New AVP-D Diagnostic Testing

We recently learned of a new article on copeptin-based diagnostic tests (Hypertonic Saline vs. Arginine), published in the New England Journal of Medicine by Julie Refardt, M.D., Ph.D., and Cihan Atila, M.D., Ph.D. of Basal University in Switzerland.
This study and its findings present an important step in improving the diagnostic challenges in AVP-D (central diabetes insipidus). 10% of patients with AVP-D (DI) are diagnosed with histiocytosis. LCH, ECD, and RDD are the diagnoses that are seen with AVP-D (DI).
We were thrilled to spend a few minutes with Cihan Atila, M.D., Ph.D. to learn more about the study findings and its importance to improving the diagnosis of AVP-D (DI). histio.org/his...

[@brandicash7877]

Have you ever seen a person with congenital DI? Where the mother developed gestational DI and the child was born with the disorder?

[@Histiocytosis]

Hi Brandi, we have not heard of any cases like that. We actually brought your question to Dr. Atila, the physician in this video, and he said if it happens/happened "Either this is pure coincidence, or I could imagine the following: The mother could have a very mild congenital/hereditary form of DI/AVP-D. Pregnancy could then lead to an increased degradation of vasopressin by the placenta, and symptoms would then appear for the first time during pregnancy and “resolve” after pregnancy. We sometimes see this in very mild forms" He added that he would suggest a genetic test to the mother.
Hope that helps answer your question!