A friend of mine suffered from this at the age of 35, it took about a year to get the diagnosis. You could always see he was in permanent pain and then they have him this treatment and it was like night and day - you could see him just relax. The difference was incredible.
@@austinpowers8550 I'm about your age and am 10 months into treatment with little result from what my rheumatologist said is the max oral dose prescribed for treatment of RA. I got growths or nodules on my wrists and hands that funking screw up my daily life. Can't make fists, can't open simple screw off lids, and the trigger locking of fingers is extremely, torturously, painful. I feel you man. people hear "arthritis" and instantly assume no big damn deal, as I likely would have myself, prior to actually being cursed with RA.
This video has hardly been out an hour and friends are already sending this to me. Thank you for explaining one of the drugs I take, it feels better to have a stronger understanding of what it is and does.
Very interesting video!! I had methotrexate therapy when I was 28 and again when I was 34 to help manage my autoimmune disease (granulomatosis with polyangiitis). I’m very grateful for the science that made this possible.
i just went to the doctor yesterday because of arthritis symptoms, swelling, crooked fingers, & weak joints. thank you so much for posting this, it really helps me understand the condition and not be so afraid.
My rheumatologist FINALLY convinced me to start this last year at 50 after decades of RA pain - I cannot believe the difference. When I was prescribed it, I had a few people and the pharmacist recommend that I not take it since it is deadly 😒....glad I didn't listen.
I just want to say thank you so much for these videos, I have ADD and it makes it really hard for me to concentrate on subjects like these, but somehow you've made it easy enough for me to understand. Thank you again, love this channel!
My partner was on Methotrexate, it nearly killed him. Our GP was quick to get him into hospital when his blood test results suddenly went haywire. Meds were changed and his rheumatoid arthritis is much worse now, but at least he’s still alive.
I’ve been for over 10 years on mtx for psoriatic arthritis. I stopped taking it because it gave me terrible side affects. I feel much better with changing my diet ie not eating nightshade veggies….
@@ozdreamtimewizard1329 I have PsA and am very interested in any dietary (or other tips) you might be willing to share. Am able to garden etc, active and then rest. Underweight, 63, dx’d at age 59. (stress? toxins? meds? life of insomnia? My diet was always healthy/active. Didn’t realize impacts of stressors . . . )
A relative of mine took methotrexate and wound up passing in their 50s from RA complications. It does not work for everyone. She was racked with pain and the RA effected her vital organs. It might work for mild arthritis for a while. She told me the methotrexate caused her to be very tired.
I was diagnosed with RA at the age of four and I started methotrexate at 6 up until 14. Although methotrexate helped me, the side effects were hell. I’m 26 now and it’s interesting to see and understand the science behind this drug that I used to take soo often. Although I don’t see myself ever going back on this drug, I love to see how much it has helped people because this condition is no joke. I wouldn’t wish an RA flare up on no one!
Good for you. I feel like a lot of the drugs prescribed to my relative had such bad side effects that they killed her. The dr was making her take prednisone until her face swelled like a chipmunk and it damaged her lungs giving her clots. She was underweight from all the drugs her bones and teeth deteriorated. The cure is worse than the disease.
@@studentaccount4354 oh no I’m so sorry to hear that. Yes I’m on prednisone right now and my Rheumatologist is trying to get me off it completely. Steroids are something that we really shouldn’t be on long term especially on high doses because it can do more harm then good. Do any other relatives have RA?
@@chriscruzA35O-9OO That chronic pain is really the worst. Waking up in pain and not even being able to get comfortable laying down sucks so much. I’m glad you’ve been able to find what works for you!
I use take ibuprofen a lot but it started mess with my kidneys i started visit my doc (awesome doctor)and he prescribed hydrocodone and now my kidneys are 100
I have Multiple Sclerosis, and have had several treatments of methotrexate infusions when I had relapses. I went through two years where I was getting methotrexate infusions (along with high dose steroid infusions) every 4-5 months when we were trying to get the relapses under control. I HATED the treatments, I always felts like death afterwards. For about a week after each treatment I had a low appetite, was very lethargic, I thought I smelled like death no matter how often I bathed, I couldn't concentrate, I was just basically no use to anyone, including myself, for the first few weeks after treatment. Then when I started feeling myself again it was time for another treatment. The dose used for RA must be much less than what I was subjected to, as I'm sure if RA patients had my experiences the use of methotrexate to treat it would be much lower.
Hi professor Dave, is it safe to handle cytotoxic tablets in a pharmacy setting? Is there any proof that coated or blistered cytotoxic tablets are safe to handle? Hope you can help me with clarity as obvious as the answer may be.
I never knew about this, seems to be hit or miss from the comments (like any drug can be) but its interesting to know about. My mom's relatives all suffer from arthritis and so does she. I also have had it in both of my wrists all my life (I'm 28 years old now) and it gets very painful sometimes
I am not suffering from rheumatoid arthritis, I currently suffer from reactive arthritis and the rheumatologist's diagnosis is that it might be early stages of either psoriatic arthritis or anylosing spondylitis. Therefore, he prescribed weekly injections of methotrexate for the next three months. Am I to accept that for the rest of my life I am dependent on methotrexate or?
My mom has RA as well as lupus, and her lupus has attacked her nerves in her spine. Throughout her life, she has developed herniated and fully ruptured disks and is now almost fully disabled and likely will not be able to walk in as little as two years. We are speaking to her doctor to see if this is an option.
This was an extremely useful video for us as my wife is currently on methotrexate -one tablet once a week, for a very rare skin rash, that did not respond to any other treatments. Many thanks for this explanation of the drug- it is a big help, and far better than the doctor's "Erm take this anti cancer drug for a year, it will cure you but you need blood tests every week and mri scans every six months !"
