help me
then check our Phage vid: ua-cam.com/video/V73nEGXUeBY/v-deo.html ;)
@@biolution ok
Wow. These graphics are sexier than porno.
Glad you like them!
When SARS-CoV-3?
nobody knows. The virus might mutateor there could be another variant jumping in the future.