Method for titer determination for volumetric Karl Fischer titration on Metrohm® Instruments

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  • Опубліковано 21 сер 2024
  • This video shows how to determine the titer of a volumetric Karl Fischer Titrant using a Metrohm instrument.

КОМЕНТАРІ • 5

  • @gloryifeoma8410
    @gloryifeoma8410 Рік тому +1

    Thanks for the video.Please is Titre determination also the same as standardization?

    • @MerckLifeScience
      @MerckLifeScience  Рік тому

      Hi Glory - Yes, standardization is another expression for titer determination and mainly used in Pharmacopeias. It means we determine the exact concentration of a titrant and compensate influences from the equipment and environment. Please let us know if you have any other questions!

  • @yerayferrero
    @yerayferrero 3 місяці тому

    Is it mandatory to conduct a suitability test before measuring a sample for the first time?

  • @ashrafmohamed4614
    @ashrafmohamed4614 Рік тому

    what is the benefits for doing Drift determination ?

    • @MerckLifeScience
      @MerckLifeScience  Рік тому +1

      Hi Ashraf Mohamed - A stable drift for a correct water determination is absolutely necessary. What does this mean? A titration cell is never 100% tight, we always have traces of water entering the titration cell during a titration process.
      The drift is the amount of water which enters into the titration cell per minute. It is measured in µg/minute. The amount of water that enters here during a sample titration is subtracted from the result. To do this, the drift is determined and the titrator software automatically subtracts the portion in the sample results.
      It is recommended that the drift is below 25µg/minute for volumetric titration, for coulometric titration it should be below 15µg/minute. It's important that the drift is stable and does not go up and down when starting a sample titration.
      Please let us know if you have any other questions!