Do you have one of these over remicade maybe??? I have chrons and RA and while I’m on remicade they’ve been considering this methotrexate eventually so I’d love more information from a smart person on the biologic drugs and things
Some years ago, I lost my mother to Methotrexate. Due to an error in anamnesis at the beginning of what was planned to be a minor short-term stay in a renowned Austrian hospital, her weekly arthritis-stabilizing dose of MTX was given to her as daily dose. The OD led to effects like an uncontrolled chemotherapy (which it actually was); her bone-marrow was completely destroyed, her immune-system broke down, she had to be reanimated and for the remaining horrible months of her life she had to be tube-fed and most of the time artificially respirated. Even though I know, that her death was not the "fault" of this drug, but the consequence of medical malpractice, I was triggered by this praise of Methotrexate as an antiarthriticum beyond my limits...
Very good to know. I'm so sorry for your loss and all the trouble you were put through, I only wish you could have held those responsible, accountable. I have history with medical malpractice and it's a fucking disease on its own.
@@Chris-mt4yq Thank you. As a matter of fact, the hospital gave me the choice between a long court process with uncertain outcomes here and a spontaneous financial help which empowered me to bring my mother home for her last months with a professional 24h-nurse for all the medical supplies she needed there. You can imagine, what I chose in my mother's interest... Also, I just did not have the strength to fight in this situation...
So sorry for your loss and trauma! Malpractice is the worse. This med saved my husband who was on his third hip replacement in his early 20s and has a fused elbow, dramatically stopped his decaying bones. So for us it's a lifesaver instead but totally understand your PTSD (I have a lot of medical PTSD due to malpractice since I was hard to diagnose for decades and given pills that turned out to be opioids without my consent and knowledge - was hell to get off them but did!). But yes, you are absolutely supposed to take MTX only once a week and only continue if the side-effects aren't bad (like in my husband's case). Plus folic acid, no alcohol. He's more fit now at 51 than in his 20s.
I too am on this drug along with Folic acid. Before I was barely able to go to the shop around the corner. Now I'm back climbing mountains again. In taking this drug I was warned against drinking alcohol, and no more than 1 unit per week (UK). I'm assuming that this due to it's affect on the liver as mentioned in the piece, but would be interested to know if there's more to this.
I'm interested in knowing more about that too. It wasn't explained to me whether I need to be off of alcohol for 24 hours prior or off of alcohol for 24 hours following a dose, so I do both just to be safe. I'm still pretty worried about it though because my blood tests have been showing that I need to drink much more water.
@@kingspud1983 A unit of alcohol, in the UK at least is a tot of spirit abv 40%, half a glass of wine or a nip (third of a pint) of beer or cider per week. Remember some products can contain alcohol that are not thought of as drinks, such as other dedication.
I am a 31 year old RA patient. I have been taking methotraxate and folic acid for years now. I wish I found this explanation earlier as nobody explained how essential taking folic acid is.
I’ve had RA since I was 13. It’s amazing to actually learn about this stuff properly. At least I know now why it’s important to take my folic acid everyday. Love your work Dave!
@@musclemania30 I have in the past, but when I was much younger. I used to get a very upset stomach. I’m fine on it now. I’m also on a low dose and I have no problems with it.
@@alisontheanimal4009 took my first dose and it was actually only 15mg but my stomach didn’t like it one bit, after a while I was ok and if that’s all I have I’ll be ok.
My 3 y/o daughter will be starting on this after being diagnosed with poly-JIA, and I found this video gave me a lot of peace after initially worrying about such a young girl needing to be put on a drug potentially long-term; after watching the video and understanding the mechanism, I am much more at peace when thinking about the prognosis, her future, and the effectiveness. Thank you for this video!
I hope your daughter is doing well ❤. I was diagnosed with Poly JIA at 2yrs and am 31 now. I started methotrexate intentions at a young age. Stay strong momma!!
Thank you. I am on methotrexate as a kind of catch all because I can't get a diagnosis for various autoimmune conditions and can't afford to see a specialist. But it has improved my quality of life. I am so glad to get a proper explanation of how it works I couldn't make sense of it myself. If you have a moment could you tell me anything about the consequence of long term use? Thank You really Thank You
There're no consequences of long-term use, the benefits far outweigh any possible risks, of course within the right dose range of 15-30 mg per week with an addition of folic acid 15 mg 1 tabl. per week. Very safe drug generally, but still requires at least yearly checks (morphology, creatinine, ALT)
I take this drug. It took a long time to build up enough to begin feeling the therapeutic effects (approximately 6 to 8 weeks) but it has really helped a lot. Thank you for helping me understand this better. I'm going to review this with some of my science interested buddies to see if I can explore this a little further.
I have had RA for 22 years. Initially was diagnosed with lupus and found out in March of 2023 that I actually have rheumatoid arthritis…long story. My new doctor wants to take me off of hydroxychloroquine (which has never given me any issues) and put me on methotrexate. She gave me 90 days to decide. During that time, I decided to eliminate gluten, watch sugar, do intermittent fasting and increase my Vitamin D. I’m taking 4000 iu of Vitamin D plus I take a multivitamin which has 1000 iu. I noticed an immediate difference after increasing my vitamin D. My biggest complaint is having one or two stiff fingers when I wake up, and I refuse to take methotrexate for those symptoms.
I’m was diagnosed with RA in March 2023. I too am scared to take the methotrexate. Currently on the hydro one. Not sure it works but will try till the end of the year to see if any improvements. Right now every day is different but always pain somewhere in my body.
Sir, i have to learn electrostatic potential & capacitance, current electricity, moving charges and magnetism, alternating current and electromagnetic waves.... These are some of the chapters in NCERT physics book which is for STEM students in India.. Sir, i did try to find it in ur playlist but i couldn't find any so i suppose you haven't posted any of the topics of those chapters... I would really love to learn them from you but since my exams are on 28 march i can't wait for you to create it & then watch it (and i also dont even know if you are going to make videos on those topic or not) so i would really really appreciate it if you share me the channel of someone who has made videos on those topic plus who explained as well as you...
