I think they need to standardized prerequisites for trials, stratified by nutritional status. Is this medicine useful for people who have an i sufficient diet? Is it useful for people whose blood test shows they don't have any deficiencies? EDIT: Seems obvious that the trials should be paid for by the companies that make the meds, but not conducted by them.
Good question: There are a few ways of working around this: 1) If the study provides data where you could calculate the confidence interval that's a good option (only takes a minute or so to plug into RevMan, Stata etc). E.g. if they provide means, SD, sample size or for dichotomous outcomes number of events and number of participants 2) If you don't have the above data - you could also look at sample size. Either informally by making a judgement based on the sample size or more formally by calculating an optimal information size. Hope this helps.
In an open label trial, the participants and the researchers know to which study arm participants are allocated. This relates to sections of the video on detection bias and blinding, and item 4 of the CASP checklist.
Depends on the type of intervention and comparator. For some interventions (e.g. service level interventions like assertive outreach) the nature of the healthcare system could make an important difference to outcomes so it would be good to note. Whereas if you were to look at other interventions (e.g. pharmacological interventions) where the study was conducted often may not be as important. Hope this helps.
I was lost, now I'm found thanks to you and this series.
A fantastic series of videos - very helpful! Thank you.
Really glad you found them helpful!
Really very helpful! Informative, educational, simply presented! Thank you!
Glad it was helpful. Thanks for the feedback.
Thank you so much!very helful
This is a treasure, thanks a lot for making this highly informative video, appreciate your time and efforts
Really glad you found it helpful. We always appreciate the feedback.
I think they need to standardized prerequisites for trials, stratified by nutritional status. Is this medicine useful for people who have an i sufficient diet? Is it useful for people whose blood test shows they don't have any deficiencies?
EDIT: Seems obvious that the trials should be paid for by the companies that make the meds, but not conducted by them.
The quizzes no longer work, it says you need to reactivate them
Does anybody know, if there is a new, working link for the quiz?
Very helpful, thank you
How can I answer question 8 if the article doesn’t show confidence intervals help
Good question:
There are a few ways of working around this:
1) If the study provides data where you could calculate the confidence interval that's a good option (only takes a minute or so to plug into RevMan, Stata etc). E.g. if they provide means, SD, sample size or for dichotomous outcomes number of events and number of participants
2) If you don't have the above data - you could also look at sample size. Either informally by making a judgement based on the sample size or more formally by calculating an optimal information size.
Hope this helps.
Thanks for this!! Just one question what if its an open labeled RCT?
In an open label trial, the participants and the researchers know to which study arm participants are allocated.
This relates to sections of the video on detection bias and blinding, and item 4 of the CASP checklist.
Thanks for the video super it's concise!!
Glad it was helpful. Thanks for the feedback.
Link for the series: ua-cam.com/play/PLKav5fAJIAOJark_WyTcOb_wKIwjNJ35s.html
really useful video, thanks
Glad it was helpful!
If one group is in USA and one in U.K. for question 6 could u point out that it may be not equal
Depends on the type of intervention and comparator. For some interventions (e.g. service level interventions like assertive outreach) the nature of the healthcare system could make an important difference to outcomes so it would be good to note. Whereas if you were to look at other interventions (e.g. pharmacological interventions) where the study was conducted often may not be as important. Hope this helps.
Nice video