Thanks! That was a good video! We're grateful it is so well tolerated by my husband and keeps him healthy :) He's had RA since he was 2 years old and started MTX therapy in the late 90's. Previously, he was on gold injections as his DMARD. He'd already lost both hips and had replacements before he started MTX. No such degradation since. About the T-cells inhibition: specialists recommended holding off MTX for 2 weeks after getting his covid vaccines so it wouldn't interfere with the immune response.
My daughter was diagnosed with RA at 19, which made us realize she’d had it a lot younger from the symptoms of her past. She ended up doing a program dietarily and is not on any RA drugs. She follows a strict dietary guideline and stays in remission. If she goes off of it, the symptoms return. Its far better at this time, then to be on methotrexate, which the side effects can cause infertility and other problems or the body forming a resistance to methotrexate. Then, trying to switch to other methods, like expensive biologics that aren’t necessarily covered by insurance. Its probably one of the worst diagnoses next to cancer. Science finally caught up with understanding that there is a gut problem connected to the joint flare ups. But, they don’t know if the gut problem is part of the disease or the other way around. We know its genetic and the gene gets switched on. Once that happens, you have RA for the rest of your life. My hope is that developments with CRSPR could possibly suppress the expression of RA. That said, I’m not anti drug. If you have severe flare ups, the joint damage is irreversible. If you need the drugs to knock that inflammation out of the ball park, then don’t hesitate to do so.
Hi, I was recently diagnosed in the ER, still haven't seen a specialist but considering going the anti inflammatory route. Can you share your daughters diet ? I was sadly put on this drug after an ectopic pregnancy and I did not love how it made me feel. It appears to be the most common drug. I want to prepare myself before my first rehumatoid appointment. It would be sincerely appreciated.
@@florita846 Google Clint Paddison. He explains what to eat and when. It takes about 4 months of eating a certain way and learning how to do it at the same time. A big learning curve and emotional roller coaster to make such drastic changes in one’s life that seem so inconvenient. But, the pain is far more inconvenient than the dietary changes.
Thank you for posting this. I've just been prescribed it for RA/AS and severe eye inflammation which has caused about 90% loss of vision in 1 eye. Apparently it is great for Uveitis and related issues so we're starting me on this then will be adding infusion therapy too (Once cleared with insurance so ..... could be awhile). Love to everyone suffering and needing this kind of medication. Never give up hope.
@@VrindaNewLife I've just changed my regimt (This week) so now I am on Methotrexate and instead of Remicade I have moved over to Humira shots every 2 weeks. Since I have been on Methotrexate I have had no noticeable eye inflammation/Uveitis. I have very severe eye problems (Multiple eye diseases such as RP, also Glaucoma and a whole lot of other things) but since being on the Methotrexate + Remicade I have had no ocular inflammation. I have been told the Methotrexate alone can really reduce it BUT if your Uveitis is related to hla-b27 (Which it turns out mine was) then adding something like Remicade/Humira can be a big help too. I switched to Humira as I can do the injection at home instead of going in for the infusions every 8 weeks (And it's a whole lot cheaper).
Prof. Dave, this is all easy for you to say but I got lost shortly into the video. Regardless this is good information for patients suffering RA and trying to talk to their Dr. about treatment.
Thank you for this I have been struggling with RA for 15 years and never considered this drug even though its been the go to drug at the beginning. I am on biologicals and they don't help only steroids for now I hope to get some relief.
Weird, here in Canada they always start non-biologicals first, then go on to the next until they find the right one for you. It's a matter of cost but also side-effects. My husband has been on metha for decades and it went very well for him so he never needed upgrading. Definitely talk to your specialists if you aren't getting proper relief, you never know if a simpler or different type of RA medicine would work or not. There was nothing in the 70s for kids (my husband was 2 when it happened) and after so many painful treatments, finally that worked and he's had a huge slow down of his bone decaying since.
Hey, Dave! Do you have a video on the subject of how a human's perception of color works? I, for example, find it odd that there are nodes in the eyeball designated for shorter waves that are responsible for seeing blue, but you'll only see specific shades of blue depending on which type of colorblindness you have (and that tritanopia allows cyan, despite it being a mix of green and blue).
@@ProfessorDaveExplains I did watch it in full, but from what I recall, it does not tell me about how being colorblind works. Thanks for the video regardless!
5:46....Dave, you should point out that there is only ONE functional group difference between the two molecules !! Maybe just highlight the amine group to show judt how similar.
Just found out I have RA. I thought it was an eye infection but it was the white of my left eye having redness and inflammation. Thus also explained my hand and shoulder pain too.
I have Ankylosing Spondylitis, and have been prescribed this med twice in the 5 years since diagnosis. Each time I've refused it. Everyone says it has helped them, but the side effects were rough. Thankfully I had a grace period of 2 years with a biologic, which eventually stopped being effective. I lost health insurance after those 2 years and have been mostly on Sulfsalazine and occasional NSAID. Methotrexate scares me, but I do appreciate the explanation of how it works in this video, but still dont want it.😊
As someone who suffers from RA. I am on Methotrexate, the Folic acid supplement and Prednisone. Before I was on these drugs, I was in Chronic pain and barely able to move let alone do anything like, Work, Walk, Cook, Clean etc etc. Just 3 days after I started treatment I was able to live a full life again. These drugs are a "miracle" (If there is such things) and it made my love and confidence in proper scientific medicine so much deeper and profound.
Hi Professor Dave. I have a request that you may find interesting or not, it’s a mathematical one. I have always found it hard to understand “Inter-universal Teichmüller theory”, “The Collatz Conjecture”, and “The Birch and Swinnerton-Dyer Conjecture”. If you would make a video on one of these topics that would really help 😊 I’m studying a Master’s in mathematics in Denmark. I’m sorry for my English, I’m not mothertongue in English. Btw, I love your content.
@@jaisere Wow, thanks! I really appreciate that. I do try to keep up my language skills, even though I’m studying something completely opposite to that.
For anyone who is about to go on mtx or even currently on it: I was diagnosed with RA I think at 22, and it was so bad I could not walk or even hold a tissue. I’ve been self injecting MTX once a week for years now and straight up forget that i even have arthritis. I highly suggest injecting it over taking it orally. Some will tolerate it but for me it made me borderline suicidal. I passed out the first times I took the injection, I hate needles, but trust me when I say the injection will save your life. Highly highly recommend. Always listen to your own body & take frequent blood tests tho, everyone responds differently to different drugs. Also try other less harmful drugs first if your dr suggests it, and definitely take folic acid as well. Also no binge drinking! I felt extremely hopeless with my RA but self injecting mtx is only a few $ a month (it is a generic drug, if it costs too much or has a name they’re likely charging you extra for the packaging, no joke) and can be extremely worth it. I’m not a dr! Always listen to your dr first.
10 years ago, at the age of 17 I started getting reactive arthritis symptoms. I've been pursuing help through the NHS the entire time. Unfortunately, I've only just started to get the help I've always needed 10 years later, with my condition becoming chronic. I tested positive for hlab27 and subsequently suffer with psoratic arthritis, psoriosis etc. I'm picking up my pescription for methotrexate today. Hopefully it helps with most of my immune system issues, but I will keep this comment updated if anyone requests it. If you're going through anything similar and see this weeks, months or years down the line, drop a comment so I get a notifcation and I'll let you know how it is going.
@@bahawbahawtv Well I took it for 11 weeks, only recently stopped. It's hard to say if it helps as I took it during the warmest months of the year when I typically have less symptoms anyway. But I had to stop as it was just causing me to feel horrible. No energy, toilet situation wasn't great, and the mouth ulcers are painful. I got ulcers on the back of my throat, something I'd never had before.
Take my word for it....if you get put on Methotrexate, don't take Folic Acid! Instead, take 5-Methylfolate, the active form of Folate. If I had know this, I wouldn't have had to retire, at age 53, due to extreme metabolic dysfunction. Also, 5-Methylfolate will allow the Folate Cycle to be active in relation to the Methionine cycle but since Methotrexate affects DHFR and DHFR is also part of the Biopterin Cycle, be cognizant for the potential of Dopamine regulation problems leading to anxiety. Learn your genetics and how to hack your neurotransmitters.
Happy womens month. As women have more chances at auto immune, its very amazing to see drugs woman are taking explained. My gma took methotrexate for RA for most of my life. She took gold pills of some sort before methotrexate became an option for her.
My Dermatologist prescribed me this for erythroderma. This drug has essentially saved my life. Anyone who has had to take prednisolone for autoimmune issues understands how much this drug protects from the adverse effects of more short term treatment options.
I was diagnosed with RA.the pain in my hands is debilitating. I was on Humira,got covid Humira stopped working. Ins wanted a $400 co pay for Simpony.started methotrexate havent had pain so far no side effect
And….then you end up with neutropenia, as it wipes out your neutrophils. At least warn people of these adverse effects so they can make informed decisions
Methotrexate gave me back my mobility, but it almost killed me, by causing internal bleeding, and a stroke. 'Thanks', god! Fortunately, other meds came to the rescue. Once more, medical science defeats god's evil plans :) .
A friend of mine suffered from this at the age of 35, it took about a year to get the diagnosis. You could always see he was in permanent pain and then they have him this treatment and it was like night and day - you could see him just relax. The difference was incredible.
I'm 35 and dealing with it now. My left hand is barely functional. Every knuckle and joint started getting growths on it.
@@austinpowers8550 Sorry to hear that, the condition is no joke. I hope you respond just as positively to treatment as my friend did. Best wishes.
I’m 27 with RA and I’m better than before taking methotrexate
@@austinpowers8550 how are you feeling now?
@@austinpowers8550 I'm about your age and am 10 months into treatment with little result from what my rheumatologist said is the max oral dose prescribed for treatment of RA. I got growths or nodules on my wrists and hands that funking screw up my daily life. Can't make fists, can't open simple screw off lids, and the trigger locking of fingers is extremely, torturously, painful.
I feel you man. people hear "arthritis" and instantly assume no big damn deal, as I likely would have myself, prior to actually being cursed with RA.
Having this at 24 really sucks… praying for all of yall to feel better.
Sorry to hear. I'm 40. Recently diagnosed
I'm 20 with lupus, not very fun. Probably gonna be on mtx tomorrow
Bro me too at 24 suffering from this
This video has hardly been out an hour and friends are already sending this to me. Thank you for explaining one of the drugs I take, it feels better to have a stronger understanding of what it is and does.
As a nurse this makes for an amazing review and helps me daily to care for my patients. Thanks professor Dave
Very interesting video!! I had methotrexate therapy when I was 28 and again when I was 34 to help manage my autoimmune disease (granulomatosis with polyangiitis). I’m very grateful for the science that made this possible.
i just went to the doctor yesterday because of arthritis symptoms, swelling, crooked fingers, & weak joints. thank you so much for posting this, it really helps me understand the condition and not be so afraid.
Are you ok right now after taking mtxpg
My rheumatologist FINALLY convinced me to start this last year at 50 after decades of RA pain - I cannot believe the difference. When I was prescribed it, I had a few people and the pharmacist recommend that I not take it since it is deadly 😒....glad I didn't listen.
I just want to say thank you so much for these videos, I have ADD and it makes it really hard for me to concentrate on subjects like these, but somehow you've made it easy enough for me to understand. Thank you again, love this channel!
I have ADHD and arthritis. Do you have arthritis?
My partner was on Methotrexate, it nearly killed him. Our GP was quick to get him into hospital when his blood test results suddenly went haywire. Meds were changed and his rheumatoid arthritis is much worse now, but at least he’s still alive.
I’ve been for over 10 years on mtx for psoriatic arthritis. I stopped taking it because it gave me terrible side affects. I feel much better with changing my diet ie not eating nightshade veggies….
@@ozdreamtimewizard1329 I have PsA and am very interested in any dietary (or other tips) you might be willing to share.
Am able to garden etc, active and then rest. Underweight, 63, dx’d at age 59. (stress? toxins? meds? life of insomnia? My diet was always healthy/active. Didn’t realize impacts of stressors . . . )
Excellent explanation - I will pass on to some of my patients!
A relative of mine took methotrexate and wound up passing in their 50s from RA complications. It does not work for everyone. She was racked with pain and the RA effected her vital organs. It might work for mild arthritis for a while. She told me the methotrexate caused her to be very tired.
Dear Professor Dave, I appreciate your content, immensely. Very accurate. Very precise. Very enjoyable.
Thank you; this was so well done.
I was diagnosed with RA at the age of four and I started methotrexate at 6 up until 14. Although methotrexate helped me, the side effects were hell. I’m 26 now and it’s interesting to see and understand the science behind this drug that I used to take soo often. Although I don’t see myself ever going back on this drug, I love to see how much it has helped people because this condition is no joke. I wouldn’t wish an RA flare up on no one!
Good for you. I feel like a lot of the drugs prescribed to my relative had such bad side effects that they killed her. The dr was making her take prednisone until her face swelled like a chipmunk and it damaged her lungs giving her clots. She was underweight from all the drugs her bones and teeth deteriorated. The cure is worse than the disease.
I was in constant chronic pain I’m 27 and methotrexate allopurinol help me a lot the change is bug
@@studentaccount4354 oh no I’m so sorry to hear that. Yes I’m on prednisone right now and my Rheumatologist is trying to get me off it completely. Steroids are something that we really shouldn’t be on long term especially on high doses because it can do more harm then good. Do any other relatives have RA?
@@chriscruzA35O-9OO That chronic pain is really the worst. Waking up in pain and not even being able to get comfortable laying down sucks so much. I’m glad you’ve been able to find what works for you!
I use take ibuprofen a lot but it started mess with my kidneys i started visit my doc (awesome doctor)and he prescribed hydrocodone and now my kidneys are 100
im going to use this playlist to help me in pharamcy tech training
Thanks Dave I will ask my Doc about this when I see her tomorrow
I have Multiple Sclerosis, and have had several treatments of methotrexate infusions when I had relapses. I went through two years where I was getting methotrexate infusions (along with high dose steroid infusions) every 4-5 months when we were trying to get the relapses under control. I HATED the treatments, I always felts like death afterwards. For about a week after each treatment I had a low appetite, was very lethargic, I thought I smelled like death no matter how often I bathed, I couldn't concentrate, I was just basically no use to anyone, including myself, for the first few weeks after treatment. Then when I started feeling myself again it was time for another treatment. The dose used for RA must be much less than what I was subjected to, as I'm sure if RA patients had my experiences the use of methotrexate to treat it would be much lower.
Hi professor Dave, is it safe to handle cytotoxic tablets in a pharmacy setting? Is there any proof that coated or blistered cytotoxic tablets are safe to handle? Hope you can help me with clarity as obvious as the answer may be.
I never knew about this, seems to be hit or miss from the comments (like any drug can be) but its interesting to know about. My mom's relatives all suffer from arthritis and so does she. I also have had it in both of my wrists all my life (I'm 28 years old now) and it gets very painful sometimes
Hi and thanks for this info. Do you know if Meto is safe to use With HBOT, which is a powerful tool against inflammation.
I am not suffering from rheumatoid arthritis, I currently suffer from reactive arthritis and the rheumatologist's diagnosis is that it might be early stages of either psoriatic arthritis or anylosing spondylitis. Therefore, he prescribed weekly injections of methotrexate for the next three months. Am I to accept that for the rest of my life I am dependent on methotrexate or?
My mom has RA as well as lupus, and her lupus has attacked her nerves in her spine. Throughout her life, she has developed herniated and fully ruptured disks and is now almost fully disabled and likely will not be able to walk in as little as two years.
We are speaking to her doctor to see if this is an option.
I'm currently on Methotrexate and have to do weekly injections for my autoimmunity (systemic sclerosis). Love the content Professor Dave!
Is your Mtx working for you? Hope so! (dose? folate too? anything else?)
I love your videos and you are a good teacher! (from HK student)
This was an extremely useful video for us as my wife is currently on methotrexate -one tablet once a week, for a very rare skin rash, that did not respond to any other treatments. Many thanks for this explanation of the drug- it is a big help, and far better than the doctor's "Erm take this anti cancer drug for a year, it will cure you but you need blood tests every week and mri scans every six months !"
Do you have one of these over remicade maybe??? I have chrons and RA and while I’m on remicade they’ve been considering this methotrexate eventually so I’d love more information from a smart person on the biologic drugs and things
Some years ago, I lost my mother to Methotrexate. Due to an error in anamnesis at the beginning of what was planned to be a minor short-term stay in a renowned Austrian hospital, her weekly arthritis-stabilizing dose of MTX was given to her as daily dose. The OD led to effects like an uncontrolled chemotherapy (which it actually was); her bone-marrow was completely destroyed, her immune-system broke down, she had to be reanimated and for the remaining horrible months of her life she had to be tube-fed and most of the time artificially respirated. Even though I know, that her death was not the "fault" of this drug, but the consequence of medical malpractice, I was triggered by this praise of Methotrexate as an antiarthriticum beyond my limits...
Very good to know. I'm so sorry for your loss and all the trouble you were put through, I only wish you could have held those responsible, accountable. I have history with medical malpractice and it's a fucking disease on its own.
I'm sorry for your loss
@@Chris-mt4yq Thank you. As a matter of fact, the hospital gave me the choice between a long court process with uncertain outcomes here and a spontaneous financial help which empowered me to bring my mother home for her last months with a professional 24h-nurse for all the medical supplies she needed there. You can imagine, what I chose in my mother's interest... Also, I just did not have the strength to fight in this situation...
@@SangheiliSpecOp Thank you!
So sorry for your loss and trauma! Malpractice is the worse. This med saved my husband who was on his third hip replacement in his early 20s and has a fused elbow, dramatically stopped his decaying bones. So for us it's a lifesaver instead but totally understand your PTSD (I have a lot of medical PTSD due to malpractice since I was hard to diagnose for decades and given pills that turned out to be opioids without my consent and knowledge - was hell to get off them but did!). But yes, you are absolutely supposed to take MTX only once a week and only continue if the side-effects aren't bad (like in my husband's case). Plus folic acid, no alcohol. He's more fit now at 51 than in his 20s.
Thank you so much!!
Thanks for this! Any vids on Psoriatic Arthritis - which seems to yield extreme vascular damage - fast.
I too am on this drug along with Folic acid. Before I was barely able to go to the shop around the corner. Now I'm back climbing mountains again. In taking this drug I was warned against drinking alcohol, and no more than 1 unit per week (UK). I'm assuming that this due to it's affect on the liver as mentioned in the piece, but would be interested to know if there's more to this.
I'm interested in knowing more about that too. It wasn't explained to me whether I need to be off of alcohol for 24 hours prior or off of alcohol for 24 hours following a dose, so I do both just to be safe.
I'm still pretty worried about it though because my blood tests have been showing that I need to drink much more water.
@@kingspud1983 A unit of alcohol, in the UK at least is a tot of spirit abv 40%, half a glass of wine or a nip (third of a pint) of beer or cider per week. Remember some products can contain alcohol that are not thought of as drinks, such as other dedication.
Tony, how bad was your arthritis?
I am a 31 year old RA patient. I have been taking methotraxate and folic acid for years now. I wish I found this explanation earlier as nobody explained how essential taking folic acid is.
I’ve had RA since I was 13. It’s amazing to actually learn about this stuff properly. At least I know now why it’s important to take my folic acid everyday. Love your work Dave!
Do you take medication 💊?
@@NIYA-7 yes, on top of methotrexate I take several other medications, everything from disease modifiers to anti inflammatories.
@@alisontheanimal4009 I’m starting methotrexate today, do you suffer from any side effects and if so what are they? I’m only taking 25mg/week
@@musclemania30 I have in the past, but when I was much younger. I used to get a very upset stomach. I’m fine on it now. I’m also on a low dose and I have no problems with it.
@@alisontheanimal4009 took my first dose and it was actually only 15mg but my stomach didn’t like it one bit, after a while I was ok and if that’s all I have I’ll be ok.
Does it weaken my immune system?
Feaver and other decease caught rapidly.
My 3 y/o daughter will be starting on this after being diagnosed with poly-JIA, and I found this video gave me a lot of peace after initially worrying about such a young girl needing to be put on a drug potentially long-term; after watching the video and understanding the mechanism, I am much more at peace when thinking about the prognosis, her future, and the effectiveness. Thank you for this video!
How is your daughter doing?
@@charlie_crem235 Hi there, thank you so much for asking
I hope your daughter is doing well ❤. I was diagnosed with Poly JIA at 2yrs and am 31 now. I started methotrexate intentions at a young age. Stay strong momma!!
Thank you. I am on methotrexate as a kind of catch all because I can't get a diagnosis for various autoimmune conditions and can't afford to see a specialist. But it has improved my quality of life. I am so glad to get a proper explanation of how it works I couldn't make sense of it myself. If you have a moment could you tell me anything about the consequence of long term use? Thank You really Thank You
There're no consequences of long-term use, the benefits far outweigh any possible risks, of course within the right dose range of 15-30 mg per week with an addition of folic acid 15 mg 1 tabl. per week. Very safe drug generally, but still requires at least yearly checks (morphology, creatinine, ALT)
@@wojciechchmiel2443 Thank You!
I take this drug. It took a long time to build up enough to begin feeling the therapeutic effects (approximately 6 to 8 weeks) but it has really helped a lot.
Thank you for helping me understand this better. I'm going to review this with some of my science interested buddies to see if I can explore this a little further.
Are you still on it? What was your weekly dose? Did you have RA.
I have had RA for 22 years. Initially was diagnosed with lupus and found out in March of 2023 that I actually have rheumatoid arthritis…long story. My new doctor wants to take me off of hydroxychloroquine (which has never given me any issues) and put me on methotrexate. She gave me 90 days to decide. During that time, I decided to eliminate gluten, watch sugar, do intermittent fasting and increase my Vitamin D. I’m taking 4000 iu of Vitamin D plus I take a multivitamin which has 1000 iu. I noticed an immediate difference after increasing my vitamin D. My biggest complaint is having one or two stiff fingers when I wake up, and I refuse to take methotrexate for those symptoms.
U havent taken any meds yet? Im scared of methotrexate side effects
I’m was diagnosed with RA in March 2023. I too am scared to take the methotrexate. Currently on the hydro one. Not sure it works but will try till the end of the year to see if any improvements. Right now every day is different but always pain somewhere in my body.
Are you taking any medicine please reply
@@VrindaNewLife yes, I’m still taking 200 mg of hydroxychloroquine daily.
@@GS-uc9yl thankyou so much for reply your eye sight is ok now?
Someone please tell me is it okay to take methotrexate or is it harmful in the long run
Sir, i have to learn electrostatic potential & capacitance, current electricity, moving charges and magnetism, alternating current and electromagnetic waves.... These are some of the chapters in NCERT physics book which is for STEM students in India.. Sir, i did try to find it in ur playlist but i couldn't find any so i suppose you haven't posted any of the topics of those chapters... I would really love to learn them from you but since my exams are on 28 march i can't wait for you to create it & then watch it (and i also dont even know if you are going to make videos on those topic or not) so i would really really appreciate it if you share me the channel of someone who has made videos on those topic plus who explained as well as you...
Thanks! That was a good video! We're grateful it is so well tolerated by my husband and keeps him healthy :) He's had RA since he was 2 years old and started MTX therapy in the late 90's. Previously, he was on gold injections as his DMARD. He'd already lost both hips and had replacements before he started MTX. No such degradation since. About the T-cells inhibition: specialists recommended holding off MTX for 2 weeks after getting his covid vaccines so it wouldn't interfere with the immune response.
I'm sorry for your recent loss.
My daughter was diagnosed with RA at 19, which made us realize she’d had it a lot younger from the symptoms of her past. She ended up doing a program dietarily and is not on any RA drugs. She follows a strict dietary guideline and stays in remission. If she goes off of it, the symptoms return.
Its far better at this time, then to be on methotrexate, which the side effects can cause infertility and other problems or the body forming a resistance to methotrexate. Then, trying to switch to other methods, like expensive biologics that aren’t necessarily covered by insurance. Its probably one of the worst diagnoses next to cancer.
Science finally caught up with understanding that there is a gut problem connected to the joint flare ups. But, they don’t know if the gut problem is part of the disease or the other way around. We know its genetic and the gene gets switched on. Once that happens, you have RA for the rest of your life. My hope is that developments with CRSPR could possibly suppress the expression of RA. That said, I’m not anti drug.
If you have severe flare ups, the joint damage is irreversible. If you need the drugs to knock that inflammation out of the ball park, then don’t hesitate to do so.
Hi, I was recently diagnosed in the ER, still haven't seen a specialist but considering going the anti inflammatory route. Can you share your daughters diet ? I was sadly put on this drug after an ectopic pregnancy and I did not love how it made me feel. It appears to be the most common drug. I want to prepare myself before my first rehumatoid appointment. It would be sincerely appreciated.
Who created the diet plan for her?
@@BP-wv2xqDr. Brook Goldner Goodbye autoimmune
I would appreciate very much if u can share the diet of your daughter.ive been on.methotrexate for 10 yrs due to RA.
@@florita846 Google Clint Paddison. He explains what to eat and when. It takes about 4 months of eating a certain way and learning how to do it at the same time. A big learning curve and emotional roller coaster to make such drastic changes in one’s life that seem so inconvenient. But, the pain is far more inconvenient than the dietary changes.
It's cool (and kind of scary in a way) how by a chance something works very well with something we did not predict.
And it's not the first. There's a certain heart drug that had similar beneficial effects as well.
Thank you for posting this. I've just been prescribed it for RA/AS and severe eye inflammation which has caused about 90% loss of vision in 1 eye. Apparently it is great for Uveitis and related issues so we're starting me on this then will be adding infusion therapy too (Once cleared with insurance so ..... could be awhile). Love to everyone suffering and needing this kind of medication. Never give up hope.
Hope you are doing well please reply regarding your uveitis ....is there any improvement ?
@@VrindaNewLife I've just changed my regimt (This week) so now I am on Methotrexate and instead of Remicade I have moved over to Humira shots every 2 weeks. Since I have been on Methotrexate I have had no noticeable eye inflammation/Uveitis. I have very severe eye problems (Multiple eye diseases such as RP, also Glaucoma and a whole lot of other things) but since being on the Methotrexate + Remicade I have had no ocular inflammation. I have been told the Methotrexate alone can really reduce it BUT if your Uveitis is related to hla-b27 (Which it turns out mine was) then adding something like Remicade/Humira can be a big help too. I switched to Humira as I can do the injection at home instead of going in for the infusions every 8 weeks (And it's a whole lot cheaper).
Prof. Dave, this is all easy for you to say but I got lost shortly into the video. Regardless this is good information for patients suffering RA and trying to talk to their Dr. about treatment.
hey Dave, is there graphene in the covid vaccines? and is it toxic? i don't remember if you addressed these questions in your videos on vaccine.
There is no graphene in vaccines. That's just something stupid someone made up.
Thank you for this I have been struggling with RA for 15 years and never considered this drug even though its been the go to drug at the beginning. I am on biologicals and they don't help only steroids for now I hope to get some relief.
Weird, here in Canada they always start non-biologicals first, then go on to the next until they find the right one for you. It's a matter of cost but also side-effects. My husband has been on metha for decades and it went very well for him so he never needed upgrading. Definitely talk to your specialists if you aren't getting proper relief, you never know if a simpler or different type of RA medicine would work or not. There was nothing in the 70s for kids (my husband was 2 when it happened) and after so many painful treatments, finally that worked and he's had a huge slow down of his bone decaying since.
Hey, Dave! Do you have a video on the subject of how a human's perception of color works? I, for example, find it odd that there are nodes in the eyeball designated for shorter waves that are responsible for seeing blue, but you'll only see specific shades of blue depending on which type of colorblindness you have (and that tritanopia allows cyan, despite it being a mix of green and blue).
Check my tutorial on visual processing in the biopsychology playlist!
@@ProfessorDaveExplains I did watch it in full, but from what I recall, it does not tell me about how being colorblind works. Thanks for the video regardless!
5:46....Dave, you should point out that there is only ONE functional group difference between the two molecules !! Maybe just highlight the amine group to show judt how similar.
Just found out I have RA. I thought it was an eye infection but it was the white of my left eye having redness and inflammation. Thus also explained my hand and shoulder pain too.
Wait I have eye inflammation whenever I have RA flare up but doctors don’t connect the 2 even after me mentioning it so many times.
My daughter was in agony and on ketamine and fentanyl and still crying until we started treatment for ra and now on no opioids
I have Ankylosing Spondylitis, and have been prescribed this med twice in the 5 years since diagnosis. Each time I've refused it. Everyone says it has helped them, but the side effects were rough.
Thankfully I had a grace period of 2 years with a biologic, which eventually stopped being effective.
I lost health insurance after those 2 years and have been mostly on Sulfsalazine and occasional NSAID.
Methotrexate scares me, but I do appreciate the explanation of how it works in this video, but still dont want it.😊
This guy is good!
As someone who suffers from RA. I am on Methotrexate, the Folic acid supplement and Prednisone.
Before I was on these drugs, I was in Chronic pain and barely able to move let alone do anything like, Work, Walk, Cook, Clean etc etc.
Just 3 days after I started treatment I was able to live a full life again. These drugs are a "miracle" (If there is such things) and it made my love and confidence in proper scientific medicine so much deeper and profound.
Nice to know ^_^
@@prla5400 - Why is that nice for you to know? I am curious.
@@shannonjhanlen i assume they just meant its nice to know it worked so well for you.
Did you adjust your diet at all?
@@eugeniebreida1583 - what on Earth for? Diet has nothing to do with Auto immune diseases.
Hi Professor Dave.
I have a request that you may find interesting or not, it’s a mathematical one. I have always found it hard to understand “Inter-universal Teichmüller theory”, “The Collatz Conjecture”, and “The Birch and Swinnerton-Dyer Conjecture”. If you would make a video on one of these topics that would really help 😊
I’m studying a Master’s in mathematics in Denmark. I’m sorry for my English, I’m not mothertongue in English.
Btw, I love your content.
Your english is better than most native speakers!
@@jaisere Wow, thanks! I really appreciate that.
I do try to keep up my language skills, even though I’m studying something completely opposite to that.
great intro
I anticipated DHFR, because I had to study methotrexate with folate metabolism as a method for selection of production clones.
THERE IT IS :D
*wait my fingers are a little bit like that but I don't have any pain or issues*
Go see a doctor
Some men just want to watch the world learn
For anyone who is about to go on mtx or even currently on it:
I was diagnosed with RA I think at 22, and it was so bad I could not walk or even hold a tissue. I’ve been self injecting MTX once a week for years now and straight up forget that i even have arthritis. I highly suggest injecting it over taking it orally. Some will tolerate it but for me it made me borderline suicidal. I passed out the first times I took the injection, I hate needles, but trust me when I say the injection will save your life. Highly highly recommend. Always listen to your own body & take frequent blood tests tho, everyone responds differently to different drugs. Also try other less harmful drugs first if your dr suggests it, and definitely take folic acid as well. Also no binge drinking!
I felt extremely hopeless with my RA but self injecting mtx is only a few $ a month (it is a generic drug, if it costs too much or has a name they’re likely charging you extra for the packaging, no joke) and can be extremely worth it. I’m not a dr! Always listen to your dr first.
Glad it’s working, may I ask your age today? (years on MTX?)
Someone I know took methotrexate and died in her 50s. She got the fibrosis and it killed her.
👍
That shit is nasty. Lots of side effects for me.....
10 years ago, at the age of 17 I started getting reactive arthritis symptoms. I've been pursuing help through the NHS the entire time. Unfortunately, I've only just started to get the help I've always needed 10 years later, with my condition becoming chronic. I tested positive for hlab27 and subsequently suffer with psoratic arthritis, psoriosis etc. I'm picking up my pescription for methotrexate today. Hopefully it helps with most of my immune system issues, but I will keep this comment updated if anyone requests it. If you're going through anything similar and see this weeks, months or years down the line, drop a comment so I get a notifcation and I'll let you know how it is going.
Does mtx helps u? How r you now?
@@bahawbahawtv Well I took it for 11 weeks, only recently stopped. It's hard to say if it helps as I took it during the warmest months of the year when I typically have less symptoms anyway. But I had to stop as it was just causing me to feel horrible. No energy, toilet situation wasn't great, and the mouth ulcers are painful. I got ulcers on the back of my throat, something I'd never had before.
hi
Take my word for it....if you get put on Methotrexate, don't take Folic Acid! Instead, take 5-Methylfolate, the active form of Folate. If I had know this, I wouldn't have had to retire, at age 53, due to extreme metabolic dysfunction. Also, 5-Methylfolate will allow the Folate Cycle to be active in relation to the Methionine cycle but since Methotrexate affects DHFR and DHFR is also part of the Biopterin Cycle, be cognizant for the potential of Dopamine regulation problems leading to anxiety. Learn your genetics and how to hack your neurotransmitters.
I put this drug away on the shelf today in my pharmacy lol
Pouvez-vous expliquer encore plus svp?
Happy womens month.
As women have more chances at auto immune, its very amazing to see drugs woman are taking explained.
My gma took methotrexate for RA for most of my life. She took gold pills of some sort before methotrexate became an option for her.
My Dermatologist prescribed me this for erythroderma. This drug has essentially saved my life. Anyone who has had to take prednisolone for autoimmune issues understands how much this drug protects from the adverse effects of more short term treatment options.
More pharm, dude.
おはようございます
Gazoontite
Intro for 5 year olds content for uni students XD
I was diagnosed with RA.the pain in my hands is debilitating. I was on Humira,got covid Humira stopped working. Ins wanted a $400 co pay for Simpony.started methotrexate havent had pain so far no side effect
And….then you end up with neutropenia, as it wipes out your neutrophils. At least warn people of these adverse effects so they can make informed decisions
Is it any good for covid? Asking for a friend......an idiot friend.
Methotrexate gave me back my mobility, but it almost killed me, by causing internal bleeding, and a stroke.
'Thanks', god!
Fortunately, other meds came to the rescue.
Once more, medical science defeats god's evil plans :) .